Click here to switch to the map view.

The map label for this gene is zraS [C]

Identifier: 77458877

GI number: 77458877

Start: 3039104

End: 3040774

Strand: Reverse

Name: zraS [C]

Synonym: Pfl01_2652

Alternate gene names: 77458877

Gene position: 3040774-3039104 (Counterclockwise)

Preceding gene: 77458878

Following gene: 77458876

Centisome position: 47.23

GC content: 60.86

Gene sequence:

>1671_bases
GTGACCGTCACCGTGCCGCTGTCGGAACGAGCACTGATCCTTGCGCCCCTGGGGCGCGACAGCCAGGTTGCGCTGATGAT
CCTCAACGAGGCCGGCTACGGTGGTCTGATCACGCCCGATCTGGCTACGCTCTGTGCCGAACTTGAACCCGGCGCCGGGT
TACTGCTAATCGCCGCCGAGGCCCTGCGTGGCCCGGAGCTGGAATCCCTGCTGTCATATCTCGATCAACAGCCCGCCTGG
TCAGACCTGCCGATTGTGCTACTGACACACCATGGCGGCTCAGGACAGGGCCCCTCGTCTCAGCTCAGCAAATTACTGGG
CAACGTGACGTTTCTTGAGCGCCCTTTCCATCCGGTGACCTTGGTCAGCCTGATCTCCACGGCCCTGCGAGGGCGACGAC
GACAATACGAGGCCCGCGATCGCCTGATCGACCTGAGCAATAGCGAGCGGCGCCTGCAATCAACCCTCGAAACCCTCGAG
CAACAAGTCGAGGAACGCACGGCGCAACTGCGGCACAACGAAGAAGCTCTTCGTCAGTCACAAAAGATGGAAGCGGTCGG
TCAACTCACCGGCGGTATCGCCCACGACTTCAACAACATGCTGACCGGCATCATCGGCAGTCTCGAACTGCTGCGTCGGC
GACTGGCTCGTGGCCGGCTTGACGATCTCGACAGCCTGATCGATCTCGGAGTGACTTCGGCCAACCGCGCCGCCGGTCTG
ACCCATCGTCTGCTGGCGTTTTCCCGTCGCCAATCGCTGGATTCCAAAGCCGTACAGATGAACGATCTGGTGCAATCGAT
GGGTGAACTCCTGCAGCGCAGCCTCAACGAAAGCGTTCAGCTGGACATGCGCCTGCATAAAGAATTGTGGGTGGCCGAGG
CGGATCCGAATCAACTGGAAAGCGCCCTGCTCAACCTGGTGATCAACGCGCGTGACGCGATGCCCGATGGCGGCAACCTG
GTGGTCGAGACCGGAAATCAGGTGCTTGAGCGGGATTTCACCGACGCTTACAGCAACCTGGAACCCGGCGATTATGTCGT
TTTGAGCGTGACGGACAACGGCTGCGGCATGCCCGAAAGTGTGATCAATCGCGCGTTCGACCCGTTTTTCACCACCAAGC
CGATCGGCCAGGGTACCGGCCTGGGCCTGTCGATGATCTACGGTTTCAGCAAGCAATCCGGGGGGCATGTGTCGATCGAC
AGCAAGATCGATGAGGGCACCACGGTCAAACTCTATCTGCCGCGTTTCCAGGGCGAATCGCTGCCTCACGCACCGACAGA
CATGGAACAGGCGCCCGACGCCGTGGAAGGCGAAACCGTCTTGATCGTCGAAGACGACCCGGCCGTGCGCGTGCTGGTCA
GTGCGGTATTGAGTGAATTGGGTTACGGATTTGTCGAAGCCAGCGATGCCGACGGTGCCGTGCCGATTCTGGATTCGGAG
CAGCGCATCGACCTGCTGATCAGCGACGTCGGTCTGCCGGGCATGAATGGTCGGCAACTGGCGGAAATCGGCAGGCAATA
CCGGCCAGACCTGAAGGTACTGTTCATCACAGGTTATGCCGAACACGCGGCAGTGCGCGGCGGGTTCCTCGACCCGGGCA
TGCAGATGATCACCAAGCCGTTCACCTTCGACCTGCTGACGGCGAAGGTGAGGGAGATGATTCGCGGGTGA

Upstream 100 bases:

>100_bases
GCATGACCATCGGTGAACCGCTGGACGCCTTCCAGGGCGTACTGCGCGGCGTGCCTACTTACCTCGGCGCGAGTAATCCG
CTGCTCAAGGATGACAACTT

Downstream 100 bases:

>100_bases
CGCTTTGCTCCTTGTCCTCCCTGACAGACGGTAACTTCCCATAAGCGGCCAACTGCGAAGCATAGGCCGCTTTTGCATGC
TCGAAACCTGTCAACTCTGA

Product: histidine kinase

Products: NA

Alternate protein names: Blue-light-activated histidine kinase; Response regulator [H]

Number of amino acids: Translated: 556; Mature: 555

Protein sequence:

>556_residues
MTVTVPLSERALILAPLGRDSQVALMILNEAGYGGLITPDLATLCAELEPGAGLLLIAAEALRGPELESLLSYLDQQPAW
SDLPIVLLTHHGGSGQGPSSQLSKLLGNVTFLERPFHPVTLVSLISTALRGRRRQYEARDRLIDLSNSERRLQSTLETLE
QQVEERTAQLRHNEEALRQSQKMEAVGQLTGGIAHDFNNMLTGIIGSLELLRRRLARGRLDDLDSLIDLGVTSANRAAGL
THRLLAFSRRQSLDSKAVQMNDLVQSMGELLQRSLNESVQLDMRLHKELWVAEADPNQLESALLNLVINARDAMPDGGNL
VVETGNQVLERDFTDAYSNLEPGDYVVLSVTDNGCGMPESVINRAFDPFFTTKPIGQGTGLGLSMIYGFSKQSGGHVSID
SKIDEGTTVKLYLPRFQGESLPHAPTDMEQAPDAVEGETVLIVEDDPAVRVLVSAVLSELGYGFVEASDADGAVPILDSE
QRIDLLISDVGLPGMNGRQLAEIGRQYRPDLKVLFITGYAEHAAVRGGFLDPGMQMITKPFTFDLLTAKVREMIRG

Sequences:

>Translated_556_residues
MTVTVPLSERALILAPLGRDSQVALMILNEAGYGGLITPDLATLCAELEPGAGLLLIAAEALRGPELESLLSYLDQQPAW
SDLPIVLLTHHGGSGQGPSSQLSKLLGNVTFLERPFHPVTLVSLISTALRGRRRQYEARDRLIDLSNSERRLQSTLETLE
QQVEERTAQLRHNEEALRQSQKMEAVGQLTGGIAHDFNNMLTGIIGSLELLRRRLARGRLDDLDSLIDLGVTSANRAAGL
THRLLAFSRRQSLDSKAVQMNDLVQSMGELLQRSLNESVQLDMRLHKELWVAEADPNQLESALLNLVINARDAMPDGGNL
VVETGNQVLERDFTDAYSNLEPGDYVVLSVTDNGCGMPESVINRAFDPFFTTKPIGQGTGLGLSMIYGFSKQSGGHVSID
SKIDEGTTVKLYLPRFQGESLPHAPTDMEQAPDAVEGETVLIVEDDPAVRVLVSAVLSELGYGFVEASDADGAVPILDSE
QRIDLLISDVGLPGMNGRQLAEIGRQYRPDLKVLFITGYAEHAAVRGGFLDPGMQMITKPFTFDLLTAKVREMIRG
>Mature_555_residues
TVTVPLSERALILAPLGRDSQVALMILNEAGYGGLITPDLATLCAELEPGAGLLLIAAEALRGPELESLLSYLDQQPAWS
DLPIVLLTHHGGSGQGPSSQLSKLLGNVTFLERPFHPVTLVSLISTALRGRRRQYEARDRLIDLSNSERRLQSTLETLEQ
QVEERTAQLRHNEEALRQSQKMEAVGQLTGGIAHDFNNMLTGIIGSLELLRRRLARGRLDDLDSLIDLGVTSANRAAGLT
HRLLAFSRRQSLDSKAVQMNDLVQSMGELLQRSLNESVQLDMRLHKELWVAEADPNQLESALLNLVINARDAMPDGGNLV
VETGNQVLERDFTDAYSNLEPGDYVVLSVTDNGCGMPESVINRAFDPFFTTKPIGQGTGLGLSMIYGFSKQSGGHVSIDS
KIDEGTTVKLYLPRFQGESLPHAPTDMEQAPDAVEGETVLIVEDDPAVRVLVSAVLSELGYGFVEASDADGAVPILDSEQ
RIDLLISDVGLPGMNGRQLAEIGRQYRPDLKVLFITGYAEHAAVRGGFLDPGMQMITKPFTFDLLTAKVREMIRG

Specific function: Photosensitive kinase and response regulator that is involved in increased bacterial virulence upon exposure to light [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=250, Percent_Identity=30, Blast_Score=103, Evalue=4e-23,
Organism=Escherichia coli, GI1788549, Length=283, Percent_Identity=30.0353356890459, Blast_Score=103, Evalue=4e-23,
Organism=Escherichia coli, GI1788713, Length=383, Percent_Identity=25.5874673629243, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI87081816, Length=404, Percent_Identity=24.2574257425743, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI48994928, Length=382, Percent_Identity=24.869109947644, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790300, Length=251, Percent_Identity=27.8884462151394, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI145693157, Length=280, Percent_Identity=24.6428571428571, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 60593; Mature: 60462

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTVPLSERALILAPLGRDSQVALMILNEAGYGGLITPDLATLCAELEPGAGLLLIAAE
CEEEEECCCCEEEEEECCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCEEEEEHH
ALRGPELESLLSYLDQQPAWSDLPIVLLTHHGGSGQGPSSQLSKLLGNVTFLERPFHPVT
HHCCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHCCCHHHCCCCCHHH
LVSLISTALRGRRRQYEARDRLIDLSNSERRLQSTLETLEQQVEERTAQLRHNEEALRQS
HHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
QKMEAVGQLTGGIAHDFNNMLTGIIGSLELLRRRLARGRLDDLDSLIDLGVTSANRAAGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHH
THRLLAFSRRQSLDSKAVQMNDLVQSMGELLQRSLNESVQLDMRLHKELWVAEADPNQLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHEEECCCHHHHH
SALLNLVINARDAMPDGGNLVVETGNQVLERDFTDAYSNLEPGDYVVLSVTDNGCGMPES
HHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHH
VINRAFDPFFTTKPIGQGTGLGLSMIYGFSKQSGGHVSIDSKIDEGTTVKLYLPRFQGES
HHHHCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCEEEECCCCCCCCEEEEEEECCCCCC
LPHAPTDMEQAPDAVEGETVLIVEDDPAVRVLVSAVLSELGYGFVEASDADGAVPILDSE
CCCCCCCHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCC
QRIDLLISDVGLPGMNGRQLAEIGRQYRPDLKVLFITGYAEHAAVRGGFLDPGMQMITKP
CHHHHHEECCCCCCCCCHHHHHHHHHHCCCEEEEEEECCHHHHHHCCCCCCCCHHHHHCC
FTFDLLTAKVREMIRG
CHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TVTVPLSERALILAPLGRDSQVALMILNEAGYGGLITPDLATLCAELEPGAGLLLIAAE
EEEEECCCCEEEEEECCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCEEEEEHH
ALRGPELESLLSYLDQQPAWSDLPIVLLTHHGGSGQGPSSQLSKLLGNVTFLERPFHPVT
HHCCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHCCCHHHCCCCCHHH
LVSLISTALRGRRRQYEARDRLIDLSNSERRLQSTLETLEQQVEERTAQLRHNEEALRQS
HHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
QKMEAVGQLTGGIAHDFNNMLTGIIGSLELLRRRLARGRLDDLDSLIDLGVTSANRAAGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHH
THRLLAFSRRQSLDSKAVQMNDLVQSMGELLQRSLNESVQLDMRLHKELWVAEADPNQLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHEEECCCHHHHH
SALLNLVINARDAMPDGGNLVVETGNQVLERDFTDAYSNLEPGDYVVLSVTDNGCGMPES
HHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHH
VINRAFDPFFTTKPIGQGTGLGLSMIYGFSKQSGGHVSIDSKIDEGTTVKLYLPRFQGES
HHHHCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCEEEECCCCCCCCEEEEEEECCCCCC
LPHAPTDMEQAPDAVEGETVLIVEDDPAVRVLVSAVLSELGYGFVEASDADGAVPILDSE
CCCCCCCHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCC
QRIDLLISDVGLPGMNGRQLAEIGRQYRPDLKVLFITGYAEHAAVRGGFLDPGMQMITKP
CHHHHHEECCCCCCCCCHHHHHHHHHHCCCEEEEEEECCHHHHHHCCCCCCCCHHHHHCC
FTFDLLTAKVREMIRG
CHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA