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The map label for this gene is ndk [H]

Identifier: 77460826

GI number: 77460826

Start: 5206726

End: 5207151

Strand: Reverse

Name: ndk [H]

Synonym: Pfl01_4605

Alternate gene names: 77460826

Gene position: 5207151-5206726 (Counterclockwise)

Preceding gene: 77460827

Following gene: 77460825

Centisome position: 80.88

GC content: 55.16

Gene sequence:

>426_bases
ATGGCTGTTCAACGTACTTTCTCCATCATCAAGCCTGACGCCGTTGCTAAAAACGTGATCGGCAAGATCACCACTCGCTT
CGAAGACGCTGGCCTGCGCGTTGTAGCTTCGAAACTGAAGCAACTGTCGAAAGCCGAAGCCGAAGGCTTCTACGCTGAGC
ACAGCGCTCGTGGTTTCTTCGGCGAATTGGTTGCCTTCATGACTTCGGGTCCTGTTGTCGTTCAGGTTCTGGAAGGCGAA
AACGCCATCGCTCGCAACCGTGAGCTGATGGGCGCTACCAACCCTAAAGAAGCTGCTCCAGGCACCATCCGTGCTGACTT
CGCTGAATCGATCGACGCCAACGCCGTTCACGGTTCGGACTCCGAAGCCGCTGCTGCTCGCGAAATCGCTTACTTCTTCG
CAGCTACTGAAGTAACCACTCGCTAA

Upstream 100 bases:

>100_bases
GAATTGGACTGATCGTCCTCGCAGGTTAGGCAATACCCAAGAACCCGCGTATAATTCGCGGGTTTAATTTTTCGCAAATT
ACCGTTTCTGGAGTTACACC

Downstream 100 bases:

>100_bases
GCATTGGCTTAAGAGTGAAGGTGAATCCATGACGACATCGACTGTTAAAAACAACCTGCTGGGTCTGACCCAGCCGGAAA
TGGAAAAATTCTTCGACTCA

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 141; Mature: 140

Protein sequence:

>141_residues
MAVQRTFSIIKPDAVAKNVIGKITTRFEDAGLRVVASKLKQLSKAEAEGFYAEHSARGFFGELVAFMTSGPVVVQVLEGE
NAIARNRELMGATNPKEAAPGTIRADFAESIDANAVHGSDSEAAAAREIAYFFAATEVTTR

Sequences:

>Translated_141_residues
MAVQRTFSIIKPDAVAKNVIGKITTRFEDAGLRVVASKLKQLSKAEAEGFYAEHSARGFFGELVAFMTSGPVVVQVLEGE
NAIARNRELMGATNPKEAAPGTIRADFAESIDANAVHGSDSEAAAAREIAYFFAATEVTTR
>Mature_140_residues
AVQRTFSIIKPDAVAKNVIGKITTRFEDAGLRVVASKLKQLSKAEAEGFYAEHSARGFFGELVAFMTSGPVVVQVLEGEN
AIARNRELMGATNPKEAAPGTIRADFAESIDANAVHGSDSEAAAAREIAYFFAATEVTTR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=139, Percent_Identity=46.7625899280576, Blast_Score=132, Evalue=1e-31,
Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=42.3357664233577, Blast_Score=124, Evalue=3e-29,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=42.3357664233577, Blast_Score=124, Evalue=3e-29,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=42.3357664233577, Blast_Score=124, Evalue=3e-29,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=42.3357664233577, Blast_Score=124, Evalue=3e-29,
Organism=Homo sapiens, GI66392203, Length=137, Percent_Identity=42.3357664233577, Blast_Score=124, Evalue=4e-29,
Organism=Homo sapiens, GI38045913, Length=137, Percent_Identity=42.3357664233577, Blast_Score=122, Evalue=1e-28,
Organism=Homo sapiens, GI4557797, Length=137, Percent_Identity=42.3357664233577, Blast_Score=122, Evalue=1e-28,
Organism=Homo sapiens, GI4826862, Length=137, Percent_Identity=37.956204379562, Blast_Score=110, Evalue=4e-25,
Organism=Homo sapiens, GI37574614, Length=141, Percent_Identity=36.8794326241135, Blast_Score=93, Evalue=7e-20,
Organism=Homo sapiens, GI7019465, Length=141, Percent_Identity=36.8794326241135, Blast_Score=93, Evalue=8e-20,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=38.2352941176471, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI4505413, Length=136, Percent_Identity=38.2352941176471, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI30023828, Length=143, Percent_Identity=31.4685314685315, Blast_Score=78, Evalue=2e-15,
Organism=Homo sapiens, GI148839372, Length=130, Percent_Identity=33.8461538461538, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1788866, Length=141, Percent_Identity=61.7021276595745, Blast_Score=182, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI17506807, Length=136, Percent_Identity=44.1176470588235, Blast_Score=125, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6322783, Length=135, Percent_Identity=42.962962962963, Blast_Score=126, Evalue=1e-30,
Organism=Drosophila melanogaster, GI45549037, Length=137, Percent_Identity=46.7153284671533, Blast_Score=135, Evalue=6e-33,
Organism=Drosophila melanogaster, GI18860097, Length=131, Percent_Identity=35.1145038167939, Blast_Score=82, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15036; Mature: 14905

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVQRTFSIIKPDAVAKNVIGKITTRFEDAGLRVVASKLKQLSKAEAEGFYAEHSARGFF
CCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHCCCHHH
GELVAFMTSGPVVVQVLEGENAIARNRELMGATNPKEAAPGTIRADFAESIDANAVHGSD
HHHHHHHCCCCEEEEEECCCCHHHHCCHHCCCCCCCCCCCCCEEHHHHHCCCCCCCCCCC
SEAAAAREIAYFFAATEVTTR
CHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AVQRTFSIIKPDAVAKNVIGKITTRFEDAGLRVVASKLKQLSKAEAEGFYAEHSARGFF
CCCHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHCCCHHH
GELVAFMTSGPVVVQVLEGENAIARNRELMGATNPKEAAPGTIRADFAESIDANAVHGSD
HHHHHHHCCCCEEEEEECCCCHHHHCCHHCCCCCCCCCCCCCEEHHHHHCCCCCCCCCCC
SEAAAAREIAYFFAATEVTTR
CHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA