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The map label for this gene is glxR [H]

Identifier: 77457823

GI number: 77457823

Start: 1783136

End: 1784029

Strand: Reverse

Name: glxR [H]

Synonym: Pfl01_1596

Alternate gene names: 77457823

Gene position: 1784029-1783136 (Counterclockwise)

Preceding gene: 77457824

Following gene: 77457822

Centisome position: 27.71

GC content: 62.75

Gene sequence:

>894_bases
ATGGCTAAAATCGGATTTATCGGCACCGGCATCATGGGCCACCCAATGGCGGCGAACCTGCAGAAAGCCGGTCACAGCCT
GTTCCTGTCGGCGCACCACGATGCTGCCCCTGCCGACCTGGTCGCCGCTGGCGCCGTCGCTCTGGCCAACCCGCGCGAAG
TGGCTCAGGAAGCTGAATTCATCATCGTCATGGTGCCGGATACCCCGCAGGTCGAAGACGTGCTGTTCCGCGCCGACGGC
GTCGCGGCCGGCATCGGCAAAGGCAAGGTGGTGATCGACATGAGCTCGATCTCGCCGACCGCCACCAAGGCTTTTGCCGC
GAAGATCAACGAGAAAGGTGCGCAATACCTCGACGCCCCGGTGTCCGGCGGTGAAGTCGGCGCCAAGGCCGCGACCCTGA
GCATCATGGTCGGTGGCGACGCCGATGCCTTCGAACGCGCACTGCCGCTGTTCCAGGCCATGGGCAAGAACATCACCCTG
GTCGGTGGCAATGGCGACGGTCAGACCGCCAAGGTGGCGAACCAGATCATCGTTGCCCTGAACATTCAGGCCGTCGCCGA
AGCCCTGCTGTTCGCCTCGAAAAACGGTGCCGATCCAGCCAAGGTGCGTGAGGCATTGATGGGCGGTTTCGCCTCCTCGA
AGATTCTCGAAGTGCACGGCGAGCGCATGATCAAGGGCACCTTCGATCCGGGCTTCCGCATCAGCCTGCACCAGAAGGAC
CTGAACCTGGCCCTGCAAGGCGCCAAGGAGCTGAACATCAACCTGCCGAACACCGCCAACGCCCAGCAAGTGTTCAGCAC
CTGCGCGGCCATCGGTGGCAGCAACTGGGACCACTCGGCGCTGATCAAGGGCCTGGAACACATGGCCAACTTCACGATTC
GCGACAAGAAGTAA

Upstream 100 bases:

>100_bases
ACCGCTGACCACCACTGAAGCGGGCCTCGGCTGGCTGAAGACCCACAACGCGATCTGACCCCTATTTGCTTGAGCAAGAC
AAAAACAAGAGGAATTTCTC

Downstream 100 bases:

>100_bases
GTTGCGTCCCTGACCCGCTCCCTGTGGGAGCGGGCTTGCCCGCGATGGCATCGACTCGCTCGGCCTGAAAGACCGCAGCG
CCTGAATCGCTGGCAAGCCA

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MAKIGFIGTGIMGHPMAANLQKAGHSLFLSAHHDAAPADLVAAGAVALANPREVAQEAEFIIVMVPDTPQVEDVLFRADG
VAAGIGKGKVVIDMSSISPTATKAFAAKINEKGAQYLDAPVSGGEVGAKAATLSIMVGGDADAFERALPLFQAMGKNITL
VGGNGDGQTAKVANQIIVALNIQAVAEALLFASKNGADPAKVREALMGGFASSKILEVHGERMIKGTFDPGFRISLHQKD
LNLALQGAKELNINLPNTANAQQVFSTCAAIGGSNWDHSALIKGLEHMANFTIRDKK

Sequences:

>Translated_297_residues
MAKIGFIGTGIMGHPMAANLQKAGHSLFLSAHHDAAPADLVAAGAVALANPREVAQEAEFIIVMVPDTPQVEDVLFRADG
VAAGIGKGKVVIDMSSISPTATKAFAAKINEKGAQYLDAPVSGGEVGAKAATLSIMVGGDADAFERALPLFQAMGKNITL
VGGNGDGQTAKVANQIIVALNIQAVAEALLFASKNGADPAKVREALMGGFASSKILEVHGERMIKGTFDPGFRISLHQKD
LNLALQGAKELNINLPNTANAQQVFSTCAAIGGSNWDHSALIKGLEHMANFTIRDKK
>Mature_296_residues
AKIGFIGTGIMGHPMAANLQKAGHSLFLSAHHDAAPADLVAAGAVALANPREVAQEAEFIIVMVPDTPQVEDVLFRADGV
AAGIGKGKVVIDMSSISPTATKAFAAKINEKGAQYLDAPVSGGEVGAKAATLSIMVGGDADAFERALPLFQAMGKNITLV
GGNGDGQTAKVANQIIVALNIQAVAEALLFASKNGADPAKVREALMGGFASSKILEVHGERMIKGTFDPGFRISLHQKDL
NLALQGAKELNINLPNTANAQQVFSTCAAIGGSNWDHSALIKGLEHMANFTIRDKK

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=297, Percent_Identity=32.3232323232323, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI40556376, Length=286, Percent_Identity=29.7202797202797, Blast_Score=124, Evalue=9e-29,
Organism=Escherichia coli, GI1786719, Length=288, Percent_Identity=66.3194444444444, Blast_Score=389, Evalue=1e-110,
Organism=Escherichia coli, GI145693186, Length=291, Percent_Identity=42.2680412371134, Blast_Score=222, Evalue=2e-59,
Organism=Escherichia coli, GI1790315, Length=299, Percent_Identity=36.4548494983278, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1789092, Length=282, Percent_Identity=29.7872340425532, Blast_Score=101, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17557316, Length=286, Percent_Identity=31.8181818181818, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24655230, Length=285, Percent_Identity=35.7894736842105, Blast_Score=141, Evalue=5e-34,
Organism=Drosophila melanogaster, GI19922568, Length=285, Percent_Identity=35.7894736842105, Blast_Score=141, Evalue=5e-34,
Organism=Drosophila melanogaster, GI28574115, Length=280, Percent_Identity=27.5, Blast_Score=106, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30773; Mature: 30642

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIGFIGTGIMGHPMAANLQKAGHSLFLSAHHDAAPADLVAAGAVALANPREVAQEAEF
CCEEEEEECCCCCCCCHHHHHHCCCEEEEEECCCCCCHHHHHHCHHEECCHHHHHCCCCE
IIVMVPDTPQVEDVLFRADGVAAGIGKGKVVIDMSSISPTATKAFAAKINEKGAQYLDAP
EEEECCCCCCHHHHHEECCCCEECCCCCEEEEEECCCCCHHHHHHHHHHHHCCHHEECCC
VSGGEVGAKAATLSIMVGGDADAFERALPLFQAMGKNITLVGGNGDGQTAKVANQIIVAL
CCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHCEEEEEE
NIQAVAEALLFASKNGADPAKVREALMGGFASSKILEVHGERMIKGTFDPGFRISLHQKD
EHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHEEECCCEEEEECCCCCEEEEEECCC
LNLALQGAKELNINLPNTANAQQVFSTCAAIGGSNWDHSALIKGLEHMANFTIRDKK
CCEEEECCEEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEECCC
>Mature Secondary Structure 
AKIGFIGTGIMGHPMAANLQKAGHSLFLSAHHDAAPADLVAAGAVALANPREVAQEAEF
CEEEEEECCCCCCCCHHHHHHCCCEEEEEECCCCCCHHHHHHCHHEECCHHHHHCCCCE
IIVMVPDTPQVEDVLFRADGVAAGIGKGKVVIDMSSISPTATKAFAAKINEKGAQYLDAP
EEEECCCCCCHHHHHEECCCCEECCCCCEEEEEECCCCCHHHHHHHHHHHHCCHHEECCC
VSGGEVGAKAATLSIMVGGDADAFERALPLFQAMGKNITLVGGNGDGQTAKVANQIIVAL
CCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHCEEEEEE
NIQAVAEALLFASKNGADPAKVREALMGGFASSKILEVHGERMIKGTFDPGFRISLHQKD
EHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHEEECCCEEEEECCCCCEEEEEECCC
LNLALQGAKELNINLPNTANAQQVFSTCAAIGGSNWDHSALIKGLEHMANFTIRDKK
CCEEEECCEEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]