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The map label for this gene is lysR [H]

Identifier: 77461512

GI number: 77461512

Start: 5954329

End: 5955240

Strand: Direct

Name: lysR [H]

Synonym: Pfl01_5291

Alternate gene names: 77461512

Gene position: 5954329-5955240 (Clockwise)

Preceding gene: 77461509

Following gene: 77461514

Centisome position: 92.48

GC content: 66.01

Gene sequence:

>912_bases
ATGCGCCTTCGTCATATCGAGATTTTCCAGGCCATTCGCCAGACGGGCTCGGTCAGCGCCGCTGCGCAGTTGCTGCACGT
CTCGCAACCGGCGGTGACCAAGGTGCTGCAGCACGCCGAGCAGCAGCTGGGCTTTCCGTTGTTTCTGCGGGTGCGCGGCA
AGTTGCAGGCGACCCCGGAAGCGCTGGAACTGGAGCGCGAAGTCGATAAGGTCACCGAAAGCCTGCAAGGCGTGCGGCGT
CTGGCCCAGAGCCTGCGCCGCGCACCCGGTCACAGCCTGCGGATCGGCGCGACCCCGGCGCTGGCGCTGTCGTTGCTGCC
GCCGGCGATCCAGCAGTGGACAGCGCAGTTCCCGGACATCGCCTGCGAACTGTCGAGCGCCCACAGCCGCGAGCTGATGC
AGAACCTGCTGATGCGCGAAGTGGACGTGGCCCTGACGTTACAGTTGCCGGATCATCCTGGGCTGAAGGCCCAGGCATTG
GCCTCGGGGGTTCTGGTGGCATTGGCGCCGAGAGGTTATTGGCCGGAGGAAGATGCCGGTCAGCCGTTGCCGCTGATGGC
GTTGGCCGGGGCGCCGCTGATCGGGCTGTCCAGTGCCGATCCGCTGGCCGCCCGCCTCGATAGTTATCTTGAAGCGGTCG
AACCGCCGCCGCGTGTGCGGATTGCCGTGCAGACGTATTCGCTGGCGCGGGCGATGGTGGAATCCGGAGCTGGCGTGGCG
GTAATCGATCCGTTCACCGCGCTGGGTGCCTCATCGGCCACCACCTCTATCCGCCCTCTCGCCCCGCCGCTACCGATCAC
GCTGTACGCCGTGACCCGCGCCACTGAACCTTTGCCGCACACCCTGAATGATTTGCTGCAGATCTTCAGTCAGCGAGCCC
GGGAACAACTCGACCGACTGATGCGCCCTTAA

Upstream 100 bases:

>100_bases
TTAATCGTTCTTGAAGATGAGGCCGAGGTTAGGGTGAGGTGACAGGCGCCGAACAATGAATAAAGATGCCAGACCTATAA
ACAAAGGTTATGGAATCGTC

Downstream 100 bases:

>100_bases
AGGACATAAAACAGAATCGCCACAAAGTGCAGCAAGCTTCCGGCGATCACGAATAGATGCCAGATCCCGTGGGCATGCCG
CAACCGATGGTCGAGGGCAA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MRLRHIEIFQAIRQTGSVSAAAQLLHVSQPAVTKVLQHAEQQLGFPLFLRVRGKLQATPEALELEREVDKVTESLQGVRR
LAQSLRRAPGHSLRIGATPALALSLLPPAIQQWTAQFPDIACELSSAHSRELMQNLLMREVDVALTLQLPDHPGLKAQAL
ASGVLVALAPRGYWPEEDAGQPLPLMALAGAPLIGLSSADPLAARLDSYLEAVEPPPRVRIAVQTYSLARAMVESGAGVA
VIDPFTALGASSATTSIRPLAPPLPITLYAVTRATEPLPHTLNDLLQIFSQRAREQLDRLMRP

Sequences:

>Translated_303_residues
MRLRHIEIFQAIRQTGSVSAAAQLLHVSQPAVTKVLQHAEQQLGFPLFLRVRGKLQATPEALELEREVDKVTESLQGVRR
LAQSLRRAPGHSLRIGATPALALSLLPPAIQQWTAQFPDIACELSSAHSRELMQNLLMREVDVALTLQLPDHPGLKAQAL
ASGVLVALAPRGYWPEEDAGQPLPLMALAGAPLIGLSSADPLAARLDSYLEAVEPPPRVRIAVQTYSLARAMVESGAGVA
VIDPFTALGASSATTSIRPLAPPLPITLYAVTRATEPLPHTLNDLLQIFSQRAREQLDRLMRP
>Mature_303_residues
MRLRHIEIFQAIRQTGSVSAAAQLLHVSQPAVTKVLQHAEQQLGFPLFLRVRGKLQATPEALELEREVDKVTESLQGVRR
LAQSLRRAPGHSLRIGATPALALSLLPPAIQQWTAQFPDIACELSSAHSRELMQNLLMREVDVALTLQLPDHPGLKAQAL
ASGVLVALAPRGYWPEEDAGQPLPLMALAGAPLIGLSSADPLAARLDSYLEAVEPPPRVRIAVQTYSLARAMVESGAGVA
VIDPFTALGASSATTSIRPLAPPLPITLYAVTRATEPLPHTLNDLLQIFSQRAREQLDRLMRP

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=309, Percent_Identity=31.7152103559871, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI157672245, Length=229, Percent_Identity=29.6943231441048, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87081904, Length=208, Percent_Identity=28.8461538461538, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1787806, Length=242, Percent_Identity=21.900826446281, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788481, Length=157, Percent_Identity=29.2993630573248, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1786401, Length=242, Percent_Identity=24.7933884297521, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1790262, Length=159, Percent_Identity=27.6729559748428, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32768; Mature: 32768

Theoretical pI: Translated: 8.51; Mature: 8.51

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLRHIEIFQAIRQTGSVSAAAQLLHVSQPAVTKVLQHAEQQLGFPLFLRVRGKLQATPE
CCCHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCHH
ALELEREVDKVTESLQGVRRLAQSLRRAPGHSLRIGATPALALSLLPPAIQQWTAQFPDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCHHHHHHHHHCCHH
ACELSSAHSRELMQNLLMREVDVALTLQLPDHPGLKAQALASGVLVALAPRGYWPEEDAG
HHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCHHHHHHCCCEEEEECCCCCCCCCCC
QPLPLMALAGAPLIGLSSADPLAARLDSYLEAVEPPPRVRIAVQTYSLARAMVESGAGVA
CCCCHHHHCCCCEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHCCCCEE
VIDPFTALGASSATTSIRPLAPPLPITLYAVTRATEPLPHTLNDLLQIFSQRAREQLDRL
EECCHHHHCCCCCCCCCCCCCCCCCEEEEEEHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
MRP
CCC
>Mature Secondary Structure
MRLRHIEIFQAIRQTGSVSAAAQLLHVSQPAVTKVLQHAEQQLGFPLFLRVRGKLQATPE
CCCHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCHH
ALELEREVDKVTESLQGVRRLAQSLRRAPGHSLRIGATPALALSLLPPAIQQWTAQFPDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCHHHHHHHHHCCHH
ACELSSAHSRELMQNLLMREVDVALTLQLPDHPGLKAQALASGVLVALAPRGYWPEEDAG
HHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCHHHHHHCCCEEEEECCCCCCCCCCC
QPLPLMALAGAPLIGLSSADPLAARLDSYLEAVEPPPRVRIAVQTYSLARAMVESGAGVA
CCCCHHHHCCCCEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHCCCCEE
VIDPFTALGASSATTSIRPLAPPLPITLYAVTRATEPLPHTLNDLLQIFSQRAREQLDRL
EECCHHHHCCCCCCCCCCCCCCCCCEEEEEEHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
MRP
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]