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The map label for this gene is hisM [H]

Identifier: 77457435

GI number: 77457435

Start: 1380097

End: 1380807

Strand: Reverse

Name: hisM [H]

Synonym: Pfl01_1208

Alternate gene names: 77457435

Gene position: 1380807-1380097 (Counterclockwise)

Preceding gene: 77457436

Following gene: 77457434

Centisome position: 21.45

GC content: 61.04

Gene sequence:

>711_bases
ATGATCGAACTCCTGCAGGAATACTGGAAAGCCTTCCTTTATACCGACGGTCAGAACATCACTGGTCTTGCGATGACGAT
GTGGCTGCTCAGCGCCTCGATCTTCTTCGGCTTCATCGTGTCGATTCCGCTGTCGATCGCCCGGGTCTCGCCGCACTTCT
ACATCCGCTGGCCGGTGCAGTTCTACACCTACCTGTTCCGTGGCACGCCGCTCTATATCCAGCTGCTGATCTGCTACACC
GGGATCTACAGCCTGGCCGCCGTGCGCGCGCAGCCGCTGCTCGACAGTTTCTTTCGCGATGCGATGAACTGCACGATCCT
GGCCTTCGCCCTCAACACTTGCGCCTACACCACGGAGATTTTCGCCGGGGCGATCCGCAGCATGAACCACGGTGAGGTCG
AAGCGGCCAAGGCCTACGGGCTGACCGGCTGGAAGCTGTATGCCTACGTGATCATGCCGTCGGCGCTGCGCCGTTCGTTG
CCGTACTACAGCAACGAAGTGATCCTGATGCTGCACTCGACCACCGTGGCCTTCACCGCGACCATCCCCGACATTCTGAA
AGTCGCGCGGGACGCCAACTCGGCGACCTTCCTGACCTTTCAGTCGTTCGGCATCGCCGCGCTGATCTACCTGACCATCA
CCTTTGCGCTGGTCGGCCTGTTCCGCCTTGCCGAACGCCGATGGCTGGCGTTCCTCGGCCCGACCCACTAG

Upstream 100 bases:

>100_bases
TGCTCGCCGCGTTGATTTACCTGCTCATCACCAGTGCCTCGAACTTCATCCTGCGCTGGCTCGAACGCCGCTACGCCGCC
GGTGCAAGGGAGGCCGTACG

Downstream 100 bases:

>100_bases
GACCCATTAGAGATGCGTCATCAGATACACGACCTGCTGGCCCCGCTGCCGGGGACCGCACGACAGATCCACAGCTTTCA
TTTTGGCCCGGACAAGGCCC

Product: amino acid ABC transporter permease

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MIELLQEYWKAFLYTDGQNITGLAMTMWLLSASIFFGFIVSIPLSIARVSPHFYIRWPVQFYTYLFRGTPLYIQLLICYT
GIYSLAAVRAQPLLDSFFRDAMNCTILAFALNTCAYTTEIFAGAIRSMNHGEVEAAKAYGLTGWKLYAYVIMPSALRRSL
PYYSNEVILMLHSTTVAFTATIPDILKVARDANSATFLTFQSFGIAALIYLTITFALVGLFRLAERRWLAFLGPTH

Sequences:

>Translated_236_residues
MIELLQEYWKAFLYTDGQNITGLAMTMWLLSASIFFGFIVSIPLSIARVSPHFYIRWPVQFYTYLFRGTPLYIQLLICYT
GIYSLAAVRAQPLLDSFFRDAMNCTILAFALNTCAYTTEIFAGAIRSMNHGEVEAAKAYGLTGWKLYAYVIMPSALRRSL
PYYSNEVILMLHSTTVAFTATIPDILKVARDANSATFLTFQSFGIAALIYLTITFALVGLFRLAERRWLAFLGPTH
>Mature_236_residues
MIELLQEYWKAFLYTDGQNITGLAMTMWLLSASIFFGFIVSIPLSIARVSPHFYIRWPVQFYTYLFRGTPLYIQLLICYT
GIYSLAAVRAQPLLDSFFRDAMNCTILAFALNTCAYTTEIFAGAIRSMNHGEVEAAKAYGLTGWKLYAYVIMPSALRRSL
PYYSNEVILMLHSTTVAFTATIPDILKVARDANSATFLTFQSFGIAALIYLTITFALVGLFRLAERRWLAFLGPTH

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4160

COG function: function code E; ABC-type arginine/histidine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788645, Length=235, Percent_Identity=58.2978723404255, Blast_Score=297, Evalue=5e-82,
Organism=Escherichia coli, GI1787086, Length=212, Percent_Identity=32.5471698113208, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1788226, Length=191, Percent_Identity=32.4607329842932, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1787030, Length=209, Percent_Identity=27.2727272727273, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788646, Length=214, Percent_Identity=27.5700934579439, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786873, Length=215, Percent_Identity=24.6511627906977, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1786874, Length=214, Percent_Identity=27.1028037383178, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 26695; Mature: 26695

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIELLQEYWKAFLYTDGQNITGLAMTMWLLSASIFFGFIVSIPLSIARVSPHFYIRWPVQ
CHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEEHHH
FYTYLFRGTPLYIQLLICYTGIYSLAAVRAQPLLDSFFRDAMNCTILAFALNTCAYTTEI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FAGAIRSMNHGEVEAAKAYGLTGWKLYAYVIMPSALRRSLPYYSNEVILMLHSTTVAFTA
HHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCEEEEEE
TIPDILKVARDANSATFLTFQSFGIAALIYLTITFALVGLFRLAERRWLAFLGPTH
HHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MIELLQEYWKAFLYTDGQNITGLAMTMWLLSASIFFGFIVSIPLSIARVSPHFYIRWPVQ
CHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEEHHH
FYTYLFRGTPLYIQLLICYTGIYSLAAVRAQPLLDSFFRDAMNCTILAFALNTCAYTTEI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FAGAIRSMNHGEVEAAKAYGLTGWKLYAYVIMPSALRRSLPYYSNEVILMLHSTTVAFTA
HHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCEEEEEE
TIPDILKVARDANSATFLTFQSFGIAALIYLTITFALVGLFRLAERRWLAFLGPTH
HHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]