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The map label for this gene is hisQ [H]

Identifier: 77457436

GI number: 77457436

Start: 1380804

End: 1381532

Strand: Reverse

Name: hisQ [H]

Synonym: Pfl01_1209

Alternate gene names: 77457436

Gene position: 1381532-1380804 (Counterclockwise)

Preceding gene: 77457437

Following gene: 77457435

Centisome position: 21.46

GC content: 60.77

Gene sequence:

>729_bases
ATGTTCGAAACCCTCTTACAAAATCTGGGGCTCTCCGCCTTCAGCCTCAAGGGCTTTGGCCCGTTGCTGTTGGAAGGCAC
CTGGATGACCATCAAATTGTCGGCGTTGTCGCTGCTGGTGGCCGTGTTGCTCGGCCTGCTCGGCGCCAGTGCCAAGCTGT
CAAAAATCAAGCTGCTGCGCCTGCCCGCCCAGCTCTACACCACGCTGATTCGCGGGGTGCCGGACCTGGTGCTGATGCTG
CTGATCTTCTACAGCCTGCAAACCTGGCTGACGACGCTCACCGATTACCTGGAATGGGAATACATCGAGATCGACCCGTT
CAGTGCCGGGGTCCTGACCCTGGGCTTCATTTATGGCGCGTACTTCACTGAAACCTTTCGCGGGGCGATTCTCGCCGTGC
CGCGCGGTCAGGTCGAAGCCGCCACCGCCTATGGTCTCAAGCGCGGCCAGCGCTTTCGCTTCGTGGTGTTCCCGCAAATG
ATGCGCTTCGCCCTGCCGGGCATCGGCAACAACTGGATGGTGATGCTCAAGGCCACCGCGCTGGTTTCGATCATCGGCCT
GGCCGATCTGGTCAAGGCCGCACAGGACGCCGGCAAGAGCACCTATCAGCTGTTTTACTTCCTGGTGCTCGCCGCGTTGA
TTTACCTGCTCATCACCAGTGCCTCGAACTTCATCCTGCGCTGGCTCGAACGCCGCTACGCCGCCGGTGCAAGGGAGGCC
GTACGATGA

Upstream 100 bases:

>100_bases
AAAAGAAACACTTTGGCGATCTGAATCTGTACAGCGGCAAATAATGCCCCGGCGCCCATCCTCGATGGGCGCCTTTTTCA
TTCAGTCAGGTTGCTGATTT

Downstream 100 bases:

>100_bases
TCGAACTCCTGCAGGAATACTGGAAAGCCTTCCTTTATACCGACGGTCAGAACATCACTGGTCTTGCGATGACGATGTGG
CTGCTCAGCGCCTCGATCTT

Product: amino acid ABC transporter permease

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MFETLLQNLGLSAFSLKGFGPLLLEGTWMTIKLSALSLLVAVLLGLLGASAKLSKIKLLRLPAQLYTTLIRGVPDLVLML
LIFYSLQTWLTTLTDYLEWEYIEIDPFSAGVLTLGFIYGAYFTETFRGAILAVPRGQVEAATAYGLKRGQRFRFVVFPQM
MRFALPGIGNNWMVMLKATALVSIIGLADLVKAAQDAGKSTYQLFYFLVLAALIYLLITSASNFILRWLERRYAAGAREA
VR

Sequences:

>Translated_242_residues
MFETLLQNLGLSAFSLKGFGPLLLEGTWMTIKLSALSLLVAVLLGLLGASAKLSKIKLLRLPAQLYTTLIRGVPDLVLML
LIFYSLQTWLTTLTDYLEWEYIEIDPFSAGVLTLGFIYGAYFTETFRGAILAVPRGQVEAATAYGLKRGQRFRFVVFPQM
MRFALPGIGNNWMVMLKATALVSIIGLADLVKAAQDAGKSTYQLFYFLVLAALIYLLITSASNFILRWLERRYAAGAREA
VR
>Mature_242_residues
MFETLLQNLGLSAFSLKGFGPLLLEGTWMTIKLSALSLLVAVLLGLLGASAKLSKIKLLRLPAQLYTTLIRGVPDLVLML
LIFYSLQTWLTTLTDYLEWEYIEIDPFSAGVLTLGFIYGAYFTETFRGAILAVPRGQVEAATAYGLKRGQRFRFVVFPQM
MRFALPGIGNNWMVMLKATALVSIIGLADLVKAAQDAGKSTYQLFYFLVLAALIYLLITSASNFILRWLERRYAAGAREA
VR

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4215

COG function: function code E; ABC-type arginine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788646, Length=225, Percent_Identity=58.6666666666667, Blast_Score=268, Evalue=2e-73,
Organism=Escherichia coli, GI1787087, Length=217, Percent_Identity=35.4838709677419, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1787030, Length=212, Percent_Identity=34.9056603773585, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1788645, Length=210, Percent_Identity=35.2380952380952, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1788226, Length=219, Percent_Identity=30.1369863013699, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1786873, Length=219, Percent_Identity=25.5707762557078, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1786874, Length=220, Percent_Identity=29.5454545454545, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1787086, Length=219, Percent_Identity=27.8538812785388, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI87082239, Length=215, Percent_Identity=28.3720930232558, Blast_Score=75, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 26910; Mature: 26910

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFETLLQNLGLSAFSLKGFGPLLLEGTWMTIKLSALSLLVAVLLGLLGASAKLSKIKLLR
CHHHHHHHCCCCEEECCCCCCCEEECCCCEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LPAQLYTTLIRGVPDLVLMLLIFYSLQTWLTTLTDYLEWEYIEIDPFSAGVLTLGFIYGA
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHHHH
YFTETFRGAILAVPRGQVEAATAYGLKRGQRFRFVVFPQMMRFALPGIGNNWMVMLKATA
HHHHHHCCEEEECCCCCHHHHHHHHHHCCCEEEEEECHHHHHHHCCCCCCCHHHHHHHHH
LVSIIGLADLVKAAQDAGKSTYQLFYFLVLAALIYLLITSASNFILRWLERRYAAGAREA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHH
VR
CC
>Mature Secondary Structure
MFETLLQNLGLSAFSLKGFGPLLLEGTWMTIKLSALSLLVAVLLGLLGASAKLSKIKLLR
CHHHHHHHCCCCEEECCCCCCCEEECCCCEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LPAQLYTTLIRGVPDLVLMLLIFYSLQTWLTTLTDYLEWEYIEIDPFSAGVLTLGFIYGA
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHHHH
YFTETFRGAILAVPRGQVEAATAYGLKRGQRFRFVVFPQMMRFALPGIGNNWMVMLKATA
HHHHHHCCEEEECCCCCHHHHHHHHHHCCCEEEEEECHHHHHHHCCCCCCCHHHHHHHHH
LVSIIGLADLVKAAQDAGKSTYQLFYFLVLAALIYLLITSASNFILRWLERRYAAGAREA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHH
VR
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]