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The map label for this gene is creC [H]

Identifier: 77461416

GI number: 77461416

Start: 5843720

End: 5845138

Strand: Reverse

Name: creC [H]

Synonym: Pfl01_5195

Alternate gene names: 77461416

Gene position: 5845138-5843720 (Counterclockwise)

Preceding gene: 77461417

Following gene: 77461414

Centisome position: 90.79

GC content: 62.51

Gene sequence:

>1419_bases
ATGACGCTGGGGCTGCGAATTTTCCTGGTGTACGTGCTGTTCATCGGCCTGACCGGGTATTTCGTGCTCAACACGGTGAT
GGAAGAAATCCGCCCGGGCGTGCGCCAGTCCACCGAAGAAACCCTGGTCGACACCGCCAACCTGATGGCAGAAATCTTGC
GGGACGATTTCAAGGCCGGCACCCTCAACCAGAATCGCTGGCCGCAGCTGCTTCGCGCCTATGGCGAACGCCAGCCGAAG
GCGACGATCTGGGGCCTGGCAAAAAACCAGGTCAACCACCGGATCTACGTTACCGACGCCAAGGGCATCGTGGTGCTGGA
CTCCAGCGGTGTTGCGGTCGGTCAGGACTACTCGCGCTGGAACGACGTCTACCTGACCCTGCGCGGTGAATACGGCGCAC
GTTCCAGCCGCAGTGACCCGAATGATCCGAATTCTTCAGTGATGCACGTCGGCGCGCCGATCCGCGACAACGGCGCGATC
ATCGGCGTGGTCACGGTCGCCAAACCCAACAGTTCACTGCAACCCTATGTCGATCGCACCGAGCGCCGCTTGCTCGGTTA
CGGCGCCGGATTGATCGTCCTCGGCCTGCTGCTCGGCGCCGTGCTGTCGTGGTGGCTGAGCCGCGCGCTGCACCGCTTGA
CCGTTTACGCCCAGGCCGTGAGCGAAGGCCGTCGGGTGGCGGTGCCGCACTATCGCGGCGGCGAGCTGGAGCAGTTGGCG
ACCGCCGTCGAGCAGATGCGCACCCAGCTCGAAGGCAAGGCCTACGTCGAGCGCTATGTGCACACGTTGACTCACGAATT
GAAGAGCCCGCTGGCCGCCATTCGTGGTGCCGCCGAGTTGTTGCAGGACGAGATGTCGGCGGATCAGCGATTGCGTTTTG
TCGGCAACATCGACAGTGAAAGTGCCCGGATGCAACAGTTGATCGAGCGCCTGCTCGATCTGGCTCAGGTGGAGCAGCGT
CAGGGTCTTGAAGAGCGCGTCGCCGTGCCGCTCGTGGCGCTGGTCGATGAAGTCTTGCAGGCACAGACCGCACGGATTGC
AGGGCGGCAATTGAGAATCGAACGGGCCATCCCCGCCGATCTGGCGTTGCTCGGCGAGCCGTTTCTGCTGCGCCAGGCCT
TGGGCAATCTGCTGGAAAACGCGCTGGACTTCACGCCACCCAAGGGCTTGTTGCGATTTGATGCCGAGCGGGTTGGCGAG
GAGATTGTGTTTTGTCTGTTCAACGAGGCCGCGGCCATTCCCGATTACGCGCTGACGCGTCTGACCGAGCGCTTTTACTC
ATTGCCGCGTCCTGACAGCGGGCGCAAAAGCACAGGGCTTGGGCTGAATTTCGTTGAGGAAGTGGTCAAGTTGCACGGTG
GTTCTCTGCGCATCGAGAACCTCGCAGGCGGCGTGCAGGTGCAGGTGCACCTGCCGTGA

Upstream 100 bases:

>100_bases
TCAAAAGCGTGCGCGCCAAATTGCGTCTCGTACGCGCCGAGGCCGAGCCGATCCAGACCCATCGCGGCCTCGGCTACAGC
TACAGTCCGGGGAATAGCTG

Downstream 100 bases:

>100_bases
CCCGCCCGGCAGAACGTCGCCCGCTCAGGACGGTGTTGCGGCCTCGTTGAGTCGAGCCTTGTTTCGGCGATGCGCCCATT
GCAGCGCCGGTCGCTCGACC

Product: sensory histidine kinase CreC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MTLGLRIFLVYVLFIGLTGYFVLNTVMEEIRPGVRQSTEETLVDTANLMAEILRDDFKAGTLNQNRWPQLLRAYGERQPK
ATIWGLAKNQVNHRIYVTDAKGIVVLDSSGVAVGQDYSRWNDVYLTLRGEYGARSSRSDPNDPNSSVMHVGAPIRDNGAI
IGVVTVAKPNSSLQPYVDRTERRLLGYGAGLIVLGLLLGAVLSWWLSRALHRLTVYAQAVSEGRRVAVPHYRGGELEQLA
TAVEQMRTQLEGKAYVERYVHTLTHELKSPLAAIRGAAELLQDEMSADQRLRFVGNIDSESARMQQLIERLLDLAQVEQR
QGLEERVAVPLVALVDEVLQAQTARIAGRQLRIERAIPADLALLGEPFLLRQALGNLLENALDFTPPKGLLRFDAERVGE
EIVFCLFNEAAAIPDYALTRLTERFYSLPRPDSGRKSTGLGLNFVEEVVKLHGGSLRIENLAGGVQVQVHLP

Sequences:

>Translated_472_residues
MTLGLRIFLVYVLFIGLTGYFVLNTVMEEIRPGVRQSTEETLVDTANLMAEILRDDFKAGTLNQNRWPQLLRAYGERQPK
ATIWGLAKNQVNHRIYVTDAKGIVVLDSSGVAVGQDYSRWNDVYLTLRGEYGARSSRSDPNDPNSSVMHVGAPIRDNGAI
IGVVTVAKPNSSLQPYVDRTERRLLGYGAGLIVLGLLLGAVLSWWLSRALHRLTVYAQAVSEGRRVAVPHYRGGELEQLA
TAVEQMRTQLEGKAYVERYVHTLTHELKSPLAAIRGAAELLQDEMSADQRLRFVGNIDSESARMQQLIERLLDLAQVEQR
QGLEERVAVPLVALVDEVLQAQTARIAGRQLRIERAIPADLALLGEPFLLRQALGNLLENALDFTPPKGLLRFDAERVGE
EIVFCLFNEAAAIPDYALTRLTERFYSLPRPDSGRKSTGLGLNFVEEVVKLHGGSLRIENLAGGVQVQVHLP
>Mature_471_residues
TLGLRIFLVYVLFIGLTGYFVLNTVMEEIRPGVRQSTEETLVDTANLMAEILRDDFKAGTLNQNRWPQLLRAYGERQPKA
TIWGLAKNQVNHRIYVTDAKGIVVLDSSGVAVGQDYSRWNDVYLTLRGEYGARSSRSDPNDPNSSVMHVGAPIRDNGAII
GVVTVAKPNSSLQPYVDRTERRLLGYGAGLIVLGLLLGAVLSWWLSRALHRLTVYAQAVSEGRRVAVPHYRGGELEQLAT
AVEQMRTQLEGKAYVERYVHTLTHELKSPLAAIRGAAELLQDEMSADQRLRFVGNIDSESARMQQLIERLLDLAQVEQRQ
GLEERVAVPLVALVDEVLQAQTARIAGRQLRIERAIPADLALLGEPFLLRQALGNLLENALDFTPPKGLLRFDAERVGEE
IVFCLFNEAAAIPDYALTRLTERFYSLPRPDSGRKSTGLGLNFVEEVVKLHGGSLRIENLAGGVQVQVHLP

Specific function: Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790861, Length=472, Percent_Identity=45.9745762711864, Blast_Score=416, Evalue=1e-117,
Organism=Escherichia coli, GI1788393, Length=248, Percent_Identity=28.2258064516129, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1786600, Length=237, Percent_Identity=29.957805907173, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI87082128, Length=221, Percent_Identity=28.9592760180996, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1786783, Length=243, Percent_Identity=27.1604938271605, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI145693157, Length=246, Percent_Identity=27.6422764227642, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI87081816, Length=231, Percent_Identity=27.7056277056277, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1790346, Length=247, Percent_Identity=26.7206477732794, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI48994928, Length=225, Percent_Identity=23.5555555555556, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52391; Mature: 52260

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLGLRIFLVYVLFIGLTGYFVLNTVMEEIRPGVRQSTEETLVDTANLMAEILRDDFKAG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHCCCC
TLNQNRWPQLLRAYGERQPKATIWGLAKNQVNHRIYVTDAKGIVVLDSSGVAVGQDYSRW
CCCCCHHHHHHHHHCCCCCCHHEEHHHHHCCCCEEEEEECCCEEEECCCCCEECCCHHCC
NDVYLTLRGEYGARSSRSDPNDPNSSVMHVGAPIRDNGAIIGVVTVAKPNSSLQPYVDRT
CCEEEEEECCCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEEEECCCCCCCHHHHHH
ERRLLGYGAGLIVLGLLLGAVLSWWLSRALHRLTVYAQAVSEGRRVAVPHYRGGELEQLA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHH
TAVEQMRTQLEGKAYVERYVHTLTHELKSPLAAIRGAAELLQDEMSADQRLRFVGNIDSE
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCH
SARMQQLIERLLDLAQVEQRQGLEERVAVPLVALVDEVLQAQTARIAGRQLRIERAIPAD
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHCCCHH
LALLGEPFLLRQALGNLLENALDFTPPKGLLRFDAERVGEEIVFCLFNEAAAIPDYALTR
HHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LTERFYSLPRPDSGRKSTGLGLNFVEEVVKLHGGSLRIENLAGGVQVQVHLP
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCEEEEEECC
>Mature Secondary Structure 
TLGLRIFLVYVLFIGLTGYFVLNTVMEEIRPGVRQSTEETLVDTANLMAEILRDDFKAG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHCCCC
TLNQNRWPQLLRAYGERQPKATIWGLAKNQVNHRIYVTDAKGIVVLDSSGVAVGQDYSRW
CCCCCHHHHHHHHHCCCCCCHHEEHHHHHCCCCEEEEEECCCEEEECCCCCEECCCHHCC
NDVYLTLRGEYGARSSRSDPNDPNSSVMHVGAPIRDNGAIIGVVTVAKPNSSLQPYVDRT
CCEEEEEECCCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEEEECCCCCCCHHHHHH
ERRLLGYGAGLIVLGLLLGAVLSWWLSRALHRLTVYAQAVSEGRRVAVPHYRGGELEQLA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHH
TAVEQMRTQLEGKAYVERYVHTLTHELKSPLAAIRGAAELLQDEMSADQRLRFVGNIDSE
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCH
SARMQQLIERLLDLAQVEQRQGLEERVAVPLVALVDEVLQAQTARIAGRQLRIERAIPAD
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHCCCHH
LALLGEPFLLRQALGNLLENALDFTPPKGLLRFDAERVGEEIVFCLFNEAAAIPDYALTR
HHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LTERFYSLPRPDSGRKSTGLGLNFVEEVVKLHGGSLRIENLAGGVQVQVHLP
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3531171; 7610040; 9278503; 2835585; 2228961 [H]