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The map label for this gene is hyi [H]

Identifier: 77457824

GI number: 77457824

Start: 1784072

End: 1784854

Strand: Reverse

Name: hyi [H]

Synonym: Pfl01_1597

Alternate gene names: 77457824

Gene position: 1784854-1784072 (Counterclockwise)

Preceding gene: 77457825

Following gene: 77457823

Centisome position: 27.72

GC content: 61.56

Gene sequence:

>783_bases
ATGCCGCGTTTCGCAGCCAACCTGTCCATGCTGTTCACCGAACAGGATTTCCTTGCCCGTTTCGACGCCGCCGCCAAGGC
TGGCTTCAGCGGTGTCGAGTACCTGTTCCCGTACGATTTCAGCTCCGCCGAAATCAAGGCCAGACTCGACGCCAACGGTC
TGACCCAAGTGCTGTTCAACCTGCCGGCCGGTGACTGGGCCAAGGGCGAGCGCGGTATCGCGTGCCTGCCGGACCGGGTC
GAAGAGTTCCGCGCCGGGGTCGATCTGGCCATCGCTTACGCACAGGTGCTGGGCAACACCCAGGTCAACTGCCTGGCCGG
TATCCGTCCGCAGGGCGTGGACGATGCCACCGTTGAAAAGACCTTCGTCGCCAACCTCAAGTACGCCGCCGACAAGCTGC
AAGCCGTCGGCATCAAACTGGTGATGGAAGCGATCAACACCCGCGACATCCCGGGTTTCTACCTGAACAACACGGCGCAA
GCCCTGTCGATTCGCGAGCAGGTCGGCAGCGCCAATCTGTTCCTGCAATACGACATCTATCACATGCAAATCATGGAAGG
CGATCTGGCCCGCACCCTGCAATCGCACCTGGCCGAGATCAACCATGTGCAGCTCGCCGACAACCCGGGCCGCAACGAGC
CGGGCACTGGCGAAATCAACTACCGCTTCCTGTTCGAACACCTCGATCGCATCGGTTATCAGGGCTGGGTCGGCTGCGAG
TACAAACCGCTGACCACCACTGAAGCGGGCCTCGGCTGGCTGAAGACCCACAACGCGATCTGA

Upstream 100 bases:

>100_bases
TTGCTCGACTGAACGTAACCGGCTCCCTCTCCCTCCGGGAGAGGGGACTTGATCGCGTTCAGTCTGACCAACCGTGTCAA
AACTGTTTTAGGAGACCACC

Downstream 100 bases:

>100_bases
CCCCTATTTGCTTGAGCAAGACAAAAACAAGAGGAATTTCTCATGGCTAAAATCGGATTTATCGGCACCGGCATCATGGG
CCACCCAATGGCGGCGAACC

Product: hydroxypyruvate isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MPRFAANLSMLFTEQDFLARFDAAAKAGFSGVEYLFPYDFSSAEIKARLDANGLTQVLFNLPAGDWAKGERGIACLPDRV
EEFRAGVDLAIAYAQVLGNTQVNCLAGIRPQGVDDATVEKTFVANLKYAADKLQAVGIKLVMEAINTRDIPGFYLNNTAQ
ALSIREQVGSANLFLQYDIYHMQIMEGDLARTLQSHLAEINHVQLADNPGRNEPGTGEINYRFLFEHLDRIGYQGWVGCE
YKPLTTTEAGLGWLKTHNAI

Sequences:

>Translated_260_residues
MPRFAANLSMLFTEQDFLARFDAAAKAGFSGVEYLFPYDFSSAEIKARLDANGLTQVLFNLPAGDWAKGERGIACLPDRV
EEFRAGVDLAIAYAQVLGNTQVNCLAGIRPQGVDDATVEKTFVANLKYAADKLQAVGIKLVMEAINTRDIPGFYLNNTAQ
ALSIREQVGSANLFLQYDIYHMQIMEGDLARTLQSHLAEINHVQLADNPGRNEPGTGEINYRFLFEHLDRIGYQGWVGCE
YKPLTTTEAGLGWLKTHNAI
>Mature_259_residues
PRFAANLSMLFTEQDFLARFDAAAKAGFSGVEYLFPYDFSSAEIKARLDANGLTQVLFNLPAGDWAKGERGIACLPDRVE
EFRAGVDLAIAYAQVLGNTQVNCLAGIRPQGVDDATVEKTFVANLKYAADKLQAVGIKLVMEAINTRDIPGFYLNNTAQA
LSIREQVGSANLFLQYDIYHMQIMEGDLARTLQSHLAEINHVQLADNPGRNEPGTGEINYRFLFEHLDRIGYQGWVGCEY
KPLTTTEAGLGWLKTHNAI

Specific function: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) [H]

COG id: COG3622

COG function: function code G; Hydroxypyruvate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hyi family [H]

Homologues:

Organism=Homo sapiens, GI300068962, Length=262, Percent_Identity=41.9847328244275, Blast_Score=197, Evalue=6e-51,
Organism=Homo sapiens, GI300068964, Length=243, Percent_Identity=41.5637860082305, Blast_Score=176, Evalue=3e-44,
Organism=Escherichia coli, GI1786718, Length=254, Percent_Identity=57.8740157480315, Blast_Score=305, Evalue=1e-84,
Organism=Escherichia coli, GI1789095, Length=254, Percent_Identity=46.0629921259843, Blast_Score=242, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17552022, Length=240, Percent_Identity=36.6666666666667, Blast_Score=159, Evalue=1e-39,
Organism=Drosophila melanogaster, GI17530883, Length=256, Percent_Identity=36.71875, Blast_Score=164, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017643
- InterPro:   IPR013022
- InterPro:   IPR012307 [H]

Pfam domain/function: PF01261 AP_endonuc_2 [H]

EC number: =5.3.1.22 [H]

Molecular weight: Translated: 28742; Mature: 28611

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRFAANLSMLFTEQDFLARFDAAAKAGFSGVEYLFPYDFSSAEIKARLDANGLTQVLFN
CCCHHCCEEEEEECHHHHHHHHHHHHCCCCCCEEEECCCCCCCEEEEEECCCHHHHHHHC
LPAGDWAKGERGIACLPDRVEEFRAGVDLAIAYAQVLGNTQVNCLAGIRPQGVDDATVEK
CCCCCCCCCCCCCEECHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHH
TFVANLKYAADKLQAVGIKLVMEAINTRDIPGFYLNNTAQALSIREQVGSANLFLQYDIY
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHCCCEEEEEEEEE
HMQIMEGDLARTLQSHLAEINHVQLADNPGRNEPGTGEINYRFLFEHLDRIGYQGWVGCE
EEEECCCHHHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEHHHHHHHHHHCCCCCEECCC
YKPLTTTEAGLGWLKTHNAI
CCCCCCCCCCCCCHHCCCCC
>Mature Secondary Structure 
PRFAANLSMLFTEQDFLARFDAAAKAGFSGVEYLFPYDFSSAEIKARLDANGLTQVLFN
CCHHCCEEEEEECHHHHHHHHHHHHCCCCCCEEEECCCCCCCEEEEEECCCHHHHHHHC
LPAGDWAKGERGIACLPDRVEEFRAGVDLAIAYAQVLGNTQVNCLAGIRPQGVDDATVEK
CCCCCCCCCCCCCEECHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHH
TFVANLKYAADKLQAVGIKLVMEAINTRDIPGFYLNNTAQALSIREQVGSANLFLQYDIY
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHCCCEEEEEEEEE
HMQIMEGDLARTLQSHLAEINHVQLADNPGRNEPGTGEINYRFLFEHLDRIGYQGWVGCE
EEEECCCHHHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEHHHHHHHHHHCCCCCEECCC
YKPLTTTEAGLGWLKTHNAI
CCCCCCCCCCCCCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8440684; 10561547; 9278503 [H]