Click here to switch to the map view.

The map label for this gene is degP [H]

Identifier: 75675388

GI number: 75675388

Start: 1301419

End: 1302969

Strand: Direct

Name: degP [H]

Synonym: Nwi_1195

Alternate gene names: 75675388

Gene position: 1301419-1302969 (Clockwise)

Preceding gene: 75675387

Following gene: 75675389

Centisome position: 38.25

GC content: 63.19

Gene sequence:

>1551_bases
ATGACCGACCTGCCGTCTTCCCAGTTAAAGCCCATTCGTTCTGGGGTCACCGCGCGCAGGTTCGCGTTGATGGCGTCTGT
CGTCGCGGGTGTTGGCGTAGCCGCTTACGGGCTAAGCCCTTCCGCAGACAAGGCCGAGTTCTTCATAAGTCCCGCTTATG
CGCAGGTCAACACCGACGTGAGCAAGGTCGCGCAGCCGATCGGCTTTGCCGACATCGTCGAGCGGGTGAAGCCGTCGGTA
ATTTCGGTCAAGATCCGTATGAAGGACAGGGCGGTGGCCAGCGGGGACGATTCGCCGTTCCAGCCGGGCTCGCCCATGGA
GCGGTTTTTCCGCCGCTTTGGCGGACCGGATGGCCTACCGCCAGGAATGCGCGGCCGGCGCGGTCCTGGCCTCGTGACAG
GGCAGGGCTCCGGCTTCTTCATCTCGGCTGATGGGTATGCTGTGACCAACAACCATGTCGTCGACGGCGCGGACAAGGTC
GAAGTCACGACCGACGACGGCAAGACCTACACCGCCAAGGTGATCGGGGCTGATCCGCGCACGGACATTGCCCTGATCAA
GGTCGAGGGCGGCTCCAGTTTCCCGTTTGCGAAACTGTCGGATGACAAGGTGCGGATCGGCGATTGGGTTCTCGCGGTCG
GCAATCCGTTCGGTCTTGGCGGTTCGGTGACCGCCGGCATCGTGTCGGCCAGCGGCCGTGACATTGGCACCGGCCCCTAT
GACGACTTCATCCAGATTGACGCCCCGGTCAACAAAGGTAATTCCGGCGGCCCGGCTTTCAACATGAAGGGCGACGTCAT
CGGCGTGAATACCGCGATCTATTCGCCGTCCGGCGGCAGCGTCGGCATTGCGTTCTCGATTCCCGCGAATACGGTGAAGA
GTGTCGTTGCTCAGCTCAAGGACAAAGGGTCGGTGAGCCGCGGATGGATCGGCGTCCAGATCCAGCCGGTGACTTCCGAC
ATCGCCGACAGCCTCGGTCTCAAGAAAGCCGAAGGCGCGCTGGTGGCTGAGCCGCAGGCCAACAGTCCGGCGGCCAAGGC
GGGTATAAAGTCCGGCGACGTGATCACGGCCGTCAATGGTGATCCGGTCAAGGACGCGCGCGAACTGGCGCGGACCATCG
GTAGCTTGGCGCCGGGAACGTCGATCAAGCTCAACGTCCTGCGCAAGGGCACGGACAAGGTCGTCAACCTGACGCTTGGC
ACTCTGCCCGACACCGTCGAAGCCCGAGCTGACCACTATGGCGATCGTGGCTCATCGCGCGACAACGATATTCCCAGGCT
TGGTTTGACCGTTGCGCCGGCAGGATCGGTTGCGGGTGCCGGCGGGGAAGGGGTCGTCGTGGTTGACGTGGATCCGAAAA
GCCCCGCGGCCGAGCGCGGGTTCAGGGAAGGCGACGTGATTTTGGAGGTCGCGGGAAAGAGCGTGTCCAGCTCCGCCGAC
ATACGCGAGGCAATCAAGGCGGCGCGCGCGGAAGACAAGAACAGTGTTTTGATGCGGGTTCGCACCGGCAGCACGGCGCG
TTTCGTCGCAATGCCAATTGCGAAGGGTTAA

Upstream 100 bases:

>100_bases
AATTTCTTGGTCAGCGCGCGGTAAGGTGCGAATACCCATCTTCAGGGACATGAAGTGCCGGTTTTCGGCACTATATCAAA
CCTGTCTTTTGGAGATCCGC

Downstream 100 bases:

>100_bases
GGCATGATGCCGAACGGAAGAAATCGATTCCCGGATTGGATCATGCCGATCAAAGACAAGGCTCGGTCGGGCTCGACGCG
GTCCGATCGGACTTGAGGTG

Product: peptidase S1C, Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 516; Mature: 515

Protein sequence:

>516_residues
MTDLPSSQLKPIRSGVTARRFALMASVVAGVGVAAYGLSPSADKAEFFISPAYAQVNTDVSKVAQPIGFADIVERVKPSV
ISVKIRMKDRAVASGDDSPFQPGSPMERFFRRFGGPDGLPPGMRGRRGPGLVTGQGSGFFISADGYAVTNNHVVDGADKV
EVTTDDGKTYTAKVIGADPRTDIALIKVEGGSSFPFAKLSDDKVRIGDWVLAVGNPFGLGGSVTAGIVSASGRDIGTGPY
DDFIQIDAPVNKGNSGGPAFNMKGDVIGVNTAIYSPSGGSVGIAFSIPANTVKSVVAQLKDKGSVSRGWIGVQIQPVTSD
IADSLGLKKAEGALVAEPQANSPAAKAGIKSGDVITAVNGDPVKDARELARTIGSLAPGTSIKLNVLRKGTDKVVNLTLG
TLPDTVEARADHYGDRGSSRDNDIPRLGLTVAPAGSVAGAGGEGVVVVDVDPKSPAAERGFREGDVILEVAGKSVSSSAD
IREAIKAARAEDKNSVLMRVRTGSTARFVAMPIAKG

Sequences:

>Translated_516_residues
MTDLPSSQLKPIRSGVTARRFALMASVVAGVGVAAYGLSPSADKAEFFISPAYAQVNTDVSKVAQPIGFADIVERVKPSV
ISVKIRMKDRAVASGDDSPFQPGSPMERFFRRFGGPDGLPPGMRGRRGPGLVTGQGSGFFISADGYAVTNNHVVDGADKV
EVTTDDGKTYTAKVIGADPRTDIALIKVEGGSSFPFAKLSDDKVRIGDWVLAVGNPFGLGGSVTAGIVSASGRDIGTGPY
DDFIQIDAPVNKGNSGGPAFNMKGDVIGVNTAIYSPSGGSVGIAFSIPANTVKSVVAQLKDKGSVSRGWIGVQIQPVTSD
IADSLGLKKAEGALVAEPQANSPAAKAGIKSGDVITAVNGDPVKDARELARTIGSLAPGTSIKLNVLRKGTDKVVNLTLG
TLPDTVEARADHYGDRGSSRDNDIPRLGLTVAPAGSVAGAGGEGVVVVDVDPKSPAAERGFREGDVILEVAGKSVSSSAD
IREAIKAARAEDKNSVLMRVRTGSTARFVAMPIAKG
>Mature_515_residues
TDLPSSQLKPIRSGVTARRFALMASVVAGVGVAAYGLSPSADKAEFFISPAYAQVNTDVSKVAQPIGFADIVERVKPSVI
SVKIRMKDRAVASGDDSPFQPGSPMERFFRRFGGPDGLPPGMRGRRGPGLVTGQGSGFFISADGYAVTNNHVVDGADKVE
VTTDDGKTYTAKVIGADPRTDIALIKVEGGSSFPFAKLSDDKVRIGDWVLAVGNPFGLGGSVTAGIVSASGRDIGTGPYD
DFIQIDAPVNKGNSGGPAFNMKGDVIGVNTAIYSPSGGSVGIAFSIPANTVKSVVAQLKDKGSVSRGWIGVQIQPVTSDI
ADSLGLKKAEGALVAEPQANSPAAKAGIKSGDVITAVNGDPVKDARELARTIGSLAPGTSIKLNVLRKGTDKVVNLTLGT
LPDTVEARADHYGDRGSSRDNDIPRLGLTVAPAGSVAGAGGEGVVVVDVDPKSPAAERGFREGDVILEVAGKSVSSSADI
REAIKAARAEDKNSVLMRVRTGSTARFVAMPIAKG

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=374, Percent_Identity=31.283422459893, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI24308541, Length=287, Percent_Identity=34.4947735191638, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI22129776, Length=346, Percent_Identity=31.5028901734104, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI7019477, Length=357, Percent_Identity=31.9327731092437, Blast_Score=139, Evalue=8e-33,
Organism=Escherichia coli, GI1786356, Length=461, Percent_Identity=37.3101952277657, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI1789629, Length=452, Percent_Identity=36.283185840708, Blast_Score=261, Evalue=6e-71,
Organism=Escherichia coli, GI1789630, Length=276, Percent_Identity=35.1449275362319, Blast_Score=166, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24646839, Length=264, Percent_Identity=30.3030303030303, Blast_Score=121, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 53013; Mature: 52882

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLPSSQLKPIRSGVTARRFALMASVVAGVGVAAYGLSPSADKAEFFISPAYAQVNTDV
CCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCEEEECCCCCCCCCEEEEECCHHEECCCH
SKVAQPIGFADIVERVKPSVISVKIRMKDRAVASGDDSPFQPGSPMERFFRRFGGPDGLP
HHHHHCCCHHHHHHHCCCCEEEEEEEEECCEEECCCCCCCCCCCHHHHHHHHHCCCCCCC
PGMRGRRGPGLVTGQGSGFFISADGYAVTNNHVVDGADKVEVTTDDGKTYTAKVIGADPR
CCCCCCCCCCEEEECCCEEEEECCCEEEECCEEECCCCEEEEECCCCCEEEEEEECCCCC
TDIALIKVEGGSSFPFAKLSDDKVRIGDWVLAVGNPFGLGGSVTAGIVSASGRDIGTGPY
CCEEEEEECCCCCCCCEECCCCCEEECEEEEEECCCCCCCCCCEEEEEECCCCCCCCCCC
DDFIQIDAPVNKGNSGGPAFNMKGDVIGVNTAIYSPSGGSVGIAFSIPANTVKSVVAQLK
CCEEEEECCCCCCCCCCCEEECCCCEEEEEEEEECCCCCCEEEEEECCHHHHHHHHHHHH
DKGSVSRGWIGVQIQPVTSDIADSLGLKKAEGALVAEPQANSPAAKAGIKSGDVITAVNG
HCCCCCCCEEEEEEEECHHHHHHHCCCCCCCCCEEECCCCCCCHHHCCCCCCCEEEEECC
DPVKDARELARTIGSLAPGTSIKLNVLRKGTDKVVNLTLGTLPDTVEARADHYGDRGSSR
CCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEEEECCCCCHHHHHHHHCCCCCCCC
DNDIPRLGLTVAPAGSVAGAGGEGVVVVDVDPKSPAAERGFREGDVILEVAGKSVSSSAD
CCCCCCCCEEEECCCCCCCCCCCEEEEEEECCCCCHHHCCCCCCCEEEEECCCCCCCCHH
IREAIKAARAEDKNSVLMRVRTGSTARFVAMPIAKG
HHHHHHHHHCCCCCCEEEEEECCCCEEEEEEECCCC
>Mature Secondary Structure 
TDLPSSQLKPIRSGVTARRFALMASVVAGVGVAAYGLSPSADKAEFFISPAYAQVNTDV
CCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCEEEECCCCCCCCCEEEEECCHHEECCCH
SKVAQPIGFADIVERVKPSVISVKIRMKDRAVASGDDSPFQPGSPMERFFRRFGGPDGLP
HHHHHCCCHHHHHHHCCCCEEEEEEEEECCEEECCCCCCCCCCCHHHHHHHHHCCCCCCC
PGMRGRRGPGLVTGQGSGFFISADGYAVTNNHVVDGADKVEVTTDDGKTYTAKVIGADPR
CCCCCCCCCCEEEECCCEEEEECCCEEEECCEEECCCCEEEEECCCCCEEEEEEECCCCC
TDIALIKVEGGSSFPFAKLSDDKVRIGDWVLAVGNPFGLGGSVTAGIVSASGRDIGTGPY
CCEEEEEECCCCCCCCEECCCCCEEECEEEEEECCCCCCCCCCEEEEEECCCCCCCCCCC
DDFIQIDAPVNKGNSGGPAFNMKGDVIGVNTAIYSPSGGSVGIAFSIPANTVKSVVAQLK
CCEEEEECCCCCCCCCCCEEECCCCEEEEEEEEECCCCCCEEEEEECCHHHHHHHHHHHH
DKGSVSRGWIGVQIQPVTSDIADSLGLKKAEGALVAEPQANSPAAKAGIKSGDVITAVNG
HCCCCCCCEEEEEEEECHHHHHHHCCCCCCCCCEEECCCCCCCHHHCCCCCCCEEEEECC
DPVKDARELARTIGSLAPGTSIKLNVLRKGTDKVVNLTLGTLPDTVEARADHYGDRGSSR
CCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEEEECCCCCHHHHHHHHCCCCCCCC
DNDIPRLGLTVAPAGSVAGAGGEGVVVVDVDPKSPAAERGFREGDVILEVAGKSVSSSAD
CCCCCCCCEEEECCCCCCCCCCCEEEEEEECCCCCHHHCCCCCCCEEEEECCCCCCCCHH
IREAIKAARAEDKNSVLMRVRTGSTARFVAMPIAKG
HHHHHHHHHCCCCCCEEEEEECCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]