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The map label for this gene is melC2 [H]

Identifier: 77459683

GI number: 77459683

Start: 3945795

End: 3946640

Strand: Direct

Name: melC2 [H]

Synonym: Pfl01_3461

Alternate gene names: 77459683

Gene position: 3945795-3946640 (Clockwise)

Preceding gene: 77459682

Following gene: 77459685

Centisome position: 61.29

GC content: 55.79

Gene sequence:

>846_bases
ATGGATATTCGCCGTAACCACCGGGATCTGTCCCGGGAAGAGAAATCCGCCTTCATCAACGCAGTCCTCAGGCTGAAAAA
CAACGTCAACAGCGTGCTGCGTCCCGGTCAGCAAAGCCGTTACGATGACTTCGTTCAGATCCACAAAAACTCAATGGGAC
GTGGCAATCCGCTCGCACCCAGCCCTCATCAAAGCCCCTTGTTTTATCCGTGGCACCGGGTCCTGATCCGCCAGTTCGAA
CTGGAGCTGCAGGCCGCCGCCGATGACCCTCGCATCACACTGCCCTACTGGAACTGGCAAATCGGCGGCGCCGACAATCC
ATTCACCTCGGACTTCATGGGCGGCAACGGTGACAATACCCAGAATCAGCTGGTAACCAGCGGACCCTTTTCCAATAACC
AGTCGCCATTCATTGTCTCGGTATGGGACGAGGGTGTCGGTGACGCGGGCTTGCGTCGCAATCTCGGGGCTGCGGGCGCC
TTGCCGTCACCAGAAACCGTCATCTCGGCCCTGAACAGAACGTCCTATTGGATGGAGCCGGGCGGTTGGGAAAACTTTTC
CGAACGTGAACTGCACAATCCCGTGCATGCCTGGATCGGAGGCAACATGATGGAGGCATCCTCTCCCAATGACCCGATAT
TCTTCCTGCATCATTGTTATCTGGATCTGCTCTGGGAGCGCTGGAAACACCAGCATCCGAACGTTCCCTCTTTCCCGCAG
GAGGAACTGAGCAACTCGACACTGGTCTTTCACCCCGAAAACGAACTCGCTCCGTGGCCTCAAAGCTTCACCATTGAGCA
GACTCTTTTTACCGAAGAACTGGGTTATCGATATGAATACCTGTGA

Upstream 100 bases:

>100_bases
AAGAGTATTCGTACCTGTCACGTCGAATGCCATGAGCTGGGCGTAATCTCCGCGGGCAGGCAGACTTCATTGGGCAATCA
ACCCATGGAGATTTGGCAAT

Downstream 100 bases:

>100_bases
ACGGCACCGGATTCAGTTGCCCAGCGTCAAACCGTTCGCCGGCAGCGGCAATGCCGTCTTATAGCGCACCTGCTTGAGCG
CAAAACTTGACCGAATGTTG

Product: tyrosinase

Products: NA

Alternate protein names: Monophenol monooxygenase [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MDIRRNHRDLSREEKSAFINAVLRLKNNVNSVLRPGQQSRYDDFVQIHKNSMGRGNPLAPSPHQSPLFYPWHRVLIRQFE
LELQAAADDPRITLPYWNWQIGGADNPFTSDFMGGNGDNTQNQLVTSGPFSNNQSPFIVSVWDEGVGDAGLRRNLGAAGA
LPSPETVISALNRTSYWMEPGGWENFSERELHNPVHAWIGGNMMEASSPNDPIFFLHHCYLDLLWERWKHQHPNVPSFPQ
EELSNSTLVFHPENELAPWPQSFTIEQTLFTEELGYRYEYL

Sequences:

>Translated_281_residues
MDIRRNHRDLSREEKSAFINAVLRLKNNVNSVLRPGQQSRYDDFVQIHKNSMGRGNPLAPSPHQSPLFYPWHRVLIRQFE
LELQAAADDPRITLPYWNWQIGGADNPFTSDFMGGNGDNTQNQLVTSGPFSNNQSPFIVSVWDEGVGDAGLRRNLGAAGA
LPSPETVISALNRTSYWMEPGGWENFSERELHNPVHAWIGGNMMEASSPNDPIFFLHHCYLDLLWERWKHQHPNVPSFPQ
EELSNSTLVFHPENELAPWPQSFTIEQTLFTEELGYRYEYL
>Mature_281_residues
MDIRRNHRDLSREEKSAFINAVLRLKNNVNSVLRPGQQSRYDDFVQIHKNSMGRGNPLAPSPHQSPLFYPWHRVLIRQFE
LELQAAADDPRITLPYWNWQIGGADNPFTSDFMGGNGDNTQNQLVTSGPFSNNQSPFIVSVWDEGVGDAGLRRNLGAAGA
LPSPETVISALNRTSYWMEPGGWENFSERELHNPVHAWIGGNMMEASSPNDPIFFLHHCYLDLLWERWKHQHPNVPSFPQ
EELSNSTLVFHPENELAPWPQSFTIEQTLFTEELGYRYEYL

Specific function: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tyrosinase family [H]

Homologues:

Organism=Homo sapiens, GI4507753, Length=341, Percent_Identity=27.2727272727273, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI4507757, Length=340, Percent_Identity=25.2941176470588, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17505853, Length=278, Percent_Identity=29.136690647482, Blast_Score=103, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17554098, Length=250, Percent_Identity=30, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71999521, Length=180, Percent_Identity=31.6666666666667, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI193202602, Length=246, Percent_Identity=28.0487804878049, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008922
- InterPro:   IPR002227 [H]

Pfam domain/function: PF00264 Tyrosinase [H]

EC number: =1.14.18.1 [H]

Molecular weight: Translated: 32243; Mature: 32243

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00498 TYROSINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIRRNHRDLSREEKSAFINAVLRLKNNVNSVLRPGQQSRYDDFVQIHKNSMGRGNPLAP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCC
SPHQSPLFYPWHRVLIRQFELELQAAADDPRITLPYWNWQIGGADNPFTSDFMGGNGDNT
CCCCCCCCCHHHHHHHHHHHHHHEECCCCCEEEECCCCEEECCCCCCCCCCCCCCCCCCC
QNQLVTSGPFSNNQSPFIVSVWDEGVGDAGLRRNLGAAGALPSPETVISALNRTSYWMEP
CCCEEECCCCCCCCCCEEEECCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHEEECC
GGWENFSERELHNPVHAWIGGNMMEASSPNDPIFFLHHCYLDLLWERWKHQHPNVPSFPQ
CCCCCCCHHHHCCCHHHHHCCCEEECCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCH
EELSNSTLVFHPENELAPWPQSFTIEQTLFTEELGYRYEYL
HHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHCCEECCC
>Mature Secondary Structure
MDIRRNHRDLSREEKSAFINAVLRLKNNVNSVLRPGQQSRYDDFVQIHKNSMGRGNPLAP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCC
SPHQSPLFYPWHRVLIRQFELELQAAADDPRITLPYWNWQIGGADNPFTSDFMGGNGDNT
CCCCCCCCCHHHHHHHHHHHHHHEECCCCCEEEECCCCEEECCCCCCCCCCCCCCCCCCC
QNQLVTSGPFSNNQSPFIVSVWDEGVGDAGLRRNLGAAGALPSPETVISALNRTSYWMEP
CCCEEECCCCCCCCCCEEEECCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHEEECC
GGWENFSERELHNPVHAWIGGNMMEASSPNDPIFFLHHCYLDLLWERWKHQHPNVPSFPQ
CCCCCCCHHHHCCCHHHHHCCCEEECCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCH
EELSNSTLVFHPENELAPWPQSFTIEQTLFTEELGYRYEYL
HHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3932128 [H]