Click here to switch to the map view.

The map label for this gene is oxyR [H]

Identifier: 77456509

GI number: 77456509

Start: 328284

End: 329171

Strand: Reverse

Name: oxyR [H]

Synonym: Pfl01_0281

Alternate gene names: 77456509

Gene position: 329171-328284 (Counterclockwise)

Preceding gene: 77456511

Following gene: 77456508

Centisome position: 5.11

GC content: 62.39

Gene sequence:

>888_bases
ATGGACATCAAGCAGCTGAAATTCCTCATCGCCCTCGACGAAACCCGCCATTTCGGCCAGGCCGCCGCCCGCTGCCACAT
CACCCAGCCGACCCTGTCGATGCGCCTGCGCAGCCTCGAAGAAGAACTCGACCTGCCACTGGTCAACCGTGGCCAGCGCT
TCGAAGGGTTCACCGCGCCGGGCGAACGGGTGCTGGCCTGGGCGCGCACCGTGCTGGCGGCCTACGACGGCTTACAGGCG
GAAGCGGCGGCCTGTCGCGGCAACCTGATCGGCACCCTGCGGCTGGGCGTGGTGCCGTTGTCGAGTTTCGATGCGCTGCC
TTTGATGCAACGCCTGCACGCGCAACACCCGAACCTGCGCTTCGAACTGTCTTCGCTGAGCTCGGAACAGGTTCTGGAGC
AACTGGCGAACAACCGCATCGACATTGGCGTGTCTTACCTGGACCGCCTCGACGGCGAGCGTTTTGAATCCCTGGCGTTC
AGTGAAACGCAGATGGGCCTGCTCTACGACCAGCGATTCTTCAGTTTTGGTCAGGCGCCGCTGAGTTGGGAATCGCTGAT
CGAACTGCCACTGGGCATGCTCACCAGCGGCATGCATTTTCGCCAATCCATCGACCATAACTTCCACAGCCGTGGCCTGA
CGCCACAACCGTTGCTGCAAACCGACGCCGTTCACCAATTGTTGCAAGCCGTGCACGGTGGCCTGTGCTGCGCGGTAATG
CCACTCGATGGTGGTCTGGAAAACCTCACGGATAACCTGCGCCTGCAACCCATCGAAAACGCCCAGACCCTCGCCCGACT
GGGGCTGATCATGCGGCGCGGGGCACCACGATCGGCGTTGGCCGAGGCCTGTTTCGCGCTCTATCAAAAATCACCGACGG
ACGCTTGA

Upstream 100 bases:

>100_bases
CCTAGACCACGCCGGACAAACCCGGTTGCGGCCCGACCAATGACCCTGCCCCCGCGCAAGCGGTAGAATCGCCCACCCTT
GCCAGCGCCCCGGAGCGAAG

Downstream 100 bases:

>100_bases
TCGACGGCATCTATCGAGGGATCGACACTAGCGATTAGACGCGACATCTTGCCGCGCCTAGTCTTAACGTTGATCAATCC
ATCGGTGATGCCATGAACGC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Morphology and auto-aggregation control protein [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MDIKQLKFLIALDETRHFGQAAARCHITQPTLSMRLRSLEEELDLPLVNRGQRFEGFTAPGERVLAWARTVLAAYDGLQA
EAAACRGNLIGTLRLGVVPLSSFDALPLMQRLHAQHPNLRFELSSLSSEQVLEQLANNRIDIGVSYLDRLDGERFESLAF
SETQMGLLYDQRFFSFGQAPLSWESLIELPLGMLTSGMHFRQSIDHNFHSRGLTPQPLLQTDAVHQLLQAVHGGLCCAVM
PLDGGLENLTDNLRLQPIENAQTLARLGLIMRRGAPRSALAEACFALYQKSPTDA

Sequences:

>Translated_295_residues
MDIKQLKFLIALDETRHFGQAAARCHITQPTLSMRLRSLEEELDLPLVNRGQRFEGFTAPGERVLAWARTVLAAYDGLQA
EAAACRGNLIGTLRLGVVPLSSFDALPLMQRLHAQHPNLRFELSSLSSEQVLEQLANNRIDIGVSYLDRLDGERFESLAF
SETQMGLLYDQRFFSFGQAPLSWESLIELPLGMLTSGMHFRQSIDHNFHSRGLTPQPLLQTDAVHQLLQAVHGGLCCAVM
PLDGGLENLTDNLRLQPIENAQTLARLGLIMRRGAPRSALAEACFALYQKSPTDA
>Mature_295_residues
MDIKQLKFLIALDETRHFGQAAARCHITQPTLSMRLRSLEEELDLPLVNRGQRFEGFTAPGERVLAWARTVLAAYDGLQA
EAAACRGNLIGTLRLGVVPLSSFDALPLMQRLHAQHPNLRFELSSLSSEQVLEQLANNRIDIGVSYLDRLDGERFESLAF
SETQMGLLYDQRFFSFGQAPLSWESLIELPLGMLTSGMHFRQSIDHNFHSRGLTPQPLLQTDAVHQLLQAVHGGLCCAVM
PLDGGLENLTDNLRLQPIENAQTLARLGLIMRRGAPRSALAEACFALYQKSPTDA

Specific function: Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstre

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790399, Length=286, Percent_Identity=29.3706293706294, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI157672245, Length=242, Percent_Identity=25.2066115702479, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787879, Length=149, Percent_Identity=28.8590604026846, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1788297, Length=246, Percent_Identity=24.7967479674797, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788887, Length=149, Percent_Identity=30.8724832214765, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI145693105, Length=297, Percent_Identity=22.5589225589226, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1790208, Length=146, Percent_Identity=28.7671232876712, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI2367136, Length=183, Percent_Identity=26.2295081967213, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1787806, Length=280, Percent_Identity=22.1428571428571, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32774; Mature: 32774

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIKQLKFLIALDETRHFGQAAARCHITQPTLSMRLRSLEEELDLPLVNRGQRFEGFTAP
CCHHHHHHHHEEHHHHHHHHHHHHEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GERVLAWARTVLAAYDGLQAEAAACRGNLIGTLRLGVVPLSSFDALPLMQRLHAQHPNLR
HHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEECEEECCCCCHHHHHHHHHCCCCCCE
FELSSLSSEQVLEQLANNRIDIGVSYLDRLDGERFESLAFSETQMGLLYDQRFFSFGQAP
EEHHHCCHHHHHHHHHCCCEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LSWESLIELPLGMLTSGMHFRQSIDHNFHSRGLTPQPLLQTDAVHQLLQAVHGGLCCAVM
CCHHHHHHHHHHHHHCCHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEE
PLDGGLENLTDNLRLQPIENAQTLARLGLIMRRGAPRSALAEACFALYQKSPTDA
ECCCCHHHHCCCCEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MDIKQLKFLIALDETRHFGQAAARCHITQPTLSMRLRSLEEELDLPLVNRGQRFEGFTAP
CCHHHHHHHHEEHHHHHHHHHHHHEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GERVLAWARTVLAAYDGLQAEAAACRGNLIGTLRLGVVPLSSFDALPLMQRLHAQHPNLR
HHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEECEEECCCCCHHHHHHHHHCCCCCCE
FELSSLSSEQVLEQLANNRIDIGVSYLDRLDGERFESLAFSETQMGLLYDQRFFSFGQAP
EEHHHCCHHHHHHHHHCCCEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LSWESLIELPLGMLTSGMHFRQSIDHNFHSRGLTPQPLLQTDAVHQLLQAVHGGLCCAVM
CCHHHHHHHHHHHHHCCHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEE
PLDGGLENLTDNLRLQPIENAQTLARLGLIMRRGAPRSALAEACFALYQKSPTDA
ECCCCHHHHCCCCEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]