Click here to switch to the map view.

The map label for this gene is 75674670

Identifier: 75674670

GI number: 75674670

Start: 529085

End: 529831

Strand: Direct

Name: 75674670

Synonym: Nwi_0472

Alternate gene names: NA

Gene position: 529085-529831 (Clockwise)

Preceding gene: 75674669

Following gene: 75674671

Centisome position: 15.55

GC content: 68.14

Gene sequence:

>747_bases
GTGGCGGTTCTCGTCACACGGCCTGAACCGGACAATGAAACCACGGCGTCGGCGCTGCGTGCGATGGGGCGCGAGGCGTT
GTTGTCACCGGTGTTGCGCTTCGAGGCGGCTGCTTTCGAAATCGACCGGGGCGCGAATTATGGCGCGGTCATTGTCACCA
GCGCCAACGCGCTGCGCGCGCTCGCCGTCCATCCGGGGATTGAATCGCTGCTGAAGCTGGCCGTGTTCGCGGTCGGCCGT
CACACCGCCGAGGCCGCGCGCCGGGTCGGCTTCCAGGATGTGGTGGCGGCGGCCGGAGACGCCGCGGCATTGTGCGAACT
CATCGTGAAGCGTGTCCGCGCGAAATCCCTGCCGAAGGGCGCCAGGATTCTCTATCTCGCCGCGGCTGACCGCTCATGCG
ATCTCGCGGGGAAGCTCGAAGGGCACGGTTTGGCCGTCGTGACGACGACATGTTACCGGATGGCGCCGGTGGCGAGCCTG
TCCCGCGAGGTCTGTGACGCGTTCGCCGCGCACCGGATATCAGCGGTGCTGCATTATTCGCGCCGCAGCGCCCGTGCGTT
CCTGGATGCCGTCCGGATCGGGGGCGTCGAGATATCGGCCCTGGCGGTCCCGCAATGTTGCATCTCGGGCGCGGTCGCCT
CCGTTCTGCGGGATGCAGGCGCGCCCCATGTGGTGGAGGCGAGCGCCCCGGCGGAGGAAGCTGTCCTGGAGGCGTTGGAT
TGTGCGTTGCGGCCGGCGTCGCAGTAA

Upstream 100 bases:

>100_bases
GCGCGCGCCGATGCCGCCGCGCTCGGTGCGGACGCGGCGCATGAACTGCGCGAGCGAGCCGGTGAAAAATTCTTCACCCT
GTTTGCCGGAGCGTGAAGGC

Downstream 100 bases:

>100_bases
GACGTGCGTTACGGTCGTAATCGCGATAAACAGGGAGAAGGGGTCTCGAATCGATACTCGATGTGTCGCCGCAATGGGGA
ACCGTGACGATGGCAGATGA

Product: uroporphyrinogen III synthase HEM4

Products: uroporphyrinogen III; H2O

Alternate protein names: Uroporphyrinogen III Synthase; Uroporphyrinogen-III Synthase Protein

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MAVLVTRPEPDNETTASALRAMGREALLSPVLRFEAAAFEIDRGANYGAVIVTSANALRALAVHPGIESLLKLAVFAVGR
HTAEAARRVGFQDVVAAAGDAAALCELIVKRVRAKSLPKGARILYLAAADRSCDLAGKLEGHGLAVVTTTCYRMAPVASL
SREVCDAFAAHRISAVLHYSRRSARAFLDAVRIGGVEISALAVPQCCISGAVASVLRDAGAPHVVEASAPAEEAVLEALD
CALRPASQ

Sequences:

>Translated_248_residues
MAVLVTRPEPDNETTASALRAMGREALLSPVLRFEAAAFEIDRGANYGAVIVTSANALRALAVHPGIESLLKLAVFAVGR
HTAEAARRVGFQDVVAAAGDAAALCELIVKRVRAKSLPKGARILYLAAADRSCDLAGKLEGHGLAVVTTTCYRMAPVASL
SREVCDAFAAHRISAVLHYSRRSARAFLDAVRIGGVEISALAVPQCCISGAVASVLRDAGAPHVVEASAPAEEAVLEALD
CALRPASQ
>Mature_247_residues
AVLVTRPEPDNETTASALRAMGREALLSPVLRFEAAAFEIDRGANYGAVIVTSANALRALAVHPGIESLLKLAVFAVGRH
TAEAARRVGFQDVVAAAGDAAALCELIVKRVRAKSLPKGARILYLAAADRSCDLAGKLEGHGLAVVTTTCYRMAPVASLS
REVCDAFAAHRISAVLHYSRRSARAFLDAVRIGGVEISALAVPQCCISGAVASVLRDAGAPHVVEASAPAEEAVLEALDC
ALRPASQ

Specific function: Unknown

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.2.1.75

Molecular weight: Translated: 25789; Mature: 25658

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVLVTRPEPDNETTASALRAMGREALLSPVLRFEAAAFEIDRGANYGAVIVTSANALRA
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEECCCHHHH
LAVHPGIESLLKLAVFAVGRHTAEAARRVGFQDVVAAAGDAAALCELIVKRVRAKSLPKG
HHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCC
ARILYLAAADRSCDLAGKLEGHGLAVVTTTCYRMAPVASLSREVCDAFAAHRISAVLHYS
CEEEEEEECCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRSARAFLDAVRIGGVEISALAVPQCCISGAVASVLRDAGAPHVVEASAPAEEAVLEALD
HHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHH
CALRPASQ
HHCCCCCC
>Mature Secondary Structure 
AVLVTRPEPDNETTASALRAMGREALLSPVLRFEAAAFEIDRGANYGAVIVTSANALRA
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEECCCHHHH
LAVHPGIESLLKLAVFAVGRHTAEAARRVGFQDVVAAAGDAAALCELIVKRVRAKSLPKG
HHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCC
ARILYLAAADRSCDLAGKLEGHGLAVVTTTCYRMAPVASLSREVCDAFAAHRISAVLHYS
CEEEEEEECCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRSARAFLDAVRIGGVEISALAVPQCCISGAVASVLRDAGAPHVVEASAPAEEAVLEALD
HHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHH
CALRPASQ
HHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: hydroxymethylbilane

Specific reaction: hydroxymethylbilane = uroporphyrinogen III + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA