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The map label for this gene is spkF [H]

Identifier: 75909789

GI number: 75909789

Start: 4463339

End: 4464976

Strand: Direct

Name: spkF [H]

Synonym: Ava_3584

Alternate gene names: 75909789

Gene position: 4463339-4464976 (Clockwise)

Preceding gene: 75909788

Following gene: 75909790

Centisome position: 70.12

GC content: 43.59

Gene sequence:

>1638_bases
GTGCTACAGTTGTTAGATCGTTATGTGCCACTACAGACCTTGGGTGCGGGGGGTTTTGCACAAATTTATACCGTTTGGGA
TGAAAAGACCCAAACGGAAAAAGTGCTAAAGGTGTTGATAGAAGATTCCCCAAAGGCGTTGGAATTATTTACGCAAGAGG
CAGAAGTTTTAGTCAGGTTACGCCATCCTGGTGTCCCCAAAGTTGAGGCTGATGGTCATTTTCAAGTTAATTTATCCAAT
CCCAAGCCGCGCCAACTACCTTGTTTGGTAATGGAAAAAATTAACGGGCCGACTTTGGAGGAAATGTTGAACAAATATCC
CCAGGGATGCCCAGAAAATTTGGTATTAAACTGGTTAACTCAAGGGATCAAGATTTTACAAGAATTACATAAGCATCAAA
TCATACATCGTGATATCAAACCTTCTAATTTGATGTTACGTACTCCCTCGCCCAGTGTCATCTCTCAAGGGGGAACAGGA
TGGGAACAATTAGTTTTAATTGATTTCGGTGGGGCAAAACAATTTAATACAGGAAGACAGCGCCAAGAATCTAGTTCCAC
AAGGTTATTTTCTTCGGGTTACAGTCCACCAGAACAAGTGACGGGTGGGCATATCGGGCCGAGTGTTGATTTTTATGCCC
TCGGTCGTACGATGATTGAATTACTCACAGGTAAGTATCCACCAGAGTTGGAAGATCCCCAGACGGGGGTTTTGCATTGG
CGTAATAGAGTTACTATCAGACCTGAGTTGGCAGATTTACTAGATGAGATGGTGCATGAGGATGTGCGATCGCGCCCGGC
GAATGCTGCTATGATTCAAAAGCGGTTAACAAAAATTAACCAGCCCGCTTCAGGACAGAACAATTTTCAACAGTGGTTAA
CACAGCTTGCCAATCAACTAGCACTATTAAATCAATCTACAGAGCAAGTTTTCAGCAACTTGGGACAAACCTTAGGCAAA
ATCCTGCGGTGGATTGCACAGACAATAGTGAAAATCATCACAGCTTGTTTTTCCACCATTTGGGCAATGTTGTTAACTGG
TCTTGGTGCGAGTGTAGGAACGATCGCTGGATTTATTTTGGCATATCGCACAAACTTAGGCGATCGCTTAATAGAATTTA
TTGCCAGTCAATTACCCGAATTAATACCTAACCCTGAATCAGGATTTGGTGCAGAAATCATCGTATTTGCGGCCGCAGGC
TTAGGTACAGCCTGGGGACTGACAGCATCCGGATGTTTTGCCCAAAGACGGCGGTTTTTAGTCGCCTCATTCATGGGGAT
AATCAGCTACGCCTTTGGCTGGTTATTGTGGCAAATCATCACATCAACCGCAGATAGCGGTGAAGGTTTAGTAGGCGCAA
CCTCCATAGCCGTATTTTTACTAGCTCTAAGTATGAGTTTCCGTAGCCATCACATAGTTTATGCCATGATTGGCTCATTT
GGAACAGCGATCGTTGTGGCAATTTTGATAGTTTTAGGTTTTCCCACTACCGTTTTACAATTTTCTAATCGTCACCTCTG
GTCAGAATTATCCTTACCTATCATCTTCTTTAGCTCTATCGGTATTTTGATGAGCTTTTGGTTAGGCGTAAGCTACTACC
TCATTGTGCCAGGATTGCGGTTTTTGGGTTGGCGTTGA

Upstream 100 bases:

>100_bases
CTTGGTATACCGTTCTTCTGGGGTTCACTGCATAAATCCTGACTGTCAACGTCCCTACCCCCAGCCCTGGGGTAACAAAT
TTTGTAACAGCTGTGGCGCG

Downstream 100 bases:

>100_bases
TTGTTAGGGGTTTAGAGGTTTAGGGGTGTAGGGGGAAATTTGACAACCGAAAATTGTACAGATGCGATTAATCGCGTCTC
TAACAAACACAAATTAAGAC

Product: serine/threonine protein kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 545; Mature: 545

Protein sequence:

>545_residues
MLQLLDRYVPLQTLGAGGFAQIYTVWDEKTQTEKVLKVLIEDSPKALELFTQEAEVLVRLRHPGVPKVEADGHFQVNLSN
PKPRQLPCLVMEKINGPTLEEMLNKYPQGCPENLVLNWLTQGIKILQELHKHQIIHRDIKPSNLMLRTPSPSVISQGGTG
WEQLVLIDFGGAKQFNTGRQRQESSSTRLFSSGYSPPEQVTGGHIGPSVDFYALGRTMIELLTGKYPPELEDPQTGVLHW
RNRVTIRPELADLLDEMVHEDVRSRPANAAMIQKRLTKINQPASGQNNFQQWLTQLANQLALLNQSTEQVFSNLGQTLGK
ILRWIAQTIVKIITACFSTIWAMLLTGLGASVGTIAGFILAYRTNLGDRLIEFIASQLPELIPNPESGFGAEIIVFAAAG
LGTAWGLTASGCFAQRRRFLVASFMGIISYAFGWLLWQIITSTADSGEGLVGATSIAVFLLALSMSFRSHHIVYAMIGSF
GTAIVVAILIVLGFPTTVLQFSNRHLWSELSLPIIFFSSIGILMSFWLGVSYYLIVPGLRFLGWR

Sequences:

>Translated_545_residues
MLQLLDRYVPLQTLGAGGFAQIYTVWDEKTQTEKVLKVLIEDSPKALELFTQEAEVLVRLRHPGVPKVEADGHFQVNLSN
PKPRQLPCLVMEKINGPTLEEMLNKYPQGCPENLVLNWLTQGIKILQELHKHQIIHRDIKPSNLMLRTPSPSVISQGGTG
WEQLVLIDFGGAKQFNTGRQRQESSSTRLFSSGYSPPEQVTGGHIGPSVDFYALGRTMIELLTGKYPPELEDPQTGVLHW
RNRVTIRPELADLLDEMVHEDVRSRPANAAMIQKRLTKINQPASGQNNFQQWLTQLANQLALLNQSTEQVFSNLGQTLGK
ILRWIAQTIVKIITACFSTIWAMLLTGLGASVGTIAGFILAYRTNLGDRLIEFIASQLPELIPNPESGFGAEIIVFAAAG
LGTAWGLTASGCFAQRRRFLVASFMGIISYAFGWLLWQIITSTADSGEGLVGATSIAVFLLALSMSFRSHHIVYAMIGSF
GTAIVVAILIVLGFPTTVLQFSNRHLWSELSLPIIFFSSIGILMSFWLGVSYYLIVPGLRFLGWR
>Mature_545_residues
MLQLLDRYVPLQTLGAGGFAQIYTVWDEKTQTEKVLKVLIEDSPKALELFTQEAEVLVRLRHPGVPKVEADGHFQVNLSN
PKPRQLPCLVMEKINGPTLEEMLNKYPQGCPENLVLNWLTQGIKILQELHKHQIIHRDIKPSNLMLRTPSPSVISQGGTG
WEQLVLIDFGGAKQFNTGRQRQESSSTRLFSSGYSPPEQVTGGHIGPSVDFYALGRTMIELLTGKYPPELEDPQTGVLHW
RNRVTIRPELADLLDEMVHEDVRSRPANAAMIQKRLTKINQPASGQNNFQQWLTQLANQLALLNQSTEQVFSNLGQTLGK
ILRWIAQTIVKIITACFSTIWAMLLTGLGASVGTIAGFILAYRTNLGDRLIEFIASQLPELIPNPESGFGAEIIVFAAAG
LGTAWGLTASGCFAQRRRFLVASFMGIISYAFGWLLWQIITSTADSGEGLVGATSIAVFLLALSMSFRSHHIVYAMIGSF
GTAIVVAILIVLGFPTTVLQFSNRHLWSELSLPIIFFSSIGILMSFWLGVSYYLIVPGLRFLGWR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI299758415, Length=255, Percent_Identity=28.2352941176471, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI41352712, Length=255, Percent_Identity=28.2352941176471, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI299758411, Length=223, Percent_Identity=29.1479820627803, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI225637562, Length=150, Percent_Identity=32, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI41281753, Length=150, Percent_Identity=32, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI225637560, Length=150, Percent_Identity=32, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI37596297, Length=226, Percent_Identity=27.8761061946903, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI120659787, Length=226, Percent_Identity=29.2035398230088, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4503427, Length=223, Percent_Identity=28.6995515695067, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI120659785, Length=220, Percent_Identity=28.6363636363636, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI19923468, Length=220, Percent_Identity=28.6363636363636, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI120659782, Length=220, Percent_Identity=28.6363636363636, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI153281169, Length=223, Percent_Identity=28.6995515695067, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI225735561, Length=230, Percent_Identity=26.9565217391304, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI32698688, Length=223, Percent_Identity=26.0089686098655, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI62241001, Length=221, Percent_Identity=27.1493212669683, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI57222269, Length=224, Percent_Identity=26.3392857142857, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI115529463, Length=268, Percent_Identity=26.1194029850746, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI5031689, Length=266, Percent_Identity=26.3157894736842, Blast_Score=66, Evalue=7e-11,
Organism=Homo sapiens, GI153945765, Length=223, Percent_Identity=26.0089686098655, Blast_Score=66, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17565634, Length=224, Percent_Identity=30.3571428571429, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI115532862, Length=228, Percent_Identity=28.5087719298246, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71988995, Length=228, Percent_Identity=28.5087719298246, Blast_Score=66, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI115532860, Length=228, Percent_Identity=28.5087719298246, Blast_Score=66, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6320102, Length=240, Percent_Identity=29.5833333333333, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6325053, Length=266, Percent_Identity=27.4436090225564, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI161076714, Length=226, Percent_Identity=30.5309734513274, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI85724948, Length=220, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI85724946, Length=220, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17737415, Length=220, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45552377, Length=220, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45552375, Length=220, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI85724764, Length=244, Percent_Identity=28.2786885245902, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI85724762, Length=244, Percent_Identity=28.2786885245902, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI85724760, Length=244, Percent_Identity=28.2786885245902, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI85724758, Length=244, Percent_Identity=28.2786885245902, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI85724756, Length=244, Percent_Identity=28.2786885245902, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017441
- InterPro:   IPR017442 [H]

Pfam domain/function: PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 60400; Mature: 60400

Theoretical pI: Translated: 8.32; Mature: 8.32

Prosite motif: PS00108 PROTEIN_KINASE_ST ; PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQLLDRYVPLQTLGAGGFAQIYTVWDEKTQTEKVLKVLIEDSPKALELFTQEAEVLVRL
CHHHHHHHCCHHHCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
RHPGVPKVEADGHFQVNLSNPKPRQLPCLVMEKINGPTLEEMLNKYPQGCPENLVLNWLT
CCCCCCCEECCCEEEEEECCCCCCCCHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHH
QGIKILQELHKHQIIHRDIKPSNLMLRTPSPSVISQGGTGWEQLVLIDFGGAKQFNTGRQ
HHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHCCCCCCCEEEEEEECCCCCCCCCCHH
RQESSSTRLFSSGYSPPEQVTGGHIGPSVDFYALGRTMIELLTGKYPPELEDPQTGVLHW
HHHHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHEE
RNRVTIRPELADLLDEMVHEDVRSRPANAAMIQKRLTKINQPASGQNNFQQWLTQLANQL
CCCEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
ALLNQSTEQVFSNLGQTLGKILRWIAQTIVKIITACFSTIWAMLLTGLGASVGTIAGFIL
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
AYRTNLGDRLIEFIASQLPELIPNPESGFGAEIIVFAAAGLGTAWGLTASGCFAQRRRFL
HHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHH
VASFMGIISYAFGWLLWQIITSTADSGEGLVGATSIAVFLLALSMSFRSHHIVYAMIGSF
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
GTAIVVAILIVLGFPTTVLQFSNRHLWSELSLPIIFFSSIGILMSFWLGVSYYLIVPGLR
HHHHHHHHHHHHCCCHHHHHHHCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
FLGWR
HHCCC
>Mature Secondary Structure
MLQLLDRYVPLQTLGAGGFAQIYTVWDEKTQTEKVLKVLIEDSPKALELFTQEAEVLVRL
CHHHHHHHCCHHHCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
RHPGVPKVEADGHFQVNLSNPKPRQLPCLVMEKINGPTLEEMLNKYPQGCPENLVLNWLT
CCCCCCCEECCCEEEEEECCCCCCCCHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHH
QGIKILQELHKHQIIHRDIKPSNLMLRTPSPSVISQGGTGWEQLVLIDFGGAKQFNTGRQ
HHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHCCCCCCCEEEEEEECCCCCCCCCCHH
RQESSSTRLFSSGYSPPEQVTGGHIGPSVDFYALGRTMIELLTGKYPPELEDPQTGVLHW
HHHHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHEE
RNRVTIRPELADLLDEMVHEDVRSRPANAAMIQKRLTKINQPASGQNNFQQWLTQLANQL
CCCEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
ALLNQSTEQVFSNLGQTLGKILRWIAQTIVKIITACFSTIWAMLLTGLGASVGTIAGFIL
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
AYRTNLGDRLIEFIASQLPELIPNPESGFGAEIIVFAAAGLGTAWGLTASGCFAQRRRFL
HHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHH
VASFMGIISYAFGWLLWQIITSTADSGEGLVGATSIAVFLLALSMSFRSHHIVYAMIGSF
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
GTAIVVAILIVLGFPTTVLQFSNRHLWSELSLPIIFFSSIGILMSFWLGVSYYLIVPGLR
HHHHHHHHHHHHCCCHHHHHHHCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
FLGWR
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12168951; 8905231 [H]