Click here to switch to the map view.

The map label for this gene is wzb [C]

Identifier: 77460393

GI number: 77460393

Start: 4710736

End: 4711200

Strand: Reverse

Name: wzb [C]

Synonym: Pfl01_4172

Alternate gene names: 77460393

Gene position: 4711200-4710736 (Counterclockwise)

Preceding gene: 77460394

Following gene: 77460392

Centisome position: 73.17

GC content: 63.87

Gene sequence:

>465_bases
ATGCGCGTTCTGTTCGTGTGCCTGGGCAACATCTGCCGTTCGCCCACCGCCGAAGGCGTGTTGCGCCACAAGTTGCGCGA
AGCGGGGCTGGCGGATCAGGTCGAAGTGGCTTCCGCCGGCACCGGTGACTGGCACGTCGGCAATCCGCCGGACAAGCGCA
GTCAGGCTGCGGCCAAGCTGCGCGGTTATGACCTGTCGGCGCAACGCGCGCAGCAGGTCAGCCGCGCCGATTTCGCCAGT
TACGACCTGATCCTTGCCATGGACAACAGCAACCTGCGCAACCTCAAGGCCTTGCAACCGTCCACCGGCAAGGCCGAGCT
GGACCTGTTTCTGCGCCGCTATGCAGGCGTGGTCGACGAGGTGCCGGATCCGTACTACGACGGCGATCAGGGTTTCGAGC
AGGTGCTGGATCTGATCGAGCGTGCCTGCGATCAGTTGCTGATCGAAGTGAAGGGGCGGTTATGA

Upstream 100 bases:

>100_bases
ACGGCGTGCGGATTCATGTGGCGGACGCGTTGATCGCGCCGCCGACCGGGGTCGACACCGCCGAAGACCTCGAGCGCGTC
CGTCGCCTGCTGGAGGCCTG

Downstream 100 bases:

>100_bases
GTTTGCAGGTACAGCCGCAGGTTTCCCTGAAACCCTTCAATACCTTCGGCGTCGACGTTCGCGCGCAGCTGTTTGCCGAA
GCCCACAGCGACGCCGATGT

Product: protein tyrosine phosphatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 154; Mature: 154

Protein sequence:

>154_residues
MRVLFVCLGNICRSPTAEGVLRHKLREAGLADQVEVASAGTGDWHVGNPPDKRSQAAAKLRGYDLSAQRAQQVSRADFAS
YDLILAMDNSNLRNLKALQPSTGKAELDLFLRRYAGVVDEVPDPYYDGDQGFEQVLDLIERACDQLLIEVKGRL

Sequences:

>Translated_154_residues
MRVLFVCLGNICRSPTAEGVLRHKLREAGLADQVEVASAGTGDWHVGNPPDKRSQAAAKLRGYDLSAQRAQQVSRADFAS
YDLILAMDNSNLRNLKALQPSTGKAELDLFLRRYAGVVDEVPDPYYDGDQGFEQVLDLIERACDQLLIEVKGRL
>Mature_154_residues
MRVLFVCLGNICRSPTAEGVLRHKLREAGLADQVEVASAGTGDWHVGNPPDKRSQAAAKLRGYDLSAQRAQQVSRADFAS
YDLILAMDNSNLRNLKALQPSTGKAELDLFLRRYAGVVDEVPDPYYDGDQGFEQVLDLIERACDQLLIEVKGRL

Specific function: Dephosphorylates Wzc. Required For The Extracellular Polysaccharide Colanic Acid Synthesis. Probably Involved In The Export Of Colanic Acid From The Cell To Medium. [C]

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family [H]

Homologues:

Organism=Homo sapiens, GI4757714, Length=152, Percent_Identity=42.7631578947368, Blast_Score=116, Evalue=8e-27,
Organism=Homo sapiens, GI6005988, Length=153, Percent_Identity=41.1764705882353, Blast_Score=111, Evalue=3e-25,
Organism=Homo sapiens, GI96304457, Length=76, Percent_Identity=46.0526315789474, Blast_Score=70, Evalue=9e-13,
Organism=Escherichia coli, GI1788375, Length=146, Percent_Identity=34.9315068493151, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI87081812, Length=145, Percent_Identity=33.7931034482759, Blast_Score=69, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6325330, Length=151, Percent_Identity=36.4238410596026, Blast_Score=107, Evalue=8e-25,
Organism=Drosophila melanogaster, GI78706766, Length=153, Percent_Identity=38.562091503268, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI78706768, Length=153, Percent_Identity=38.562091503268, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI78706770, Length=152, Percent_Identity=38.1578947368421, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI78706772, Length=152, Percent_Identity=38.1578947368421, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI78706764, Length=129, Percent_Identity=40.3100775193798, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI78711846, Length=159, Percent_Identity=38.9937106918239, Blast_Score=90, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000106
- InterPro:   IPR017867 [H]

Pfam domain/function: PF01451 LMWPc [H]

EC number: =3.1.3.48 [H]

Molecular weight: Translated: 17003; Mature: 17003

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLFVCLGNICRSPTAEGVLRHKLREAGLADQVEVASAGTGDWHVGNPPDKRSQAAAKL
CCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHH
RGYDLSAQRAQQVSRADFASYDLILAMDNSNLRNLKALQPSTGKAELDLFLRRYAGVVDE
CCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHC
VPDPYYDGDQGFEQVLDLIERACDQLLIEVKGRL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRVLFVCLGNICRSPTAEGVLRHKLREAGLADQVEVASAGTGDWHVGNPPDKRSQAAAKL
CCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHH
RGYDLSAQRAQQVSRADFASYDLILAMDNSNLRNLKALQPSTGKAELDLFLRRYAGVVDE
CCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHC
VPDPYYDGDQGFEQVLDLIERACDQLLIEVKGRL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]