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The map label for this gene is mmgC [H]

Identifier: 77459092

GI number: 77459092

Start: 3307150

End: 3308277

Strand: Reverse

Name: mmgC [H]

Synonym: Pfl01_2867

Alternate gene names: 77459092

Gene position: 3308277-3307150 (Counterclockwise)

Preceding gene: 77459093

Following gene: 77459091

Centisome position: 51.38

GC content: 63.65

Gene sequence:

>1128_bases
ATGATTCCCAATGACGACCAACAACAAATCCGCGACATGGCCCGGCAGTTTGCCGAGGAACGGCTCAAACCGTTTGCCGC
CGAGTGGGATCGCGAGCACCGCTTTCCGAAAGAGGCCATCGGCGAAATGGCCGGGCTGGGCTTCTTCGGCATGCTGGTGC
CGGAGCAGTGGGGCGGTTGCGACACCGGTTACCTGGCCTACGCCATGGCCCTGGAAGAAATCGCTGCCGGCGACGGCGCC
TGCTCGACGATCATGAGCGTGCACAACTCGGTGGGTTGCGTGCCGATCCTCAAGTTCGGCAACGACGACCAGCGCGAACG
CTTCCTCAAGCCGCTGGCCAGCGGCGAGATGCTCGGTGCTTTCGCGTTGACCGAACCTCAGGCCGGTTCCGATGCCAGCA
GCCTGAAAACCCGCGCGCGGCTGGAAGGCGATCACTACGTGCTCAACGGCTGCAAACAGTTCATCACTTCCGGGCAGAAC
GCCGGGATCGTGATCGTGTTTGCCGTGACTGATCCGAGTGCCGGCAAGCGCGGGATCAGCGCGTTCATCGTGCCGACCGA
CTCGCCGGGCTACAAAGTCGCACGCGTCGAAGACAAGCTCGGCCAGCACGCCTCGGACACCTGCCAGATTCTGTTCGAAG
ACGTGAAAGTGCCGGTGGCCAACCGGTTGGGCGAGGAGGGTGAGGGCTACAAGATCGCTCTGGCCAACCTCGAAGGCGGC
CGTGTCGGTATCGCTTCGCAATCGGTGGGCATGGCCCGCGCCGCGTTCGAAGCGGCACGCGATTACGCCCGCGAACGCGA
CACCTTCGGCAAGCCGATCATCGAGCATCAGGCCGTGGCGTTCCGCCTGGCGGACATGGCGACCCAGATCGCCGTGGCGC
GGCAGATGGTGCATTACGCCGCCGCCCTGCGCGACAGCGGTCAGCCAGCACTGGTCGAGGCGTCGATGGCCAAACTGTTC
GCCTCGGAAATGGCCGAGAAGGTCTGCTCCATGGCCTTGCAAACCCTCGGCGGTTACGGTTACCTCAACGACTTCCCGCT
GGAGCGCATCTACCGCGACGTGCGGGTCTGCCAGATCTACGAAGGCACCAGCGACATACAGCGCATGGTCATTTCGCGCA
ATCTTTGA

Upstream 100 bases:

>100_bases
AGAAAGGCCTGAAACGCGGCGTCGCGGCGATCTGCATCGGCGGCGGCGAAGCCACGGCGATGGCTGTCGAGTGCGTCTGA
ACCCGAGTTAAGGATTTGCC

Downstream 100 bases:

>100_bases
GAAGGAATCTGCACATGAGTTACGAAACGATTTTGCTGGAAACCCATGGCCGCGTCGGCCTGATTACCCTCAATCGCCCG
CAGGCGCTGAATGCCCTGAA

Product: acyl-CoA dehydrogenase-like protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MIPNDDQQQIRDMARQFAEERLKPFAAEWDREHRFPKEAIGEMAGLGFFGMLVPEQWGGCDTGYLAYAMALEEIAAGDGA
CSTIMSVHNSVGCVPILKFGNDDQRERFLKPLASGEMLGAFALTEPQAGSDASSLKTRARLEGDHYVLNGCKQFITSGQN
AGIVIVFAVTDPSAGKRGISAFIVPTDSPGYKVARVEDKLGQHASDTCQILFEDVKVPVANRLGEEGEGYKIALANLEGG
RVGIASQSVGMARAAFEAARDYARERDTFGKPIIEHQAVAFRLADMATQIAVARQMVHYAAALRDSGQPALVEASMAKLF
ASEMAEKVCSMALQTLGGYGYLNDFPLERIYRDVRVCQIYEGTSDIQRMVISRNL

Sequences:

>Translated_375_residues
MIPNDDQQQIRDMARQFAEERLKPFAAEWDREHRFPKEAIGEMAGLGFFGMLVPEQWGGCDTGYLAYAMALEEIAAGDGA
CSTIMSVHNSVGCVPILKFGNDDQRERFLKPLASGEMLGAFALTEPQAGSDASSLKTRARLEGDHYVLNGCKQFITSGQN
AGIVIVFAVTDPSAGKRGISAFIVPTDSPGYKVARVEDKLGQHASDTCQILFEDVKVPVANRLGEEGEGYKIALANLEGG
RVGIASQSVGMARAAFEAARDYARERDTFGKPIIEHQAVAFRLADMATQIAVARQMVHYAAALRDSGQPALVEASMAKLF
ASEMAEKVCSMALQTLGGYGYLNDFPLERIYRDVRVCQIYEGTSDIQRMVISRNL
>Mature_375_residues
MIPNDDQQQIRDMARQFAEERLKPFAAEWDREHRFPKEAIGEMAGLGFFGMLVPEQWGGCDTGYLAYAMALEEIAAGDGA
CSTIMSVHNSVGCVPILKFGNDDQRERFLKPLASGEMLGAFALTEPQAGSDASSLKTRARLEGDHYVLNGCKQFITSGQN
AGIVIVFAVTDPSAGKRGISAFIVPTDSPGYKVARVEDKLGQHASDTCQILFEDVKVPVANRLGEEGEGYKIALANLEGG
RVGIASQSVGMARAAFEAARDYARERDTFGKPIIEHQAVAFRLADMATQIAVARQMVHYAAALRDSGQPALVEASMAKLF
ASEMAEKVCSMALQTLGGYGYLNDFPLERIYRDVRVCQIYEGTSDIQRMVISRNL

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=371, Percent_Identity=47.1698113207547, Blast_Score=353, Evalue=2e-97,
Organism=Homo sapiens, GI4501859, Length=372, Percent_Identity=38.7096774193548, Blast_Score=297, Evalue=1e-80,
Organism=Homo sapiens, GI7656849, Length=373, Percent_Identity=40.7506702412869, Blast_Score=288, Evalue=8e-78,
Organism=Homo sapiens, GI4557231, Length=373, Percent_Identity=38.8739946380697, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI187960098, Length=373, Percent_Identity=38.8739946380697, Blast_Score=275, Evalue=4e-74,
Organism=Homo sapiens, GI226958412, Length=374, Percent_Identity=37.1657754010695, Blast_Score=271, Evalue=8e-73,
Organism=Homo sapiens, GI21361497, Length=353, Percent_Identity=40.5099150141643, Blast_Score=255, Evalue=4e-68,
Organism=Homo sapiens, GI226958414, Length=339, Percent_Identity=37.4631268436578, Blast_Score=251, Evalue=9e-67,
Organism=Homo sapiens, GI4557235, Length=335, Percent_Identity=38.5074626865672, Blast_Score=218, Evalue=7e-57,
Organism=Homo sapiens, GI76496475, Length=335, Percent_Identity=38.5074626865672, Blast_Score=218, Evalue=7e-57,
Organism=Homo sapiens, GI4501857, Length=368, Percent_Identity=33.1521739130435, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI4503943, Length=371, Percent_Identity=31.8059299191375, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI7669494, Length=359, Percent_Identity=31.4763231197772, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI211971008, Length=290, Percent_Identity=31.3793103448276, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI48976061, Length=290, Percent_Identity=31.3793103448276, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI38505218, Length=351, Percent_Identity=28.2051282051282, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI218563752, Length=246, Percent_Identity=26.8292682926829, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1786223, Length=371, Percent_Identity=30.7277628032345, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI87081958, Length=349, Percent_Identity=32.6647564469914, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI87082384, Length=272, Percent_Identity=31.9852941176471, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI87081702, Length=359, Percent_Identity=25.0696378830084, Blast_Score=92, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17570075, Length=374, Percent_Identity=38.5026737967914, Blast_Score=272, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17506239, Length=362, Percent_Identity=37.0165745856354, Blast_Score=267, Evalue=6e-72,
Organism=Caenorhabditis elegans, GI17534899, Length=378, Percent_Identity=38.8888888888889, Blast_Score=265, Evalue=4e-71,
Organism=Caenorhabditis elegans, GI17508101, Length=370, Percent_Identity=35.6756756756757, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI17569725, Length=378, Percent_Identity=37.5661375661376, Blast_Score=260, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI17538396, Length=378, Percent_Identity=34.3915343915344, Blast_Score=256, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI17533517, Length=373, Percent_Identity=35.656836461126, Blast_Score=244, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI71985184, Length=379, Percent_Identity=35.6200527704486, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI71990804, Length=276, Percent_Identity=39.4927536231884, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17551932, Length=377, Percent_Identity=31.0344827586207, Blast_Score=200, Evalue=9e-52,
Organism=Caenorhabditis elegans, GI17505929, Length=361, Percent_Identity=31.3019390581717, Blast_Score=194, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI17534353, Length=373, Percent_Identity=31.0991957104558, Blast_Score=189, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71982178, Length=272, Percent_Identity=33.8235294117647, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=37.8260869565217, Blast_Score=177, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI71985192, Length=297, Percent_Identity=35.3535353535354, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17531909, Length=239, Percent_Identity=35.5648535564854, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17562446, Length=287, Percent_Identity=29.616724738676, Blast_Score=120, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI17531913, Length=177, Percent_Identity=35.0282485875706, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI86563383, Length=323, Percent_Identity=28.4829721362229, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI86563381, Length=323, Percent_Identity=28.4829721362229, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21356377, Length=372, Percent_Identity=46.2365591397849, Blast_Score=342, Evalue=3e-94,
Organism=Drosophila melanogaster, GI24646207, Length=370, Percent_Identity=43.5135135135135, Blast_Score=313, Evalue=9e-86,
Organism=Drosophila melanogaster, GI24666513, Length=370, Percent_Identity=40, Blast_Score=293, Evalue=9e-80,
Organism=Drosophila melanogaster, GI24660351, Length=377, Percent_Identity=40.053050397878, Blast_Score=276, Evalue=2e-74,
Organism=Drosophila melanogaster, GI21355753, Length=376, Percent_Identity=37.2340425531915, Blast_Score=251, Evalue=7e-67,
Organism=Drosophila melanogaster, GI281363737, Length=335, Percent_Identity=37.910447761194, Blast_Score=222, Evalue=3e-58,
Organism=Drosophila melanogaster, GI19920834, Length=377, Percent_Identity=29.973474801061, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI221473076, Length=339, Percent_Identity=25.6637168141593, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45550141, Length=339, Percent_Identity=25.6637168141593, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 40853; Mature: 40853

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPNDDQQQIRDMARQFAEERLKPFAAEWDREHRFPKEAIGEMAGLGFFGMLVPEQWGGC
CCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHCCCHHHHHCCCCCCCC
DTGYLAYAMALEEIAAGDGACSTIMSVHNSVGCVPILKFGNDDQRERFLKPLASGEMLGA
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCHHEE
FALTEPQAGSDASSLKTRARLEGDHYVLNGCKQFITSGQNAGIVIVFAVTDPSAGKRGIS
EEECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCE
AFIVPTDSPGYKVARVEDKLGQHASDTCQILFEDVKVPVANRLGEEGEGYKIALANLEGG
EEEEECCCCCCEEEEEHHHHCCCCHHHHHHHHHHHCCCHHHHCCCCCCCEEEEEEECCCC
RVGIASQSVGMARAAFEAARDYARERDTFGKPIIEHQAVAFRLADMATQIAVARQMVHYA
EEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AALRDSGQPALVEASMAKLFASEMAEKVCSMALQTLGGYGYLNDFPLERIYRDVRVCQIY
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHEEE
EGTSDIQRMVISRNL
CCHHHHHHHHHHCCC
>Mature Secondary Structure
MIPNDDQQQIRDMARQFAEERLKPFAAEWDREHRFPKEAIGEMAGLGFFGMLVPEQWGGC
CCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHCCCHHHHHCCCCCCCC
DTGYLAYAMALEEIAAGDGACSTIMSVHNSVGCVPILKFGNDDQRERFLKPLASGEMLGA
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCHHEE
FALTEPQAGSDASSLKTRARLEGDHYVLNGCKQFITSGQNAGIVIVFAVTDPSAGKRGIS
EEECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCE
AFIVPTDSPGYKVARVEDKLGQHASDTCQILFEDVKVPVANRLGEEGEGYKIALANLEGG
EEEEECCCCCCEEEEEHHHHCCCCHHHHHHHHHHHCCCHHHHCCCCCCCEEEEEEECCCC
RVGIASQSVGMARAAFEAARDYARERDTFGKPIIEHQAVAFRLADMATQIAVARQMVHYA
EEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AALRDSGQPALVEASMAKLFASEMAEKVCSMALQTLGGYGYLNDFPLERIYRDVRVCQIY
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHEEE
EGTSDIQRMVISRNL
CCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]