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The map label for this gene is clpX

Identifier: 74317694

GI number: 74317694

Start: 1764004

End: 1765275

Strand: Reverse

Name: clpX

Synonym: Tbd_1676

Alternate gene names: 74317694

Gene position: 1765275-1764004 (Counterclockwise)

Preceding gene: 74317695

Following gene: 74317693

Centisome position: 60.67

GC content: 62.34

Gene sequence:

>1272_bases
ATGGCGGACAAAGGCTCGGGAGACAAGCTCCTTTACTGTTCCTTCTGCGGCAAAAGCCAGCACGAGGTGCGCAAGCTCAT
CGCGGGACCGTCGGTGTTCATCTGCGACGAATGCGTCGAACTGTGCAACGACATCATCCGTGAGGAGATCCAGCAGGCCG
ATAGCCAGAAGGGCGCAAGTTCCGATCTGCCGACGCCGCACGAGATCAGCGGCATTCTCGACCAATACGTGATCGGGCAG
GGCCAGGCGAAGAAGGCCCTGGCGGTCGCGGTCTACAACCACTACAAGCGCCTGCGCAGCAGCTCGGGAAGCGGCGACGT
CGAACTGGCAAAGAGCAACATCCTGCTGATCGGGCCGACCGGCTCGGGCAAGACCCTGCTCGCGCAGACGCTCGCACGCC
TGCTCAACGTTCCCTTCGTGATCGCCGACGCGACGACGCTGACCGAAGCGGGTTATGTCGGTGAAGACGTCGAGAACATC
ATCCAGAAGCTGCTGCAGAAGTGCGATTACGACGTCGACAAGGCGAAGCAGGGCATCGTTTACATCGACGAAATCGACAA
AATCTCGCGCAAGGCCGACAACCCCTCGATCACCCGCGATGTATCGGGCGAGGGCGTGCAGCAGGCCCTGCTCAAGCTGA
TCGAAGGCACGACCGCGTCGGTGCCGCCGCAGGGCGGGCGCAAGCATCCGAACCAGGAATTCGTCCAGGTCGACACCAGC
AACATCCTGTTCATTTGCGGCGGCGCGTTCAGCGGGCTCGAGAAGGTGATTCGCGGGCGTACCGAGAAGGGCGGGATCGG
TTTTGGCGCACAGGTCAAGAACGTCGACGAGAACAAGCGCGACGCCGAACTGCTGCATCAGGTCGAGCCGGAGGATCTCA
TCAAGTACGGGTTGATCCCCGAATTCGTCGGCCGTCTGCCGGTGGTTGCGACGCTCGACGAACTTGACGAGGCGGCGCTC
GTGCAGATCCTGACCGAGCCGAAGAACGCCCTGACCAAGCAGTTCGCGAAACTTTTCAAGATGGAAGGCGTCGATCTTGA
ATTCCGCGACGATGCGCTCAACGCGATCGCCAAGCGCGCGCTGCTGCGCCGCACCGGCGCGCGCGGCCTGCGCTCAATCA
TCGAGCACGCGCTGCTCGACACCATGTACGACCTGCCTTCGCTCAAGGGCGTGAGCAAGGTCGTCGTCGACAATGCCCTC
ATCAGCGGCGAAGGCCAGCCTTTGCTGATCTACTCGGAGCAGGGTGACCAACCGCTCGCGGCCGGAGCCTGA

Upstream 100 bases:

>100_bases
TCGCGACAACTTCATGAGTGCCGAGGACTCGGTGAAGTACGGGCTGGTCGACAAGGTCCTGACCAGCCGCAACGAAGCAG
GCAACTAGCAAGGAAACTTC

Downstream 100 bases:

>100_bases
TCGATGATGGCCGACGGGGAACCAGTCGGCCATCTTGAATTCCAAACTATGCCCCCCAACTGGGACAAGCGTGGTTGACA
TGCCGCGCGTCCTTTCCCCA

Product: ATP-dependent protease ATP-binding subunit ClpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MADKGSGDKLLYCSFCGKSQHEVRKLIAGPSVFICDECVELCNDIIREEIQQADSQKGASSDLPTPHEISGILDQYVIGQ
GQAKKALAVAVYNHYKRLRSSSGSGDVELAKSNILLIGPTGSGKTLLAQTLARLLNVPFVIADATTLTEAGYVGEDVENI
IQKLLQKCDYDVDKAKQGIVYIDEIDKISRKADNPSITRDVSGEGVQQALLKLIEGTTASVPPQGGRKHPNQEFVQVDTS
NILFICGGAFSGLEKVIRGRTEKGGIGFGAQVKNVDENKRDAELLHQVEPEDLIKYGLIPEFVGRLPVVATLDELDEAAL
VQILTEPKNALTKQFAKLFKMEGVDLEFRDDALNAIAKRALLRRTGARGLRSIIEHALLDTMYDLPSLKGVSKVVVDNAL
ISGEGQPLLIYSEQGDQPLAAGA

Sequences:

>Translated_423_residues
MADKGSGDKLLYCSFCGKSQHEVRKLIAGPSVFICDECVELCNDIIREEIQQADSQKGASSDLPTPHEISGILDQYVIGQ
GQAKKALAVAVYNHYKRLRSSSGSGDVELAKSNILLIGPTGSGKTLLAQTLARLLNVPFVIADATTLTEAGYVGEDVENI
IQKLLQKCDYDVDKAKQGIVYIDEIDKISRKADNPSITRDVSGEGVQQALLKLIEGTTASVPPQGGRKHPNQEFVQVDTS
NILFICGGAFSGLEKVIRGRTEKGGIGFGAQVKNVDENKRDAELLHQVEPEDLIKYGLIPEFVGRLPVVATLDELDEAAL
VQILTEPKNALTKQFAKLFKMEGVDLEFRDDALNAIAKRALLRRTGARGLRSIIEHALLDTMYDLPSLKGVSKVVVDNAL
ISGEGQPLLIYSEQGDQPLAAGA
>Mature_422_residues
ADKGSGDKLLYCSFCGKSQHEVRKLIAGPSVFICDECVELCNDIIREEIQQADSQKGASSDLPTPHEISGILDQYVIGQG
QAKKALAVAVYNHYKRLRSSSGSGDVELAKSNILLIGPTGSGKTLLAQTLARLLNVPFVIADATTLTEAGYVGEDVENII
QKLLQKCDYDVDKAKQGIVYIDEIDKISRKADNPSITRDVSGEGVQQALLKLIEGTTASVPPQGGRKHPNQEFVQVDTSN
ILFICGGAFSGLEKVIRGRTEKGGIGFGAQVKNVDENKRDAELLHQVEPEDLIKYGLIPEFVGRLPVVATLDELDEAALV
QILTEPKNALTKQFAKLFKMEGVDLEFRDDALNAIAKRALLRRTGARGLRSIIEHALLDTMYDLPSLKGVSKVVVDNALI
SGEGQPLLIYSEQGDQPLAAGA

Specific function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP

COG id: COG1219

COG function: function code O; ATP-dependent protease Clp, ATPase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family

Homologues:

Organism=Homo sapiens, GI7242140, Length=329, Percent_Identity=52.2796352583587, Blast_Score=309, Evalue=3e-84,
Organism=Escherichia coli, GI1786642, Length=415, Percent_Identity=77.3493975903614, Blast_Score=642, Evalue=0.0,
Organism=Escherichia coli, GI1790366, Length=100, Percent_Identity=46, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71982908, Length=311, Percent_Identity=48.5530546623794, Blast_Score=272, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI71982905, Length=324, Percent_Identity=47.5308641975309, Blast_Score=272, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI71988663, Length=388, Percent_Identity=39.9484536082474, Blast_Score=254, Evalue=6e-68,
Organism=Caenorhabditis elegans, GI71988660, Length=248, Percent_Identity=41.9354838709677, Blast_Score=173, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6319704, Length=427, Percent_Identity=40.0468384074941, Blast_Score=266, Evalue=5e-72,
Organism=Drosophila melanogaster, GI24648291, Length=307, Percent_Identity=48.8599348534202, Blast_Score=287, Evalue=1e-77,
Organism=Drosophila melanogaster, GI24648289, Length=307, Percent_Identity=48.8599348534202, Blast_Score=287, Evalue=1e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPX_THIDA (Q3SI99)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_315434.1
- HSSP:   P0A6H5
- ProteinModelPortal:   Q3SI99
- STRING:   Q3SI99
- GeneID:   3673063
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_1676
- NMPDR:   fig|292415.3.peg.1773
- eggNOG:   COG1219
- HOGENOM:   HBG745965
- OMA:   CGKSQEQ
- PhylomeDB:   Q3SI99
- ProtClustDB:   PRK05342
- BioCyc:   TDEN292415:TBD_1676-MONOMER
- HAMAP:   MF_00175
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR019489
- InterPro:   IPR004487
- InterPro:   IPR010603
- PANTHER:   PTHR11262:SF4
- SMART:   SM00382
- TIGRFAMs:   TIGR00382

Pfam domain/function: PF07724 AAA_2; PF10431 ClpB_D2-small; PF06689 zf-C4_ClpX

EC number: NA

Molecular weight: Translated: 45738; Mature: 45607

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADKGSGDKLLYCSFCGKSQHEVRKLIAGPSVFICDECVELCNDIIREEIQQADSQKGAS
CCCCCCCCEEEEEECCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCC
SDLPTPHEISGILDQYVIGQGQAKKALAVAVYNHYKRLRSSSGSGDVELAKSNILLIGPT
CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEEECC
GSGKTLLAQTLARLLNVPFVIADATTLTEAGYVGEDVENIIQKLLQKCDYDVDKAKQGIV
CCCHHHHHHHHHHHHCCCEEEECCHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHCCCEE
YIDEIDKISRKADNPSITRDVSGEGVQQALLKLIEGTTASVPPQGGRKHPNQEFVQVDTS
EEEHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCC
NILFICGGAFSGLEKVIRGRTEKGGIGFGAQVKNVDENKRDAELLHQVEPEDLIKYGLIP
CEEEEECCHHHHHHHHHCCCCCCCCCCCCCEECCCCCCHHHHHHHHHCCHHHHHHHCCCH
EFVGRLPVVATLDELDEAALVQILTEPKNALTKQFAKLFKMEGVDLEFRDDALNAIAKRA
HHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEECHHHHHHHHHHH
LLRRTGARGLRSIIEHALLDTMYDLPSLKGVSKVVVDNALISGEGQPLLIYSEQGDQPLA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHEECCCCCEEEEECCCCCCCCC
AGA
CCC
>Mature Secondary Structure 
ADKGSGDKLLYCSFCGKSQHEVRKLIAGPSVFICDECVELCNDIIREEIQQADSQKGAS
CCCCCCCEEEEEECCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCC
SDLPTPHEISGILDQYVIGQGQAKKALAVAVYNHYKRLRSSSGSGDVELAKSNILLIGPT
CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEEECC
GSGKTLLAQTLARLLNVPFVIADATTLTEAGYVGEDVENIIQKLLQKCDYDVDKAKQGIV
CCCHHHHHHHHHHHHCCCEEEECCHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHCCCEE
YIDEIDKISRKADNPSITRDVSGEGVQQALLKLIEGTTASVPPQGGRKHPNQEFVQVDTS
EEEHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCC
NILFICGGAFSGLEKVIRGRTEKGGIGFGAQVKNVDENKRDAELLHQVEPEDLIKYGLIP
CEEEEECCHHHHHHHHHCCCCCCCCCCCCCEECCCCCCHHHHHHHHHCCHHHHHHHCCCH
EFVGRLPVVATLDELDEAALVQILTEPKNALTKQFAKLFKMEGVDLEFRDDALNAIAKRA
HHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEECHHHHHHHHHHH
LLRRTGARGLRSIIEHALLDTMYDLPSLKGVSKVVVDNALISGEGQPLLIYSEQGDQPLA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHEECCCCCEEEEECCCCCCCCC
AGA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA