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The map label for this gene is hemN [H]

Identifier: 77458040

GI number: 77458040

Start: 2025099

End: 2026481

Strand: Reverse

Name: hemN [H]

Synonym: Pfl01_1813

Alternate gene names: 77458040

Gene position: 2026481-2025099 (Counterclockwise)

Preceding gene: 77458041

Following gene: 77458038

Centisome position: 31.47

GC content: 62.55

Gene sequence:

>1383_bases
ATGCTCGACGCCATTCGTTGGGACACCGATTTGATCCGCCGCTACGACCTGGCGGGGCCGCGCTACACCTCGTACCCGAC
GGCCGTGCAATTTCACAGTCAGGTCGGCACCTTCGACCTGTTTCACGCCCTGCGCGACAGCCGCAAGGCCCTGCGCCCGC
TGTCGCTGTACGTGCACGTGCCGTTCTGCGCGAACATTTGCTACTACTGCGCCTGCAACAAGGTCATCACCAAGGATCGC
GGCCGCGCGTTGCCTTATCTGCAACGGCTCGAGCAGGAAATCCAATTGATCGCCTGCCACCTCGACCCGGCGCAGAAAGT
CGAGCAACTGCACTTCGGCGGCGGCACGCCGACCTTTCTCAGCCACGATGAATTGCGGCAGTTGATGGCGCACCTGCGCA
AGCACTTCAATCTGCTGGACGATGATTCTGGCGACTACGGCATCGAAATCGACCCGCGCGAAGCCGACTGGTCGACCATG
GGCCTGCTGCGGGAACTGGGCTTCAACCGGGTCAGCATCGGCCTGCAGGATCTCGACCCGGCGGTGCAGCGGGCGGTCAA
TCGCCTGCAAAGCCTGGAAGAAACCCGCGCGGTGATCGACGCGGCGCGGACCCTGCAATTTCGCTCGATCAACATCGACC
TGATTTACGGCCTGCCCAAACAGACCCCGGACAACTTCGCCCGCACCGTCGAGGAAGTCATCAGCCTGCAACCGGACCGG
CTCTCGGTGTTCAACTACGCGCACCTGCCGGAACGCTTCATGCCGCAGCGGCGGATCAACGGCAACGAACTGCCGAGCCC
GGCGCAGAAACTGGAAATGCTGCAACGCACCATCGAACAACTGACCGCCGCCGGCTACCGCTACATCGGCATGGACCACT
TCGCCCTGCCCGACGATGAACTGGCGATTGCTCAGGAAGAGTCGACCCTGCAACGCAATTTCCAGGGCTACACCACCCAC
GGCCATTGCGACTTGATCGGCCTGGGCGTGTCGGCCATCAGCCAGATCGGCGACCTGTACTGCCAGAACAGCAGCGACCT
CAATCACTACCAGAACACCCTCGCCGGCGCGCAACTGGCCACCAGCCGGGGCCTGGTGTGCAACGCCGACGATCGCCTGC
GCCGCGCGGTAATTCAGCAACTGATCTGCAACTTCAGCCTGGATTTCGCCGAGATCGAGCGCAGTTTCAACATCGATTTT
CAGGGCTACTTCGGCGCGCTCTGGCCGCAATTGCAGGGCATGGCGCAGGACGGGTTGATCGAACTGGATCGCGAGCGCAT
CACCGTGCTACCGGCCGGGCGCCTGCTGGTACGTTCGGTGTGCATGGTGTTCGACGCGTATCTGGAGCAGCAGAACCGCC
AGCGTTTTTCGCGGGTGATCTAG

Upstream 100 bases:

>100_bases
TGGCTGATGGGCCACTGATCCCGTTGATGCAAATCAAGATGCCTTTTCGCGCCCTCCCCTAGACTCGGCACACTGCCAGC
CTATCCGGGGGAATGCCCGC

Downstream 100 bases:

>100_bases
CTCTTCATCAGCAGCGAGTTGGTTTTCAGGTTCTGGTCAGCGGTCAGGCTCGACTGGTCGATGACCTTGGCCAGGGACAG
ATTGGCAGTAATCAGGCCGT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MLDAIRWDTDLIRRYDLAGPRYTSYPTAVQFHSQVGTFDLFHALRDSRKALRPLSLYVHVPFCANICYYCACNKVITKDR
GRALPYLQRLEQEIQLIACHLDPAQKVEQLHFGGGTPTFLSHDELRQLMAHLRKHFNLLDDDSGDYGIEIDPREADWSTM
GLLRELGFNRVSIGLQDLDPAVQRAVNRLQSLEETRAVIDAARTLQFRSINIDLIYGLPKQTPDNFARTVEEVISLQPDR
LSVFNYAHLPERFMPQRRINGNELPSPAQKLEMLQRTIEQLTAAGYRYIGMDHFALPDDELAIAQEESTLQRNFQGYTTH
GHCDLIGLGVSAISQIGDLYCQNSSDLNHYQNTLAGAQLATSRGLVCNADDRLRRAVIQQLICNFSLDFAEIERSFNIDF
QGYFGALWPQLQGMAQDGLIELDRERITVLPAGRLLVRSVCMVFDAYLEQQNRQRFSRVI

Sequences:

>Translated_460_residues
MLDAIRWDTDLIRRYDLAGPRYTSYPTAVQFHSQVGTFDLFHALRDSRKALRPLSLYVHVPFCANICYYCACNKVITKDR
GRALPYLQRLEQEIQLIACHLDPAQKVEQLHFGGGTPTFLSHDELRQLMAHLRKHFNLLDDDSGDYGIEIDPREADWSTM
GLLRELGFNRVSIGLQDLDPAVQRAVNRLQSLEETRAVIDAARTLQFRSINIDLIYGLPKQTPDNFARTVEEVISLQPDR
LSVFNYAHLPERFMPQRRINGNELPSPAQKLEMLQRTIEQLTAAGYRYIGMDHFALPDDELAIAQEESTLQRNFQGYTTH
GHCDLIGLGVSAISQIGDLYCQNSSDLNHYQNTLAGAQLATSRGLVCNADDRLRRAVIQQLICNFSLDFAEIERSFNIDF
QGYFGALWPQLQGMAQDGLIELDRERITVLPAGRLLVRSVCMVFDAYLEQQNRQRFSRVI
>Mature_460_residues
MLDAIRWDTDLIRRYDLAGPRYTSYPTAVQFHSQVGTFDLFHALRDSRKALRPLSLYVHVPFCANICYYCACNKVITKDR
GRALPYLQRLEQEIQLIACHLDPAQKVEQLHFGGGTPTFLSHDELRQLMAHLRKHFNLLDDDSGDYGIEIDPREADWSTM
GLLRELGFNRVSIGLQDLDPAVQRAVNRLQSLEETRAVIDAARTLQFRSINIDLIYGLPKQTPDNFARTVEEVISLQPDR
LSVFNYAHLPERFMPQRRINGNELPSPAQKLEMLQRTIEQLTAAGYRYIGMDHFALPDDELAIAQEESTLQRNFQGYTTH
GHCDLIGLGVSAISQIGDLYCQNSSDLNHYQNTLAGAQLATSRGLVCNADDRLRRAVIQQLICNFSLDFAEIERSFNIDF
QGYFGALWPQLQGMAQDGLIELDRERITVLPAGRLLVRSVCMVFDAYLEQQNRQRFSRVI

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=249, Percent_Identity=30.5220883534137, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI87082341, Length=460, Percent_Identity=51.304347826087, Blast_Score=461, Evalue=1e-131,
Organism=Escherichia coli, GI1789325, Length=404, Percent_Identity=25.7425742574257, Blast_Score=100, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 52526; Mature: 52526

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDAIRWDTDLIRRYDLAGPRYTSYPTAVQFHSQVGTFDLFHALRDSRKALRPLSLYVHV
CCCCHHCCHHHHHHHHCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCEEEEEEC
PFCANICYYCACNKVITKDRGRALPYLQRLEQEIQLIACHLDPAQKVEQLHFGGGTPTFL
CHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHEEEECCCHHHHHHHHHCCCCCCCCC
SHDELRQLMAHLRKHFNLLDDDSGDYGIEIDPREADWSTMGLLRELGFNRVSIGLQDLDP
CHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCHHHHHHHHHCCCCEEECCHHHCCH
AVQRAVNRLQSLEETRAVIDAARTLQFRSINIDLIYGLPKQTPDNFARTVEEVISLQPDR
HHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCC
LSVFNYAHLPERFMPQRRINGNELPSPAQKLEMLQRTIEQLTAAGYRYIGMDHFALPDDE
CHHHHHHHCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCC
LAIAQEESTLQRNFQGYTTHGHCDLIGLGVSAISQIGDLYCQNSSDLNHYQNTLAGAQLA
HHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
TSRGLVCNADDRLRRAVIQQLICNFSLDFAEIERSFNIDFQGYFGALWPQLQGMAQDGLI
HCCCCEECCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHCHHHCCCE
ELDRERITVLPAGRLLVRSVCMVFDAYLEQQNRQRFSRVI
EECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLDAIRWDTDLIRRYDLAGPRYTSYPTAVQFHSQVGTFDLFHALRDSRKALRPLSLYVHV
CCCCHHCCHHHHHHHHCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCEEEEEEC
PFCANICYYCACNKVITKDRGRALPYLQRLEQEIQLIACHLDPAQKVEQLHFGGGTPTFL
CHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHEEEECCCHHHHHHHHHCCCCCCCCC
SHDELRQLMAHLRKHFNLLDDDSGDYGIEIDPREADWSTMGLLRELGFNRVSIGLQDLDP
CHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCHHHHHHHHHCCCCEEECCHHHCCH
AVQRAVNRLQSLEETRAVIDAARTLQFRSINIDLIYGLPKQTPDNFARTVEEVISLQPDR
HHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCC
LSVFNYAHLPERFMPQRRINGNELPSPAQKLEMLQRTIEQLTAAGYRYIGMDHFALPDDE
CHHHHHHHCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCC
LAIAQEESTLQRNFQGYTTHGHCDLIGLGVSAISQIGDLYCQNSSDLNHYQNTLAGAQLA
HHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
TSRGLVCNADDRLRRAVIQQLICNFSLDFAEIERSFNIDFQGYFGALWPQLQGMAQDGLI
HCCCCEECCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHCHHHCCCE
ELDRERITVLPAGRLLVRSVCMVFDAYLEQQNRQRFSRVI
EECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9767567; 10984043 [H]