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The map label for this gene is cusR [H]

Identifier: 75675389

GI number: 75675389

Start: 1303301

End: 1304017

Strand: Direct

Name: cusR [H]

Synonym: Nwi_1196

Alternate gene names: 75675389

Gene position: 1303301-1304017 (Clockwise)

Preceding gene: 75675388

Following gene: 75675391

Centisome position: 38.31

GC content: 59.83

Gene sequence:

>717_bases
ATGGTGATGGAAAGACAACCTTTGGACAATTCCAGTAACCAGATGCGCCTGCTGATCATCGAGGACGATCGCGAGTCCGC
GGACTACCTCGTGAAGGCGTTTCGCGAGGTCGGACATATCGCGGAACTCGCCAGAGACGGCGAGGAAGGCCTCTCCTTTG
CCGACGGCGGGGACTACGACGTACTGGTGATCGATCGGATGCTGCCCAAGCGCGACGGGCTTTCCGTGATCGGCTGCCTG
CGCGAGAAAGGCATCCTCACTCCGGTGCTCATTCTCTCTGCGCTCGGCCAGGTCGACGATCGCATCAAGGGCTTGCGCGC
CGGCGGCGACGACTATCTGCCTAAACCGTACTCATTTGCCGAGTTGCTGGCGCGGGTGGAGGTCCTGTCGCGTCGTCATG
GCGGGCGCGCCGAAGAAACGCTCTATCGTGTCGGCGATCTCGAACTGGACCGGCTGTCACGCCGCGTTGCGCGGGGTGGA
GAGGAACTGACGCTTCAGCCGCGTGAGTTTCGCCTGTTGGAGTATCTCATGAAGCATGCGGGTCAGGTCGTGACCCGAAC
CATGCTGCTGGAGAATGTCTGGGATTATCATTTTGATCCGCAGACTAACGTCATCGACGTGCATATCTCGCGGTTGCGTT
CCAAGATCGATAAAGGTTTCGAGCAGCCTCTGCTGCACACCATCCGTGGCGCCGGATACATGGTGCGGAGTGGTTAG

Upstream 100 bases:

>100_bases
CTAGGGCGGTGGAGTTGCCCCAAGCTTCACCGCCCGTTTTTTGCACGGCGGCCGCCGGGGCGTGGTCTTTGCGGTCTTGC
GCGCGCGGAATGAGCGCGCC

Downstream 100 bases:

>100_bases
AACACGGTAGATTTTGAAAACCTCCGACCATTAGAGCGTTTTCAAGCGAAGTGGATATCGGTTCGCATGACGAAAACGCG
TCTAAACAACAATATAGAGC

Product: two-component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MVMERQPLDNSSNQMRLLIIEDDRESADYLVKAFREVGHIAELARDGEEGLSFADGGDYDVLVIDRMLPKRDGLSVIGCL
REKGILTPVLILSALGQVDDRIKGLRAGGDDYLPKPYSFAELLARVEVLSRRHGGRAEETLYRVGDLELDRLSRRVARGG
EELTLQPREFRLLEYLMKHAGQVVTRTMLLENVWDYHFDPQTNVIDVHISRLRSKIDKGFEQPLLHTIRGAGYMVRSG

Sequences:

>Translated_238_residues
MVMERQPLDNSSNQMRLLIIEDDRESADYLVKAFREVGHIAELARDGEEGLSFADGGDYDVLVIDRMLPKRDGLSVIGCL
REKGILTPVLILSALGQVDDRIKGLRAGGDDYLPKPYSFAELLARVEVLSRRHGGRAEETLYRVGDLELDRLSRRVARGG
EELTLQPREFRLLEYLMKHAGQVVTRTMLLENVWDYHFDPQTNVIDVHISRLRSKIDKGFEQPLLHTIRGAGYMVRSG
>Mature_238_residues
MVMERQPLDNSSNQMRLLIIEDDRESADYLVKAFREVGHIAELARDGEEGLSFADGGDYDVLVIDRMLPKRDGLSVIGCL
REKGILTPVLILSALGQVDDRIKGLRAGGDDYLPKPYSFAELLARVEVLSRRHGGRAEETLYRVGDLELDRLSRRVARGG
EELTLQPREFRLLEYLMKHAGQVVTRTMLLENVWDYHFDPQTNVIDVHISRLRSKIDKGFEQPLLHTIRGAGYMVRSG

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=45.7013574660633, Blast_Score=216, Evalue=1e-57,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=39.7260273972603, Blast_Score=175, Evalue=3e-45,
Organism=Escherichia coli, GI1790552, Length=224, Percent_Identity=40.1785714285714, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=37.5565610859729, Blast_Score=144, Evalue=4e-36,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=33.6363636363636, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1787375, Length=220, Percent_Identity=30.4545454545455, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786911, Length=219, Percent_Identity=35.1598173515982, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=35.9307359307359, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1789809, Length=226, Percent_Identity=30.0884955752212, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1788394, Length=233, Percent_Identity=31.7596566523605, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=32.7354260089686, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=29.646017699115, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=26.9911504424779, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI145693140, Length=187, Percent_Identity=33.6898395721925, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=34.6534653465347, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27017; Mature: 27017

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMERQPLDNSSNQMRLLIIEDDRESADYLVKAFREVGHIAELARDGEEGLSFADGGDYD
CCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCEE
VLVIDRMLPKRDGLSVIGCLREKGILTPVLILSALGQVDDRIKGLRAGGDDYLPKPYSFA
EEEEECCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
ELLARVEVLSRRHGGRAEETLYRVGDLELDRLSRRVARGGEELTLQPREFRLLEYLMKHA
HHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHH
GQVVTRTMLLENVWDYHFDPQTNVIDVHISRLRSKIDKGFEQPLLHTIRGAGYMVRSG
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCCEEEECC
>Mature Secondary Structure
MVMERQPLDNSSNQMRLLIIEDDRESADYLVKAFREVGHIAELARDGEEGLSFADGGDYD
CCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCEE
VLVIDRMLPKRDGLSVIGCLREKGILTPVLILSALGQVDDRIKGLRAGGDDYLPKPYSFA
EEEEECCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
ELLARVEVLSRRHGGRAEETLYRVGDLELDRLSRRVARGGEELTLQPREFRLLEYLMKHA
HHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHH
GQVVTRTMLLENVWDYHFDPQTNVIDVHISRLRSKIDKGFEQPLLHTIRGAGYMVRSG
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]