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The map label for this gene is clpP

Identifier: 74317695

GI number: 74317695

Start: 1765288

End: 1765926

Strand: Reverse

Name: clpP

Synonym: Tbd_1677

Alternate gene names: 74317695

Gene position: 1765926-1765288 (Counterclockwise)

Preceding gene: 74317696

Following gene: 74317694

Centisome position: 60.69

GC content: 60.56

Gene sequence:

>639_bases
ATGCTATATGATTTCGAACGGACCGCCCCCGAACCGCAGGGGCTCGGCCTGGTGCCGATGGTGGTCGAGCAGAGCGGTCG
GGGCGAGCGCGCCTACGACATTTACTCCCGCCTCCTCAAGGAACGGGTCATTTTCCTCGTCGGGCCAGTGAACGACGCGA
CGGCCAACCTGATCGTCGCGCAGATGCTTTTCCTCGAATCGGAAAACCCGGACAAGGACATCTATCTGTACATCAACTCG
CCGGGCGGATCGGTGTCCGCCGGCCTCGCGATCTACGACACGATGCAGTTCATCAAGCCTGACGTGTCGACGCTCTGCAT
CGGCCAAGCTGCGAGCATGGGCGCGTTCCTGCTGACCGCAGGCGCCAAGGGCAAGCGTTACTGCCTACCCAACTCGCGCG
TCATGATCCACCAGCCTCTCGGCGGATTCCAGGGCCAGGCGTCGGACATCGAGATCCATGCCAAGGAAATTCTCTATTTG
AAAGCACGACTGAACGGCATGCTCGCGAAGCATACCGGCCAGAGTCTCGAAGTGATCGATCGGGACACCGATCGCGACAA
CTTCATGAGTGCCGAGGACTCGGTGAAGTACGGGCTGGTCGACAAGGTCCTGACCAGCCGCAACGAAGCAGGCAACTAG

Upstream 100 bases:

>100_bases
AGTCCCTGGCGCTCGAGGAGAACGTGGTAGCATGGGTCGCAGATCAGGCTACCGTGGTAGATGTGGCAACCTCTTTTGAC
GAACTGATGGGACGTGCCTG

Downstream 100 bases:

>100_bases
CAAGGAAACTTCATGGCGGACAAAGGCTCGGGAGACAAGCTCCTTTACTGTTCCTTCTGCGGCAAAAGCCAGCACGAGGT
GCGCAAGCTCATCGCGGGAC

Product: ATP-dependent Clp protease proteolytic subunit ClpP

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MLYDFERTAPEPQGLGLVPMVVEQSGRGERAYDIYSRLLKERVIFLVGPVNDATANLIVAQMLFLESENPDKDIYLYINS
PGGSVSAGLAIYDTMQFIKPDVSTLCIGQAASMGAFLLTAGAKGKRYCLPNSRVMIHQPLGGFQGQASDIEIHAKEILYL
KARLNGMLAKHTGQSLEVIDRDTDRDNFMSAEDSVKYGLVDKVLTSRNEAGN

Sequences:

>Translated_212_residues
MLYDFERTAPEPQGLGLVPMVVEQSGRGERAYDIYSRLLKERVIFLVGPVNDATANLIVAQMLFLESENPDKDIYLYINS
PGGSVSAGLAIYDTMQFIKPDVSTLCIGQAASMGAFLLTAGAKGKRYCLPNSRVMIHQPLGGFQGQASDIEIHAKEILYL
KARLNGMLAKHTGQSLEVIDRDTDRDNFMSAEDSVKYGLVDKVLTSRNEAGN
>Mature_212_residues
MLYDFERTAPEPQGLGLVPMVVEQSGRGERAYDIYSRLLKERVIFLVGPVNDATANLIVAQMLFLESENPDKDIYLYINS
PGGSVSAGLAIYDTMQFIKPDVSTLCIGQAASMGAFLLTAGAKGKRYCLPNSRVMIHQPLGGFQGQASDIEIHAKEILYL
KARLNGMLAKHTGQSLEVIDRDTDRDNFMSAEDSVKYGLVDKVLTSRNEAGN

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=200, Percent_Identity=57, Blast_Score=249, Evalue=1e-66,
Organism=Escherichia coli, GI1786641, Length=208, Percent_Identity=74.0384615384615, Blast_Score=329, Evalue=1e-91,
Organism=Caenorhabditis elegans, GI17538017, Length=188, Percent_Identity=57.4468085106383, Blast_Score=230, Evalue=4e-61,
Organism=Drosophila melanogaster, GI20129427, Length=192, Percent_Identity=57.8125, Blast_Score=244, Evalue=3e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_THIDA (Q3SI98)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_315435.1
- ProteinModelPortal:   Q3SI98
- SMR:   Q3SI98
- STRING:   Q3SI98
- MEROPS:   S14.001
- GeneID:   3673064
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_1677
- NMPDR:   fig|292415.3.peg.1774
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   TGQPFER
- PhylomeDB:   Q3SI98
- BioCyc:   TDEN292415:TBD_1677-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 23252; Mature: 23252

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 112-112 ACT_SITE 137-137

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYDFERTAPEPQGLGLVPMVVEQSGRGERAYDIYSRLLKERVIFLVGPVNDATANLIVA
CCCCCCCCCCCCCCCCEEEHEECCCCCCCHHHHHHHHHHHHCEEEEEECCCCHHHHHHHH
QMLFLESENPDKDIYLYINSPGGSVSAGLAIYDTMQFIKPDVSTLCIGQAASMGAFLLTA
HHHHHCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCHHHEECCCCCCCCEEEEEC
GAKGKRYCLPNSRVMIHQPLGGFQGQASDIEIHAKEILYLKARLNGMLAKHTGQSLEVID
CCCCCEEECCCCCEEEECCCCCCCCCCCCEEEEHHHHEEEEHHHCCHHHHCCCCCEEEEE
RDTDRDNFMSAEDSVKYGLVDKVLTSRNEAGN
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLYDFERTAPEPQGLGLVPMVVEQSGRGERAYDIYSRLLKERVIFLVGPVNDATANLIVA
CCCCCCCCCCCCCCCCEEEHEECCCCCCCHHHHHHHHHHHHCEEEEEECCCCHHHHHHHH
QMLFLESENPDKDIYLYINSPGGSVSAGLAIYDTMQFIKPDVSTLCIGQAASMGAFLLTA
HHHHHCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCHHHEECCCCCCCCEEEEEC
GAKGKRYCLPNSRVMIHQPLGGFQGQASDIEIHAKEILYLKARLNGMLAKHTGQSLEVID
CCCCCEEECCCCCEEEECCCCCCCCCCCCEEEEHHHHEEEEHHHCCHHHHCCCCCEEEEE
RDTDRDNFMSAEDSVKYGLVDKVLTSRNEAGN
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA