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The map label for this gene is envZ [H]

Identifier: 74318371

GI number: 74318371

Start: 2427465

End: 2428751

Strand: Reverse

Name: envZ [H]

Synonym: Tbd_2353

Alternate gene names: 74318371

Gene position: 2428751-2427465 (Counterclockwise)

Preceding gene: 74318372

Following gene: 74318369

Centisome position: 83.47

GC content: 71.17

Gene sequence:

>1287_bases
ATGGTACGCATCGCCAGTTCGCTCTACGCGCGCACGGCGCTGACGCTGGCCATCGCTTTCGTCCTCTTTCAGGCCGCCGC
CTTCGCGGTCGTATACCGCACCCTGATCATCCCGCTGGCCGAGCGCTCGGCCGACGACCTCGCGGGCCTGATCGTGCTGT
CGGCTCAGACCTGGGTCGAACTGCCGCCGCAAACCCGCGCCGCGTTCGAGCGGGAACTGGCGGACCGGCACGGTCTGCGT
CTCACGGCCGGCGATCCCGGCGCGGTCGCCGACGCGCCGCAGTTCGCGTTCCGTGCGCAGATCGAGACCGCCCTCAGCCG
CCGCGTGGGCGAGCCGGTCAAGCTTCGGGGGGTGCCCGGGACACGCGCGGCCTGGCTCGACATCCCGACCGGCGGCCATG
CCCTGCAGGTCGGCTTCTACCCGGCGCGCTACGCGGTGAAGCCGCCGCTGGCGGCGATCGCTGTGATCGCGCTCGGCGCC
CTGCTCAGTCTGGTGACCGCGCTGCTGCTCGTGCGCCGCATCACGCTTCCGCTCGCGCGGGCGGCGCGGGCCGCACGGCA
GGTCGGCGCGGGCCAGCTCCCCGAGCCGCTGCCGGAGACCGGCCCGGCCGAGGTCGCCGAACTCGCGCGTCGCTTCAACA
CCATGGCGACCGAGGTCCGCGAGCTGCTCGACAACCGCACGACCCTGCTCGCCGGAATCTCGCACGACCTGCGCACGCCG
ATGACCCGGCTCCAGCTCCATCTCGAAATGCTGCGCGACGCGCCGAGCCCGGCACGAATCGATCGCGCCGTCGCCGACCT
CGCCGACATGAACAAGCTCATCACAGGCTATCTCGAACTCGCGCGCACGACCCAGGCCGAGGCGAAGACGCGCTTCGACC
TCGCGGTCCTGCTCGAGGAAGTCGCGACCGACGCGGGCCTGGCGGGATTTTCCGCGGCGCCGTGCACGGTCGAGGCGGGC
CGCCTGGCACTGCGCCAGATCGTGTCGAACCTGATCCAGAATGCGCAGCGCTACGGGGACGCAGCGACGGTCGAACTCGA
ACTCGAATGCTCGGAGCTGGGGGCGCGGGTGACCGTGCGCGATGCGGGACCGGGGATTCCGGAAGATCAGCTGGAGAAGG
TGTTCCGGCCGTTCTACCGGCTCGAGGCATCGCGCTCGGAAGCGACCGGCGGAAGCGGTCTCGGGCTTGCGATCGTCCGG
CAGTTGGCGGCGACCCACGGTTGGAAAGTCTCGCTGGCCAACCGCAAGACCGGCGGGCTCGAGGCGGTGCTCGAAATCCG
CCGCTAG

Upstream 100 bases:

>100_bases
CAAGAAAATCGAGGACGACCCGACGAACCCCGCCTACATCCGCACCCAGCGCGGGCAGGGTTATCTGTTCGTGCCCCAGG
GCAAGGGCTGACGCCCGGCG

Downstream 100 bases:

>100_bases
CCCGAACGGGAAGTCAGGAAGGGCAGTGCCTGCTGCTGCGGCGCAGAATCCGCAGTTCGATGAATAACAGGGTCAGACTG
AACATCGACATGCGGCAGGT

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MVRIASSLYARTALTLAIAFVLFQAAAFAVVYRTLIIPLAERSADDLAGLIVLSAQTWVELPPQTRAAFERELADRHGLR
LTAGDPGAVADAPQFAFRAQIETALSRRVGEPVKLRGVPGTRAAWLDIPTGGHALQVGFYPARYAVKPPLAAIAVIALGA
LLSLVTALLLVRRITLPLARAARAARQVGAGQLPEPLPETGPAEVAELARRFNTMATEVRELLDNRTTLLAGISHDLRTP
MTRLQLHLEMLRDAPSPARIDRAVADLADMNKLITGYLELARTTQAEAKTRFDLAVLLEEVATDAGLAGFSAAPCTVEAG
RLALRQIVSNLIQNAQRYGDAATVELELECSELGARVTVRDAGPGIPEDQLEKVFRPFYRLEASRSEATGGSGLGLAIVR
QLAATHGWKVSLANRKTGGLEAVLEIRR

Sequences:

>Translated_428_residues
MVRIASSLYARTALTLAIAFVLFQAAAFAVVYRTLIIPLAERSADDLAGLIVLSAQTWVELPPQTRAAFERELADRHGLR
LTAGDPGAVADAPQFAFRAQIETALSRRVGEPVKLRGVPGTRAAWLDIPTGGHALQVGFYPARYAVKPPLAAIAVIALGA
LLSLVTALLLVRRITLPLARAARAARQVGAGQLPEPLPETGPAEVAELARRFNTMATEVRELLDNRTTLLAGISHDLRTP
MTRLQLHLEMLRDAPSPARIDRAVADLADMNKLITGYLELARTTQAEAKTRFDLAVLLEEVATDAGLAGFSAAPCTVEAG
RLALRQIVSNLIQNAQRYGDAATVELELECSELGARVTVRDAGPGIPEDQLEKVFRPFYRLEASRSEATGGSGLGLAIVR
QLAATHGWKVSLANRKTGGLEAVLEIRR
>Mature_428_residues
MVRIASSLYARTALTLAIAFVLFQAAAFAVVYRTLIIPLAERSADDLAGLIVLSAQTWVELPPQTRAAFERELADRHGLR
LTAGDPGAVADAPQFAFRAQIETALSRRVGEPVKLRGVPGTRAAWLDIPTGGHALQVGFYPARYAVKPPLAAIAVIALGA
LLSLVTALLLVRRITLPLARAARAARQVGAGQLPEPLPETGPAEVAELARRFNTMATEVRELLDNRTTLLAGISHDLRTP
MTRLQLHLEMLRDAPSPARIDRAVADLADMNKLITGYLELARTTQAEAKTRFDLAVLLEEVATDAGLAGFSAAPCTVEAG
RLALRQIVSNLIQNAQRYGDAATVELELECSELGARVTVRDAGPGIPEDQLEKVFRPFYRLEASRSEATGGSGLGLAIVR
QLAATHGWKVSLANRKTGGLEAVLEIRR

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=444, Percent_Identity=29.954954954955, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1790346, Length=263, Percent_Identity=31.9391634980989, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1788393, Length=266, Percent_Identity=30.8270676691729, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1787894, Length=304, Percent_Identity=31.9078947368421, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1790551, Length=285, Percent_Identity=29.8245614035088, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1786783, Length=280, Percent_Identity=27.8571428571429, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1786600, Length=208, Percent_Identity=29.3269230769231, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1790861, Length=282, Percent_Identity=28.7234042553192, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082128, Length=263, Percent_Identity=29.277566539924, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1789149, Length=219, Percent_Identity=30.1369863013699, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI145693157, Length=230, Percent_Identity=23.9130434782609, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1786912, Length=222, Percent_Identity=27.9279279279279, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI48994928, Length=226, Percent_Identity=28.7610619469027, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1789403, Length=334, Percent_Identity=27.8443113772455, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790436, Length=207, Percent_Identity=28.5024154589372, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1788279, Length=282, Percent_Identity=24.822695035461, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788549, Length=202, Percent_Identity=24.7524752475248, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 45955; Mature: 45955

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRIASSLYARTALTLAIAFVLFQAAAFAVVYRTLIIPLAERSADDLAGLIVLSAQTWVE
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEEECHHHHC
LPPQTRAAFERELADRHGLRLTAGDPGAVADAPQFAFRAQIETALSRRVGEPVKLRGVPG
CCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCC
TRAAWLDIPTGGHALQVGFYPARYAVKPPLAAIAVIALGALLSLVTALLLVRRITLPLAR
CCEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AARAARQVGAGQLPEPLPETGPAEVAELARRFNTMATEVRELLDNRTTLLAGISHDLRTP
HHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHH
MTRLQLHLEMLRDAPSPARIDRAVADLADMNKLITGYLELARTTQAEAKTRFDLAVLLEE
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VATDAGLAGFSAAPCTVEAGRLALRQIVSNLIQNAQRYGDAATVELELECSELGARVTVR
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEHHHHCCEEEEE
DAGPGIPEDQLEKVFRPFYRLEASRSEATGGSGLGLAIVRQLAATHGWKVSLANRKTGGL
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCH
EAVLEIRR
HHHHHHCC
>Mature Secondary Structure
MVRIASSLYARTALTLAIAFVLFQAAAFAVVYRTLIIPLAERSADDLAGLIVLSAQTWVE
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEEECHHHHC
LPPQTRAAFERELADRHGLRLTAGDPGAVADAPQFAFRAQIETALSRRVGEPVKLRGVPG
CCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCC
TRAAWLDIPTGGHALQVGFYPARYAVKPPLAAIAVIALGALLSLVTALLLVRRITLPLAR
CCEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AARAARQVGAGQLPEPLPETGPAEVAELARRFNTMATEVRELLDNRTTLLAGISHDLRTP
HHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHH
MTRLQLHLEMLRDAPSPARIDRAVADLADMNKLITGYLELARTTQAEAKTRFDLAVLLEE
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VATDAGLAGFSAAPCTVEAGRLALRQIVSNLIQNAQRYGDAATVELELECSELGARVTVR
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEHHHHCCEEEEE
DAGPGIPEDQLEKVFRPFYRLEASRSEATGGSGLGLAIVRQLAATHGWKVSLANRKTGGL
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCH
EAVLEIRR
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]