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The map label for this gene is 77458080

Identifier: 77458080

GI number: 77458080

Start: 2109176

End: 2110546

Strand: Reverse

Name: 77458080

Synonym: Pfl01_1853

Alternate gene names: NA

Gene position: 2110546-2109176 (Counterclockwise)

Preceding gene: 77458082

Following gene: 77458079

Centisome position: 32.78

GC content: 61.27

Gene sequence:

>1371_bases
ATGACAAAACCACGTTCGAAAAAGGCTCTTTTCATTGGCCTGCCACTGGCCCTGGCGATCAGTGCCGCAGCAGGCTTCGC
AGCCTGGGATTACTGGCTCAACGACAATCCCGGCTATCCGGTCAAGGTGATGGACCAGGCCCGCGAGATGCACCAGCACC
TGCTGTCCTTCGACAGCCACATCACCGTCCTTCAGGACTTCGGCACCCACGGCAATGAAGCCGACAAGGACGGCCCCGGT
CAGTTCGACCTGATAAAAGCCAATCGCGGGCAACTGTCCGGTGCAGCACTGACGATTTTCGGCTGGCCGGAACTGTGGAA
CGGCGCCAATGCGCCGCACAAGCCTACGGCGGGTTTCGTTGAAGAGGCACGCAACCAGCAGGAGATCCGCTACAAGATCA
TCTCCGGGATGGTCCGCGACTTCCCCAATCAGGTCGGGATTGCCTACACGCCCGAAGATTTTCGGCGCCTGCACGGTGAA
GGCAAGTTCGCGATCTTCATCAGCATGCTCAACGCCTACCCGCTGGGCCACGACCTGAACCTGCTGGACCTGTGGACGGC
GCGTGGCATGCGCATGTTCGGTTTCAGCTACATCGGCAACAACGATTGGGCCGACTCATCCCGGCCGCTGCCGTTCTTCA
ATGATTCGCCGGATGCACTCGACGGCCTCTCCGACCTCGGCAAACAAGCGGTCAAGCGTCTCAACGATTTGGGCGTGATC
ATCGATGTGTCACAGATGTCGACCAAAGCCCTGGAGCAAGTCGCGCAACTGAGCCGCACGCCGATGGTGGCCTCGCACTC
GGCGCCACGGGCGATGGTCGACATCCCCCGCAACCTCAGCGACAAAGAACTGCAACTGATCAAGAACAGCGGCGGCGTGG
TGCAGGTGGTGGGCTTCTCGCAGTACCTGCGCCCGCTGACCCAGACCACCCAGGACAAGCTCAACGAACTGCGCAAAAGC
TTTGACCTGCCGCCACTGCCCAACCTCGCCGTGGCACTGATGCCGGGCGACCCGATCATCGCCGCATGGCCCGAGGCCAA
GTTCGGCCAGTACGCCAGCCGCCTCTACGCGATCCTCGACGAAGAACCCAAAGCCACGCTCAAGGACTACGGCGACGCCA
TCGATTACACCGTGCGCAAGATCGGTATCGACCACGTCGGCATCAGCTCCGACTTCAACGAAGGCGGCGGCGTCAAAGGC
TGGGAGAACGTCGGCGACATCCCCAACGTCACCGCCGAACTGATTTCGCGCGGCTACTCCGAAGCAGACATCGCCAAGCT
CTGGGGCGGCAACTTCCTGCGGGTCTGGGATCAGGTGCAGAAAGCCGCCCGACCTGCGCTGATTTCACAGCAGGACAAGA
TCAAGCCATGA

Upstream 100 bases:

>100_bases
CAGGGCGATGCGACTAAATTTCGTTGCCAATCACTCGTTCTTTCCAGATAGCAATGGCCCCTGCGCCAGCACCTTGACGG
CGAACCTGACTGAGATGGCA

Downstream 100 bases:

>100_bases
GTGATCGTCGTACGTTTCTCAAGCAGGCGGGGATTCTCGCCGCCGGCCTGCCGCTGGCCTCGGGCATCGCCCACGGCGCC
AGCACCGACAACACCACGAA

Product: peptidase M19, renal dipeptidase

Products: NA

Alternate protein names: ORF R [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MTKPRSKKALFIGLPLALAISAAAGFAAWDYWLNDNPGYPVKVMDQAREMHQHLLSFDSHITVLQDFGTHGNEADKDGPG
QFDLIKANRGQLSGAALTIFGWPELWNGANAPHKPTAGFVEEARNQQEIRYKIISGMVRDFPNQVGIAYTPEDFRRLHGE
GKFAIFISMLNAYPLGHDLNLLDLWTARGMRMFGFSYIGNNDWADSSRPLPFFNDSPDALDGLSDLGKQAVKRLNDLGVI
IDVSQMSTKALEQVAQLSRTPMVASHSAPRAMVDIPRNLSDKELQLIKNSGGVVQVVGFSQYLRPLTQTTQDKLNELRKS
FDLPPLPNLAVALMPGDPIIAAWPEAKFGQYASRLYAILDEEPKATLKDYGDAIDYTVRKIGIDHVGISSDFNEGGGVKG
WENVGDIPNVTAELISRGYSEADIAKLWGGNFLRVWDQVQKAARPALISQQDKIKP

Sequences:

>Translated_456_residues
MTKPRSKKALFIGLPLALAISAAAGFAAWDYWLNDNPGYPVKVMDQAREMHQHLLSFDSHITVLQDFGTHGNEADKDGPG
QFDLIKANRGQLSGAALTIFGWPELWNGANAPHKPTAGFVEEARNQQEIRYKIISGMVRDFPNQVGIAYTPEDFRRLHGE
GKFAIFISMLNAYPLGHDLNLLDLWTARGMRMFGFSYIGNNDWADSSRPLPFFNDSPDALDGLSDLGKQAVKRLNDLGVI
IDVSQMSTKALEQVAQLSRTPMVASHSAPRAMVDIPRNLSDKELQLIKNSGGVVQVVGFSQYLRPLTQTTQDKLNELRKS
FDLPPLPNLAVALMPGDPIIAAWPEAKFGQYASRLYAILDEEPKATLKDYGDAIDYTVRKIGIDHVGISSDFNEGGGVKG
WENVGDIPNVTAELISRGYSEADIAKLWGGNFLRVWDQVQKAARPALISQQDKIKP
>Mature_455_residues
TKPRSKKALFIGLPLALAISAAAGFAAWDYWLNDNPGYPVKVMDQAREMHQHLLSFDSHITVLQDFGTHGNEADKDGPGQ
FDLIKANRGQLSGAALTIFGWPELWNGANAPHKPTAGFVEEARNQQEIRYKIISGMVRDFPNQVGIAYTPEDFRRLHGEG
KFAIFISMLNAYPLGHDLNLLDLWTARGMRMFGFSYIGNNDWADSSRPLPFFNDSPDALDGLSDLGKQAVKRLNDLGVII
DVSQMSTKALEQVAQLSRTPMVASHSAPRAMVDIPRNLSDKELQLIKNSGGVVQVVGFSQYLRPLTQTTQDKLNELRKSF
DLPPLPNLAVALMPGDPIIAAWPEAKFGQYASRLYAILDEEPKATLKDYGDAIDYTVRKIGIDHVGISSDFNEGGGVKGW
ENVGDIPNVTAELISRGYSEADIAKLWGGNFLRVWDQVQKAARPALISQQDKIKP

Specific function: Unknown

COG id: COG2355

COG function: function code E; Zn-dependent dipeptidase, microsomal dipeptidase homolog

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M19 family [H]

Homologues:

Organism=Homo sapiens, GI11641269, Length=291, Percent_Identity=26.1168384879725, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI189458885, Length=387, Percent_Identity=25.3229974160207, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI4758190, Length=387, Percent_Identity=25.3229974160207, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI193211608, Length=141, Percent_Identity=32.6241134751773, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI193211610, Length=141, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI281362638, Length=181, Percent_Identity=29.2817679558011, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI281362636, Length=181, Percent_Identity=29.2817679558011, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI221475880, Length=310, Percent_Identity=24.1935483870968, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI161083233, Length=256, Percent_Identity=25.78125, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000180
- InterPro:   IPR008257 [H]

Pfam domain/function: PF01244 Peptidase_M19 [H]

EC number: NA

Molecular weight: Translated: 50361; Mature: 50230

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKPRSKKALFIGLPLALAISAAAGFAAWDYWLNDNPGYPVKVMDQAREMHQHLLSFDSH
CCCCCCCCEEEEECHHHHHHHHHHCHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCC
ITVLQDFGTHGNEADKDGPGQFDLIKANRGQLSGAALTIFGWPELWNGANAPHKPTAGFV
CHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEECHHHCCCCCCCCCCCHHHH
EEARNQQEIRYKIISGMVRDFPNQVGIAYTPEDFRRLHGEGKFAIFISMLNAYPLGHDLN
HHHCCHHHHHHHHHHHHHHHCCHHCCEEECHHHHHHHCCCCCEEEEEEHHHCCCCCCCCC
LLDLWTARGMRMFGFSYIGNNDWADSSRPLPFFNDSPDALDGLSDLGKQAVKRLNDLGVI
HHHHHHHCCCCHHEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEE
IDVSQMSTKALEQVAQLSRTPMVASHSAPRAMVDIPRNLSDKELQLIKNSGGVVQVVGFS
EEHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHCCCCCCCHHHHHHHCCCCCEEEEECHH
QYLRPLTQTTQDKLNELRKSFDLPPLPNLAVALMPGDPIIAAWPEAKFGQYASRLYAILD
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHC
EEPKATLKDYGDAIDYTVRKIGIDHVGISSDFNEGGGVKGWENVGDIPNVTAELISRGYS
CCCCHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCC
EADIAKLWGGNFLRVWDQVQKAARPALISQQDKIKP
HHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHCCCC
>Mature Secondary Structure 
TKPRSKKALFIGLPLALAISAAAGFAAWDYWLNDNPGYPVKVMDQAREMHQHLLSFDSH
CCCCCCCEEEEECHHHHHHHHHHCHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCC
ITVLQDFGTHGNEADKDGPGQFDLIKANRGQLSGAALTIFGWPELWNGANAPHKPTAGFV
CHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEECHHHCCCCCCCCCCCHHHH
EEARNQQEIRYKIISGMVRDFPNQVGIAYTPEDFRRLHGEGKFAIFISMLNAYPLGHDLN
HHHCCHHHHHHHHHHHHHHHCCHHCCEEECHHHHHHHCCCCCEEEEEEHHHCCCCCCCCC
LLDLWTARGMRMFGFSYIGNNDWADSSRPLPFFNDSPDALDGLSDLGKQAVKRLNDLGVI
HHHHHHHCCCCHHEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEE
IDVSQMSTKALEQVAQLSRTPMVASHSAPRAMVDIPRNLSDKELQLIKNSGGVVQVVGFS
EEHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHCCCCCCCHHHHHHHCCCCCEEEEECHH
QYLRPLTQTTQDKLNELRKSFDLPPLPNLAVALMPGDPIIAAWPEAKFGQYASRLYAILD
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHC
EEPKATLKDYGDAIDYTVRKIGIDHVGISSDFNEGGGVKGWENVGDIPNVTAELISRGYS
CCCCHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCC
EADIAKLWGGNFLRVWDQVQKAARPALISQQDKIKP
HHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2536663 [H]