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The map label for this gene is hemA

Identifier: 74318510

GI number: 74318510

Start: 2565117

End: 2566367

Strand: Direct

Name: hemA

Synonym: Tbd_2492

Alternate gene names: 74318510

Gene position: 2565117-2566367 (Clockwise)

Preceding gene: 74318509

Following gene: 74318511

Centisome position: 88.15

GC content: 67.71

Gene sequence:

>1251_bases
ATGCAGCTGCTCACCCTCGGGGTCAATCATCACACCGCACCGCTCGCGATCCGCGAACAGGTAGCCTTCGGGCCCGACAA
GCTCGTCCAGGCGCTGCATGAACTAACCCTGAGCAAGCGCGCGTCCGAAGCCGCGATTCTGTCGACCTGCAACCGCACCG
AGCTTTACGTCAACACCGTGTCGCCCGACGCGCTCTCGCAGTGGTTCGCCGACTTCCATCATCTCGACGTGCGCGAACTC
GCGCCCTATCTCTACACGCTGCCGCGTGAAAAAGCCGCGCAGCACGCGTTTCGCGTCGCGGCCGGGCTCGACTCGATGGT
GCTCGGCGAGACCCAGATCCTCGGCCAGATGAAGCAGGCGGTCGCCGCCGCCGAGGAAGCCGGCACGCTCGGGCTGCTGC
TGCACAAGTTGTTCCAGCGCACCTTTTCGGTCGCCAAGGAGGTCCGCAGCAGCACCGAAATCGGCGCCAACTCGGTATCG
ATGGCGGCTGCCGCGGTGCGGCTCGCCGAGCGCATTTTCCCGAGCGTCAAGGAACAGGCCTGCCTGTTCATCGGCGCCGG
CGAAATGATCGAGCTGTGCATGACTCATTTCGCTGCCCAGCATCCGCGCCGCATGACCGTCGCCAACCGCACGACCGAGC
GCGCGCGCCCGCTGGCCGAGCGCTTCAACGCGGGCGTGATCCCGCTGACCGCGCTCCCGGACGAAGTCGCCGCCTACGAC
ATCATCATCACCTCGACCGCGAGCCCGCTGCCCATCCTCGGCAAGGGCATGCTCGAGCGCGCGATCCGGCAGCGCCGCCA
CCGCCCGATCTTCATCGTCGACCTCGCCGTGCCGCGCGACGTCGAAGCGGAAGTCGCCGACATGAACGACGTCTTCCTCT
ACAGCGTCGACGACCTCGGCCAGGTGGTGCGCGAGGGAATGGACAACCGCGTCGCGCAGGTCGCGCAGGCCGAGGCGATC
ATCGAGACCAGCGTCGCGAGCTTCATCCACTGGATGGAGGGACGCGAGCTCGTTCCGGTCATCCGCGGCCTGCGCGACGC
CGCCGAGCGCCATCGCCGCCACGAACTCGACAAGGCCCACAAGGCGCTCGCGCGCGGTGACGATCCCCACGCGGTGCTCG
ATGCGATGAGCCACGGCCTCGCGAACAAATTCCTGCACGCGCCGACCCACGGCCTGAGCCACGCCACGCCCGAGGAGCGC
GCCGAACTGGTCCGCCTGATCAGCCAGCTCTACGGGCTGCACCCGGAATGA

Upstream 100 bases:

>100_bases
ATCGCGGGCGTTACTACGACCGCCTCGACTTCGCCGCGCGCGGCCGGGGCCGCGGGTAAAGTAGAATAGCGGTCTCCTGT
TTCGGCCTTCCGCCGTCGTC

Downstream 100 bases:

>100_bases
AGGCGACGCTCGCCGACAAGCTCGCGCGCGCCGACGAGCGACTCGAAGAGCTCGACGCCCTCCTCGCGCAGCCCGAGGTC
GCGGCGGACATGGACAGTTA

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MQLLTLGVNHHTAPLAIREQVAFGPDKLVQALHELTLSKRASEAAILSTCNRTELYVNTVSPDALSQWFADFHHLDVREL
APYLYTLPREKAAQHAFRVAAGLDSMVLGETQILGQMKQAVAAAEEAGTLGLLLHKLFQRTFSVAKEVRSSTEIGANSVS
MAAAAVRLAERIFPSVKEQACLFIGAGEMIELCMTHFAAQHPRRMTVANRTTERARPLAERFNAGVIPLTALPDEVAAYD
IIITSTASPLPILGKGMLERAIRQRRHRPIFIVDLAVPRDVEAEVADMNDVFLYSVDDLGQVVREGMDNRVAQVAQAEAI
IETSVASFIHWMEGRELVPVIRGLRDAAERHRRHELDKAHKALARGDDPHAVLDAMSHGLANKFLHAPTHGLSHATPEER
AELVRLISQLYGLHPE

Sequences:

>Translated_416_residues
MQLLTLGVNHHTAPLAIREQVAFGPDKLVQALHELTLSKRASEAAILSTCNRTELYVNTVSPDALSQWFADFHHLDVREL
APYLYTLPREKAAQHAFRVAAGLDSMVLGETQILGQMKQAVAAAEEAGTLGLLLHKLFQRTFSVAKEVRSSTEIGANSVS
MAAAAVRLAERIFPSVKEQACLFIGAGEMIELCMTHFAAQHPRRMTVANRTTERARPLAERFNAGVIPLTALPDEVAAYD
IIITSTASPLPILGKGMLERAIRQRRHRPIFIVDLAVPRDVEAEVADMNDVFLYSVDDLGQVVREGMDNRVAQVAQAEAI
IETSVASFIHWMEGRELVPVIRGLRDAAERHRRHELDKAHKALARGDDPHAVLDAMSHGLANKFLHAPTHGLSHATPEER
AELVRLISQLYGLHPE
>Mature_416_residues
MQLLTLGVNHHTAPLAIREQVAFGPDKLVQALHELTLSKRASEAAILSTCNRTELYVNTVSPDALSQWFADFHHLDVREL
APYLYTLPREKAAQHAFRVAAGLDSMVLGETQILGQMKQAVAAAEEAGTLGLLLHKLFQRTFSVAKEVRSSTEIGANSVS
MAAAAVRLAERIFPSVKEQACLFIGAGEMIELCMTHFAAQHPRRMTVANRTTERARPLAERFNAGVIPLTALPDEVAAYD
IIITSTASPLPILGKGMLERAIRQRRHRPIFIVDLAVPRDVEAEVADMNDVFLYSVDDLGQVVREGMDNRVAQVAQAEAI
IETSVASFIHWMEGRELVPVIRGLRDAAERHRRHELDKAHKALARGDDPHAVLDAMSHGLANKFLHAPTHGLSHATPEER
AELVRLISQLYGLHPE

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=418, Percent_Identity=43.3014354066986, Blast_Score=334, Evalue=5e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_THIDA (Q3SG11)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_316250.1
- ProteinModelPortal:   Q3SG11
- SMR:   Q3SG11
- STRING:   Q3SG11
- GeneID:   3671811
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_2492
- NMPDR:   fig|292415.3.peg.2565
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- PhylomeDB:   Q3SG11
- ProtClustDB:   PRK00045
- BioCyc:   TDEN292415:TBD_2492-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 45872; Mature: 45872

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00747 GLUTR; PS00012 PHOSPHOPANTETHEINE

Important sites: ACT_SITE 50-50 BINDING 105-105 BINDING 116-116

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLLTLGVNHHTAPLAIREQVAFGPDKLVQALHELTLSKRASEAAILSTCNRTELYVNTV
CCEEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
SPDALSQWFADFHHLDVRELAPYLYTLPREKAAQHAFRVAAGLDSMVLGETQILGQMKQA
CHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
VAAAEEAGTLGLLLHKLFQRTFSVAKEVRSSTEIGANSVSMAAAAVRLAERIFPSVKEQA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC
CLFIGAGEMIELCMTHFAAQHPRRMTVANRTTERARPLAERFNAGVIPLTALPDEVAAYD
EEEECCHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHCCCCEEEECCCHHHHHEE
IIITSTASPLPILGKGMLERAIRQRRHRPIFIVDLAVPRDVEAEVADMNDVFLYSVDDLG
EEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHCCCCEEEEEHHHHH
QVVREGMDNRVAQVAQAEAIIETSVASFIHWMEGRELVPVIRGLRDAAERHRRHELDKAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KALARGDDPHAVLDAMSHGLANKFLHAPTHGLSHATPEERAELVRLISQLYGLHPE
HHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQLLTLGVNHHTAPLAIREQVAFGPDKLVQALHELTLSKRASEAAILSTCNRTELYVNTV
CCEEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
SPDALSQWFADFHHLDVRELAPYLYTLPREKAAQHAFRVAAGLDSMVLGETQILGQMKQA
CHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
VAAAEEAGTLGLLLHKLFQRTFSVAKEVRSSTEIGANSVSMAAAAVRLAERIFPSVKEQA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC
CLFIGAGEMIELCMTHFAAQHPRRMTVANRTTERARPLAERFNAGVIPLTALPDEVAAYD
EEEECCHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHCCCCEEEECCCHHHHHEE
IIITSTASPLPILGKGMLERAIRQRRHRPIFIVDLAVPRDVEAEVADMNDVFLYSVDDLG
EEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHCCCCEEEEEHHHHH
QVVREGMDNRVAQVAQAEAIIETSVASFIHWMEGRELVPVIRGLRDAAERHRRHELDKAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KALARGDDPHAVLDAMSHGLANKFLHAPTHGLSHATPEERAELVRLISQLYGLHPE
HHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA