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The map label for this gene is murB

Identifier: 77460392

GI number: 77460392

Start: 4709720

End: 4710739

Strand: Reverse

Name: murB

Synonym: Pfl01_4171

Alternate gene names: 77460392

Gene position: 4710739-4709720 (Counterclockwise)

Preceding gene: 77460393

Following gene: 77460391

Centisome position: 73.17

GC content: 63.53

Gene sequence:

>1020_bases
ATGAGTTTGCAGGTACAGCCGCAGGTTTCCCTGAAACCCTTCAATACCTTCGGCGTCGACGTTCGCGCGCAGCTGTTTGC
CGAAGCCCACAGCGACGCCGATGTGCGCGAAGCCCTGGCATATGCGAGTGCCCATGATGTGCCGTTGCTGGTGATCGGCG
GCGGCAGCAATCTGTTGCTCACGGCGGACATCCCGGCGCTGGTGCTGCGCATGGCCAGCCGTGGCATCCGCGTCATCAGC
GACGACGGCAACCGCGTGGTGATCGAAGCCGAAGCTGGCGAGCCGTGGCACCCGTTCGTGCAGCACACGCTGGCGCAGGG
TTTTTCCGGGCTGGAGAATCTCAGTCTGATCCCCGGCACTGTCGGCGCCGCGCCGATGCAGAACATCGGTGCCTACGGTG
TCGAGATCAAGGATGTGTTCGCCGGCCTGACGGCGCTGGATCGCCAGACCGGCGAGCTGCGTGACTTCAGTCTGGAGGAG
TGCCGGTTCGCCTACCGCGACAGCGTGTTCAAACAGCAGCCGGGTCGTTGGTTGATCCTGCGAGTGCGCTTCGCATTGAA
TCGAGTCGCGCATCTGCACCTGGAATACGGCCCGGTGCGGCAGCGCCTGACCGAGCAGGGCATCGAGCAGCCGACGCCGA
CGGATGTCAGCCGCGCCATTTGCAGCATCCGCAGTGAAAAACTGCCGGATCCGGCGGTGCTCGGCAATGCCGGCAGCTTC
TTCAAGAACCCGCTGGTGTCGGCGGCCGTGGTCGCACAGATCAAGGCGCAGCACCCGGATCTGGTGGCCTACGCGCAACC
GGACGGGCAGATGAAACTCGCGGCCGGCTGGTTGATCGAGCGAGCGGGCTGGAAAGGTTTCCGCGAGGCCGATGCCGGCG
TGCATAAATTGCAGGCGCTGGTGCTGGTCAACTACGGCGCGGCGACCGGGCTGCAATTGCTCGATCTGGCCCAGCGCATC
CAGAAAGACATTGCAGAACGTTTCAATGTCGAACTGGAAATGGAGCCCAATCGCTATTGA

Upstream 100 bases:

>100_bases
TGCCGGATCCGTACTACGACGGCGATCAGGGTTTCGAGCAGGTGCTGGATCTGATCGAGCGTGCCTGCGATCAGTTGCTG
ATCGAAGTGAAGGGGCGGTT

Downstream 100 bases:

>100_bases
GGCTACGCTTTCAAGTCTGGACCCAAAGCCCTGCACTATTTAAAAAAGTGCAGGGCTTTTTTGTTAATCGCGGGTTAACG
TAGCCAGCTAACGATACCAG

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MSLQVQPQVSLKPFNTFGVDVRAQLFAEAHSDADVREALAYASAHDVPLLVIGGGSNLLLTADIPALVLRMASRGIRVIS
DDGNRVVIEAEAGEPWHPFVQHTLAQGFSGLENLSLIPGTVGAAPMQNIGAYGVEIKDVFAGLTALDRQTGELRDFSLEE
CRFAYRDSVFKQQPGRWLILRVRFALNRVAHLHLEYGPVRQRLTEQGIEQPTPTDVSRAICSIRSEKLPDPAVLGNAGSF
FKNPLVSAAVVAQIKAQHPDLVAYAQPDGQMKLAAGWLIERAGWKGFREADAGVHKLQALVLVNYGAATGLQLLDLAQRI
QKDIAERFNVELEMEPNRY

Sequences:

>Translated_339_residues
MSLQVQPQVSLKPFNTFGVDVRAQLFAEAHSDADVREALAYASAHDVPLLVIGGGSNLLLTADIPALVLRMASRGIRVIS
DDGNRVVIEAEAGEPWHPFVQHTLAQGFSGLENLSLIPGTVGAAPMQNIGAYGVEIKDVFAGLTALDRQTGELRDFSLEE
CRFAYRDSVFKQQPGRWLILRVRFALNRVAHLHLEYGPVRQRLTEQGIEQPTPTDVSRAICSIRSEKLPDPAVLGNAGSF
FKNPLVSAAVVAQIKAQHPDLVAYAQPDGQMKLAAGWLIERAGWKGFREADAGVHKLQALVLVNYGAATGLQLLDLAQRI
QKDIAERFNVELEMEPNRY
>Mature_338_residues
SLQVQPQVSLKPFNTFGVDVRAQLFAEAHSDADVREALAYASAHDVPLLVIGGGSNLLLTADIPALVLRMASRGIRVISD
DGNRVVIEAEAGEPWHPFVQHTLAQGFSGLENLSLIPGTVGAAPMQNIGAYGVEIKDVFAGLTALDRQTGELRDFSLEEC
RFAYRDSVFKQQPGRWLILRVRFALNRVAHLHLEYGPVRQRLTEQGIEQPTPTDVSRAICSIRSEKLPDPAVLGNAGSFF
KNPLVSAAVVAQIKAQHPDLVAYAQPDGQMKLAAGWLIERAGWKGFREADAGVHKLQALVLVNYGAATGLQLLDLAQRIQ
KDIAERFNVELEMEPNRY

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

Organism=Escherichia coli, GI1790407, Length=327, Percent_Identity=43.4250764525994, Blast_Score=254, Evalue=4e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_PSEPF (Q3K8J6)

Other databases:

- EMBL:   CP000094
- RefSeq:   YP_349899.1
- ProteinModelPortal:   Q3K8J6
- SMR:   Q3K8J6
- STRING:   Q3K8J6
- GeneID:   3712535
- GenomeReviews:   CP000094_GR
- KEGG:   pfo:Pfl01_4171
- eggNOG:   COG0812
- HOGENOM:   HBG686573
- OMA:   GAAPMQN
- ProtClustDB:   PRK00046
- BioCyc:   PFLU205922:PFL_4171-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 37105; Mature: 36974

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 166-166 ACT_SITE 239-239 ACT_SITE 335-335

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLQVQPQVSLKPFNTFGVDVRAQLFAEAHSDADVREALAYASAHDVPLLVIGGGSNLLL
CCEECCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEECCCCEEE
TADIPALVLRMASRGIRVISDDGNRVVIEAEAGEPWHPFVQHTLAQGFSGLENLSLIPGT
ECCHHHHHHHHHHCCCEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEECCCC
VGAAPMQNIGAYGVEIKDVFAGLTALDRQTGELRDFSLEECRFAYRDSVFKQQPGRWLIL
CCCCCHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEE
RVRFALNRVAHLHLEYGPVRQRLTEQGIEQPTPTDVSRAICSIRSEKLPDPAVLGNAGSF
EEHHHHHHHHHEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEECCCCHH
FKNPLVSAAVVAQIKAQHPDLVAYAQPDGQMKLAAGWLIERAGWKGFREADAGVHKLQAL
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEHHHHHHHHCCCCCHHHHHHHHHHHEEE
VLVNYGAATGLQLLDLAQRIQKDIAERFNVELEMEPNRY
EEEECCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCC
>Mature Secondary Structure 
SLQVQPQVSLKPFNTFGVDVRAQLFAEAHSDADVREALAYASAHDVPLLVIGGGSNLLL
CEECCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEECCCCEEE
TADIPALVLRMASRGIRVISDDGNRVVIEAEAGEPWHPFVQHTLAQGFSGLENLSLIPGT
ECCHHHHHHHHHHCCCEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEECCCC
VGAAPMQNIGAYGVEIKDVFAGLTALDRQTGELRDFSLEECRFAYRDSVFKQQPGRWLIL
CCCCCHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEE
RVRFALNRVAHLHLEYGPVRQRLTEQGIEQPTPTDVSRAICSIRSEKLPDPAVLGNAGSF
EEHHHHHHHHHEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEECCCCHH
FKNPLVSAAVVAQIKAQHPDLVAYAQPDGQMKLAAGWLIERAGWKGFREADAGVHKLQAL
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEHHHHHHHHCCCCCHHHHHHHHHHHEEE
VLVNYGAATGLQLLDLAQRIQKDIAERFNVELEMEPNRY
EEEECCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA