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The map label for this gene is murB

Identifier: 75675247

GI number: 75675247

Start: 1149463

End: 1150380

Strand: Direct

Name: murB

Synonym: Nwi_1054

Alternate gene names: 75675247

Gene position: 1149463-1150380 (Clockwise)

Preceding gene: 75675245

Following gene: 75675248

Centisome position: 33.79

GC content: 63.29

Gene sequence:

>918_bases
ATGACCTTCCCCGACATCGTTCCGGAACTGAAATCGCGAATGCCGGACTTGCGCGGGCGGCTGCTGGCGAACGAGTCGCT
GGCGCCGTTGACCTGGTTTCGCGTCGGTGGTCCGGCGCAGGCGTTGTTCACGCCGGCTGATGAGGATGACCTTGCTTATT
TTCTGAGCCATCTGCCGGAGGAAATACCGGTCTGCTGCATCGGCGTGGGCTCCAACCTGATCGTGCGCGATCGCGGGCTG
CCCGGCGTGGTGATTCGCCTGCCGCCACGCGGCTTCGGCGAGATCACGATCGATGGCGATGCCGTGCACGCCGGCGCCGC
CGCGCTTGACAAGCGTGTCGCGGAAGCGGCCGCTGCTGCCAGCATCAGCGGGCTTGAATTCTACTTCGGCATTCCCGGCA
CCATCGGCGGCGCGCTACGTATGAACGCAGGCGCCAACGGCAGCGAAACCAGGGATGTTCTCGTCGAAGCCCGCGCGCTC
AGCCGCCGTGGCGAAAGGATGACCTTCGACAATTTCGCCATGGCGTTTGACTATCGCAGCAGCGGAATAGATCCCTCCGT
CATCTTCACCGGCGCGATGTTTCGTGGCCGTATCGCCGAGCCGCAAGCGATCCGTGCGCGCATGAACGAGGTGCAGGCTC
ATCGCGAGACGGTGCAGCCGATCCGCGAAAAGACCGGTGGCTCGACGTTCAAGAATCCGCCAGGTCAGAGCGCGTGGAAA
CTGATCGATGCCGCCGGGATGCGCGGTCATCGCGTCGGCGGCGCGCAGGTGTCGGACATGCACTGCAATTTTCTCATCAA
CACCGGAGAGGCAACCGCGCGCGACATCGAAACCCTGGGGGAGAGCGTACGCGAGCGGGTAAAACGGCATTCCGGTGTCG
ATCTGCAATGGGAAATCAAACGGATCGGATTGGGATAG

Upstream 100 bases:

>100_bases
TGCGTTCCACCGATCCGAAAGGCAACCTACACGTTCGTCATGGCCGGGCTTGTCCCGGCCATCCACGTCTTTTGAGTTAT
TAAGTCGGTAGGTGGTTTCA

Downstream 100 bases:

>100_bases
GGCTCATGCGCATCACCATTCTGTTCGGCGGCAGCAACAAGGAGCGTCTGGTTTCAGTCGCGAGCGCGCAGGCGCTCCAT
CACGCATTGCCGGAGGCCGA

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MTFPDIVPELKSRMPDLRGRLLANESLAPLTWFRVGGPAQALFTPADEDDLAYFLSHLPEEIPVCCIGVGSNLIVRDRGL
PGVVIRLPPRGFGEITIDGDAVHAGAAALDKRVAEAAAAASISGLEFYFGIPGTIGGALRMNAGANGSETRDVLVEARAL
SRRGERMTFDNFAMAFDYRSSGIDPSVIFTGAMFRGRIAEPQAIRARMNEVQAHRETVQPIREKTGGSTFKNPPGQSAWK
LIDAAGMRGHRVGGAQVSDMHCNFLINTGEATARDIETLGESVRERVKRHSGVDLQWEIKRIGLG

Sequences:

>Translated_305_residues
MTFPDIVPELKSRMPDLRGRLLANESLAPLTWFRVGGPAQALFTPADEDDLAYFLSHLPEEIPVCCIGVGSNLIVRDRGL
PGVVIRLPPRGFGEITIDGDAVHAGAAALDKRVAEAAAAASISGLEFYFGIPGTIGGALRMNAGANGSETRDVLVEARAL
SRRGERMTFDNFAMAFDYRSSGIDPSVIFTGAMFRGRIAEPQAIRARMNEVQAHRETVQPIREKTGGSTFKNPPGQSAWK
LIDAAGMRGHRVGGAQVSDMHCNFLINTGEATARDIETLGESVRERVKRHSGVDLQWEIKRIGLG
>Mature_304_residues
TFPDIVPELKSRMPDLRGRLLANESLAPLTWFRVGGPAQALFTPADEDDLAYFLSHLPEEIPVCCIGVGSNLIVRDRGLP
GVVIRLPPRGFGEITIDGDAVHAGAAALDKRVAEAAAAASISGLEFYFGIPGTIGGALRMNAGANGSETRDVLVEARALS
RRGERMTFDNFAMAFDYRSSGIDPSVIFTGAMFRGRIAEPQAIRARMNEVQAHRETVQPIREKTGGSTFKNPPGQSAWKL
IDAAGMRGHRVGGAQVSDMHCNFLINTGEATARDIETLGESVRERVKRHSGVDLQWEIKRIGLG

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_NITWN (Q3STS5)

Other databases:

- EMBL:   CP000115
- RefSeq:   YP_317668.1
- ProteinModelPortal:   Q3STS5
- SMR:   Q3STS5
- STRING:   Q3STS5
- GeneID:   3677013
- GenomeReviews:   CP000115_GR
- KEGG:   nwi:Nwi_1054
- NMPDR:   fig|323098.3.peg.1756
- eggNOG:   COG0812
- HOGENOM:   HBG686573
- OMA:   SKKHAGF
- ProtClustDB:   PRK13905
- BioCyc:   NWIN323098:NWI_1054-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 32966; Mature: 32835

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 179-179 ACT_SITE 228-228 ACT_SITE 298-298

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFPDIVPELKSRMPDLRGRLLANESLAPLTWFRVGGPAQALFTPADEDDLAYFLSHLPE
CCCHHHHHHHHHHCHHHHHHHHCCCCCCCEEEEECCCCCCEEECCCCCHHHHHHHHHCCH
EIPVCCIGVGSNLIVRDRGLPGVVIRLPPRGFGEITIDGDAVHAGAAALDKRVAEAAAAA
HCCEEEEECCCCEEEEECCCCEEEEECCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHH
SISGLEFYFGIPGTIGGALRMNAGANGSETRDVLVEARALSRRGERMTFDNFAMAFDYRS
HCCCEEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEECCEEEEEECCC
SGIDPSVIFTGAMFRGRIAEPQAIRARMNEVQAHRETVQPIREKTGGSTFKNPPGQSAWK
CCCCHHEEEECHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
LIDAAGMRGHRVGGAQVSDMHCNFLINTGEATARDIETLGESVRERVKRHSGVDLQWEIK
HHHHCCCCCCCCCCCEEECEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
RIGLG
EECCC
>Mature Secondary Structure 
TFPDIVPELKSRMPDLRGRLLANESLAPLTWFRVGGPAQALFTPADEDDLAYFLSHLPE
CCHHHHHHHHHHCHHHHHHHHCCCCCCCEEEEECCCCCCEEECCCCCHHHHHHHHHCCH
EIPVCCIGVGSNLIVRDRGLPGVVIRLPPRGFGEITIDGDAVHAGAAALDKRVAEAAAAA
HCCEEEEECCCCEEEEECCCCEEEEECCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHH
SISGLEFYFGIPGTIGGALRMNAGANGSETRDVLVEARALSRRGERMTFDNFAMAFDYRS
HCCCEEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEECCEEEEEECCC
SGIDPSVIFTGAMFRGRIAEPQAIRARMNEVQAHRETVQPIREKTGGSTFKNPPGQSAWK
CCCCHHEEEECHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
LIDAAGMRGHRVGGAQVSDMHCNFLINTGEATARDIETLGESVRERVKRHSGVDLQWEIK
HHHHCCCCCCCCCCCEEECEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
RIGLG
EECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA