Click here to switch to the map view.

The map label for this gene is phoQ [H]

Identifier: 77459993

GI number: 77459993

Start: 4268764

End: 4270077

Strand: Reverse

Name: phoQ [H]

Synonym: Pfl01_3771

Alternate gene names: 77459993

Gene position: 4270077-4268764 (Counterclockwise)

Preceding gene: 77459994

Following gene: 77459991

Centisome position: 66.32

GC content: 61.95

Gene sequence:

>1314_bases
GTGAGATCGATCCAGCGCCGCTTGAGTCTGGGGTTGATCAGCGTGCTGGTGGTCGTCGGCGTACTGCTGGCGCAAACCAG
TCTGTGGTTGTTCGAGGTGGGATTGCAGCGCTATCTCGAAGCCGGCTTGCGTAACGACAGCGAGAGCCTGTTGGTGGCGC
TGGTTCGCGGGCCACAGGGTTTGCAGCTGGATGAGCGGCACTTGTCGCCGGCCTATCAGCGACCGTTTTCCGGGCATTAC
TTCCGCATCGATTTCGCCGACAGCCATTGGCGCTCCCGCTCGTTGTGGGATCAGGATCTGCCGTTGCTCGAACGCTCCGG
TCTGCACAGCAACCTGCAACTGGGGCCGGACGGTCAGCAACTGCTGGTGCTGCGTTCGGACTACCGACGGCTCGGCCAGT
CGATTTCCATCAGCGTGGCTCAGGATTACACCCCGGTGCGCGAGAGCTTCCAGCGCATGCGGCAGATCGGTCTCGGCCTC
GGGCTCGCCGGGTTGCTGCTGATTCTATTGCTGCAACGCCTGACCGTGCGCCGCGCCTTGCGTCCGCTGGAAAAGGCTCG
CGAACAGATCGCCCAGTTGCAGCAGGGCCAGCGTTCACAACTCGATGAACAAGTGCCGGCGGAACTGGAGCCGCTGGTGG
CGCAGATCAACCACTTGCTGGCGCACACCGAAGACAGCCTCAAGCGCTCGCGCAATGCTCTGGGCAATCTCGGGCATGCG
CTGAAAACCCCGTTGGCAGTGCTGCTCAGTCTGGCGTCGAGTGAAAGGCTCGACGCACACCCGGAGCTGCGCAAGATTCT
CAAGGAACAACTGGAGCAGGTTCAGCAGCGACTGAATCGCGAACTCAATCGTGCGCGCCTGTCCGGCGATGCGTTGCCGG
GAGCGCTGTTCGATTGCGATGCGGAGCTGCCGGGGCTGCTGTCGACGTTGAACATGATTCATGGCGAGCATCTGGAGTTG
AGTTATGTGGCACCGCCGGGCCTGCAATTGCCGTGGGATCGTGAGGATCTGCTGGAACTGCTCGGCAATCTGTTGGACAA
CGCCTGCAAGTGGGCGGATGCCGAGGTGCGACTGAGCGTGCTTGAGCGGACGGATGGCTTCGCCCTGAGCGTTGAAGATG
ACGGGCCGGGAATTCCCGAATTGCAGCGTGCTCAGGTGTTCAGTCGTGGTACGCGACTGGACGAGCAGACCGACGGGCAT
GGCTTGGGCCTGGGGATTGTGCGCGACATCGTCGACACCTGGGGTGGGTTGCTGGTGTTGGGTGAGAGTGAGTGGGGCGG
TTTGAAGGTGGTGATCGAATTGCCTAAACGCTGA

Upstream 100 bases:

>100_bases
ACGTGCTGGAAGTCCACGTCAACCACCTGCGGCGCAAGCTCGGCAAGAGCGTGATCGAAACCCGTCGTGGTCAGGGTTAT
CTGTTTGGCGGACAGGCTTC

Downstream 100 bases:

>100_bases
TTTCCGTCATTCCACAAACCTGTGGGAGCAGCCAGGCGGGCTCCCACAGGGACTTTGCGATGAACCCTAGACCCGAAACT
GATCCATCAGACTCTGCTGC

Product: periplasmic sensor Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MRSIQRRLSLGLISVLVVVGVLLAQTSLWLFEVGLQRYLEAGLRNDSESLLVALVRGPQGLQLDERHLSPAYQRPFSGHY
FRIDFADSHWRSRSLWDQDLPLLERSGLHSNLQLGPDGQQLLVLRSDYRRLGQSISISVAQDYTPVRESFQRMRQIGLGL
GLAGLLLILLLQRLTVRRALRPLEKAREQIAQLQQGQRSQLDEQVPAELEPLVAQINHLLAHTEDSLKRSRNALGNLGHA
LKTPLAVLLSLASSERLDAHPELRKILKEQLEQVQQRLNRELNRARLSGDALPGALFDCDAELPGLLSTLNMIHGEHLEL
SYVAPPGLQLPWDREDLLELLGNLLDNACKWADAEVRLSVLERTDGFALSVEDDGPGIPELQRAQVFSRGTRLDEQTDGH
GLGLGIVRDIVDTWGGLLVLGESEWGGLKVVIELPKR

Sequences:

>Translated_437_residues
MRSIQRRLSLGLISVLVVVGVLLAQTSLWLFEVGLQRYLEAGLRNDSESLLVALVRGPQGLQLDERHLSPAYQRPFSGHY
FRIDFADSHWRSRSLWDQDLPLLERSGLHSNLQLGPDGQQLLVLRSDYRRLGQSISISVAQDYTPVRESFQRMRQIGLGL
GLAGLLLILLLQRLTVRRALRPLEKAREQIAQLQQGQRSQLDEQVPAELEPLVAQINHLLAHTEDSLKRSRNALGNLGHA
LKTPLAVLLSLASSERLDAHPELRKILKEQLEQVQQRLNRELNRARLSGDALPGALFDCDAELPGLLSTLNMIHGEHLEL
SYVAPPGLQLPWDREDLLELLGNLLDNACKWADAEVRLSVLERTDGFALSVEDDGPGIPELQRAQVFSRGTRLDEQTDGH
GLGLGIVRDIVDTWGGLLVLGESEWGGLKVVIELPKR
>Mature_437_residues
MRSIQRRLSLGLISVLVVVGVLLAQTSLWLFEVGLQRYLEAGLRNDSESLLVALVRGPQGLQLDERHLSPAYQRPFSGHY
FRIDFADSHWRSRSLWDQDLPLLERSGLHSNLQLGPDGQQLLVLRSDYRRLGQSISISVAQDYTPVRESFQRMRQIGLGL
GLAGLLLILLLQRLTVRRALRPLEKAREQIAQLQQGQRSQLDEQVPAELEPLVAQINHLLAHTEDSLKRSRNALGNLGHA
LKTPLAVLLSLASSERLDAHPELRKILKEQLEQVQQRLNRELNRARLSGDALPGALFDCDAELPGLLSTLNMIHGEHLEL
SYVAPPGLQLPWDREDLLELLGNLLDNACKWADAEVRLSVLERTDGFALSVEDDGPGIPELQRAQVFSRGTRLDEQTDGH
GLGLGIVRDIVDTWGGLLVLGESEWGGLKVVIELPKR

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=276, Percent_Identity=33.695652173913, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1788393, Length=248, Percent_Identity=27.0161290322581, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1789808, Length=278, Percent_Identity=26.6187050359712, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1790346, Length=272, Percent_Identity=27.9411764705882, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1787894, Length=271, Percent_Identity=28.4132841328413, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1786912, Length=233, Percent_Identity=29.6137339055794, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790551, Length=290, Percent_Identity=28.9655172413793, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1786783, Length=295, Percent_Identity=27.4576271186441, Blast_Score=69, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48842; Mature: 48842

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSIQRRLSLGLISVLVVVGVLLAQTSLWLFEVGLQRYLEAGLRNDSESLLVALVRGPQG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEHEECCCCC
LQLDERHLSPAYQRPFSGHYFRIDFADSHWRSRSLWDQDLPLLERSGLHSNLQLGPDGQQ
CCCCHHHCCHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCE
LLVLRSDYRRLGQSISISVAQDYTPVRESFQRMRQIGLGLGLAGLLLILLLQRLTVRRAL
EEEEHHHHHHCCCCEEEEHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
RPLEKAREQIAQLQQGQRSQLDEQVPAELEPLVAQINHLLAHTEDSLKRSRNALGNLGHA
HHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
LKTPLAVLLSLASSERLDAHPELRKILKEQLEQVQQRLNRELNRARLSGDALPGALFDCD
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECC
AELPGLLSTLNMIHGEHLELSYVAPPGLQLPWDREDLLELLGNLLDNACKWADAEVRLSV
CCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHH
LERTDGFALSVEDDGPGIPELQRAQVFSRGTRLDEQTDGHGLGLGIVRDIVDTWGGLLVL
HHCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEE
GESEWGGLKVVIELPKR
ECCCCCCEEEEEECCCC
>Mature Secondary Structure
MRSIQRRLSLGLISVLVVVGVLLAQTSLWLFEVGLQRYLEAGLRNDSESLLVALVRGPQG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEHEECCCCC
LQLDERHLSPAYQRPFSGHYFRIDFADSHWRSRSLWDQDLPLLERSGLHSNLQLGPDGQQ
CCCCHHHCCHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCE
LLVLRSDYRRLGQSISISVAQDYTPVRESFQRMRQIGLGLGLAGLLLILLLQRLTVRRAL
EEEEHHHHHHCCCCEEEEHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
RPLEKAREQIAQLQQGQRSQLDEQVPAELEPLVAQINHLLAHTEDSLKRSRNALGNLGHA
HHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
LKTPLAVLLSLASSERLDAHPELRKILKEQLEQVQQRLNRELNRARLSGDALPGALFDCD
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECC
AELPGLLSTLNMIHGEHLELSYVAPPGLQLPWDREDLLELLGNLLDNACKWADAEVRLSV
CCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHH
LERTDGFALSVEDDGPGIPELQRAQVFSRGTRLDEQTDGHGLGLGIVRDIVDTWGGLLVL
HHCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEE
GESEWGGLKVVIELPKR
ECCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA