Click here to switch to the map view.

The map label for this gene is mutL [H]

Identifier: 77456749

GI number: 77456749

Start: 603077

End: 604984

Strand: Direct

Name: mutL [H]

Synonym: Pfl01_0521

Alternate gene names: 77456749

Gene position: 603077-604984 (Clockwise)

Preceding gene: 77456748

Following gene: 77456750

Centisome position: 9.37

GC content: 64.1

Gene sequence:

>1908_bases
ATGAATCAGGTCCTGAACGCTGCCCGCATCGAACTGCTCAGCCCGCGGCTGGCGAACCAGATCGCCGCCGGTGAGGTGGT
CGAACGCCCGGCCTCGGTGATCAAGGAGCTGCTCGAAAACAGCCTCGACTCCGGCGCCAAACGTATCGACGTCGATGTTG
AACAGGGCGGCGTCAAACTGCTGCGTGTGCGTGACGACGGCAGCGGTATTTCCGCCGATGACCTGCCGCTGGCCCTGGCC
CGTCACGCCACCAGCAAGATCCGTAACCTGGAAGATCTCGAGCAGGTGATGAGCCTGGGTTTCCGGGGCGAGGCTTTGGC
ATCGATCAGCTCCGTGGCACGTCTGACCCTGACCTCGCGCACCCGCGATGCCGATCAGGCCTGGCAGGTCGAGACCGAAG
GCCGCGACATGGCGCCGCGCGTGCAGCCAGCGGCGCACCCGGTCGGCACGTCGGTGGAAGTCCGTGACCTGTTCTTCAAC
ACCCCGGCTCGGCGCAAATTCCTCAAGACCGAAAAAACCGAATTCGATCACCTGCAAGAAGTGATCAAGCGTCTGGCGCT
GGCGCGTTTCGACGTGGCGTTCCATCTGCGCCACAACGGCAAGACCATCCTCAGCCTGCACGAAGCCCACGATGACGCGG
CCCGCGCCCGGCGCGTGGCGGCGATCTGCGGTTCGGGCTTCCTCGAGCAAGCGTTGCCGATCGAAATCGAGCGCAATGGC
CTGCATTTGTGGGGCTGGGTCGGACTGCCGACCTTCAACCGCAGTCAGGCGGACTTGCAGTATTTCTTCGTCAACGGCCG
CGCGGTACGCGACAAACTGGTGGCTCACGCAGTGCGTCAGGCTTATCGCGATGTGCTGTTCAATGGCCGGCATCCGACGT
TCGCGCTGTTTTTCGAGGTCGACCCGGCAGCGGTCGACGTCAACGTGCACCCGACCAAACACGAAGTGCGCTTCCGCGAT
GGGCGCATGGTGCATGACTTCCTGTATGGCACCTTGCACCGTGCCCTCGGCGATGTGCGGCCGGAAGATCAGCTTGCCGG
TTCGGTCACCACCGCGATCGTCCGGCCAACCGGCCTTGAAGCCGGTGAGTTCGGGCCGCAGGGCGAAATGCGTCTGGCCG
CCAACGCGCTGCTGGAGCAACCGCAGGCGCAACCGGCGTTCAATACAGCGTCGGGCGCCAGCGCTGGCGGCGCCTATCAG
TATCAATACACGCCGCGTCCGCAATCGACCGTGCCGGTTGCCGAGGCTCAGGCCGCGTACCGCGAGTTTTTTGCGCCGCT
GCCCGAGGCCAACGCCAATGCGCTGCCGGCCGGTCAGGAAGACATTCCACCGCTTGGCTATGCGCTGGCGCAGCTCAAGG
GCATCTATATTCTGTCCGAGAACGCCCAGGGCCTGGTTTTGGTGGACATGCACGCCGCTCACGAGCGGATCATGTATGAG
CGCCTGAAAATTGCCATGGCCAGCGAAGGCCTGAGTGGCCAGCCGCTGCTGGTGCCGGAATCGCTGGCGGTCAGTCAACG
CGAGGCCGATTGCGCCGAAGAGCATGCGGCGTGGTTCCAGCGTCTCGGTTTCGAATTGCAGCGCCTCGGCCCGGAAACCC
TGGCCATCCGGCAGATCCCGGCCTTGCTCAAGCAGGCCGAAGCCAACCGACTGGTGGGCGATGTCTTGTCGGACTTGATG
GAATATGGCACCAGTGACCGGATCCAGGCACATCTGAACGAACTGCTCGGCACCATGGCCTGCCACGGCGCAATCCGCGC
CAACCGGCGCCTGGCCCTGCCGGAAATGAACGGCCTGCTGCGTGACATGGAAAACACCGAGCGCAGCGGTCAATGCAACC
ATGGCCGACCGACCTGGACCCAACTGGGCCTGGACGATCTGGACAAACTGTTCCTGCGCGGTCGTTGA

Upstream 100 bases:

>100_bases
TTTCGCCGGCCACGCTGCGCAGCGCCAACAATCTGAAAAGCGATGATCTGAAAGTCGGTCAGCACCTGACCATTCCTGGC
ACCGAACTGGCGTCCAAAGA

Downstream 100 bases:

>100_bases
TGAGCCAGCTTCCTCCAGCGATTTTCCTGATGGGCCCGACCGCTGCGGGCAAGACCGATCTGGCCATCGAGCTGACCAAG
GTGCTGCCGTGCGAGCTGAT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 635; Mature: 635

Protein sequence:

>635_residues
MNQVLNAARIELLSPRLANQIAAGEVVERPASVIKELLENSLDSGAKRIDVDVEQGGVKLLRVRDDGSGISADDLPLALA
RHATSKIRNLEDLEQVMSLGFRGEALASISSVARLTLTSRTRDADQAWQVETEGRDMAPRVQPAAHPVGTSVEVRDLFFN
TPARRKFLKTEKTEFDHLQEVIKRLALARFDVAFHLRHNGKTILSLHEAHDDAARARRVAAICGSGFLEQALPIEIERNG
LHLWGWVGLPTFNRSQADLQYFFVNGRAVRDKLVAHAVRQAYRDVLFNGRHPTFALFFEVDPAAVDVNVHPTKHEVRFRD
GRMVHDFLYGTLHRALGDVRPEDQLAGSVTTAIVRPTGLEAGEFGPQGEMRLAANALLEQPQAQPAFNTASGASAGGAYQ
YQYTPRPQSTVPVAEAQAAYREFFAPLPEANANALPAGQEDIPPLGYALAQLKGIYILSENAQGLVLVDMHAAHERIMYE
RLKIAMASEGLSGQPLLVPESLAVSQREADCAEEHAAWFQRLGFELQRLGPETLAIRQIPALLKQAEANRLVGDVLSDLM
EYGTSDRIQAHLNELLGTMACHGAIRANRRLALPEMNGLLRDMENTERSGQCNHGRPTWTQLGLDDLDKLFLRGR

Sequences:

>Translated_635_residues
MNQVLNAARIELLSPRLANQIAAGEVVERPASVIKELLENSLDSGAKRIDVDVEQGGVKLLRVRDDGSGISADDLPLALA
RHATSKIRNLEDLEQVMSLGFRGEALASISSVARLTLTSRTRDADQAWQVETEGRDMAPRVQPAAHPVGTSVEVRDLFFN
TPARRKFLKTEKTEFDHLQEVIKRLALARFDVAFHLRHNGKTILSLHEAHDDAARARRVAAICGSGFLEQALPIEIERNG
LHLWGWVGLPTFNRSQADLQYFFVNGRAVRDKLVAHAVRQAYRDVLFNGRHPTFALFFEVDPAAVDVNVHPTKHEVRFRD
GRMVHDFLYGTLHRALGDVRPEDQLAGSVTTAIVRPTGLEAGEFGPQGEMRLAANALLEQPQAQPAFNTASGASAGGAYQ
YQYTPRPQSTVPVAEAQAAYREFFAPLPEANANALPAGQEDIPPLGYALAQLKGIYILSENAQGLVLVDMHAAHERIMYE
RLKIAMASEGLSGQPLLVPESLAVSQREADCAEEHAAWFQRLGFELQRLGPETLAIRQIPALLKQAEANRLVGDVLSDLM
EYGTSDRIQAHLNELLGTMACHGAIRANRRLALPEMNGLLRDMENTERSGQCNHGRPTWTQLGLDDLDKLFLRGR
>Mature_635_residues
MNQVLNAARIELLSPRLANQIAAGEVVERPASVIKELLENSLDSGAKRIDVDVEQGGVKLLRVRDDGSGISADDLPLALA
RHATSKIRNLEDLEQVMSLGFRGEALASISSVARLTLTSRTRDADQAWQVETEGRDMAPRVQPAAHPVGTSVEVRDLFFN
TPARRKFLKTEKTEFDHLQEVIKRLALARFDVAFHLRHNGKTILSLHEAHDDAARARRVAAICGSGFLEQALPIEIERNG
LHLWGWVGLPTFNRSQADLQYFFVNGRAVRDKLVAHAVRQAYRDVLFNGRHPTFALFFEVDPAAVDVNVHPTKHEVRFRD
GRMVHDFLYGTLHRALGDVRPEDQLAGSVTTAIVRPTGLEAGEFGPQGEMRLAANALLEQPQAQPAFNTASGASAGGAYQ
YQYTPRPQSTVPVAEAQAAYREFFAPLPEANANALPAGQEDIPPLGYALAQLKGIYILSENAQGLVLVDMHAAHERIMYE
RLKIAMASEGLSGQPLLVPESLAVSQREADCAEEHAAWFQRLGFELQRLGPETLAIRQIPALLKQAEANRLVGDVLSDLM
EYGTSDRIQAHLNELLGTMACHGAIRANRRLALPEMNGLLRDMENTERSGQCNHGRPTWTQLGLDDLDKLFLRGR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=367, Percent_Identity=34.8773841961853, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI189458898, Length=333, Percent_Identity=29.7297297297297, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI4505911, Length=333, Percent_Identity=29.7297297297297, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI189458896, Length=326, Percent_Identity=30.9815950920245, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI4505913, Length=351, Percent_Identity=26.7806267806268, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI310128478, Length=351, Percent_Identity=26.7806267806268, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI263191589, Length=270, Percent_Identity=31.1111111111111, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI91992160, Length=271, Percent_Identity=29.1512915129151, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI91992162, Length=271, Percent_Identity=29.1512915129151, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI310128480, Length=301, Percent_Identity=24.9169435215947, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1790612, Length=563, Percent_Identity=44.582593250444, Blast_Score=432, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI71991825, Length=323, Percent_Identity=36.8421052631579, Blast_Score=185, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI17562796, Length=350, Percent_Identity=28.2857142857143, Blast_Score=130, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6323819, Length=350, Percent_Identity=35.1428571428571, Blast_Score=214, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6324247, Length=342, Percent_Identity=26.0233918128655, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6325093, Length=716, Percent_Identity=22.6256983240223, Blast_Score=114, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6323063, Length=392, Percent_Identity=26.7857142857143, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI17136968, Length=319, Percent_Identity=35.7366771159875, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI17136970, Length=396, Percent_Identity=25.5050505050505, Blast_Score=122, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 70066; Mature: 70066

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQVLNAARIELLSPRLANQIAAGEVVERPASVIKELLENSLDSGAKRIDVDVEQGGVKL
CCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEE
LRVRDDGSGISADDLPLALARHATSKIRNLEDLEQVMSLGFRGEALASISSVARLTLTSR
EEEECCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCC
TRDADQAWQVETEGRDMAPRVQPAAHPVGTSVEVRDLFFNTPARRKFLKTEKTEFDHLQE
CCCCCHHEEEECCCCCCCCCCCCCCCCCCCCEEEHHHHHCCHHHHHHHHHCCCHHHHHHH
VIKRLALARFDVAFHLRHNGKTILSLHEAHDDAARARRVAAICGSGFLEQALPIEIERNG
HHHHHHHHHHCEEEEEECCCCEEEEEHHHCCHHHHHHHHHHHHCCHHHHHCCCEEEECCC
LHLWGWVGLPTFNRSQADLQYFFVNGRAVRDKLVAHAVRQAYRDVLFNGRHPTFALFFEV
EEEEEEECCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEE
DPAAVDVNVHPTKHEVRFRDGRMVHDFLYGTLHRALGDVRPEDQLAGSVTTAIVRPTGLE
CCEEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHCHHHEEEECCCCCC
AGEFGPQGEMRLAANALLEQPQAQPAFNTASGASAGGAYQYQYTPRPQSTVPVAEAQAAY
CCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHH
REFFAPLPEANANALPAGQEDIPPLGYALAQLKGIYILSENAQGLVLVDMHAAHERIMYE
HHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCEEEEEECCCCEEEEEECHHHHHHHHHH
RLKIAMASEGLSGQPLLVPESLAVSQREADCAEEHAAWFQRLGFELQRLGPETLAIRQIP
HHHHHHHCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHH
ALLKQAEANRLVGDVLSDLMEYGTSDRIQAHLNELLGTMACHGAIRANRRLALPEMNGLL
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHHH
RDMENTERSGQCNHGRPTWTQLGLDDLDKLFLRGR
HHHHCCCCCCCCCCCCCCHHHCCHHHHHHHHHCCC
>Mature Secondary Structure
MNQVLNAARIELLSPRLANQIAAGEVVERPASVIKELLENSLDSGAKRIDVDVEQGGVKL
CCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEE
LRVRDDGSGISADDLPLALARHATSKIRNLEDLEQVMSLGFRGEALASISSVARLTLTSR
EEEECCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCC
TRDADQAWQVETEGRDMAPRVQPAAHPVGTSVEVRDLFFNTPARRKFLKTEKTEFDHLQE
CCCCCHHEEEECCCCCCCCCCCCCCCCCCCCEEEHHHHHCCHHHHHHHHHCCCHHHHHHH
VIKRLALARFDVAFHLRHNGKTILSLHEAHDDAARARRVAAICGSGFLEQALPIEIERNG
HHHHHHHHHHCEEEEEECCCCEEEEEHHHCCHHHHHHHHHHHHCCHHHHHCCCEEEECCC
LHLWGWVGLPTFNRSQADLQYFFVNGRAVRDKLVAHAVRQAYRDVLFNGRHPTFALFFEV
EEEEEEECCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEE
DPAAVDVNVHPTKHEVRFRDGRMVHDFLYGTLHRALGDVRPEDQLAGSVTTAIVRPTGLE
CCEEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHCHHHEEEECCCCCC
AGEFGPQGEMRLAANALLEQPQAQPAFNTASGASAGGAYQYQYTPRPQSTVPVAEAQAAY
CCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHH
REFFAPLPEANANALPAGQEDIPPLGYALAQLKGIYILSENAQGLVLVDMHAAHERIMYE
HHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCEEEEEECCCCEEEEEECHHHHHHHHHH
RLKIAMASEGLSGQPLLVPESLAVSQREADCAEEHAAWFQRLGFELQRLGPETLAIRQIP
HHHHHHHCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHH
ALLKQAEANRLVGDVLSDLMEYGTSDRIQAHLNELLGTMACHGAIRANRRLALPEMNGLL
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHHH
RDMENTERSGQCNHGRPTWTQLGLDDLDKLFLRGR
HHHHCCCCCCCCCCCCCCHHHCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA