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The map label for this gene is typA [H]

Identifier: 77456575

GI number: 77456575

Start: 391491

End: 393311

Strand: Direct

Name: typA [H]

Synonym: Pfl01_0347

Alternate gene names: 77456575

Gene position: 391491-393311 (Clockwise)

Preceding gene: 77456574

Following gene: 77456577

Centisome position: 6.08

GC content: 57.83

Gene sequence:

>1821_bases
GTGATCGAAAATCTACGCAACATCGCCATCATTGCCCACGTTGACCATGGTAAGACCACCCTGGTAGACAAACTCCTGCG
TCAATCCGGCACCCTGGAGCGCAACGAGCTCAACGACGAGCGCGTGATGGACTCCAACGACCAGGAAAAAGAGCGCGGCA
TTACCATTCTGGCGAAAAACACCGCCATCAACTGGAACGGCTACCACATCAACATCGTGGACACCCCGGGCCACGCCGAC
TTCGGCGGCGAAGTCGAGCGCGTAATGTCCATGGTTGACTCCGTGCTGCTGCTGGTCGACGCTCAAGACGGCCCTATGCC
GCAAACCCGTTTCGTGACCAAGAAGGCTTTCGAAGCCGGCCTGCGTCCAATCGTGGTCATCAACAAGGTTGACCGTCCGG
GCGCGCGTCCTGACTGGGTTCTGGACCAGATCTTCGATCTGTTCGACAACCTGGGCGCTACCGAAGAACAACTGGACTTC
CAGGTTGTTTACGCTTCGGCCCTGAACGGCATCGCCGGTCTGGACCACACCGCCATGGGCGAAGACATGACCGCGCTGTA
CCAGGCGGTAGTCGACCACGTTCCGCCTCCGGCTGTTGACCGTGACGGTCCGTTCCAGATGCAGATCTCCGCTCTGGACT
ACAACAGCTTCCTGGGTGTTATCGGTGTTGGCCGTATCGCTCGTGGTCGCGTCAAGCCGAACACTCCGGTTGTCGCTATC
AGCGCCGACGGCAAGCGCCGCAACGGTCGTATCCTGAAGCTGATGGGTCACCACGGTCTGCACCGCGTTGACGTTGAAGA
AGCAGCAGCCGGCGACATCGTCTGCATCAGCGGTTTCGACGAGCTGTTCATCTCCGACACCCTGTGCGACATCAACAACG
TCGAGGCGATGAAGCCGCTGACCGTTGACGAGCCAACCGTTTCCATGACCTTCCAGGTAAACGACTCGCCATTCTGCGGT
AAAGAAGGCAAGTTCGTGACCTCCCGTAACATCAAGGATCGTCTGGACAAAGAGCTGCTGTACAACGTTGCACTGCGCGT
TGAAGAAGGCGACTCGGCTGACAAGTTCAAGGTTTCCGGCCGTGGTGAGCTGCACCTCTCGGTACTGATCGAAACCATGC
GTCGCGAAGGCTTCGAGCTGGCCCTGGGCCGTCCTGAAGTGATCATCCGTGAAGTTGACGGCGTGAAGCAGGAACCGTTC
GAAAACGTGACCATCGACATCCCTGAAGAATCCCAGGGCAAGGTCATGGAAGAAATGGGTCTGCGTAAAGGCGACCTGAG
CAACATGGTGCCGGATGGCAAGGGCCGTGTTCGTCTGGAATACAACATCCCTGCTCGCGGTCTGATCGGTTTCCGTAACC
AGTTCCTGACCCTGACCAACGGTGCTGGCATCCTGACCTCGATCTTCGACCGTTACGCTCCAGTGAAGTCGGGCCACATG
TCCGGCCGTCAGAACGGCGTTCTGGTTTCGGTTGAAACCGGCAAGGCACTGACCTACTCCCTGGAAACCCTGCAGGCTCG
TGGCAAGCTGTTCGTAGAACACGGCCAGGAGATCTACAACGGTCAGATCGTTGGTCAGAACTCCCGCGACAACGACCTGG
GTGTGAACCCGACTAAAGGCAAGAAGCTCGACAACATGCGTGCTTCGGGTAAAGACGAAACCATCGCTCTGGTCCCACCT
GTTCGCTTCACCCTGGAACAGGCTCTGGAATACATCCAGGAAGACGAGCTGTGCGAAGTGACTCCTAAGTCCATCCGTCT
TCGCAAGAAGATCCTGGACGAAAGCGAGCGTACCCGCGCTGCCAAGAAAGCCAAGGCGTAA

Upstream 100 bases:

>100_bases
CCCCGACACCGCCGTCAAGCTGTAACGGCCATGCCGGACACTACTGTCAATCGCTGCCAAGACTTGTCAGCAAACCGAAT
CCTCTGATCGAGATACACAA

Downstream 100 bases:

>100_bases
TTTAGCCCAGGCTTAAAAAAACGCCCCCGGTCGAGAGACCGGGGGCGTTTTTGTTTATTCGGGGAAAAGTGCTGAACCTC
AAAAGCCCCCTCACCCTAAC

Product: GTP-binding protein TypA

Products: NA

Alternate protein names: Tyrosine phosphorylated protein A [H]

Number of amino acids: Translated: 606; Mature: 606

Protein sequence:

>606_residues
MIENLRNIAIIAHVDHGKTTLVDKLLRQSGTLERNELNDERVMDSNDQEKERGITILAKNTAINWNGYHINIVDTPGHAD
FGGEVERVMSMVDSVLLLVDAQDGPMPQTRFVTKKAFEAGLRPIVVINKVDRPGARPDWVLDQIFDLFDNLGATEEQLDF
QVVYASALNGIAGLDHTAMGEDMTALYQAVVDHVPPPAVDRDGPFQMQISALDYNSFLGVIGVGRIARGRVKPNTPVVAI
SADGKRRNGRILKLMGHHGLHRVDVEEAAAGDIVCISGFDELFISDTLCDINNVEAMKPLTVDEPTVSMTFQVNDSPFCG
KEGKFVTSRNIKDRLDKELLYNVALRVEEGDSADKFKVSGRGELHLSVLIETMRREGFELALGRPEVIIREVDGVKQEPF
ENVTIDIPEESQGKVMEEMGLRKGDLSNMVPDGKGRVRLEYNIPARGLIGFRNQFLTLTNGAGILTSIFDRYAPVKSGHM
SGRQNGVLVSVETGKALTYSLETLQARGKLFVEHGQEIYNGQIVGQNSRDNDLGVNPTKGKKLDNMRASGKDETIALVPP
VRFTLEQALEYIQEDELCEVTPKSIRLRKKILDESERTRAAKKAKA

Sequences:

>Translated_606_residues
MIENLRNIAIIAHVDHGKTTLVDKLLRQSGTLERNELNDERVMDSNDQEKERGITILAKNTAINWNGYHINIVDTPGHAD
FGGEVERVMSMVDSVLLLVDAQDGPMPQTRFVTKKAFEAGLRPIVVINKVDRPGARPDWVLDQIFDLFDNLGATEEQLDF
QVVYASALNGIAGLDHTAMGEDMTALYQAVVDHVPPPAVDRDGPFQMQISALDYNSFLGVIGVGRIARGRVKPNTPVVAI
SADGKRRNGRILKLMGHHGLHRVDVEEAAAGDIVCISGFDELFISDTLCDINNVEAMKPLTVDEPTVSMTFQVNDSPFCG
KEGKFVTSRNIKDRLDKELLYNVALRVEEGDSADKFKVSGRGELHLSVLIETMRREGFELALGRPEVIIREVDGVKQEPF
ENVTIDIPEESQGKVMEEMGLRKGDLSNMVPDGKGRVRLEYNIPARGLIGFRNQFLTLTNGAGILTSIFDRYAPVKSGHM
SGRQNGVLVSVETGKALTYSLETLQARGKLFVEHGQEIYNGQIVGQNSRDNDLGVNPTKGKKLDNMRASGKDETIALVPP
VRFTLEQALEYIQEDELCEVTPKSIRLRKKILDESERTRAAKKAKA
>Mature_606_residues
MIENLRNIAIIAHVDHGKTTLVDKLLRQSGTLERNELNDERVMDSNDQEKERGITILAKNTAINWNGYHINIVDTPGHAD
FGGEVERVMSMVDSVLLLVDAQDGPMPQTRFVTKKAFEAGLRPIVVINKVDRPGARPDWVLDQIFDLFDNLGATEEQLDF
QVVYASALNGIAGLDHTAMGEDMTALYQAVVDHVPPPAVDRDGPFQMQISALDYNSFLGVIGVGRIARGRVKPNTPVVAI
SADGKRRNGRILKLMGHHGLHRVDVEEAAAGDIVCISGFDELFISDTLCDINNVEAMKPLTVDEPTVSMTFQVNDSPFCG
KEGKFVTSRNIKDRLDKELLYNVALRVEEGDSADKFKVSGRGELHLSVLIETMRREGFELALGRPEVIIREVDGVKQEPF
ENVTIDIPEESQGKVMEEMGLRKGDLSNMVPDGKGRVRLEYNIPARGLIGFRNQFLTLTNGAGILTSIFDRYAPVKSGHM
SGRQNGVLVSVETGKALTYSLETLQARGKLFVEHGQEIYNGQIVGQNSRDNDLGVNPTKGKKLDNMRASGKDETIALVPP
VRFTLEQALEYIQEDELCEVTPKSIRLRKKILDESERTRAAKKAKA

Specific function: Probably interacts with the ribosomes in a GTP dependent manner. GTPase that mediates interactions between enteropathogenic E.coli (EPEC) and epithelial cells [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=503, Percent_Identity=27.4353876739563, Blast_Score=156, Evalue=5e-38,
Organism=Homo sapiens, GI94966754, Length=133, Percent_Identity=41.3533834586466, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI18390331, Length=208, Percent_Identity=33.6538461538462, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI4503483, Length=147, Percent_Identity=36.0544217687075, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI25306287, Length=145, Percent_Identity=37.2413793103448, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI19923640, Length=145, Percent_Identity=37.2413793103448, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI25306283, Length=145, Percent_Identity=37.2413793103448, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI34147630, Length=272, Percent_Identity=30.8823529411765, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI310132016, Length=111, Percent_Identity=38.7387387387387, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI310110807, Length=111, Percent_Identity=38.7387387387387, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI310123363, Length=111, Percent_Identity=38.7387387387387, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI217272894, Length=136, Percent_Identity=35.2941176470588, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI217272892, Length=136, Percent_Identity=35.2941176470588, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI94966752, Length=129, Percent_Identity=31.7829457364341, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI223555963, Length=308, Percent_Identity=24.3506493506494, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI5729864, Length=308, Percent_Identity=24.3506493506494, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI4503471, Length=269, Percent_Identity=26.0223048327138, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI48994988, Length=605, Percent_Identity=70.9090909090909, Blast_Score=879, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=551, Percent_Identity=28.1306715063521, Blast_Score=142, Evalue=9e-35,
Organism=Escherichia coli, GI1789738, Length=152, Percent_Identity=40.1315789473684, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1790412, Length=235, Percent_Identity=30.2127659574468, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1789737, Length=235, Percent_Identity=30.2127659574468, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1790835, Length=145, Percent_Identity=31.7241379310345, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17557151, Length=230, Percent_Identity=36.5217391304348, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17533571, Length=178, Percent_Identity=36.5168539325843, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17556745, Length=142, Percent_Identity=38.7323943661972, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71988811, Length=130, Percent_Identity=37.6923076923077, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71988819, Length=130, Percent_Identity=37.6923076923077, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17552882, Length=179, Percent_Identity=34.0782122905028, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17556456, Length=236, Percent_Identity=29.2372881355932, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI25141371, Length=251, Percent_Identity=27.8884462151394, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323320, Length=497, Percent_Identity=28.3702213279678, Blast_Score=143, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6324707, Length=149, Percent_Identity=38.9261744966443, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6320593, Length=149, Percent_Identity=38.9261744966443, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6323098, Length=149, Percent_Identity=38.255033557047, Blast_Score=101, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6324761, Length=280, Percent_Identity=28.2142857142857, Blast_Score=94, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6322359, Length=153, Percent_Identity=36.6013071895425, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324166, Length=142, Percent_Identity=34.5070422535211, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324550, Length=191, Percent_Identity=32.4607329842932, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI78706572, Length=498, Percent_Identity=27.3092369477912, Blast_Score=140, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24582462, Length=148, Percent_Identity=40.5405405405405, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI28574573, Length=139, Percent_Identity=37.410071942446, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24585711, Length=151, Percent_Identity=35.7615894039735, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24585713, Length=151, Percent_Identity=35.7615894039735, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24585709, Length=151, Percent_Identity=35.7615894039735, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI281363316, Length=273, Percent_Identity=31.8681318681319, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17864358, Length=273, Percent_Identity=31.8681318681319, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21357743, Length=137, Percent_Identity=38.6861313868613, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI221458488, Length=133, Percent_Identity=41.3533834586466, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI19921738, Length=240, Percent_Identity=31.25, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI28572034, Length=163, Percent_Identity=33.7423312883436, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17137380, Length=259, Percent_Identity=24.7104247104247, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 67066; Mature: 67066

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIENLRNIAIIAHVDHGKTTLVDKLLRQSGTLERNELNDERVMDSNDQEKERGITILAKN
CCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCHHCCCCHHCCCCCCCHHHCCEEEEEEC
TAINWNGYHINIVDTPGHADFGGEVERVMSMVDSVLLLVDAQDGPMPQTRFVTKKAFEAG
EEEECCCEEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHC
LRPIVVINKVDRPGARPDWVLDQIFDLFDNLGATEEQLDFQVVYASALNGIAGLDHTAMG
CCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCHHHCEEEEEEEHHHCCCCCCCCCCCC
EDMTALYQAVVDHVPPPAVDRDGPFQMQISALDYNSFLGVIGVGRIARGRVKPNTPVVAI
CHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHCHHHCCCCCCCCCEEEE
SADGKRRNGRILKLMGHHGLHRVDVEEAAAGDIVCISGFDELFISDTLCDINNVEAMKPL
ECCCCCCCCCEEEEECCCCCEEECHHHCCCCCEEEECCCHHHHHHHHHCCCCCCCCCCCC
TVDEPTVSMTFQVNDSPFCGKEGKFVTSRNIKDRLDKELLYNVALRVEEGDSADKFKVSG
CCCCCCEEEEEEECCCCCCCCCCCEEECCCHHHHHHHHHHHHEEEEEECCCCCCEEEECC
RGELHLSVLIETMRREGFELALGRPEVIIREVDGVKQEPFENVTIDIPEESQGKVMEEMG
CCCEEHHHHHHHHHHCCCEEECCCCCEEEEECCCCCCCCCCCCEEECCCCCCCHHHHHHC
LRKGDLSNMVPDGKGRVRLEYNIPARGLIGFRNQFLTLTNGAGILTSIFDRYAPVKSGHM
CCCCCHHHCCCCCCCEEEEEECCCCCCEECCCCCEEEEECCCHHHHHHHHHHCCCCCCCC
SGRQNGVLVSVETGKALTYSLETLQARGKLFVEHGQEIYNGQIVGQNSRDNDLGVNPTKG
CCCCCCEEEEEECCCEEEEEHHHHHHCCCEEEECCHHHHCCEEEECCCCCCCCCCCCCCC
KKLDNMRASGKDETIALVPPVRFTLEQALEYIQEDELCEVTPKSIRLRKKILDESERTRA
CCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCHHHHHHH
AKKAKA
HHHCCC
>Mature Secondary Structure
MIENLRNIAIIAHVDHGKTTLVDKLLRQSGTLERNELNDERVMDSNDQEKERGITILAKN
CCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCHHCCCCHHCCCCCCCHHHCCEEEEEEC
TAINWNGYHINIVDTPGHADFGGEVERVMSMVDSVLLLVDAQDGPMPQTRFVTKKAFEAG
EEEECCCEEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHC
LRPIVVINKVDRPGARPDWVLDQIFDLFDNLGATEEQLDFQVVYASALNGIAGLDHTAMG
CCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCHHHCEEEEEEEHHHCCCCCCCCCCCC
EDMTALYQAVVDHVPPPAVDRDGPFQMQISALDYNSFLGVIGVGRIARGRVKPNTPVVAI
CHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHCHHHCCCCCCCCCEEEE
SADGKRRNGRILKLMGHHGLHRVDVEEAAAGDIVCISGFDELFISDTLCDINNVEAMKPL
ECCCCCCCCCEEEEECCCCCEEECHHHCCCCCEEEECCCHHHHHHHHHCCCCCCCCCCCC
TVDEPTVSMTFQVNDSPFCGKEGKFVTSRNIKDRLDKELLYNVALRVEEGDSADKFKVSG
CCCCCCEEEEEEECCCCCCCCCCCEEECCCHHHHHHHHHHHHEEEEEECCCCCCEEEECC
RGELHLSVLIETMRREGFELALGRPEVIIREVDGVKQEPFENVTIDIPEESQGKVMEEMG
CCCEEHHHHHHHHHHCCCEEECCCCCEEEEECCCCCCCCCCCCEEECCCCCCCHHHHHHC
LRKGDLSNMVPDGKGRVRLEYNIPARGLIGFRNQFLTLTNGAGILTSIFDRYAPVKSGHM
CCCCCHHHCCCCCCCEEEEEECCCCCCEECCCCCEEEEECCCHHHHHHHHHHCCCCCCCC
SGRQNGVLVSVETGKALTYSLETLQARGKLFVEHGQEIYNGQIVGQNSRDNDLGVNPTKG
CCCCCCEEEEEECCCEEEEEHHHHHHCCCEEEECCHHHHCCEEEECCCCCCCCCCCCCCC
KKLDNMRASGKDETIALVPPVRFTLEQALEYIQEDELCEVTPKSIRLRKKILDESERTRA
CCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCHHHHHHH
AKKAKA
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9622352 [H]