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The map label for this gene is fur [H]

Identifier: 77456987

GI number: 77456987

Start: 891856

End: 892260

Strand: Direct

Name: fur [H]

Synonym: Pfl01_0760

Alternate gene names: 77456987

Gene position: 891856-892260 (Clockwise)

Preceding gene: 77456985

Following gene: 77456989

Centisome position: 13.85

GC content: 54.07

Gene sequence:

>405_bases
ATGGTTGAAAATAGCGAACTACGCAAAGCCGGCCTCAAAGTGACCCTGCCACGGGTCAAGATCCTGCAAATGCTCGACTC
CACCGAGCAGCGTCACATGAGTGCCGAGGACGTCTACAAGGCGTTGATGGAAGCTGGCGAGGATGTCGGTCTGGCCACGG
TTTACCGTGTTCTGACCCAGTTCGAAGCGGCTGGCCTCGTGGTCCGTCACAACTTCGACGGCGGCCACGCGGTATTCGAA
TTGGCCGATGGTGGCCACCACGACCATATGGTTAACGTGGAGTCGGGCGAAGTCATCGAATTCTTCGACGAAGAAATCGA
AAAACTTCAGAAGGCGATCGTCGAGAAGCACGATTACGAGTTGGTTGATCACAATCTCGTCCTGTACGTACGCAAGAAAA
AGTAA

Upstream 100 bases:

>100_bases
CATCGGTGGGCGACTTCCACTATCTTGGCTGGGACAACGTAAACGCCGATCATACCCGCATTAAGAGAAGCTGCGAAGCA
GCATCGCGAGAAAGCTGACC

Downstream 100 bases:

>100_bases
GCATGTCGCGCGAATTTCAGGTTCGCGAAACGAACGAAGGCGACCCGAGGGTCGCCTTCGTGCTTTCTGCGGTTCTTAAA
CCTTTGCGGTTACGACCATC

Product: ferric uptake regulator family protein

Products: NA

Alternate protein names: Ferric uptake regulator [H]

Number of amino acids: Translated: 134; Mature: 134

Protein sequence:

>134_residues
MVENSELRKAGLKVTLPRVKILQMLDSTEQRHMSAEDVYKALMEAGEDVGLATVYRVLTQFEAAGLVVRHNFDGGHAVFE
LADGGHHDHMVNVESGEVIEFFDEEIEKLQKAIVEKHDYELVDHNLVLYVRKKK

Sequences:

>Translated_134_residues
MVENSELRKAGLKVTLPRVKILQMLDSTEQRHMSAEDVYKALMEAGEDVGLATVYRVLTQFEAAGLVVRHNFDGGHAVFE
LADGGHHDHMVNVESGEVIEFFDEEIEKLQKAIVEKHDYELVDHNLVLYVRKKK
>Mature_134_residues
MVENSELRKAGLKVTLPRVKILQMLDSTEQRHMSAEDVYKALMEAGEDVGLATVYRVLTQFEAAGLVVRHNFDGGHAVFE
LADGGHHDHMVNVESGEVIEFFDEEIEKLQKAIVEKHDYELVDHNLVLYVRKKK

Specific function: Fur acts as a repressor, employing Fe(2+) as a cofactor to bind the operator of the iron transport operon. Involved in exotoxin A regulation, siderophore regulation and manganese susceptibility [H]

COG id: COG0735

COG function: function code P; Fe2+/Zn2+ uptake regulation proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Fur family [H]

Homologues:

Organism=Escherichia coli, GI1786899, Length=126, Percent_Identity=56.3492063492063, Blast_Score=152, Evalue=5e-39,

Paralogues:

None

Copy number: 3432 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002481
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01475 FUR [H]

EC number: NA

Molecular weight: Translated: 15246; Mature: 15246

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVENSELRKAGLKVTLPRVKILQMLDSTEQRHMSAEDVYKALMEAGEDVGLATVYRVLTQ
CCCCCHHHHCCCEEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHH
FEAAGLVVRHNFDGGHAVFELADGGHHDHMVNVESGEVIEFFDEEIEKLQKAIVEKHDYE
HHHCCEEEEECCCCCEEEEEECCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCE
LVDHNLVLYVRKKK
EECCCEEEEEEECC
>Mature Secondary Structure
MVENSELRKAGLKVTLPRVKILQMLDSTEQRHMSAEDVYKALMEAGEDVGLATVYRVLTQ
CCCCCHHHHCCCEEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHH
FEAAGLVVRHNFDGGHAVFELADGGHHDHMVNVESGEVIEFFDEEIEKLQKAIVEKHDYE
HHHCCEEEEECCCCCEEEEEECCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCE
LVDHNLVLYVRKKK
EECCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8478325; 9852033; 10984043 [H]