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The map label for this gene is map [H]

Identifier: 77457327

GI number: 77457327

Start: 1273902

End: 1274684

Strand: Reverse

Name: map [H]

Synonym: Pfl01_1100

Alternate gene names: 77457327

Gene position: 1274684-1273902 (Counterclockwise)

Preceding gene: 77457351

Following gene: 77457326

Centisome position: 19.8

GC content: 59.9

Gene sequence:

>783_bases
ATGACCGTCACCCTCAAAACTCCCGAGGACATCGCTGGCATGCGTGTCGCCGGCAAACTGGCCGCCGATGTGCTGGAAAT
GATTGCCGAACACGTAAAACCGGGCGTGACCACCGATGAGCTGAACCAGATCTGCCACGACTATATCGTCGACGTGCAGA
AAGCCATCCCTGCCCCGCTCAACTACAAGGGCTACCCGAAGTCGATCTGTACCTCGATCAACCATGTGGTCTGCCACGGC
ATCCCGAACGACAAGCCGCTGAAAAACGGCGACACCCTGAACATCGACGTCACCGTGATCAAGGACGGCTACCACGGCGA
CACCAGCCGCATGTTCCACGTCGGCACCGTGCCGGTCTGGGCCGAGCGCCTGTCGCAAGTCACCCAGGAGTGCATGTACA
AGGCGATCGAAATCGTCAAACCCGGCTGCCGCCTCGGTGACATCGGCGAAATCATCCAGAAGCACGCGGAAAAGAACGGC
TTCTCGGTGGTGCGCGAGTTCTGCGGCCATGGCATCGGCAAGGTATTCCACGAAGAACCGCAAATCCTGCACTACGGTCG
CGCCGGCACCGGCATGGAACTGAAGGCCGGCATGACCTTTACCATCGAACCGATGATCAACCAGGGCAAGGCCGACACCA
AAGTACTGGGCGACGGCTGGACCGCGATCACCAAGGATCGCAAGCTGTCAGCACAGTGGGAACACACTTTGCTTGTCACC
GACACCGGCTACGAGATCTTCACCCTGCGCAGCGACGACACCATCCCGCGCATCTCGGCCTGA

Upstream 100 bases:

>100_bases
CGCCTTTGGTCTGTTAGAATCGCATTTTTCGGGGCCGCCAAATCAACAGCTGCGCCCCTGTTCGTATCAGCAAGCGCCGC
CGAGCGCAGAGAGAGTCTGT

Downstream 100 bases:

>100_bases
CCCAGACACCGTTCCCAGCCTATAGAAGGAAAGCCAATCGATGCCGCAGGTGGATCCCGAACTCTTCGACCGCGGCCAGT
TCCAGGCTGAACTGGCCCTG

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MTVTLKTPEDIAGMRVAGKLAADVLEMIAEHVKPGVTTDELNQICHDYIVDVQKAIPAPLNYKGYPKSICTSINHVVCHG
IPNDKPLKNGDTLNIDVTVIKDGYHGDTSRMFHVGTVPVWAERLSQVTQECMYKAIEIVKPGCRLGDIGEIIQKHAEKNG
FSVVREFCGHGIGKVFHEEPQILHYGRAGTGMELKAGMTFTIEPMINQGKADTKVLGDGWTAITKDRKLSAQWEHTLLVT
DTGYEIFTLRSDDTIPRISA

Sequences:

>Translated_260_residues
MTVTLKTPEDIAGMRVAGKLAADVLEMIAEHVKPGVTTDELNQICHDYIVDVQKAIPAPLNYKGYPKSICTSINHVVCHG
IPNDKPLKNGDTLNIDVTVIKDGYHGDTSRMFHVGTVPVWAERLSQVTQECMYKAIEIVKPGCRLGDIGEIIQKHAEKNG
FSVVREFCGHGIGKVFHEEPQILHYGRAGTGMELKAGMTFTIEPMINQGKADTKVLGDGWTAITKDRKLSAQWEHTLLVT
DTGYEIFTLRSDDTIPRISA
>Mature_259_residues
TVTLKTPEDIAGMRVAGKLAADVLEMIAEHVKPGVTTDELNQICHDYIVDVQKAIPAPLNYKGYPKSICTSINHVVCHGI
PNDKPLKNGDTLNIDVTVIKDGYHGDTSRMFHVGTVPVWAERLSQVTQECMYKAIEIVKPGCRLGDIGEIIQKHAEKNGF
SVVREFCGHGIGKVFHEEPQILHYGRAGTGMELKAGMTFTIEPMINQGKADTKVLGDGWTAITKDRKLSAQWEHTLLVTD
TGYEIFTLRSDDTIPRISA

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=256, Percent_Identity=50.390625, Blast_Score=270, Evalue=8e-73,
Organism=Homo sapiens, GI40385867, Length=247, Percent_Identity=42.5101214574899, Blast_Score=215, Evalue=4e-56,
Organism=Escherichia coli, GI1786364, Length=259, Percent_Identity=64.0926640926641, Blast_Score=345, Evalue=2e-96,
Organism=Caenorhabditis elegans, GI71996291, Length=249, Percent_Identity=47.7911646586345, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6323273, Length=244, Percent_Identity=46.3114754098361, Blast_Score=234, Evalue=1e-62,
Organism=Drosophila melanogaster, GI21355531, Length=246, Percent_Identity=48.3739837398374, Blast_Score=243, Evalue=7e-65,
Organism=Drosophila melanogaster, GI24583427, Length=250, Percent_Identity=45.6, Blast_Score=229, Evalue=9e-61,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 28668; Mature: 28537

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTLKTPEDIAGMRVAGKLAADVLEMIAEHVKPGVTTDELNQICHDYIVDVQKAIPAPL
CEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCC
NYKGYPKSICTSINHVVCHGIPNDKPLKNGDTLNIDVTVIKDGYHGDTSRMFHVGTVPVW
CCCCCCHHHHHHHHHEEEECCCCCCCCCCCCEEEEEEEEEECCCCCCCCCEEEECCCHHH
AERLSQVTQECMYKAIEIVKPGCRLGDIGEIIQKHAEKNGFSVVREFCGHGIGKVFHEEP
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCHHHHHCCCC
QILHYGRAGTGMELKAGMTFTIEPMINQGKADTKVLGDGWTAITKDRKLSAQWEHTLLVT
CEEEECCCCCCCEEECCCEEEEECCCCCCCCCCEEECCCCEEEECCCCCCCCCCEEEEEE
DTGYEIFTLRSDDTIPRISA
ECCEEEEEEECCCCCCCCCC
>Mature Secondary Structure 
TVTLKTPEDIAGMRVAGKLAADVLEMIAEHVKPGVTTDELNQICHDYIVDVQKAIPAPL
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCC
NYKGYPKSICTSINHVVCHGIPNDKPLKNGDTLNIDVTVIKDGYHGDTSRMFHVGTVPVW
CCCCCCHHHHHHHHHEEEECCCCCCCCCCCCEEEEEEEEEECCCCCCCCCEEEECCCHHH
AERLSQVTQECMYKAIEIVKPGCRLGDIGEIIQKHAEKNGFSVVREFCGHGIGKVFHEEP
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCHHHHHCCCC
QILHYGRAGTGMELKAGMTFTIEPMINQGKADTKVLGDGWTAITKDRKLSAQWEHTLLVT
CEEEECCCCCCCEEECCCEEEEECCCCCCCCCCEEECCCCEEEECCCCCCCCCCEEEEEE
DTGYEIFTLRSDDTIPRISA
ECCEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]