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The map label for this gene is pepA [H]

Identifier: 77457216

GI number: 77457216

Start: 1149299

End: 1150789

Strand: Reverse

Name: pepA [H]

Synonym: Pfl01_0989

Alternate gene names: 77457216

Gene position: 1150789-1149299 (Counterclockwise)

Preceding gene: 77457225

Following gene: 77457215

Centisome position: 17.87

GC content: 63.31

Gene sequence:

>1491_bases
ATGGAACTGGTTGTAAAAAGCGTTAGCCCAGAAACGTTGAAAACCGCCACCCTGGTGGTTGCCGTCGGCGAAGGCCGCAA
ACTCGGTGCCGCCGCCAGGCAGGTCGACGAACTGAGCGGCGGCGCCATCAGCGCCGTGCTCAAGCGTGGCGACCTGGCCG
GCAAGGTCGGCCAGAGCCTGTTGCTGCACAGCCTGCCGAACCTGAAAGCCGAACGCGTGCTGCTGGTGGGCGTGGGCAAG
GATGAAGAACTGGGCGACCGTCCGTTCCGCAAGATCGTCGCCGGCATCCTCAACACCCTCAAAGGCCTGGGCGGCAGCGA
CGCCGTACTGGCACTCGATGAAATCATCGTCAAGAACCGTGACAGTTACGGCAAGACCCGTCTGCTGGCCGAAACCCTGG
TCGACGGCGAATACACCTTCGACCAGTTCAAGAGCCAGAAAGCCGAACCGCGCGCCCTGAAGAAAATCACCCTGCTGACC
ATCAAGGCCGCTCAGGCCGAAGTGCAACGCGCCGTGAACCACGCCACCGCGATCGCCAACGGCATGGCATTCACCCGTAA
CCTGGGCAACCTGCCGCCGAACATCTGCCACCCGACTTTCCTCGGCGAGCAAGCCAAGAACCTCGGCAAAGAGTTCAAGG
ATCTGAAAGTCGAAGTCCTCGACGAGAAGAAGATCAAGTCGCTGGGCATGGGTTCGTTCTACGCCGTCGGCCAGGGCAGC
GCCCAGCCGCCGCGCCTGATCGTCATGCAATACAACGGCGGCAAGAAATCCGAGAAGCCGTACGCACTGGTCGGTAAAGG
CATCACCTTCGACACCGGCGGCATCAGCCTGAAACCGGGCGCCGGCATGGACGAGATGAAATACGACATGGGTGGCGCGG
CCAGCGTGTTCGGCACCCTGCGCGCCGTGCTGGAACTGAAACTGCCGATCAACCTGGTGTGCATTCTGGCCTGCGCCGAG
AACATGCCGAGCGGCACTGCTTCGCGTCCGGGCGACATCGTCACCACCATGAGCGGCCAGACCGTGGAAATCCTCAACAC
CGACGCCGAAGGCCGTCTGGTGCTGTGCGATGCCCTGACCTACTCCGAGCGCTTCAAGCCGCAAGCGGTGATCGACATCG
CCACCCTGACCGGTGCCTGCGTCGTTGCCCTGGGCGCCCACACTTCGGGCCTGCTGGGCAACAACGACGAACTGATCGAG
CAATTGCTGAGCGCCGGCAAGGCTGCCGACGACCGCGCCTGGCAACTGCCGCTGTTCGATGAGTACCAGGAGCAACTGGA
CAGCCCGTTCGCCGACATCGCCAACATCGGCGGTCCGAAGGCCGGCACCATCACCGCCGCCTGCTTCCTGTCGCGCTTCA
CCAAGAACCTGAACTGGGCGCACCTGGATATCGCAGGCACCGCCTGGACCAGCGGCGGCAAGGACAAGGGCGCAACCGGC
CGTCCGGTTCCGCTGTTGACCCAATACTTGCTGGACCGCGCCAAAGCCTGA

Upstream 100 bases:

>100_bases
CTCTGTCGCAGGCACTGGCCTGCGCCTCTTCTCTCTATAAGCAGGCGACGGCGGACACGTCGAACGCCTGTGTGTTGACC
ATTCATTCAGGGATCCGGAC

Downstream 100 bases:

>100_bases
AACCGATGACTGCGAGCGGCGCCTCTCTTGAGGGGCGCCGCTCGCAGCTCAGGAACCGCAATGACCAAAGTCGACTTTTA
TATCCTGCCCAGCGCCGATC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MELVVKSVSPETLKTATLVVAVGEGRKLGAAARQVDELSGGAISAVLKRGDLAGKVGQSLLLHSLPNLKAERVLLVGVGK
DEELGDRPFRKIVAGILNTLKGLGGSDAVLALDEIIVKNRDSYGKTRLLAETLVDGEYTFDQFKSQKAEPRALKKITLLT
IKAAQAEVQRAVNHATAIANGMAFTRNLGNLPPNICHPTFLGEQAKNLGKEFKDLKVEVLDEKKIKSLGMGSFYAVGQGS
AQPPRLIVMQYNGGKKSEKPYALVGKGITFDTGGISLKPGAGMDEMKYDMGGAASVFGTLRAVLELKLPINLVCILACAE
NMPSGTASRPGDIVTTMSGQTVEILNTDAEGRLVLCDALTYSERFKPQAVIDIATLTGACVVALGAHTSGLLGNNDELIE
QLLSAGKAADDRAWQLPLFDEYQEQLDSPFADIANIGGPKAGTITAACFLSRFTKNLNWAHLDIAGTAWTSGGKDKGATG
RPVPLLTQYLLDRAKA

Sequences:

>Translated_496_residues
MELVVKSVSPETLKTATLVVAVGEGRKLGAAARQVDELSGGAISAVLKRGDLAGKVGQSLLLHSLPNLKAERVLLVGVGK
DEELGDRPFRKIVAGILNTLKGLGGSDAVLALDEIIVKNRDSYGKTRLLAETLVDGEYTFDQFKSQKAEPRALKKITLLT
IKAAQAEVQRAVNHATAIANGMAFTRNLGNLPPNICHPTFLGEQAKNLGKEFKDLKVEVLDEKKIKSLGMGSFYAVGQGS
AQPPRLIVMQYNGGKKSEKPYALVGKGITFDTGGISLKPGAGMDEMKYDMGGAASVFGTLRAVLELKLPINLVCILACAE
NMPSGTASRPGDIVTTMSGQTVEILNTDAEGRLVLCDALTYSERFKPQAVIDIATLTGACVVALGAHTSGLLGNNDELIE
QLLSAGKAADDRAWQLPLFDEYQEQLDSPFADIANIGGPKAGTITAACFLSRFTKNLNWAHLDIAGTAWTSGGKDKGATG
RPVPLLTQYLLDRAKA
>Mature_496_residues
MELVVKSVSPETLKTATLVVAVGEGRKLGAAARQVDELSGGAISAVLKRGDLAGKVGQSLLLHSLPNLKAERVLLVGVGK
DEELGDRPFRKIVAGILNTLKGLGGSDAVLALDEIIVKNRDSYGKTRLLAETLVDGEYTFDQFKSQKAEPRALKKITLLT
IKAAQAEVQRAVNHATAIANGMAFTRNLGNLPPNICHPTFLGEQAKNLGKEFKDLKVEVLDEKKIKSLGMGSFYAVGQGS
AQPPRLIVMQYNGGKKSEKPYALVGKGITFDTGGISLKPGAGMDEMKYDMGGAASVFGTLRAVLELKLPINLVCILACAE
NMPSGTASRPGDIVTTMSGQTVEILNTDAEGRLVLCDALTYSERFKPQAVIDIATLTGACVVALGAHTSGLLGNNDELIE
QLLSAGKAADDRAWQLPLFDEYQEQLDSPFADIANIGGPKAGTITAACFLSRFTKNLNWAHLDIAGTAWTSGGKDKGATG
RPVPLLTQYLLDRAKA

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=484, Percent_Identity=36.1570247933884, Blast_Score=261, Evalue=8e-70,
Organism=Homo sapiens, GI47155554, Length=274, Percent_Identity=36.8613138686131, Blast_Score=145, Evalue=1e-34,
Organism=Escherichia coli, GI1790710, Length=498, Percent_Identity=55.0200803212851, Blast_Score=549, Evalue=1e-157,
Organism=Escherichia coli, GI87082123, Length=292, Percent_Identity=40.4109589041096, Blast_Score=191, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI17556903, Length=295, Percent_Identity=35.5932203389831, Blast_Score=149, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17565172, Length=309, Percent_Identity=26.8608414239482, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI20129969, Length=489, Percent_Identity=29.4478527607362, Blast_Score=203, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24662227, Length=484, Percent_Identity=29.7520661157025, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24661038, Length=469, Percent_Identity=30.4904051172708, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI21355725, Length=469, Percent_Identity=30.2771855010661, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI161077148, Length=483, Percent_Identity=28.7784679089027, Blast_Score=185, Evalue=7e-47,
Organism=Drosophila melanogaster, GI20130057, Length=483, Percent_Identity=28.7784679089027, Blast_Score=185, Evalue=7e-47,
Organism=Drosophila melanogaster, GI21355645, Length=492, Percent_Identity=27.8455284552846, Blast_Score=184, Evalue=8e-47,
Organism=Drosophila melanogaster, GI24662223, Length=492, Percent_Identity=27.8455284552846, Blast_Score=184, Evalue=8e-47,
Organism=Drosophila melanogaster, GI19922386, Length=481, Percent_Identity=29.9376299376299, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI20129963, Length=489, Percent_Identity=28.6298568507157, Blast_Score=165, Evalue=7e-41,
Organism=Drosophila melanogaster, GI221379063, Length=310, Percent_Identity=35.1612903225806, Blast_Score=151, Evalue=9e-37,
Organism=Drosophila melanogaster, GI221379062, Length=310, Percent_Identity=35.1612903225806, Blast_Score=151, Evalue=9e-37,
Organism=Drosophila melanogaster, GI21357381, Length=310, Percent_Identity=35.1612903225806, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24646701, Length=269, Percent_Identity=27.8810408921933, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24646703, Length=269, Percent_Identity=27.8810408921933, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21358201, Length=269, Percent_Identity=27.8810408921933, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 52570; Mature: 52570

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELVVKSVSPETLKTATLVVAVGEGRKLGAAARQVDELSGGAISAVLKRGDLAGKVGQSL
CCEEEECCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHH
LLHSLPNLKAERVLLVGVGKDEELGDRPFRKIVAGILNTLKGLGGSDAVLALDEIIVKNR
HHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
DSYGKTRLLAETLVDGEYTFDQFKSQKAEPRALKKITLLTIKAAQAEVQRAVNHATAIAN
CCCCHHHHHHHHHCCCCCCHHHHHCCCCCCHHHHEEEEEEEHHHHHHHHHHHHHHHHHHH
GMAFTRNLGNLPPNICHPTFLGEQAKNLGKEFKDLKVEVLDEKKIKSLGMGSFYAVGQGS
CHHHHHHCCCCCCCCCCCHHCCHHHHHHHHHHHHCEEEECCHHHHHHCCCCCEEEECCCC
AQPPRLIVMQYNGGKKSEKPYALVGKGITFDTGGISLKPGAGMDEMKYDMGGAASVFGTL
CCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHHCCCCHHHHHHHH
RAVLELKLPINLVCILACAENMPSGTASRPGDIVTTMSGQTVEILNTDAEGRLVLCDALT
HHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEEEECCC
YSERFKPQAVIDIATLTGACVVALGAHTSGLLGNNDELIEQLLSAGKAADDRAWQLPLFD
HHHHCCCCCEEEHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCEEECCCHH
EYQEQLDSPFADIANIGGPKAGTITAACFLSRFTKNLNWAHLDIAGTAWTSGGKDKGATG
HHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECEEECCCCCCCCCCC
RPVPLLTQYLLDRAKA
CCHHHHHHHHHHHCCC
>Mature Secondary Structure
MELVVKSVSPETLKTATLVVAVGEGRKLGAAARQVDELSGGAISAVLKRGDLAGKVGQSL
CCEEEECCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHH
LLHSLPNLKAERVLLVGVGKDEELGDRPFRKIVAGILNTLKGLGGSDAVLALDEIIVKNR
HHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
DSYGKTRLLAETLVDGEYTFDQFKSQKAEPRALKKITLLTIKAAQAEVQRAVNHATAIAN
CCCCHHHHHHHHHCCCCCCHHHHHCCCCCCHHHHEEEEEEEHHHHHHHHHHHHHHHHHHH
GMAFTRNLGNLPPNICHPTFLGEQAKNLGKEFKDLKVEVLDEKKIKSLGMGSFYAVGQGS
CHHHHHHCCCCCCCCCCCHHCCHHHHHHHHHHHHCEEEECCHHHHHHCCCCCEEEECCCC
AQPPRLIVMQYNGGKKSEKPYALVGKGITFDTGGISLKPGAGMDEMKYDMGGAASVFGTL
CCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHHCCCCHHHHHHHH
RAVLELKLPINLVCILACAENMPSGTASRPGDIVTTMSGQTVEILNTDAEGRLVLCDALT
HHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEEEECCC
YSERFKPQAVIDIATLTGACVVALGAHTSGLLGNNDELIEQLLSAGKAADDRAWQLPLFD
HHHHCCCCCEEEHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCEEECCCHH
EYQEQLDSPFADIANIGGPKAGTITAACFLSRFTKNLNWAHLDIAGTAWTSGGKDKGATG
HHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECEEECCCCCCCCCCC
RPVPLLTQYLLDRAKA
CCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA