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The map label for this gene is fabG [C]

Identifier: 75675769

GI number: 75675769

Start: 1724688

End: 1725368

Strand: Direct

Name: fabG [C]

Synonym: Nwi_1577

Alternate gene names: 75675769

Gene position: 1724688-1725368 (Clockwise)

Preceding gene: 75675768

Following gene: 75675770

Centisome position: 50.69

GC content: 66.81

Gene sequence:

>681_bases
ATGCAAGGAAAGGTCATCGCCGTCACCGGAGCTTCCGGCGCGCTGGGCAAGGTGGTCGTGGATGCCGCCATCACGCGCGG
CGCCAGGGCGGCCTGCATTAACCGGGCTGTGGCAAGGGGCGATGCCACGGCCGACCGGATCGAATTGGGCGGCGTCGATC
TGACTGATCCCGCACAGGCCTTGCAAGCCATCGATGCGGCGGCCGCGCATTTCGGCCGGCTCGACGTTCTCGTCAACGTT
GCCGGCGCGTTTGCCTTCGAAACCGTCGCGGACGGCGATCCGAAGACCTGGCAGCGCCTTTACGCGATCAATGTGGCGAC
CGCGCTGAACGCCTCGCGAGCGGCGATCCCGCATCTGGTTGCGTCCGGCGCCGGACGCATCGTCAACATCGGTGCGATCG
GTGCCTTGCAGGCGGGCGTTGGCATGGGCGCCTATGCGGCGTCGAAAGCGGCCGTGCATCGGCTGACCGAAGCGCTTGCC
TCCGAGTTGAAAGGCAAGGTGACCGTCAACGCCGTCCTGCCCTCGACGATCGACACGCCGGCCAATCGCAGGGACATGCC
GAAAGCGGATTTCGCGACCTGGGTGACGGCGGACGAACTGGCTGATGTCATCCTGTTTCTGGCAAGCGATGCGGCGAGCG
GCGTGACCGGGGCGCTGCTTCCCGTGCGCGGACGCGTTTGA

Upstream 100 bases:

>100_bases
CGCCTCGGATTTCGAGACCCGGACGCAGGACAAGCTGGCGAAGCAGGGTTGAGACCCGCCCTCTTTCATTAGCAGCCGTT
CCGGGCTGGAGGCTCATGCA

Downstream 100 bases:

>100_bases
ATCGCGATCCATCGTTATATATAATTGAATATAATATCTTTGTGTCTCGAGCTTCGCTTCTCGTTGAACTGGAGAAGCTT
GCTGTTTGACGCGCCGTCTT

Product: 3-ketoacyl-(acyl-carrier-protein) reductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MQGKVIAVTGASGALGKVVVDAAITRGARAACINRAVARGDATADRIELGGVDLTDPAQALQAIDAAAAHFGRLDVLVNV
AGAFAFETVADGDPKTWQRLYAINVATALNASRAAIPHLVASGAGRIVNIGAIGALQAGVGMGAYAASKAAVHRLTEALA
SELKGKVTVNAVLPSTIDTPANRRDMPKADFATWVTADELADVILFLASDAASGVTGALLPVRGRV

Sequences:

>Translated_226_residues
MQGKVIAVTGASGALGKVVVDAAITRGARAACINRAVARGDATADRIELGGVDLTDPAQALQAIDAAAAHFGRLDVLVNV
AGAFAFETVADGDPKTWQRLYAINVATALNASRAAIPHLVASGAGRIVNIGAIGALQAGVGMGAYAASKAAVHRLTEALA
SELKGKVTVNAVLPSTIDTPANRRDMPKADFATWVTADELADVILFLASDAASGVTGALLPVRGRV
>Mature_226_residues
MQGKVIAVTGASGALGKVVVDAAITRGARAACINRAVARGDATADRIELGGVDLTDPAQALQAIDAAAAHFGRLDVLVNV
AGAFAFETVADGDPKTWQRLYAINVATALNASRAAIPHLVASGAGRIVNIGAIGALQAGVGMGAYAASKAAVHRLTEALA
SELKGKVTVNAVLPSTIDTPANRRDMPKADFATWVTADELADVILFLASDAASGVTGALLPVRGRV

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI66933014, Length=235, Percent_Identity=30.6382978723404, Blast_Score=84, Evalue=8e-17,
Organism=Homo sapiens, GI7705925, Length=242, Percent_Identity=29.3388429752066, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI208973246, Length=235, Percent_Identity=29.7872340425532, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI10190704, Length=256, Percent_Identity=29.6875, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4503817, Length=193, Percent_Identity=29.5336787564767, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI40254992, Length=235, Percent_Identity=26.3829787234043, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI31542939, Length=220, Percent_Identity=24.5454545454545, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI15277342, Length=183, Percent_Identity=31.6939890710383, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1787335, Length=239, Percent_Identity=30.5439330543933, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1789208, Length=243, Percent_Identity=29.6296296296296, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1786812, Length=243, Percent_Identity=29.6296296296296, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788459, Length=189, Percent_Identity=32.2751322751323, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1790717, Length=247, Percent_Identity=28.7449392712551, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI87082160, Length=242, Percent_Identity=28.099173553719, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI87082100, Length=183, Percent_Identity=32.7868852459016, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI2367365, Length=234, Percent_Identity=31.6239316239316, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1787820, Length=166, Percent_Identity=25.3012048192771, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1787905, Length=249, Percent_Identity=29.3172690763052, Blast_Score=62, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=204, Percent_Identity=32.3529411764706, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71994604, Length=242, Percent_Identity=29.7520661157025, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17555706, Length=240, Percent_Identity=29.5833333333333, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17561402, Length=251, Percent_Identity=24.7011952191235, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI25147288, Length=240, Percent_Identity=28.75, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17554872, Length=225, Percent_Identity=29.3333333333333, Blast_Score=70, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17560676, Length=175, Percent_Identity=27.4285714285714, Blast_Score=70, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17562904, Length=238, Percent_Identity=29.4117647058824, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17562906, Length=194, Percent_Identity=32.4742268041237, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17560150, Length=243, Percent_Identity=27.1604938271605, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=195, Percent_Identity=30.2564102564103, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562908, Length=194, Percent_Identity=31.4432989690722, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=186, Percent_Identity=29.0322580645161, Blast_Score=72, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6322226, Length=186, Percent_Identity=30.6451612903226, Blast_Score=65, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6322227, Length=197, Percent_Identity=27.9187817258883, Blast_Score=63, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28571526, Length=247, Percent_Identity=34.412955465587, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI23397609, Length=244, Percent_Identity=29.9180327868852, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21357041, Length=247, Percent_Identity=29.9595141700405, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI62472128, Length=151, Percent_Identity=35.7615894039735, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI17647337, Length=151, Percent_Identity=35.7615894039735, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI62472140, Length=151, Percent_Identity=35.7615894039735, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24644339, Length=247, Percent_Identity=30.3643724696356, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21355319, Length=176, Percent_Identity=29.5454545454545, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24639444, Length=242, Percent_Identity=28.5123966942149, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24581726, Length=132, Percent_Identity=26.5151515151515, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21357673, Length=218, Percent_Identity=27.5229357798165, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 22815; Mature: 22815

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQGKVIAVTGASGALGKVVVDAAITRGARAACINRAVARGDATADRIELGGVDLTDPAQA
CCCCEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHEEEECCCCCCCHHHH
LQAIDAAAAHFGRLDVLVNVAGAFAFETVADGDPKTWQRLYAINVATALNASRAAIPHLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHH
ASGAGRIVNIGAIGALQAGVGMGAYAASKAAVHRLTEALASELKGKVTVNAVLPSTIDTP
HCCCCCEEEECCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
ANRRDMPKADFATWVTADELADVILFLASDAASGVTGALLPVRGRV
CCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCC
>Mature Secondary Structure
MQGKVIAVTGASGALGKVVVDAAITRGARAACINRAVARGDATADRIELGGVDLTDPAQA
CCCCEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHEEEECCCCCCCHHHH
LQAIDAAAAHFGRLDVLVNVAGAFAFETVADGDPKTWQRLYAINVATALNASRAAIPHLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHH
ASGAGRIVNIGAIGALQAGVGMGAYAASKAAVHRLTEALASELKGKVTVNAVLPSTIDTP
HCCCCCEEEECCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
ANRRDMPKADFATWVTADELADVILFLASDAASGVTGALLPVRGRV
CCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA