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The map label for this gene is pycA [H]

Identifier: 77457565

GI number: 77457565

Start: 1512232

End: 1515864

Strand: Reverse

Name: pycA [H]

Synonym: Pfl01_1338

Alternate gene names: 77457565

Gene position: 1515864-1512232 (Counterclockwise)

Preceding gene: 77457566

Following gene: 77457564

Centisome position: 23.54

GC content: 64.96

Gene sequence:

>3633_bases
ATGTTCGAAAAAGTCCTGATTGCCAACCGTGGCGCGATTGCCTGCCGCATTCTGCGCACCTTGCGTGAACTGCACGTCGA
AGGCGTCGCGGTGTACTCCGAAGCCGATGCCGCCAGCCTGCACATCCTGCAAGCGGACGAAGCCCACAGCCTCGGTGAAG
GCGCCGCGGCCAGCACCTATCTGGCCGTGGACAAGATTCTCGCCATCGCCAAAGCCACTGGCGCCACCGCGATCCATCCG
GGCTACGGCTTTCTTTCCGAGAACGCGGCGTTCGCCGAAGCCTGCGCCAACCATGGCATTGCCTTCATCGGCCCGACACC
GGAGCAACTGCGGGTGTTCGGCCTCAAGCACACCGCACGGGCCCTGGCCAAACAGCACGGCGTGCCAATGCTCGAAGGCA
CCGAACTGCTCGACAGCCTCGACGCCGCGCTGATTGCCGGCGCGCAGGTCGGTTATCCGGTGATGCTCAAAAGCACCGCC
GGGGGCGGTGGCATCGGCATGCGCGTGTGCCGTAACGCCAGCGAACTGAGCGAGTCGTTCGAGGCGGTGAAGCGCCTCGG
CCAGAACAACTTCAGCGACGCCGGAGTGTTCATCGAGAAGTACATCCAGCGTGCGCGGCATCTGGAAGTCCAGGTGTTCG
GCGACGGCCAAGGCGCAGTGATCGCCCTCGGCGTGCGCGACTGCTCGGTGCAGCGGCGCAATCAGAAAGTCCTTGAGGAA
ACCCCGGCACCGAACCTGCCCGATGGCATGGCGGATGAGCTGTGCGCGGCGGCGATCAAACTGGCCAAAGCAGTGAATTA
CCGCAGCGCCGGCACCGTCGAATTCGTTTTCGACAGCGATGCGCAGCGCTTCTATTTTCTGGAAGTGAACACCCGGTTGC
AGGTTGAGCACGGCGTTACCGAACAGGTGTGGGGCGTCGATCTGGTGCGCTGGATGATTGAACTGGCGGCGGGAGATCTG
CCGCCGCTGAGCACATTGTTTGAGGGCCTGAAACCGGACGGCCACGCGATTCAGGCGCGGCTGTACGCGGAGGATCCGGG
GCGCGATTTCCAGCCGAGCCCAGGGCTGCTGACCGCTGTGGAGTTTCCTGCGGCCAACGGCATTCAACTGCGCATCGACA
CCTGGGTCGAGGCTGGCTGCGAGATCCCGCCCTACTTCGATCCGATGATCGCCAAACTCATCAGCTGGGCGCCAACCCGC
GAACAGGCCCGCGCCGAACTGCACCAGGCCCTCGGCGACAGCCTGCTGTACGGCGTGGAAACCAACCGCGACTACCTGCG
GCAGATTCTGCTCGATACACCGTTCGCCAGCGGTCAGCCCTGGACCCGTTGCCTGGAAGGTCTGGTGTACCAGGCCAACA
CCTTCGAAGTGCTGAGCGCCGGCACCCAGACCAGCGTCCAGGACTACCCCGGCCGCCTCGGCTACTGGGCGGTGGGCGTG
CCACCCTCGGGGCCGATGGACAGTCGCGCGTTGCGTCTGGGCAATCGCTTGCTGGGCAATGACGAAGGCGCGGCGGCACT
GGAAATCACCATGAACGGGCCGCTGCTGCGCTTCAATTGCGACGCGGTGGTGGCGGTGACCGGGGCACCGTTGGCGCTGA
CCCTCGACGGCGAAGCGGTGCCGATGAACACCGCGCTGTTGATTGAAGCGGGCAGCCAGTTACATCTCGGCGGTTTGCTC
GACGCCGGCGCCCGCAGCTACCTGTGCCTGCGCGGCGGCCTGCAGGTGCCGGACTATCTGGGCAGCAAAAGCACCTTCAC
CCTCGGTCAGTTCGGCGGTCATGGCGGGCGAGCCCTGCGTGCCGGCGACGTGTTGCACCTGGCGCCCCTGAGCGACCGAA
GCGCCGGGCAGACCCTGGCCCCGCATCACGTCAGCGAACTGCCCGCCGTGCGCCGGATCCGGGTGATCTATGGCCCCCAC
GGCGCGCCGGAATATTTCACCGAACACTACATCGACACGTTCTTCGCCACGCACTGGGAAGTGCACTTCAACTCCAGCCG
TACCGGCGTGCGCCTGATAGGACCAAAGCCGGAATGGGTGCGCGCCGACGGCGGTGAAGCCGGGCTGCATCCGTCGAACA
TTCACGACAACCCCTATGCCATTGGTGCGGTGGACTTCACCGGCGACATGCCAGTGATCCTCGGTCCGGACGGCCCGAGC
CTTGGCGGTTTCGTGTGCCCGGTGACGGTGATCGAAGCGGATCTCTGGCAGCTCGGGCAACTGAAGGCCGGGGACAAGGT
GCAGTTTGAGCCGGTCGATCTCAAGACTGCCCGCGATCTCGCCCTGAAATGGGATGCCTCCGAGAGCTGGCCAGCCAGCG
ACGAAGTTGACGCGGTGTCTGCTCGGGCCCCATCGCTGGCATGCCAGCTCCCACAGGCCCTGGTTTCGCCTGTGATTCTG
GAGTTGGGTCAGGGCGACAAGCGGCTGGTCGGGCGTGTGTCCGGCGATACCCATCTGCTGCTGGAAATCGGCGCGCTGGA
ACTGGATCTGGTCCTGCGCTTTCGCGCCCATGCCCTGATGCAGGCGCTGGAAGGCAAAAACCTGCACGGCGTGATCGACC
TGACACCGGGCATTCGTTCGCTGCAGATCCACTACCAGCCCGAACAACTGCCGCTGGCCGATCTGCTCGGCATCGTCGCC
GGTGAATGGGATGCGGTGTGCGCCGCCCAGGACTTGCAAGTGCCGTCGCGGATCGTCCACTTGCCCCTGTCGTGGGACGA
CCCGGCCTGCCAGTTGGCGATCGAGAAATACATGACCACCGTGCGCAAGGACGCGCCGTGGTGCCCGAGCAATCTGGAGT
TCATCCGCCGCATCAACGACCTGCCGAACCTCGATGAAGTGCAGCGCACGGTATTCGATGCGAGCTATCTGGTGATGGGC
CTGGGTGACGTCTACCTTGGTGCGCCGGTCGCCACGCCGCTCGACCCGCGCCATCGGCTGGTGACCACCAAGTACAACCC
GGCGCGCACCTGGACCGCCGAGAACTCGGTGGGCATCGGCGGCGCCTACATGTGCGTGTACGGCATGGAAGGCCCCGGCG
GTTATCAGTTCGTCGGGCGCACCTTGCAGATGTGGAACCGCTATCGCGAAGTCGCCGCGTTCGACGGCAAACCGTGGCTG
CTGCGGTTTTTCGATCAGATCCGTTTCTACCCGGTCAGCGCCGAAGAACTGCTGCGCATCCGCCGGGATTTTCCCCTCGG
TCGTTTCGACCTCGACATCGAACATAGCCAGCTCAACCTCGGCGACTACCAGGCCTTTCTGCAACGCGAAGCCGAGACCA
TCGACGCCTTCCGAACGCAGCAACAGGGCGCCTTCCAGGCGGAGCGCGAACGCTGGATCGCCAGTGGCCAGGCGCACTTC
GACAGCGAAGAAGCCGTGCCGGTCAGCAGCGAAGACACACCGCTGACCAGCGGCCAGCAAAGCATCGACAGCCACATCGC
CGGCAACCTCTGGCAGGTGCAGGTCGAGGTCGGCAGCCGCGTGGCGGCCGGTGATGTGCTGGTGATTCTGGAGTCGATGA
AGATGGAAATCCCCGTGCTCGCGCCCATGGCCGGGGTGGTGCAGGACATTCGCGTGCAGCCGGGATCGGCGGTGCGTGCC
GGACAACGGGTCGTGGTGCTGGAACTCGACTGA

Upstream 100 bases:

>100_bases
TCAATGGTGACTTTCGAAATTGTGATTTTGCCGTCGGGGACGACCCCGGCGCTCATCGAAAAACTGCGGGACGGCCCGCA
TCCCCTTCAGGGGTTTTGCC

Downstream 100 bases:

>100_bases
AACCATTTGCCAAAGGATCAACCCATGAATCTGCAACTCGATGCCCTGCGCCGGGCCTACCGCAATGGCGACACCACACC
CCGGCAATTGCTGTTGGCGT

Product: allophanate hydrolase subunit 2

Products: NA

Alternate protein names: Pyruvic carboxylase A [H]

Number of amino acids: Translated: 1210; Mature: 1210

Protein sequence:

>1210_residues
MFEKVLIANRGAIACRILRTLRELHVEGVAVYSEADAASLHILQADEAHSLGEGAAASTYLAVDKILAIAKATGATAIHP
GYGFLSENAAFAEACANHGIAFIGPTPEQLRVFGLKHTARALAKQHGVPMLEGTELLDSLDAALIAGAQVGYPVMLKSTA
GGGGIGMRVCRNASELSESFEAVKRLGQNNFSDAGVFIEKYIQRARHLEVQVFGDGQGAVIALGVRDCSVQRRNQKVLEE
TPAPNLPDGMADELCAAAIKLAKAVNYRSAGTVEFVFDSDAQRFYFLEVNTRLQVEHGVTEQVWGVDLVRWMIELAAGDL
PPLSTLFEGLKPDGHAIQARLYAEDPGRDFQPSPGLLTAVEFPAANGIQLRIDTWVEAGCEIPPYFDPMIAKLISWAPTR
EQARAELHQALGDSLLYGVETNRDYLRQILLDTPFASGQPWTRCLEGLVYQANTFEVLSAGTQTSVQDYPGRLGYWAVGV
PPSGPMDSRALRLGNRLLGNDEGAAALEITMNGPLLRFNCDAVVAVTGAPLALTLDGEAVPMNTALLIEAGSQLHLGGLL
DAGARSYLCLRGGLQVPDYLGSKSTFTLGQFGGHGGRALRAGDVLHLAPLSDRSAGQTLAPHHVSELPAVRRIRVIYGPH
GAPEYFTEHYIDTFFATHWEVHFNSSRTGVRLIGPKPEWVRADGGEAGLHPSNIHDNPYAIGAVDFTGDMPVILGPDGPS
LGGFVCPVTVIEADLWQLGQLKAGDKVQFEPVDLKTARDLALKWDASESWPASDEVDAVSARAPSLACQLPQALVSPVIL
ELGQGDKRLVGRVSGDTHLLLEIGALELDLVLRFRAHALMQALEGKNLHGVIDLTPGIRSLQIHYQPEQLPLADLLGIVA
GEWDAVCAAQDLQVPSRIVHLPLSWDDPACQLAIEKYMTTVRKDAPWCPSNLEFIRRINDLPNLDEVQRTVFDASYLVMG
LGDVYLGAPVATPLDPRHRLVTTKYNPARTWTAENSVGIGGAYMCVYGMEGPGGYQFVGRTLQMWNRYREVAAFDGKPWL
LRFFDQIRFYPVSAEELLRIRRDFPLGRFDLDIEHSQLNLGDYQAFLQREAETIDAFRTQQQGAFQAERERWIASGQAHF
DSEEAVPVSSEDTPLTSGQQSIDSHIAGNLWQVQVEVGSRVAAGDVLVILESMKMEIPVLAPMAGVVQDIRVQPGSAVRA
GQRVVVLELD

Sequences:

>Translated_1210_residues
MFEKVLIANRGAIACRILRTLRELHVEGVAVYSEADAASLHILQADEAHSLGEGAAASTYLAVDKILAIAKATGATAIHP
GYGFLSENAAFAEACANHGIAFIGPTPEQLRVFGLKHTARALAKQHGVPMLEGTELLDSLDAALIAGAQVGYPVMLKSTA
GGGGIGMRVCRNASELSESFEAVKRLGQNNFSDAGVFIEKYIQRARHLEVQVFGDGQGAVIALGVRDCSVQRRNQKVLEE
TPAPNLPDGMADELCAAAIKLAKAVNYRSAGTVEFVFDSDAQRFYFLEVNTRLQVEHGVTEQVWGVDLVRWMIELAAGDL
PPLSTLFEGLKPDGHAIQARLYAEDPGRDFQPSPGLLTAVEFPAANGIQLRIDTWVEAGCEIPPYFDPMIAKLISWAPTR
EQARAELHQALGDSLLYGVETNRDYLRQILLDTPFASGQPWTRCLEGLVYQANTFEVLSAGTQTSVQDYPGRLGYWAVGV
PPSGPMDSRALRLGNRLLGNDEGAAALEITMNGPLLRFNCDAVVAVTGAPLALTLDGEAVPMNTALLIEAGSQLHLGGLL
DAGARSYLCLRGGLQVPDYLGSKSTFTLGQFGGHGGRALRAGDVLHLAPLSDRSAGQTLAPHHVSELPAVRRIRVIYGPH
GAPEYFTEHYIDTFFATHWEVHFNSSRTGVRLIGPKPEWVRADGGEAGLHPSNIHDNPYAIGAVDFTGDMPVILGPDGPS
LGGFVCPVTVIEADLWQLGQLKAGDKVQFEPVDLKTARDLALKWDASESWPASDEVDAVSARAPSLACQLPQALVSPVIL
ELGQGDKRLVGRVSGDTHLLLEIGALELDLVLRFRAHALMQALEGKNLHGVIDLTPGIRSLQIHYQPEQLPLADLLGIVA
GEWDAVCAAQDLQVPSRIVHLPLSWDDPACQLAIEKYMTTVRKDAPWCPSNLEFIRRINDLPNLDEVQRTVFDASYLVMG
LGDVYLGAPVATPLDPRHRLVTTKYNPARTWTAENSVGIGGAYMCVYGMEGPGGYQFVGRTLQMWNRYREVAAFDGKPWL
LRFFDQIRFYPVSAEELLRIRRDFPLGRFDLDIEHSQLNLGDYQAFLQREAETIDAFRTQQQGAFQAERERWIASGQAHF
DSEEAVPVSSEDTPLTSGQQSIDSHIAGNLWQVQVEVGSRVAAGDVLVILESMKMEIPVLAPMAGVVQDIRVQPGSAVRA
GQRVVVLELD
>Mature_1210_residues
MFEKVLIANRGAIACRILRTLRELHVEGVAVYSEADAASLHILQADEAHSLGEGAAASTYLAVDKILAIAKATGATAIHP
GYGFLSENAAFAEACANHGIAFIGPTPEQLRVFGLKHTARALAKQHGVPMLEGTELLDSLDAALIAGAQVGYPVMLKSTA
GGGGIGMRVCRNASELSESFEAVKRLGQNNFSDAGVFIEKYIQRARHLEVQVFGDGQGAVIALGVRDCSVQRRNQKVLEE
TPAPNLPDGMADELCAAAIKLAKAVNYRSAGTVEFVFDSDAQRFYFLEVNTRLQVEHGVTEQVWGVDLVRWMIELAAGDL
PPLSTLFEGLKPDGHAIQARLYAEDPGRDFQPSPGLLTAVEFPAANGIQLRIDTWVEAGCEIPPYFDPMIAKLISWAPTR
EQARAELHQALGDSLLYGVETNRDYLRQILLDTPFASGQPWTRCLEGLVYQANTFEVLSAGTQTSVQDYPGRLGYWAVGV
PPSGPMDSRALRLGNRLLGNDEGAAALEITMNGPLLRFNCDAVVAVTGAPLALTLDGEAVPMNTALLIEAGSQLHLGGLL
DAGARSYLCLRGGLQVPDYLGSKSTFTLGQFGGHGGRALRAGDVLHLAPLSDRSAGQTLAPHHVSELPAVRRIRVIYGPH
GAPEYFTEHYIDTFFATHWEVHFNSSRTGVRLIGPKPEWVRADGGEAGLHPSNIHDNPYAIGAVDFTGDMPVILGPDGPS
LGGFVCPVTVIEADLWQLGQLKAGDKVQFEPVDLKTARDLALKWDASESWPASDEVDAVSARAPSLACQLPQALVSPVIL
ELGQGDKRLVGRVSGDTHLLLEIGALELDLVLRFRAHALMQALEGKNLHGVIDLTPGIRSLQIHYQPEQLPLADLLGIVA
GEWDAVCAAQDLQVPSRIVHLPLSWDDPACQLAIEKYMTTVRKDAPWCPSNLEFIRRINDLPNLDEVQRTVFDASYLVMG
LGDVYLGAPVATPLDPRHRLVTTKYNPARTWTAENSVGIGGAYMCVYGMEGPGGYQFVGRTLQMWNRYREVAAFDGKPWL
LRFFDQIRFYPVSAEELLRIRRDFPLGRFDLDIEHSQLNLGDYQAFLQREAETIDAFRTQQQGAFQAERERWIASGQAHF
DSEEAVPVSSEDTPLTSGQQSIDSHIAGNLWQVQVEVGSRVAAGDVLVILESMKMEIPVLAPMAGVVQDIRVQPGSAVRA
GQRVVVLELD

Specific function: Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=440, Percent_Identity=47.5, Blast_Score=407, Evalue=1e-113,
Organism=Homo sapiens, GI65506442, Length=447, Percent_Identity=41.6107382550336, Blast_Score=332, Evalue=1e-90,
Organism=Homo sapiens, GI189095269, Length=447, Percent_Identity=41.6107382550336, Blast_Score=332, Evalue=1e-90,
Organism=Homo sapiens, GI295821183, Length=447, Percent_Identity=41.6107382550336, Blast_Score=332, Evalue=2e-90,
Organism=Homo sapiens, GI106049528, Length=449, Percent_Identity=40.9799554565702, Blast_Score=323, Evalue=6e-88,
Organism=Homo sapiens, GI106049295, Length=449, Percent_Identity=40.9799554565702, Blast_Score=323, Evalue=6e-88,
Organism=Homo sapiens, GI106049292, Length=449, Percent_Identity=40.9799554565702, Blast_Score=323, Evalue=6e-88,
Organism=Homo sapiens, GI38679977, Length=514, Percent_Identity=31.7120622568093, Blast_Score=213, Evalue=1e-54,
Organism=Homo sapiens, GI38679967, Length=514, Percent_Identity=31.7120622568093, Blast_Score=213, Evalue=1e-54,
Organism=Homo sapiens, GI38679960, Length=514, Percent_Identity=31.7120622568093, Blast_Score=212, Evalue=2e-54,
Organism=Homo sapiens, GI38679974, Length=514, Percent_Identity=31.7120622568093, Blast_Score=212, Evalue=2e-54,
Organism=Homo sapiens, GI38679971, Length=514, Percent_Identity=31.7120622568093, Blast_Score=212, Evalue=2e-54,
Organism=Homo sapiens, GI134142062, Length=511, Percent_Identity=30.9197651663405, Blast_Score=207, Evalue=4e-53,
Organism=Escherichia coli, GI1789654, Length=448, Percent_Identity=43.75, Blast_Score=338, Evalue=1e-93,
Organism=Escherichia coli, GI1786930, Length=308, Percent_Identity=33.7662337662338, Blast_Score=120, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71987519, Length=443, Percent_Identity=44.2437923250564, Blast_Score=365, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17567343, Length=448, Percent_Identity=42.8571428571429, Blast_Score=336, Evalue=5e-92,
Organism=Caenorhabditis elegans, GI17562816, Length=438, Percent_Identity=42.9223744292237, Blast_Score=327, Evalue=3e-89,
Organism=Caenorhabditis elegans, GI133931226, Length=494, Percent_Identity=28.7449392712551, Blast_Score=196, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI71997168, Length=515, Percent_Identity=27.9611650485437, Blast_Score=180, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI71997163, Length=515, Percent_Identity=27.9611650485437, Blast_Score=180, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6319685, Length=1219, Percent_Identity=43.0680885972108, Blast_Score=1045, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319695, Length=448, Percent_Identity=39.9553571428571, Blast_Score=306, Evalue=1e-83,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=39.2857142857143, Blast_Score=297, Evalue=7e-81,
Organism=Saccharomyces cerevisiae, GI6324343, Length=527, Percent_Identity=29.7912713472486, Blast_Score=200, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6323863, Length=466, Percent_Identity=30.9012875536481, Blast_Score=194, Evalue=8e-50,
Organism=Drosophila melanogaster, GI24651757, Length=424, Percent_Identity=44.5754716981132, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24651759, Length=388, Percent_Identity=43.298969072165, Blast_Score=329, Evalue=8e-90,
Organism=Drosophila melanogaster, GI281363050, Length=438, Percent_Identity=42.9223744292237, Blast_Score=326, Evalue=7e-89,
Organism=Drosophila melanogaster, GI24652224, Length=438, Percent_Identity=42.9223744292237, Blast_Score=326, Evalue=7e-89,
Organism=Drosophila melanogaster, GI24652222, Length=438, Percent_Identity=42.9223744292237, Blast_Score=326, Evalue=7e-89,
Organism=Drosophila melanogaster, GI24652220, Length=438, Percent_Identity=42.9223744292237, Blast_Score=326, Evalue=7e-89,
Organism=Drosophila melanogaster, GI24652218, Length=438, Percent_Identity=42.9223744292237, Blast_Score=326, Evalue=7e-89,
Organism=Drosophila melanogaster, GI24652212, Length=438, Percent_Identity=42.9223744292237, Blast_Score=326, Evalue=8e-89,
Organism=Drosophila melanogaster, GI24652210, Length=438, Percent_Identity=42.9223744292237, Blast_Score=326, Evalue=8e-89,
Organism=Drosophila melanogaster, GI24652214, Length=438, Percent_Identity=42.9223744292237, Blast_Score=326, Evalue=8e-89,
Organism=Drosophila melanogaster, GI19921944, Length=438, Percent_Identity=42.9223744292237, Blast_Score=326, Evalue=8e-89,
Organism=Drosophila melanogaster, GI24652216, Length=438, Percent_Identity=42.9223744292237, Blast_Score=326, Evalue=8e-89,
Organism=Drosophila melanogaster, GI161076409, Length=507, Percent_Identity=31.163708086785, Blast_Score=203, Evalue=5e-52,
Organism=Drosophila melanogaster, GI161076407, Length=507, Percent_Identity=31.163708086785, Blast_Score=203, Evalue=5e-52,
Organism=Drosophila melanogaster, GI24586460, Length=507, Percent_Identity=31.163708086785, Blast_Score=203, Evalue=5e-52,
Organism=Drosophila melanogaster, GI24586458, Length=507, Percent_Identity=31.163708086785, Blast_Score=203, Evalue=6e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.4.1.1 [H]

Molecular weight: Translated: 131419; Mature: 131419

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEKVLIANRGAIACRILRTLRELHVEGVAVYSEADAASLHILQADEAHSLGEGAAASTY
CCCCEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCCCCCCCCCCHHHH
LAVDKILAIAKATGATAIHPGYGFLSENAAFAEACANHGIAFIGPTPEQLRVFGLKHTAR
HHHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHCCEEEECCCHHHHEEECHHHHHH
ALAKQHGVPMLEGTELLDSLDAALIAGAQVGYPVMLKSTAGGGGIGMRVCRNASELSESF
HHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHCCHHHHHHHH
EAVKRLGQNNFSDAGVFIEKYIQRARHLEVQVFGDGQGAVIALGVRDCSVQRRNQKVLEE
HHHHHHCCCCCCHHHHHHHHHHHHHHCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHH
TPAPNLPDGMADELCAAAIKLAKAVNYRSAGTVEFVFDSDAQRFYFLEVNTRLQVEHGVT
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEECCEEEECCCCC
EQVWGVDLVRWMIELAAGDLPPLSTLFEGLKPDGHAIQARLYAEDPGRDFQPSPGLLTAV
HHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCCEEEEE
EFPAANGIQLRIDTWVEAGCEIPPYFDPMIAKLISWAPTREQARAELHQALGDSLLYGVE
ECCCCCCEEEEEEHHHHCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEC
TNRDYLRQILLDTPFASGQPWTRCLEGLVYQANTFEVLSAGTQTSVQDYPGRLGYWAVGV
CCHHHHHHHHHCCCCCCCCCHHHHHHHHEECCCCEEEEECCCCCCHHHCCCCCCEEEEEC
PPSGPMDSRALRLGNRLLGNDEGAAALEITMNGPLLRFNCDAVVAVTGAPLALTLDGEAV
CCCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEECCEEEEEECCCEEEEECCCEE
PMNTALLIEAGSQLHLGGLLDAGARSYLCLRGGLQVPDYLGSKSTFTLGQFGGHGGRALR
CCCEEEEEECCCEEEECCCCCCCCCEEEEEECCCCCCHHCCCCCEEEEECCCCCCCCEEE
AGDVLHLAPLSDRSAGQTLAPHHVSELPAVRRIRVIYGPHGAPEYFTEHYIDTFFATHWE
CCCEEEEECCCCCCCCCCCCCCHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHEEEE
VHFNSSRTGVRLIGPKPEWVRADGGEAGLHPSNIHDNPYAIGAVDFTGDMPVILGPDGPS
EEECCCCCCEEEECCCCCEEECCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEECCCCCC
LGGFVCPVTVIEADLWQLGQLKAGDKVQFEPVDLKTARDLALKWDASESWPASDEVDAVS
CCCEECHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCCCCCCHHH
ARAPSLACQLPQALVSPVILELGQGDKRLVGRVSGDTHLLLEIGALELDLVLRFRAHALM
CCCCHHHHHCHHHHHHHHHHHCCCCCHHEEEEECCCEEEEEEECCEEEHHHHHHHHHHHH
QALEGKNLHGVIDLTPGIRSLQIHYQPEQLPLADLLGIVAGEWDAVCAAQDLQVPSRIVH
HHHCCCCCEEEEECCCCCEEEEEEECCCCCCHHHHHHHHCCCCCHHHHHHHCCCCCEEEE
LPLSWDDPACQLAIEKYMTTVRKDAPWCPSNLEFIRRINDLPNLDEVQRTVFDASYLVMG
EECCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
LGDVYLGAPVATPLDPRHRLVTTKYNPARTWTAENSVGIGGAYMCVYGMEGPGGYQFVGR
CCCHHCCCCCCCCCCCCCCEEEECCCCCEEEECCCCCCCCEEEEEEEECCCCCCHHHHHH
TLQMWNRYREVAAFDGKPWLLRFFDQIRFYPVSAEELLRIRRDFPLGRFDLDIEHSQLNL
HHHHHHHHHHHHHCCCCHHHHHHHHHHEEEECCHHHHHHHHHCCCCCEEEEEEECCCCCC
GDYQAFLQREAETIDAFRTQQQGAFQAERERWIASGQAHFDSEEAVPVSSEDTPLTSGQQ
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHH
SIDSHIAGNLWQVQVEVGSRVAAGDVLVILESMKMEIPVLAPMAGVVQDIRVQPGSAVRA
HHHHHHCCCEEEEEEEECCEECCCHHEEEEEHHCCCCCCHHHHHHHHHHHHCCCCCCCCC
GQRVVVLELD
CCEEEEEEEC
>Mature Secondary Structure
MFEKVLIANRGAIACRILRTLRELHVEGVAVYSEADAASLHILQADEAHSLGEGAAASTY
CCCCEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCCCCCCCCCCHHHH
LAVDKILAIAKATGATAIHPGYGFLSENAAFAEACANHGIAFIGPTPEQLRVFGLKHTAR
HHHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHCCEEEECCCHHHHEEECHHHHHH
ALAKQHGVPMLEGTELLDSLDAALIAGAQVGYPVMLKSTAGGGGIGMRVCRNASELSESF
HHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHCCHHHHHHHH
EAVKRLGQNNFSDAGVFIEKYIQRARHLEVQVFGDGQGAVIALGVRDCSVQRRNQKVLEE
HHHHHHCCCCCCHHHHHHHHHHHHHHCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHH
TPAPNLPDGMADELCAAAIKLAKAVNYRSAGTVEFVFDSDAQRFYFLEVNTRLQVEHGVT
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEECCEEEECCCCC
EQVWGVDLVRWMIELAAGDLPPLSTLFEGLKPDGHAIQARLYAEDPGRDFQPSPGLLTAV
HHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCCEEEEE
EFPAANGIQLRIDTWVEAGCEIPPYFDPMIAKLISWAPTREQARAELHQALGDSLLYGVE
ECCCCCCEEEEEEHHHHCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEC
TNRDYLRQILLDTPFASGQPWTRCLEGLVYQANTFEVLSAGTQTSVQDYPGRLGYWAVGV
CCHHHHHHHHHCCCCCCCCCHHHHHHHHEECCCCEEEEECCCCCCHHHCCCCCCEEEEEC
PPSGPMDSRALRLGNRLLGNDEGAAALEITMNGPLLRFNCDAVVAVTGAPLALTLDGEAV
CCCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEECCEEEEEECCCEEEEECCCEE
PMNTALLIEAGSQLHLGGLLDAGARSYLCLRGGLQVPDYLGSKSTFTLGQFGGHGGRALR
CCCEEEEEECCCEEEECCCCCCCCCEEEEEECCCCCCHHCCCCCEEEEECCCCCCCCEEE
AGDVLHLAPLSDRSAGQTLAPHHVSELPAVRRIRVIYGPHGAPEYFTEHYIDTFFATHWE
CCCEEEEECCCCCCCCCCCCCCHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHEEEE
VHFNSSRTGVRLIGPKPEWVRADGGEAGLHPSNIHDNPYAIGAVDFTGDMPVILGPDGPS
EEECCCCCCEEEECCCCCEEECCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEECCCCCC
LGGFVCPVTVIEADLWQLGQLKAGDKVQFEPVDLKTARDLALKWDASESWPASDEVDAVS
CCCEECHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCCCCCCHHH
ARAPSLACQLPQALVSPVILELGQGDKRLVGRVSGDTHLLLEIGALELDLVLRFRAHALM
CCCCHHHHHCHHHHHHHHHHHCCCCCHHEEEEECCCEEEEEEECCEEEHHHHHHHHHHHH
QALEGKNLHGVIDLTPGIRSLQIHYQPEQLPLADLLGIVAGEWDAVCAAQDLQVPSRIVH
HHHCCCCCEEEEECCCCCEEEEEEECCCCCCHHHHHHHHCCCCCHHHHHHHCCCCCEEEE
LPLSWDDPACQLAIEKYMTTVRKDAPWCPSNLEFIRRINDLPNLDEVQRTVFDASYLVMG
EECCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
LGDVYLGAPVATPLDPRHRLVTTKYNPARTWTAENSVGIGGAYMCVYGMEGPGGYQFVGR
CCCHHCCCCCCCCCCCCCCEEEECCCCCEEEECCCCCCCCEEEEEEEECCCCCCHHHHHH
TLQMWNRYREVAAFDGKPWLLRFFDQIRFYPVSAEELLRIRRDFPLGRFDLDIEHSQLNL
HHHHHHHHHHHHHCCCCHHHHHHHHHHEEEECCHHHHHHHHHCCCCCEEEEEEECCCCCC
GDYQAFLQREAETIDAFRTQQQGAFQAERERWIASGQAHFDSEEAVPVSSEDTPLTSGQQ
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHH
SIDSHIAGNLWQVQVEVGSRVAAGDVLVILESMKMEIPVLAPMAGVVQDIRVQPGSAVRA
HHHHHHCCCEEEEEEEECCEECCCHHEEEEEHHCCCCCCHHHHHHHHHHHHCCCCCCCCC
GQRVVVLELD
CCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087; 11195096 [H]