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The map label for this gene is hisD

Identifier: 74317731

GI number: 74317731

Start: 1800556

End: 1801860

Strand: Reverse

Name: hisD

Synonym: Tbd_1713

Alternate gene names: 74317731

Gene position: 1801860-1800556 (Counterclockwise)

Preceding gene: 74317734

Following gene: 74317730

Centisome position: 61.92

GC content: 69.5

Gene sequence:

>1305_bases
GTGCTCACGCTTACCCGCCTCGACAGCGCCCAGCCTGACTTTCAGGCGCGTCTCGCCCGCCTGTTGCAGTTCGACGACGC
CACCGATGCCTCGATCGAGGAGGCCGTTGCGACGATTCTGCACGCGGTCAAAACCCGCGGCGACGCGGCGGTGCTCGAAT
ACACCGAGCGTTTCGACCGCCTGCCGGCGCCCTCGGCAGCCAGTCTCGAACTTGGCGCGGCGGAACTCGCGGCGGCCCTC
GCGGGCTTGCCGGAAGACACGCGCGCGGCGCTCGAGGCCGCCGCGGACCGGGTGCGTCGCTACCACGAAAAACAGCTGCA
GGGCTCGTGGACCTACACCGAAGACGACGGCACCGTGCTCGGGCAGAAGGTTACGCCGCTCGACCGCGTCGGGCTCTACG
TACCCGGCGGCAAGGCCGCGTATCCCTCGTCGGTCCTGATGAACGCGATTCCGGCCAAGGTCGCCGGCGTCGCCGAACTC
GTCATGGTCGTGCCGACGCCCGGCGGCGAGCGCAACGCGCTCGTGCTCGCGGCCGCGGCGATCGCCGGCGTCGACCGCGT
GTTCACCATCGGCGGCGCGCAGGCGGTCGCGGCGCTGGCGTACGGCACCGAAACCGTGCCGCAGGTCGACAAGATCGTCG
GCCCCGGCAACGCCTACGTGGCCGCGGCCAAGCGCCGCGTTTTCGGTACGGTCGGCATCGACATGATCGCCGGCCCGTCG
GAAATCCTCGTGATCGCCGACGGCAGCACGCCGGCGGAGTGGGTGGCGATGGATCTCTTTTCGCAGGCCGAGCACGACGA
ACTCGCACAGTCCATCCTGCTGTCGCCGGACCCGGACTATCTCGACGCGGTCGCCGCCGCGATCGACCAGCTCATCGTGG
AGATGCCGCGCGCCGAGGTGATCCGCACCTCCTTGACCAATCGCGGCGCGCTGATCCGGACGCACGACCTCCACGACGCC
GCGGCGATCGCCAACGCGATCGCGCCCGAGCACCTCGAGCTCGCGGTGAGCGACCCCGAGGCGCTGCTGCCGAAGCTGCG
CCATGCCGGCGCGATCTTCATGGGCAAGAATACCTGCGAGGCGCTCGGCGATTACTGTGCGGGACCGAATCACGTCCTGC
CGACCTCGCGTACTGCGCGCTTCTCGTCGCCTTTAGGCGTATACGACTTCCAGAAACGCACGAGCCTGATCCACGTGTCC
GAGGCCGGCGCGCAGACGCTCGGCCGCATCGCCGCCACGCTCGCCTACGGCGAGGGGCTGCAGGCGCATGCGCGTTCCGC
CGAATATCGCCTGACCCACAAATGA

Upstream 100 bases:

>100_bases
TTGATCGGGCTCGGAAAACCCCGAACGGACGCCCATCCAGGGCAAAACGGGTACAATCCCGGTCGTACGTTTCGACAGCC
TTCTAAAAGCAGAATCCCCC

Downstream 100 bases:

>100_bases
GCCGTACGTCGACGAGCAGGTACTGGAGCGCCGTGGTCGGCGCGCTGACGCCCTATGTGCCGGGCGAACAGCCCAAGCTC
GCCAATCTGGTCAAGCTCAA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MLTLTRLDSAQPDFQARLARLLQFDDATDASIEEAVATILHAVKTRGDAAVLEYTERFDRLPAPSAASLELGAAELAAAL
AGLPEDTRAALEAAADRVRRYHEKQLQGSWTYTEDDGTVLGQKVTPLDRVGLYVPGGKAAYPSSVLMNAIPAKVAGVAEL
VMVVPTPGGERNALVLAAAAIAGVDRVFTIGGAQAVAALAYGTETVPQVDKIVGPGNAYVAAAKRRVFGTVGIDMIAGPS
EILVIADGSTPAEWVAMDLFSQAEHDELAQSILLSPDPDYLDAVAAAIDQLIVEMPRAEVIRTSLTNRGALIRTHDLHDA
AAIANAIAPEHLELAVSDPEALLPKLRHAGAIFMGKNTCEALGDYCAGPNHVLPTSRTARFSSPLGVYDFQKRTSLIHVS
EAGAQTLGRIAATLAYGEGLQAHARSAEYRLTHK

Sequences:

>Translated_434_residues
MLTLTRLDSAQPDFQARLARLLQFDDATDASIEEAVATILHAVKTRGDAAVLEYTERFDRLPAPSAASLELGAAELAAAL
AGLPEDTRAALEAAADRVRRYHEKQLQGSWTYTEDDGTVLGQKVTPLDRVGLYVPGGKAAYPSSVLMNAIPAKVAGVAEL
VMVVPTPGGERNALVLAAAAIAGVDRVFTIGGAQAVAALAYGTETVPQVDKIVGPGNAYVAAAKRRVFGTVGIDMIAGPS
EILVIADGSTPAEWVAMDLFSQAEHDELAQSILLSPDPDYLDAVAAAIDQLIVEMPRAEVIRTSLTNRGALIRTHDLHDA
AAIANAIAPEHLELAVSDPEALLPKLRHAGAIFMGKNTCEALGDYCAGPNHVLPTSRTARFSSPLGVYDFQKRTSLIHVS
EAGAQTLGRIAATLAYGEGLQAHARSAEYRLTHK
>Mature_434_residues
MLTLTRLDSAQPDFQARLARLLQFDDATDASIEEAVATILHAVKTRGDAAVLEYTERFDRLPAPSAASLELGAAELAAAL
AGLPEDTRAALEAAADRVRRYHEKQLQGSWTYTEDDGTVLGQKVTPLDRVGLYVPGGKAAYPSSVLMNAIPAKVAGVAEL
VMVVPTPGGERNALVLAAAAIAGVDRVFTIGGAQAVAALAYGTETVPQVDKIVGPGNAYVAAAKRRVFGTVGIDMIAGPS
EILVIADGSTPAEWVAMDLFSQAEHDELAQSILLSPDPDYLDAVAAAIDQLIVEMPRAEVIRTSLTNRGALIRTHDLHDA
AAIANAIAPEHLELAVSDPEALLPKLRHAGAIFMGKNTCEALGDYCAGPNHVLPTSRTARFSSPLGVYDFQKRTSLIHVS
EAGAQTLGRIAATLAYGEGLQAHARSAEYRLTHK

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=405, Percent_Identity=41.7283950617284, Blast_Score=285, Evalue=4e-78,
Organism=Saccharomyces cerevisiae, GI6319819, Length=414, Percent_Identity=35.9903381642512, Blast_Score=246, Evalue=6e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_THIDA (Q3SI67)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_315471.1
- ProteinModelPortal:   Q3SI67
- SMR:   Q3SI67
- STRING:   Q3SI67
- GeneID:   3671296
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_1713
- NMPDR:   fig|292415.3.peg.1810
- eggNOG:   COG0141
- HOGENOM:   HBG329596
- OMA:   LDAHKNA
- ProtClustDB:   PRK00877
- BioCyc:   TDEN292415:TBD_1713-MONOMER
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 45762; Mature: 45762

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 330-330 ACT_SITE 331-331 BINDING 133-133 BINDING 194-194 BINDING 217-217 BINDING 240-240 BINDING 262-262 BINDING 265-265 BINDING 331-331 BINDING 364-364 BINDING 418-418 BINDING 423-423

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTLTRLDSAQPDFQARLARLLQFDDATDASIEEAVATILHAVKTRGDAAVLEYTERFDR
CEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC
LPAPSAASLELGAAELAAALAGLPEDTRAALEAAADRVRRYHEKQLQGSWTYTEDDGTVL
CCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEE
GQKVTPLDRVGLYVPGGKAAYPSSVLMNAIPAKVAGVAELVMVVPTPGGERNALVLAAAA
CCCCCCHHHCCEECCCCCCCCCHHHHHHHHHHHHHHHEEEEEEEECCCCCCCEEEEHHHH
IAGVDRVFTIGGAQAVAALAYGTETVPQVDKIVGPGNAYVAAAKRRVFGTVGIDMIAGPS
HHCCHHEEEECCHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHEECCHHEECCCC
EILVIADGSTPAEWVAMDLFSQAEHDELAQSILLSPDPDYLDAVAAAIDQLIVEMPRAEV
EEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHH
IRTSLTNRGALIRTHDLHDAAAIANAIAPEHLELAVSDPEALLPKLRHAGAIFMGKNTCE
HHHHHCCCCCEEEECCCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCEEEECCCHHH
ALGDYCAGPNHVLPTSRTARFSSPLGVYDFQKRTSLIHVSEAGAQTLGRIAATLAYGEGL
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCH
QAHARSAEYRLTHK
HHHHCCCCEEECCC
>Mature Secondary Structure
MLTLTRLDSAQPDFQARLARLLQFDDATDASIEEAVATILHAVKTRGDAAVLEYTERFDR
CEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC
LPAPSAASLELGAAELAAALAGLPEDTRAALEAAADRVRRYHEKQLQGSWTYTEDDGTVL
CCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEE
GQKVTPLDRVGLYVPGGKAAYPSSVLMNAIPAKVAGVAELVMVVPTPGGERNALVLAAAA
CCCCCCHHHCCEECCCCCCCCCHHHHHHHHHHHHHHHEEEEEEEECCCCCCCEEEEHHHH
IAGVDRVFTIGGAQAVAALAYGTETVPQVDKIVGPGNAYVAAAKRRVFGTVGIDMIAGPS
HHCCHHEEEECCHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHEECCHHEECCCC
EILVIADGSTPAEWVAMDLFSQAEHDELAQSILLSPDPDYLDAVAAAIDQLIVEMPRAEV
EEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHH
IRTSLTNRGALIRTHDLHDAAAIANAIAPEHLELAVSDPEALLPKLRHAGAIFMGKNTCE
HHHHHCCCCCEEEECCCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCEEEECCCHHH
ALGDYCAGPNHVLPTSRTARFSSPLGVYDFQKRTSLIHVSEAGAQTLGRIAATLAYGEGL
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCH
QAHARSAEYRLTHK
HHHHCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA