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The map label for this gene is hisC2

Identifier: 74317730

GI number: 74317730

Start: 1799486

End: 1800559

Strand: Reverse

Name: hisC2

Synonym: Tbd_1712

Alternate gene names: 74317730

Gene position: 1800559-1799486 (Counterclockwise)

Preceding gene: 74317731

Following gene: 74317729

Centisome position: 61.88

GC content: 65.46

Gene sequence:

>1074_bases
ATGAGCCGTACGTCGACGAGCAGGTACTGGAGCGCCGTGGTCGGCGCGCTGACGCCCTATGTGCCGGGCGAACAGCCCAA
GCTCGCCAATCTGGTCAAGCTCAACACCAACGAGAATCCCTACGGCCCGAGCCCAAGGGTGCTCGAGGCATTGCGCGGCG
AAGTCGGCGACACGCTGCGCCTTTATCCCGACCCGAATTCGGACCGGCTGCGCGCGGCGATTGCGGCGTACCACGCGGTC
TCCCCTGATCAGGTCTTCGTCGGCAACGGATCCGACGAAGTGCTGGCGCACACGTTTCTTGCGCTCCTGAAGCACGAGCG
GCCGGTCTTCTTTCCCGACATCACCTACAGTTTCTATCCGGTGTACTGCGGCCTTTACGGGATCGCTCATCGCGCGATTC
CGCTCGACGACGCGTTCGAGATCCGGGTCGACGATTATCTTGCGCCCAAGGGCGGCGTGATCTTCCCGAATCCGAATGCG
CCGACCGGACGGCTGCTGGCCTTGGGCGAGATCGAGCGCCTGCTCGCGGCCAATCGCGACTCGGTGGTCGTCATCGACGA
GGCCTACGTCGATTTCGGCGGCGACTCGGCCGTGCCGCTGGTCGCGCGCCATCCGCAGCTTCTCGTCACCCGCACGCTGT
CGAAGTCGCACGCGCTCGCCGGCTTGCGCGTCGGCTATGCGGTCGGCCAGGCCCCGCTGATCGAAGCGCTCAATCGCGTG
AAAGACAGTTTCAATTCGTATCCGCTCGACCGCTTCGCCCAGGCGGGTGCCCTGGCGTCGATCGAGGACCGCGCCTATTT
CGAATCGATCTGCGCGCGCGTGATCGCGACGCGCACCCGGCTCGTCGACGCCATGGAAAGCCTTGGTTTCGAGGTCCTGC
CGTCCGCGGCCAACTTCATCTTCGCGCGTCATCCCGCGCATGACGGTGAGGCGCTCGCTGCGCGGCTGCGCGAGCGCAGC
ATCATCGTCCGCCATTTCAAGAATCCGGCGCGCATCGCGCCCTTCCTGCGCATCACGGTCGGCACCGACGCACAATGCGA
TGCGCTCGTAGACGCCTTGAAAGCCCTGTGCTGA

Upstream 100 bases:

>100_bases
AGGCCGGCGCGCAGACGCTCGGCCGCATCGCCGCCACGCTCGCCTACGGCGAGGGGCTGCAGGCGCATGCGCGTTCCGCC
GAATATCGCCTGACCCACAA

Downstream 100 bases:

>100_bases
AAACGACAGCGGCCTGCTAAAATCCTTTTTACCGTCCGAAAAACGTCGCCATGCGCACCGCCCAAGTCAGCCGCAATACC
CTCGAAACCGAGATTACGGT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 2

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MSRTSTSRYWSAVVGALTPYVPGEQPKLANLVKLNTNENPYGPSPRVLEALRGEVGDTLRLYPDPNSDRLRAAIAAYHAV
SPDQVFVGNGSDEVLAHTFLALLKHERPVFFPDITYSFYPVYCGLYGIAHRAIPLDDAFEIRVDDYLAPKGGVIFPNPNA
PTGRLLALGEIERLLAANRDSVVVIDEAYVDFGGDSAVPLVARHPQLLVTRTLSKSHALAGLRVGYAVGQAPLIEALNRV
KDSFNSYPLDRFAQAGALASIEDRAYFESICARVIATRTRLVDAMESLGFEVLPSAANFIFARHPAHDGEALAARLRERS
IIVRHFKNPARIAPFLRITVGTDAQCDALVDALKALC

Sequences:

>Translated_357_residues
MSRTSTSRYWSAVVGALTPYVPGEQPKLANLVKLNTNENPYGPSPRVLEALRGEVGDTLRLYPDPNSDRLRAAIAAYHAV
SPDQVFVGNGSDEVLAHTFLALLKHERPVFFPDITYSFYPVYCGLYGIAHRAIPLDDAFEIRVDDYLAPKGGVIFPNPNA
PTGRLLALGEIERLLAANRDSVVVIDEAYVDFGGDSAVPLVARHPQLLVTRTLSKSHALAGLRVGYAVGQAPLIEALNRV
KDSFNSYPLDRFAQAGALASIEDRAYFESICARVIATRTRLVDAMESLGFEVLPSAANFIFARHPAHDGEALAARLRERS
IIVRHFKNPARIAPFLRITVGTDAQCDALVDALKALC
>Mature_356_residues
SRTSTSRYWSAVVGALTPYVPGEQPKLANLVKLNTNENPYGPSPRVLEALRGEVGDTLRLYPDPNSDRLRAAIAAYHAVS
PDQVFVGNGSDEVLAHTFLALLKHERPVFFPDITYSFYPVYCGLYGIAHRAIPLDDAFEIRVDDYLAPKGGVIFPNPNAP
TGRLLALGEIERLLAANRDSVVVIDEAYVDFGGDSAVPLVARHPQLLVTRTLSKSHALAGLRVGYAVGQAPLIEALNRVK
DSFNSYPLDRFAQAGALASIEDRAYFESICARVIATRTRLVDAMESLGFEVLPSAANFIFARHPAHDGEALAARLRERSI
IVRHFKNPARIAPFLRITVGTDAQCDALVDALKALC

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=355, Percent_Identity=30.1408450704225, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1788722, Length=261, Percent_Identity=30.6513409961686, Blast_Score=82, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6322075, Length=358, Percent_Identity=28.7709497206704, Blast_Score=117, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS82_THIDA (Q3SI68)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_315470.1
- ProteinModelPortal:   Q3SI68
- SMR:   Q3SI68
- STRING:   Q3SI68
- GeneID:   3671295
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_1712
- NMPDR:   fig|292415.3.peg.1809
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   MRGELND
- PhylomeDB:   Q3SI68
- ProtClustDB:   PRK05387
- BioCyc:   TDEN292415:TBD_1712-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 38963; Mature: 38832

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRTSTSRYWSAVVGALTPYVPGEQPKLANLVKLNTNENPYGPSPRVLEALRGEVGDTLR
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCEEE
LYPDPNSDRLRAAIAAYHAVSPDQVFVGNGSDEVLAHTFLALLKHERPVFFPDITYSFYP
ECCCCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
VYCGLYGIAHRAIPLDDAFEIRVDDYLAPKGGVIFPNPNAPTGRLLALGEIERLLAANRD
HHHHHHHHHHHCCCCCCCEEEEECCEECCCCCEEECCCCCCCCCEEEHHHHHHHHHCCCC
SVVVIDEAYVDFGGDSAVPLVARHPQLLVTRTLSKSHALAGLRVGYAVGQAPLIEALNRV
CEEEEEEHEEECCCCCCCCHHHCCCCEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
KDSFNSYPLDRFAQAGALASIEDRAYFESICARVIATRTRLVDAMESLGFEVLPSAANFI
HHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHEE
FARHPAHDGEALAARLRERSIIVRHFKNPARIAPFLRITVGTDAQCDALVDALKALC
EEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHCCEEEEEECCCCHHHHHHHHHHHHC
>Mature Secondary Structure 
SRTSTSRYWSAVVGALTPYVPGEQPKLANLVKLNTNENPYGPSPRVLEALRGEVGDTLR
CCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCEEE
LYPDPNSDRLRAAIAAYHAVSPDQVFVGNGSDEVLAHTFLALLKHERPVFFPDITYSFYP
ECCCCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
VYCGLYGIAHRAIPLDDAFEIRVDDYLAPKGGVIFPNPNAPTGRLLALGEIERLLAANRD
HHHHHHHHHHHCCCCCCCEEEEECCEECCCCCEEECCCCCCCCCEEEHHHHHHHHHCCCC
SVVVIDEAYVDFGGDSAVPLVARHPQLLVTRTLSKSHALAGLRVGYAVGQAPLIEALNRV
CEEEEEEHEEECCCCCCCCHHHCCCCEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
KDSFNSYPLDRFAQAGALASIEDRAYFESICARVIATRTRLVDAMESLGFEVLPSAANFI
HHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHEE
FARHPAHDGEALAARLRERSIIVRHFKNPARIAPFLRITVGTDAQCDALVDALKALC
EEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHCCEEEEEECCCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA