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The map label for this gene is hemC [H]

Identifier: 75674669

GI number: 75674669

Start: 528130

End: 529080

Strand: Direct

Name: hemC [H]

Synonym: Nwi_0471

Alternate gene names: 75674669

Gene position: 528130-529080 (Clockwise)

Preceding gene: 75674664

Following gene: 75674670

Centisome position: 15.52

GC content: 66.46

Gene sequence:

>951_bases
GTGCAATCCTCGGACGAGACAGACATTCTGGCAACGATCGGTACTCGGGGCAGCCCGCTGGCGCTGGCGCAGGCTCACGA
GGTGCGGGATCGGCTCGCGCGCGCGCATCAGGTGGCGCCCGAGCGGATCGCCATCAAGACCATCCGCACCTCGGGCGACG
CCATTCAGGACCGGCCGCTGTTCGATGTCGGCGGCAAGGGGCTTTTCACCAAGGAGATCGAGGAGGCGCTGCTCGCCGGC
ACCATCGACTTCGCGGTGCATTCATCCAAGGACGTGCCGACATTTCTGCCCGACGCGACCTGGCTGCCCGCCTTTCTTCC
GCGCGAGGACGTGCGCGACGTCTTCATCAGCCCGCACGCGGGTTCTTTGAACGATCTGCCGGCGGGCGCGACCGTTGGAA
CCGCCTCGCTGCGGCGGCAGGCCATGGTGCTGAAACTGCGTCCCGACCTGAAGGTCAATTCGCTGCGCGGCAATGTCGAG
ACGCGCTTGCGCAAGATTTCCGTTGGAGAAGCCGACGCAACGCTGCTCGCGCTCGCCGGCTTGAACCGGCTGGGATTGCA
GGACAAGGCGACGCGCATTCTGGAGACCGACGAATTCCTGCCCGCGGTCGGGCAGGGCGCCATCGCCATCGAGTCGCGGC
GTGATGACGACCGCATCAACGCGTTCGTGAAGGCGATCGGCGATCCTGAAACGGAAGTGGCGCTGAGCGCGGAGCGGAGC
TTTCTGGCGCTGCTCGACGGCTCCTGCCGCACTCCGATCGGCGGCCATTGCCGCGTGAACGGCGACCGCATCGATTTCCG
CGGTCTTATCATCTCTCCCGACGGCACGGAATTCTACGAGACCACGCGCGAGGGCGCGCGCGCCGATGCCGCCGCGCTCG
GTGCGGACGCGGCGCATGAACTGCGCGAGCGAGCCGGTGAAAAATTCTTCACCCTGTTTGCCGGAGCGTGA

Upstream 100 bases:

>100_bases
GCACCAGCATCGATCTATCGCCCCTATATATGGGCCTTGCGTTATTGGGCAAACCAGCGTTTCCCTGTTCCTTCTTCGCG
TAGCATTATGGGGTCCTGGC

Downstream 100 bases:

>100_bases
AGGCGTGGCGGTTCTCGTCACACGGCCTGAACCGGACAATGAAACCACGGCGTCGGCGCTGCGTGCGATGGGGCGCGAGG
CGTTGTTGTCACCGGTGTTG

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MQSSDETDILATIGTRGSPLALAQAHEVRDRLARAHQVAPERIAIKTIRTSGDAIQDRPLFDVGGKGLFTKEIEEALLAG
TIDFAVHSSKDVPTFLPDATWLPAFLPREDVRDVFISPHAGSLNDLPAGATVGTASLRRQAMVLKLRPDLKVNSLRGNVE
TRLRKISVGEADATLLALAGLNRLGLQDKATRILETDEFLPAVGQGAIAIESRRDDDRINAFVKAIGDPETEVALSAERS
FLALLDGSCRTPIGGHCRVNGDRIDFRGLIISPDGTEFYETTREGARADAAALGADAAHELRERAGEKFFTLFAGA

Sequences:

>Translated_316_residues
MQSSDETDILATIGTRGSPLALAQAHEVRDRLARAHQVAPERIAIKTIRTSGDAIQDRPLFDVGGKGLFTKEIEEALLAG
TIDFAVHSSKDVPTFLPDATWLPAFLPREDVRDVFISPHAGSLNDLPAGATVGTASLRRQAMVLKLRPDLKVNSLRGNVE
TRLRKISVGEADATLLALAGLNRLGLQDKATRILETDEFLPAVGQGAIAIESRRDDDRINAFVKAIGDPETEVALSAERS
FLALLDGSCRTPIGGHCRVNGDRIDFRGLIISPDGTEFYETTREGARADAAALGADAAHELRERAGEKFFTLFAGA
>Mature_316_residues
MQSSDETDILATIGTRGSPLALAQAHEVRDRLARAHQVAPERIAIKTIRTSGDAIQDRPLFDVGGKGLFTKEIEEALLAG
TIDFAVHSSKDVPTFLPDATWLPAFLPREDVRDVFISPHAGSLNDLPAGATVGTASLRRQAMVLKLRPDLKVNSLRGNVE
TRLRKISVGEADATLLALAGLNRLGLQDKATRILETDEFLPAVGQGAIAIESRRDDDRINAFVKAIGDPETEVALSAERS
FLALLDGSCRTPIGGHCRVNGDRIDFRGLIISPDGTEFYETTREGARADAAALGADAAHELRERAGEKFFTLFAGA

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=292, Percent_Identity=38.013698630137, Blast_Score=168, Evalue=6e-42,
Organism=Homo sapiens, GI66933009, Length=292, Percent_Identity=38.013698630137, Blast_Score=168, Evalue=7e-42,
Organism=Escherichia coli, GI48994974, Length=294, Percent_Identity=46.5986394557823, Blast_Score=239, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6319996, Length=305, Percent_Identity=34.7540983606557, Blast_Score=172, Evalue=9e-44,
Organism=Drosophila melanogaster, GI20130425, Length=258, Percent_Identity=37.5968992248062, Blast_Score=171, Evalue=5e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33986; Mature: 33986

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSSDETDILATIGTRGSPLALAQAHEVRDRLARAHQVAPERIAIKTIRTSGDAIQDRPL
CCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCC
FDVGGKGLFTKEIEEALLAGTIDFAVHSSKDVPTFLPDATWLPAFLPREDVRDVFISPHA
EECCCCCCCHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCHHHHHHEEECCCC
GSLNDLPAGATVGTASLRRQAMVLKLRPDLKVNSLRGNVETRLRKISVGEADATLLALAG
CCCCCCCCCCCCCHHHHHHEEEEEEECCCCEEECCCCCHHHHHHEEECCCCCHHHHHHHC
LNRLGLQDKATRILETDEFLPAVGQGAIAIESRRDDDRINAFVKAIGDPETEVALSAERS
CCCCCCCHHHHHHHCCHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCCHHEEECCCCC
FLALLDGSCRTPIGGHCRVNGDRIDFRGLIISPDGTEFYETTREGARADAAALGADAAHE
EEEEECCCCCCCCCCEEEECCCEEEEEEEEECCCCCHHHHHHHHCCHHHHHHHCCHHHHH
LRERAGEKFFTLFAGA
HHHHCCCEEEEEEECC
>Mature Secondary Structure
MQSSDETDILATIGTRGSPLALAQAHEVRDRLARAHQVAPERIAIKTIRTSGDAIQDRPL
CCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCC
FDVGGKGLFTKEIEEALLAGTIDFAVHSSKDVPTFLPDATWLPAFLPREDVRDVFISPHA
EECCCCCCCHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCHHHHHHEEECCCC
GSLNDLPAGATVGTASLRRQAMVLKLRPDLKVNSLRGNVETRLRKISVGEADATLLALAG
CCCCCCCCCCCCCHHHHHHEEEEEEECCCCEEECCCCCHHHHHHEEECCCCCHHHHHHHC
LNRLGLQDKATRILETDEFLPAVGQGAIAIESRRDDDRINAFVKAIGDPETEVALSAERS
CCCCCCCHHHHHHHCCHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCCHHEEECCCCC
FLALLDGSCRTPIGGHCRVNGDRIDFRGLIISPDGTEFYETTREGARADAAALGADAAHE
EEEEECCCCCCCCCCEEEECCCEEEEEEEEECCCCCHHHHHHHHCCHHHHHHHCCHHHHH
LRERAGEKFFTLFAGA
HHHHCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA