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The map label for this gene is gcvT [H]

Identifier: 77460615

GI number: 77460615

Start: 4955823

End: 4956947

Strand: Direct

Name: gcvT [H]

Synonym: Pfl01_4394

Alternate gene names: 77460615

Gene position: 4955823-4956947 (Clockwise)

Preceding gene: 77460614

Following gene: 77460616

Centisome position: 76.97

GC content: 62.67

Gene sequence:

>1125_bases
ATGTCCACCGAACAACTGTCGAAAACCCCGCTGCACGCTCTGCACCTCGAACTCGGCGCCCGCATGGTGCCGTTCGCCGG
CTACGACATGCCGGTGCAATACCCGCTGGGCGTGATGAAAGAACACCAGCACACCCGTGAGCAGGCCGGGCTGTTCGATG
TCTCGCACATGGGCCAGATCCGCCTGACCGGCGCCAATGCCGCCAAAGCCCTGGAAACCCTGGTGCCGGTGGACATCATC
GATCTGCCGGTGGGCATGCAGCGCTACGCGATGTTCACCAACGAAACCGGCGGTATTCTCGATGACCTGATGGTCGCCAA
TCTCGGCAACGACGAGCTGTTCCTGGTGGTCAACGCCGCGTGCAAGGACCAGGATCTGGCCCATCTGCAAAAACACATCG
GCGACCAGTGCAAGATCGAGCAACTGTTCGAAGAACGCGCCCTGCTCGCCCTGCAAGGCCCCGCCGCCGTGACCGTGCTG
GCACGCCTGGCACCGGAAGTGGCGAAAATGACTTTCATGCAATTCACTCGCGTGAAGCTGCTGGGCGTTGACTGCTTTGT
CAGCCGTTCGGGCTACACCGGTGAAGACGGTTTCGAAATCTCGGTTCCGGCAGTCGACGCGGAAAAACTCGCCCGCGCCC
TGCTGGCCGAACCGGAAGTCGCCGCCATCGGCCTCGGCGCCCGTGACTCGCTGCGCCTGGAAGCCGGCCTGTGCCTGTAC
GGCCACGACATGAACACCGAGACCACCCCGATCGAAGCCAGCCTGCTGTGGGCAATCTCCAAACCTCGGCGTGCCGATGG
TGCGCGCGCCGGTGGTTTCCCGGGTGCGGAGCAAGTCTTCGCTCAACAGCAAAACGGCGTGTCGCGCAAACGCGTCGGCC
TGCTGCCGCAAGAGCGTACGCCGGTCCGAGAAGGTGCAGAGATCGTCAACGAAGCGGGCGAGATCATCGGCAGCGTGTGC
AGTGGCGGTTTCGGCCCGACCCTGGGTGGCCCGTTGGCCATGGGTTACCTGGACAGCGCCTACGTCGCACTCGATACGCC
AGTCTGGGCGATTGTCCGTGGGAAAAAGGTGCCATTGCTTGTAAGCAAAATGCCATTTGTTCCACAACGCTACTATCGCG
GTTGA

Upstream 100 bases:

>100_bases
GTGCTGATCGCGCCATAAACTCGCTCTCCCTTTGGGAGAGAACACAAAACTGGCCCCCTCTCCCTCCGGGAGAGGGTTGG
TGTGAATCAAGGAGTCACGC

Downstream 100 bases:

>100_bases
TTGACTGTTTCTATAAGTAACGCGATTGCGTTATGCGTGCACTAATGTGTAACGCAATCGCCATAAAACAGTGCACTCTG
TTTACATTCGATTCGAATAT

Product: glycine cleavage system T protein

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MSTEQLSKTPLHALHLELGARMVPFAGYDMPVQYPLGVMKEHQHTREQAGLFDVSHMGQIRLTGANAAKALETLVPVDII
DLPVGMQRYAMFTNETGGILDDLMVANLGNDELFLVVNAACKDQDLAHLQKHIGDQCKIEQLFEERALLALQGPAAVTVL
ARLAPEVAKMTFMQFTRVKLLGVDCFVSRSGYTGEDGFEISVPAVDAEKLARALLAEPEVAAIGLGARDSLRLEAGLCLY
GHDMNTETTPIEASLLWAISKPRRADGARAGGFPGAEQVFAQQQNGVSRKRVGLLPQERTPVREGAEIVNEAGEIIGSVC
SGGFGPTLGGPLAMGYLDSAYVALDTPVWAIVRGKKVPLLVSKMPFVPQRYYRG

Sequences:

>Translated_374_residues
MSTEQLSKTPLHALHLELGARMVPFAGYDMPVQYPLGVMKEHQHTREQAGLFDVSHMGQIRLTGANAAKALETLVPVDII
DLPVGMQRYAMFTNETGGILDDLMVANLGNDELFLVVNAACKDQDLAHLQKHIGDQCKIEQLFEERALLALQGPAAVTVL
ARLAPEVAKMTFMQFTRVKLLGVDCFVSRSGYTGEDGFEISVPAVDAEKLARALLAEPEVAAIGLGARDSLRLEAGLCLY
GHDMNTETTPIEASLLWAISKPRRADGARAGGFPGAEQVFAQQQNGVSRKRVGLLPQERTPVREGAEIVNEAGEIIGSVC
SGGFGPTLGGPLAMGYLDSAYVALDTPVWAIVRGKKVPLLVSKMPFVPQRYYRG
>Mature_373_residues
STEQLSKTPLHALHLELGARMVPFAGYDMPVQYPLGVMKEHQHTREQAGLFDVSHMGQIRLTGANAAKALETLVPVDIID
LPVGMQRYAMFTNETGGILDDLMVANLGNDELFLVVNAACKDQDLAHLQKHIGDQCKIEQLFEERALLALQGPAAVTVLA
RLAPEVAKMTFMQFTRVKLLGVDCFVSRSGYTGEDGFEISVPAVDAEKLARALLAEPEVAAIGLGARDSLRLEAGLCLYG
HDMNTETTPIEASLLWAISKPRRADGARAGGFPGAEQVFAQQQNGVSRKRVGLLPQERTPVREGAEIVNEAGEIIGSVCS
GGFGPTLGGPLAMGYLDSAYVALDTPVWAIVRGKKVPLLVSKMPFVPQRYYRG

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=377, Percent_Identity=46.684350132626, Blast_Score=301, Evalue=5e-82,
Organism=Homo sapiens, GI257796258, Length=346, Percent_Identity=46.8208092485549, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI257796254, Length=371, Percent_Identity=42.0485175202156, Blast_Score=245, Evalue=5e-65,
Organism=Homo sapiens, GI257796256, Length=322, Percent_Identity=45.9627329192547, Blast_Score=244, Evalue=8e-65,
Organism=Homo sapiens, GI197927446, Length=322, Percent_Identity=25.1552795031056, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI21361378, Length=322, Percent_Identity=25.1552795031056, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI24797151, Length=339, Percent_Identity=23.8938053097345, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI194306651, Length=325, Percent_Identity=25.2307692307692, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1789272, Length=374, Percent_Identity=34.2245989304813, Blast_Score=175, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17560118, Length=381, Percent_Identity=43.0446194225722, Blast_Score=265, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI32563613, Length=318, Percent_Identity=23.2704402515723, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71994045, Length=339, Percent_Identity=23.3038348082596, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71994052, Length=339, Percent_Identity=23.3038348082596, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320222, Length=384, Percent_Identity=39.84375, Blast_Score=252, Evalue=6e-68,
Organism=Drosophila melanogaster, GI20129441, Length=379, Percent_Identity=41.9525065963061, Blast_Score=270, Evalue=1e-72,
Organism=Drosophila melanogaster, GI20130091, Length=320, Percent_Identity=23.4375, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 40394; Mature: 40263

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTEQLSKTPLHALHLELGARMVPFAGYDMPVQYPLGVMKEHQHTREQAGLFDVSHMGQI
CCCHHHHCCCHHHHHHHHCCEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCEECCCCCEE
RLTGANAAKALETLVPVDIIDLPVGMQRYAMFTNETGGILDDLMVANLGNDELFLVVNAA
EEECCCHHHHHHHHCCCEEEECCCCHHHHEEEECCCCCHHHHHHHHCCCCCEEEEEEECC
CKDQDLAHLQKHIGDQCKIEQLFEERALLALQGPAAVTVLARLAPEVAKMTFMQFTRVKL
CCCCHHHHHHHHCCCHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHE
LGVDCFVSRSGYTGEDGFEISVPAVDAEKLARALLAEPEVAAIGLGARDSLRLEAGLCLY
EEEEEEEECCCCCCCCCCEEEECCCCHHHHHHHHHCCCCEEEEECCCCCCEEEECCEEEE
GHDMNTETTPIEASLLWAISKPRRADGARAGGFPGAEQVFAQQQNGVSRKRVGLLPQERT
ECCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHCCCCCCCC
PVREGAEIVNEAGEIIGSVCSGGFGPTLGGPLAMGYLDSAYVALDTPVWAIVRGKKVPLL
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCEEEECCCEEEEECCCCCCEE
VSKMPFVPQRYYRG
EECCCCCCHHHCCC
>Mature Secondary Structure 
STEQLSKTPLHALHLELGARMVPFAGYDMPVQYPLGVMKEHQHTREQAGLFDVSHMGQI
CCHHHHCCCHHHHHHHHCCEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCEECCCCCEE
RLTGANAAKALETLVPVDIIDLPVGMQRYAMFTNETGGILDDLMVANLGNDELFLVVNAA
EEECCCHHHHHHHHCCCEEEECCCCHHHHEEEECCCCCHHHHHHHHCCCCCEEEEEEECC
CKDQDLAHLQKHIGDQCKIEQLFEERALLALQGPAAVTVLARLAPEVAKMTFMQFTRVKL
CCCCHHHHHHHHCCCHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHE
LGVDCFVSRSGYTGEDGFEISVPAVDAEKLARALLAEPEVAAIGLGARDSLRLEAGLCLY
EEEEEEEECCCCCCCCCCEEEECCCCHHHHHHHHHCCCCEEEEECCCCCCEEEECCEEEE
GHDMNTETTPIEASLLWAISKPRRADGARAGGFPGAEQVFAQQQNGVSRKRVGLLPQERT
ECCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHCCCCCCCC
PVREGAEIVNEAGEIIGSVCSGGFGPTLGGPLAMGYLDSAYVALDTPVWAIVRGKKVPLL
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCEEEECCCEEEEECCCCCCEE
VSKMPFVPQRYYRG
EECCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA