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The map label for this gene is clpA [H]

Identifier: 77459812

GI number: 77459812

Start: 4056993

End: 4059263

Strand: Reverse

Name: clpA [H]

Synonym: Pfl01_3590

Alternate gene names: 77459812

Gene position: 4059263-4056993 (Counterclockwise)

Preceding gene: 77459813

Following gene: 77459808

Centisome position: 63.05

GC content: 58.52

Gene sequence:

>2271_bases
ATGTTAAACCGCGAGCTCGAAGTCACCCTCAATCTTGCCTTCAAGGAGGCACGTTCGAAACGTCATGAGTTCATGACCGT
CGAACACCTGCTGCTGGCCCTATTGGACAATGAGGCTGCCGCCACCGTATTGCGTGCCTGCGGCGCAAACCTCGACAAAC
TCAAGCACGACCTGCAGGAGTTCATCGACTCCACCACGCCGCTGATCCCTGTCCATGACGAGGATCGCGAAACCCAGCCA
ACCCTGGGCTTCCAGCGTGTACTGCAACGTGCTGTCTTTCATGTGCAGAGCTCGGGCAAACGCGAAGTAACCGGCGCCAA
CGTGCTGGTTGCAATCTTCAGTGAGCAAGAGAGTCAGGCGGTGTTCCTGCTGAAACAGCAGAGCGTTGCACGCATTGATG
TCGTCAACTATATCGCCCACGGCATATCCAAAGTGCCGGGGCATGGCGATCACTCTGAAGGTGAACAAGATATGCAGGAC
GACGAGGGCGGTGAGTCTTCTTCTTCAGGCAATCCGCTGGACGCTTATGCCAGCAACCTCAACGAACTCGCACGCCAGGG
TCGGATCGATCCGCTGGTCGGACGTGAAACGGAAGTCGAGCGTGTCGCGCAGATTCTTGCGCGCCGTCGCAAGAACAATC
CGCTGCTGGTGGGCGAGGCGGGCGTGGGTAAAACCGCGATTGCCGAAGGCCTGGCCAAGCGCATTGTCGACAACCAGGTG
CCGGACCTGCTGGCCAACAGCGTCGTTTACTCACTCGATCTGGGCGCTCTGCTCGCGGGCACCAAGTATCGCGGTGATTT
CGAGAAGCGCTTCAAGGCGCTGCTCAACGAGCTGAAAAAACGTCCGCAGGCGATCCTGTTCATCGACGAGATCCACACCA
TTATCGGTGCAGGTGCCGCTTCGGGCGGCGTCATGGATGCCTCGAACCTGCTCAAGCCGCTGCTGTCGTCTGGCGACATT
CGCTGCATCGGTTCGACCACGTTCCAGGAATTCCGTGGCATCTTCGAAAAAGACCGCGCCCTGGCGCGTCGCTTCCAGAA
GGTCGATGTCGTCGAGCCATCGGTGGAAGACACCATCGGTATCCTGCGTGGCCTGAAAGGGCGTTTTGAACAGCATCATA
ATATCGAATACAGCGATGAGTCGCTGCGCGCCGCTGCGGAACTGGCTTCGCGCTACATCAATGACCGGCACATGCCGGAC
AAGGCCATCGATGTGATCGACGAGGCCGGCGCCTATCAGCGTCTGCAACCGGTCGAGAAGCGTGTGAAACGCATCGAAGT
CCCTGAAGTCGAGGACATCGTTGCGAAAATCGCGCGGATTCCGCCGAAGCACGTCACCAGCTCCGACAAGGAACTGCTGC
GTAACCTCGAGCGTGACCTGAAGCTGACGGTGTTCGGTCAGGACGCAGCGATCGATTCGCTGTCGACTGCGATCAAGCTG
TCCCGTGCCGGTCTCAAGTCGCCTGACAAGCCTGTCGGTTCGTTCCTGTTCGCAGGGCCGACCGGTGTCGGTAAAACCGA
AGCCGCGCGTCAATTGGCCAAGGCGCTGGGGATCGAACTGGTGCGTTTCGACATGTCCGAGTACATGGAGCGCCACACCG
TATCGCGTCTGATCGGTGCGCCTCCGGGTTATGTCGGTTTCGACCAGGGCGGTCTGTTGACCGAAGCGATCACCAAGCAG
CCGCATTGTGTATTGCTGCTCGATGAAATCGAGAAGGCGCATCCGGAAGTCTTCAACCTGCTGCTGCAGGTGATGGACCA
CGGTACGCTGACTGACAACAACGGGCGCAAGGCGGACTTCCGCAACGTAATCGTGATCATGACCACCAACGCCGGTGCTG
AAACGGCGGCACGTGCTTCGATCGGCTTCACCCATCAAGACCACTCGTCCGATGCGATGGAAGTGATCAAGAAGAGCTTC
ACGCCGGAATTCCGCAACCGTCTGGATACCATCATTCAGTTTGGTCGCCTCAGTCATGAGGTCATCAAAAGTGTGGTGGA
CAAGTTCCTCACCGAACTTCAGGCGCAATTGGAAGACAAGCGTGTGCTTCTGGAGGTTACCGATGCGGCGCGCAGCTGGC
TGGCGGCCGGTGGGTACGATTCGGCCATGGGCGCTCGTCCGATGGCGCGTCTGATCCAGGACAAGATCAAGCGTCCGCTG
GCGGAGGAGATTCTGTTTGGCGAGCTGGCCGAGCATGGCGGTGTGGTTCATATCGACATCAAGGATGGTGAGCTGACGTT
TGACTTCGAGACCACTGCAGAAATGGCCTGA

Upstream 100 bases:

>100_bases
CATGCAGGTCAACCAGTACGCCAGGGAAAGCCAGCATCCGCTACTCTGTGAAATCGAGAAGGACGGTTAATCGCCGACCA
CTTGGGTATGAGGTGAAGCT

Downstream 100 bases:

>100_bases
CGGCTGGTAAGTGAAAAGGCGCCTTCGGGCGCCTTTTTATTGTCTGTTTGTTTGGTGTGTATATCCGTTGCTGCGGTAAC
GGCTTCTTGGGGTTCCGCCC

Product: ATP-dependent Clp protease ATP-binding subunit ClpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 756; Mature: 756

Protein sequence:

>756_residues
MLNRELEVTLNLAFKEARSKRHEFMTVEHLLLALLDNEAAATVLRACGANLDKLKHDLQEFIDSTTPLIPVHDEDRETQP
TLGFQRVLQRAVFHVQSSGKREVTGANVLVAIFSEQESQAVFLLKQQSVARIDVVNYIAHGISKVPGHGDHSEGEQDMQD
DEGGESSSSGNPLDAYASNLNELARQGRIDPLVGRETEVERVAQILARRRKNNPLLVGEAGVGKTAIAEGLAKRIVDNQV
PDLLANSVVYSLDLGALLAGTKYRGDFEKRFKALLNELKKRPQAILFIDEIHTIIGAGAASGGVMDASNLLKPLLSSGDI
RCIGSTTFQEFRGIFEKDRALARRFQKVDVVEPSVEDTIGILRGLKGRFEQHHNIEYSDESLRAAAELASRYINDRHMPD
KAIDVIDEAGAYQRLQPVEKRVKRIEVPEVEDIVAKIARIPPKHVTSSDKELLRNLERDLKLTVFGQDAAIDSLSTAIKL
SRAGLKSPDKPVGSFLFAGPTGVGKTEAARQLAKALGIELVRFDMSEYMERHTVSRLIGAPPGYVGFDQGGLLTEAITKQ
PHCVLLLDEIEKAHPEVFNLLLQVMDHGTLTDNNGRKADFRNVIVIMTTNAGAETAARASIGFTHQDHSSDAMEVIKKSF
TPEFRNRLDTIIQFGRLSHEVIKSVVDKFLTELQAQLEDKRVLLEVTDAARSWLAAGGYDSAMGARPMARLIQDKIKRPL
AEEILFGELAEHGGVVHIDIKDGELTFDFETTAEMA

Sequences:

>Translated_756_residues
MLNRELEVTLNLAFKEARSKRHEFMTVEHLLLALLDNEAAATVLRACGANLDKLKHDLQEFIDSTTPLIPVHDEDRETQP
TLGFQRVLQRAVFHVQSSGKREVTGANVLVAIFSEQESQAVFLLKQQSVARIDVVNYIAHGISKVPGHGDHSEGEQDMQD
DEGGESSSSGNPLDAYASNLNELARQGRIDPLVGRETEVERVAQILARRRKNNPLLVGEAGVGKTAIAEGLAKRIVDNQV
PDLLANSVVYSLDLGALLAGTKYRGDFEKRFKALLNELKKRPQAILFIDEIHTIIGAGAASGGVMDASNLLKPLLSSGDI
RCIGSTTFQEFRGIFEKDRALARRFQKVDVVEPSVEDTIGILRGLKGRFEQHHNIEYSDESLRAAAELASRYINDRHMPD
KAIDVIDEAGAYQRLQPVEKRVKRIEVPEVEDIVAKIARIPPKHVTSSDKELLRNLERDLKLTVFGQDAAIDSLSTAIKL
SRAGLKSPDKPVGSFLFAGPTGVGKTEAARQLAKALGIELVRFDMSEYMERHTVSRLIGAPPGYVGFDQGGLLTEAITKQ
PHCVLLLDEIEKAHPEVFNLLLQVMDHGTLTDNNGRKADFRNVIVIMTTNAGAETAARASIGFTHQDHSSDAMEVIKKSF
TPEFRNRLDTIIQFGRLSHEVIKSVVDKFLTELQAQLEDKRVLLEVTDAARSWLAAGGYDSAMGARPMARLIQDKIKRPL
AEEILFGELAEHGGVVHIDIKDGELTFDFETTAEMA
>Mature_756_residues
MLNRELEVTLNLAFKEARSKRHEFMTVEHLLLALLDNEAAATVLRACGANLDKLKHDLQEFIDSTTPLIPVHDEDRETQP
TLGFQRVLQRAVFHVQSSGKREVTGANVLVAIFSEQESQAVFLLKQQSVARIDVVNYIAHGISKVPGHGDHSEGEQDMQD
DEGGESSSSGNPLDAYASNLNELARQGRIDPLVGRETEVERVAQILARRRKNNPLLVGEAGVGKTAIAEGLAKRIVDNQV
PDLLANSVVYSLDLGALLAGTKYRGDFEKRFKALLNELKKRPQAILFIDEIHTIIGAGAASGGVMDASNLLKPLLSSGDI
RCIGSTTFQEFRGIFEKDRALARRFQKVDVVEPSVEDTIGILRGLKGRFEQHHNIEYSDESLRAAAELASRYINDRHMPD
KAIDVIDEAGAYQRLQPVEKRVKRIEVPEVEDIVAKIARIPPKHVTSSDKELLRNLERDLKLTVFGQDAAIDSLSTAIKL
SRAGLKSPDKPVGSFLFAGPTGVGKTEAARQLAKALGIELVRFDMSEYMERHTVSRLIGAPPGYVGFDQGGLLTEAITKQ
PHCVLLLDEIEKAHPEVFNLLLQVMDHGTLTDNNGRKADFRNVIVIMTTNAGAETAARASIGFTHQDHSSDAMEVIKKSF
TPEFRNRLDTIIQFGRLSHEVIKSVVDKFLTELQAQLEDKRVLLEVTDAARSWLAAGGYDSAMGARPMARLIQDKIKRPL
AEEILFGELAEHGGVVHIDIKDGELTFDFETTAEMA

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=299, Percent_Identity=31.1036789297659, Blast_Score=152, Evalue=9e-37,
Organism=Escherichia coli, GI1787109, Length=753, Percent_Identity=66.0026560424967, Blast_Score=1025, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=398, Percent_Identity=43.7185929648241, Blast_Score=301, Evalue=1e-82,
Organism=Saccharomyces cerevisiae, GI6320464, Length=324, Percent_Identity=45.3703703703704, Blast_Score=285, Evalue=2e-77,
Organism=Saccharomyces cerevisiae, GI6323002, Length=336, Percent_Identity=40.7738095238095, Blast_Score=260, Evalue=7e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 83403; Mature: 83403

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNRELEVTLNLAFKEARSKRHEFMTVEHLLLALLDNEAAATVLRACGANLDKLKHDLQE
CCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHH
FIDSTTPLIPVHDEDRETQPTLGFQRVLQRAVFHVQSSGKREVTGANVLVAIFSEQESQA
HHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEECCCEEEEEEECCCCCCE
VFLLKQQSVARIDVVNYIAHGISKVPGHGDHSEGEQDMQDDEGGESSSSGNPLDAYASNL
EEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCCCCCHHHHHHHH
NELARQGRIDPLVGRETEVERVAQILARRRKNNPLLVGEAGVGKTAIAEGLAKRIVDNQV
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCH
PDLLANSVVYSLDLGALLAGTKYRGDFEKRFKALLNELKKRPQAILFIDEIHTIIGAGAA
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCC
SGGVMDASNLLKPLLSSGDIRCIGSTTFQEFRGIFEKDRALARRFQKVDVVEPSVEDTIG
CCCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
ILRGLKGRFEQHHNIEYSDESLRAAAELASRYINDRHMPDKAIDVIDEAGAYQRLQPVEK
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHH
RVKRIEVPEVEDIVAKIARIPPKHVTSSDKELLRNLERDLKLTVFGQDAAIDSLSTAIKL
HHHHCCCCCHHHHHHHHHHCCCHHCCCCHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHH
SRAGLKSPDKPVGSFLFAGPTGVGKTEAARQLAKALGIELVRFDMSEYMERHTVSRLIGA
HHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCC
PPGYVGFDQGGLLTEAITKQPHCVLLLDEIEKAHPEVFNLLLQVMDHGTLTDNNGRKADF
CCCCCCCCCCCHHHHHHCCCCCEEEEHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCC
RNVIVIMTTNAGAETAARASIGFTHQDHSSDAMEVIKKSFTPEFRNRLDTIIQFGRLSHE
CCEEEEEECCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
VIKSVVDKFLTELQAQLEDKRVLLEVTDAARSWLAAGGYDSAMGARPMARLIQDKIKRPL
HHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHCHH
AEEILFGELAEHGGVVHIDIKDGELTFDFETTAEMA
HHHHHHHHHHHCCCEEEEEEECCEEEEEECCCCCCC
>Mature Secondary Structure
MLNRELEVTLNLAFKEARSKRHEFMTVEHLLLALLDNEAAATVLRACGANLDKLKHDLQE
CCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHH
FIDSTTPLIPVHDEDRETQPTLGFQRVLQRAVFHVQSSGKREVTGANVLVAIFSEQESQA
HHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEECCCEEEEEEECCCCCCE
VFLLKQQSVARIDVVNYIAHGISKVPGHGDHSEGEQDMQDDEGGESSSSGNPLDAYASNL
EEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCCCCCHHHHHHHH
NELARQGRIDPLVGRETEVERVAQILARRRKNNPLLVGEAGVGKTAIAEGLAKRIVDNQV
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCH
PDLLANSVVYSLDLGALLAGTKYRGDFEKRFKALLNELKKRPQAILFIDEIHTIIGAGAA
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCC
SGGVMDASNLLKPLLSSGDIRCIGSTTFQEFRGIFEKDRALARRFQKVDVVEPSVEDTIG
CCCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
ILRGLKGRFEQHHNIEYSDESLRAAAELASRYINDRHMPDKAIDVIDEAGAYQRLQPVEK
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHH
RVKRIEVPEVEDIVAKIARIPPKHVTSSDKELLRNLERDLKLTVFGQDAAIDSLSTAIKL
HHHHCCCCCHHHHHHHHHHCCCHHCCCCHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHH
SRAGLKSPDKPVGSFLFAGPTGVGKTEAARQLAKALGIELVRFDMSEYMERHTVSRLIGA
HHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCC
PPGYVGFDQGGLLTEAITKQPHCVLLLDEIEKAHPEVFNLLLQVMDHGTLTDNNGRKADF
CCCCCCCCCCCHHHHHHCCCCCEEEEHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCC
RNVIVIMTTNAGAETAARASIGFTHQDHSSDAMEVIKKSFTPEFRNRLDTIIQFGRLSHE
CCEEEEEECCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
VIKSVVDKFLTELQAQLEDKRVLLEVTDAARSWLAAGGYDSAMGARPMARLIQDKIKRPL
HHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHCHH
AEEILFGELAEHGGVVHIDIKDGELTFDFETTAEMA
HHHHHHHHHHHCCCEEEEEEECCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]