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The map label for this gene is murC [H]

Identifier: 75675245

GI number: 75675245

Start: 1147587

End: 1148990

Strand: Direct

Name: murC [H]

Synonym: Nwi_1052

Alternate gene names: 75675245

Gene position: 1147587-1148990 (Clockwise)

Preceding gene: 75675244

Following gene: 75675247

Centisome position: 33.73

GC content: 64.6

Gene sequence:

>1404_bases
ATGAGACTGCCGCGCGAAATCGGCCCCATCCACTTCGTCGGCATCGGCGGCATCGGCATGAGCGGCATCGCCGAGGTGCT
GTGCAACCTTGGCTACACGGTGCAGGGCTCGGATGCTTCCGAGGGCGCCAACGTGGTGCGGCTGCGCGAGAAGGGCGTCA
AGGTCACGGTCGGCCACAAGGCCGGGAATGTGAACGGCGCGGATGTGCTGGTCGTTTCAACCGCGATCAAGCGCGACAAT
CCCGAACTGATGGCGGCGCGCGCCCAGCGCATTCCGGTGGTGCGCCGCGCGGAAATGCTGGCGGAACTGATGCGGCTGAA
AAGCTGTGTCGCGATCGCCGGGACACACGGCAAGACCACCACGACCTCCATGGTTGCGACGCTGCTCGACGCGGGCGATT
TCGATCCCACGGTCATCAATGGCGGGATCATCAACGCCTACGGCACCAACGCGCGTCTGGGGGCCGGTGAGTGGATGGTG
GTGGAAGCGGACGAGAGCGACGGCACCTTCCTCAAGCTGCCGACCGATGTCGCCATCGTCACCAACGTCGACGCCGAGCA
TCTCGACCACTTCAAGACGTTCGACGCCGTGCAGGACGCGTTCCGTTCGTTCGTGGAAAACGTGCCGTTCTACGGCTTCG
CGGTGATGTGCATCGATCATCCGGTGGTGCAGGCCATGGTCGGCAGGATCGAGGATCGGCGTATCATCACTTACGGACAG
AATCCGCAGGCCGATGTCAGGCTGGTCGATCTCGCGCCGAACGGTGGCGGCTCGCATTTCAAGGTCATGTTCCGCAACCG
CAAGACCGACGCCGCGCATGAAATCTCCGATCTGGTGCTGCCGATGCCGGGTCCGCATAACGCGCTCAACGCCACGGCGG
CGATCGCGGTGGCGCATGAACTGGGCATTACCGACGCGACCATCCGCAAGGCGCTCGCGGCCTTCGGCGGTGTCAAGCGC
CGCTTCACCAGAACTGGCGAGTGGAACGGCGTCACCGTCATCGACGACTACGGCCATCATCCGGTCGAGATCGCGGCGGT
GCTGAAGGCGGCGCGTGAGTCCACCGACGGCAGGGTCATCGCGGTGGTGCAGCCGCATCGCTATACGCGGCTGCAAGCAC
TATTCGAGGAGTTCTGCACCTGCTTCAACGACGCCGACACCGTAGTCGTCGCGGATGTCTATCCGGCGGGAGAGACGCCG
ATCGTGGGCATCGATCGCGATCACTTCGTGCTCGGCCTGCGCGCCCACGGTCACCGCGAGGTGGTGCCGCTGCCGGAATC
CGCGGCGCTCGCGGGTATAATTGCGGATCTTGCGAAGCAGGGAGACTACGTGGTGTGCCTCGGCGCCGGCAACATCACGC
AATGGGCCTATGCGTTGCCGGGCGAATTGAAGGCGCTGGGATGA

Upstream 100 bases:

>100_bases
CTTGATGCAGACGCGCGCGGAAAACCGCTACACACTTTTCCTCATCCCGCTCTATAAGGCCAGGCACGGCTAGCGGGAAT
CACTCGGACGAGAGACGGAC

Downstream 100 bases:

>100_bases
GGAGATCAGACGATCGTCGGATACAAATCGTCCCATTCGGGATTCACCGCGACAATTGTCCGGACTTTCCAGGTACGGGG
CCAGTGCTTGATGTTGTGTT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MRLPREIGPIHFVGIGGIGMSGIAEVLCNLGYTVQGSDASEGANVVRLREKGVKVTVGHKAGNVNGADVLVVSTAIKRDN
PELMAARAQRIPVVRRAEMLAELMRLKSCVAIAGTHGKTTTTSMVATLLDAGDFDPTVINGGIINAYGTNARLGAGEWMV
VEADESDGTFLKLPTDVAIVTNVDAEHLDHFKTFDAVQDAFRSFVENVPFYGFAVMCIDHPVVQAMVGRIEDRRIITYGQ
NPQADVRLVDLAPNGGGSHFKVMFRNRKTDAAHEISDLVLPMPGPHNALNATAAIAVAHELGITDATIRKALAAFGGVKR
RFTRTGEWNGVTVIDDYGHHPVEIAAVLKAARESTDGRVIAVVQPHRYTRLQALFEEFCTCFNDADTVVVADVYPAGETP
IVGIDRDHFVLGLRAHGHREVVPLPESAALAGIIADLAKQGDYVVCLGAGNITQWAYALPGELKALG

Sequences:

>Translated_467_residues
MRLPREIGPIHFVGIGGIGMSGIAEVLCNLGYTVQGSDASEGANVVRLREKGVKVTVGHKAGNVNGADVLVVSTAIKRDN
PELMAARAQRIPVVRRAEMLAELMRLKSCVAIAGTHGKTTTTSMVATLLDAGDFDPTVINGGIINAYGTNARLGAGEWMV
VEADESDGTFLKLPTDVAIVTNVDAEHLDHFKTFDAVQDAFRSFVENVPFYGFAVMCIDHPVVQAMVGRIEDRRIITYGQ
NPQADVRLVDLAPNGGGSHFKVMFRNRKTDAAHEISDLVLPMPGPHNALNATAAIAVAHELGITDATIRKALAAFGGVKR
RFTRTGEWNGVTVIDDYGHHPVEIAAVLKAARESTDGRVIAVVQPHRYTRLQALFEEFCTCFNDADTVVVADVYPAGETP
IVGIDRDHFVLGLRAHGHREVVPLPESAALAGIIADLAKQGDYVVCLGAGNITQWAYALPGELKALG
>Mature_467_residues
MRLPREIGPIHFVGIGGIGMSGIAEVLCNLGYTVQGSDASEGANVVRLREKGVKVTVGHKAGNVNGADVLVVSTAIKRDN
PELMAARAQRIPVVRRAEMLAELMRLKSCVAIAGTHGKTTTTSMVATLLDAGDFDPTVINGGIINAYGTNARLGAGEWMV
VEADESDGTFLKLPTDVAIVTNVDAEHLDHFKTFDAVQDAFRSFVENVPFYGFAVMCIDHPVVQAMVGRIEDRRIITYGQ
NPQADVRLVDLAPNGGGSHFKVMFRNRKTDAAHEISDLVLPMPGPHNALNATAAIAVAHELGITDATIRKALAAFGGVKR
RFTRTGEWNGVTVIDDYGHHPVEIAAVLKAARESTDGRVIAVVQPHRYTRLQALFEEFCTCFNDADTVVVADVYPAGETP
IVGIDRDHFVLGLRAHGHREVVPLPESAALAGIIADLAKQGDYVVCLGAGNITQWAYALPGELKALG

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=466, Percent_Identity=44.6351931330472, Blast_Score=332, Evalue=4e-92,
Organism=Escherichia coli, GI1790680, Length=374, Percent_Identity=31.283422459893, Blast_Score=160, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 49980; Mature: 49980

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLPREIGPIHFVGIGGIGMSGIAEVLCNLGYTVQGSDASEGANVVRLREKGVKVTVGHK
CCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCEEECCCCCCCCCEEEEECCCCEEEEECC
AGNVNGADVLVVSTAIKRDNPELMAARAQRIPVVRRAEMLAELMRLKSCVAIAGTHGKTT
CCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEECCCCCCH
TTSMVATLLDAGDFDPTVINGGIINAYGTNARLGAGEWMVVEADESDGTFLKLPTDVAIV
HHHHHHHHHHCCCCCCEEEECCEEEECCCCCEECCCCEEEEEECCCCCCEEECCCCEEEE
TNVDAEHLDHFKTFDAVQDAFRSFVENVPFYGFAVMCIDHPVVQAMVGRIEDRRIITYGQ
ECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHCCCCCCEEEEECC
NPQADVRLVDLAPNGGGSHFKVMFRNRKTDAAHEISDLVLPMPGPHNALNATAAIAVAHE
CCCCCEEEEEECCCCCCCEEEEEEECCCCCHHHHHHHEEECCCCCCCHHHHHHHEEEHHH
LGITDATIRKALAAFGGVKRRFTRTGEWNGVTVIDDYGHHPVEIAAVLKAARESTDGRVI
CCCCHHHHHHHHHHHCCHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEE
AVVQPHRYTRLQALFEEFCTCFNDADTVVVADVYPAGETPIVGIDRDHFVLGLRAHGHRE
EEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCEEEECCCCEEEEEEECCCEE
VVPLPESAALAGIIADLAKQGDYVVCLGAGNITQWAYALPGELKALG
EECCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEECCCCCCCCC
>Mature Secondary Structure
MRLPREIGPIHFVGIGGIGMSGIAEVLCNLGYTVQGSDASEGANVVRLREKGVKVTVGHK
CCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCEEECCCCCCCCCEEEEECCCCEEEEECC
AGNVNGADVLVVSTAIKRDNPELMAARAQRIPVVRRAEMLAELMRLKSCVAIAGTHGKTT
CCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEECCCCCCH
TTSMVATLLDAGDFDPTVINGGIINAYGTNARLGAGEWMVVEADESDGTFLKLPTDVAIV
HHHHHHHHHHCCCCCCEEEECCEEEECCCCCEECCCCEEEEEECCCCCCEEECCCCEEEE
TNVDAEHLDHFKTFDAVQDAFRSFVENVPFYGFAVMCIDHPVVQAMVGRIEDRRIITYGQ
ECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHCCCCCCEEEEECC
NPQADVRLVDLAPNGGGSHFKVMFRNRKTDAAHEISDLVLPMPGPHNALNATAAIAVAHE
CCCCCEEEEEECCCCCCCEEEEEEECCCCCHHHHHHHEEECCCCCCCHHHHHHHEEEHHH
LGITDATIRKALAAFGGVKRRFTRTGEWNGVTVIDDYGHHPVEIAAVLKAARESTDGRVI
CCCCHHHHHHHHHHHCCHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEE
AVVQPHRYTRLQALFEEFCTCFNDADTVVVADVYPAGETPIVGIDRDHFVLGLRAHGHRE
EEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCEEEECCCCEEEEEEECCCEE
VVPLPESAALAGIIADLAKQGDYVVCLGAGNITQWAYALPGELKALG
EECCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA