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The map label for this gene is trpS [H]

Identifier: 74317543

GI number: 74317543

Start: 1612617

End: 1613819

Strand: Reverse

Name: trpS [H]

Synonym: Tbd_1525

Alternate gene names: 74317543

Gene position: 1613819-1612617 (Counterclockwise)

Preceding gene: 74317544

Following gene: 74317542

Centisome position: 55.46

GC content: 63.76

Gene sequence:

>1203_bases
ATGTATTCCGATCGCGTTCTTTCCGGCATGCGCCCCACCGGGCGTCTGCATCTCGGCCACTATCACGGCGTGCTCAAGAA
CTGGCTGCGCCTGCAGAACGAGTACCAGTGCCTGTTCTTCGTCGCCGACTGGCATGCGCTGACGACCCACTACGACGCGC
CGCAGGCGATCGACCAGAACGTGCGCGACATGGTCGTCGACTGGCTCGCGGCCGGCATCGATCCTGCGCAGGCCACGCTC
TTCGTGCAATCGCGCGTGCTCGAACACGCGGAACTGCATCTGCTGCTGTCGATGATGACGCCGCTCGGCTGGCTCGAACG
CGTGCCGACCTACAAGGACCAGCAGGAAAAACTCAGCGAGAAGGATCTTTCGACCTACGGCTTCCTCGGCTATCCGCTGC
TGCAGAGCGCCGACATCCTGATCTACCGCGCCAACCTCGTGCCGGTCGGCGAGGATCAGGTGCCGCACATCGAGTTCACG
CGCGAGATCTGCCGTCGTTTCAACCACCTCTATGGTCGCGAGCCGGGGTTCGAGGACAAGGCGCGGTCCGCGGTCAAGAA
ACTCGGGTCGAAGAAGGCGCGTGTCTACGAGGAATGCCGCACCGCATATCAGGAGAAGGGCGACCAGGAGGCGCTGGAGT
CGGCACGGGCCCTGTTGAACGACGCGCAGAACCTGTCGATGAACGACCGCGAGCGGCTTTTCGGCTATCTCGAGGGCTCG
GGCAAGATGATCCTCGCCGAGCCCGAATCCCTGCTCACCGAAGCATCGAAAATGCCGGGTCTCGACGGGCAGAAGATGTC
GAAGTCCTACGGCAACACGATCGCACTGCGCGAAGACCCAGACGTTGTGGCGAAGAAGATCCGCACCATGCCGACCGATC
CGGCGCGGGTCCGCCGCACTGACGCGGGCAATCCGCTGAACTGCCCGGTGTGGCAGTTCCATCTCGTGTATTCCGACGAC
AACGTGCGCCAGTGGGTGACGGCCGGTTGCACCAGCGCCGGTATCGGCTGCATCGAATGCAAGCAGCCCGTGATCGATGG
CGTGCTCGCCGAGCTTGTGCCGATTCGCGAGCGGGCGCAGTACTACGAGGACAACCCCGACCAGGTGCGCAACATCCTCG
CCGACGGTAGCGAGAAGGCACAGGAACTCGCGCGCGACACGATGCGCGACGTGCGCGAGTCGATGGGACTGACCTTCGGC
TGA

Upstream 100 bases:

>100_bases
CCTGGCCGCGCTGTTGACCGGCCTCGACCCGGCGCAGCTCGTCGGCCTCATCCAGGTCGTGCTCGCCTGACTTTCCTTTT
CTAGCGCTCAAGCCAAAACC

Downstream 100 bases:

>100_bases
GCGGCGGCACGCGCATCGCGCATGGGCGCTGAATTGCGTCGTCCGCCGCCGGCCGCACTCGCCTGGCTGACCTGGGGCCT
GCTCGCGAGCCTCTATTTCG

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MYSDRVLSGMRPTGRLHLGHYHGVLKNWLRLQNEYQCLFFVADWHALTTHYDAPQAIDQNVRDMVVDWLAAGIDPAQATL
FVQSRVLEHAELHLLLSMMTPLGWLERVPTYKDQQEKLSEKDLSTYGFLGYPLLQSADILIYRANLVPVGEDQVPHIEFT
REICRRFNHLYGREPGFEDKARSAVKKLGSKKARVYEECRTAYQEKGDQEALESARALLNDAQNLSMNDRERLFGYLEGS
GKMILAEPESLLTEASKMPGLDGQKMSKSYGNTIALREDPDVVAKKIRTMPTDPARVRRTDAGNPLNCPVWQFHLVYSDD
NVRQWVTAGCTSAGIGCIECKQPVIDGVLAELVPIRERAQYYEDNPDQVRNILADGSEKAQELARDTMRDVRESMGLTFG

Sequences:

>Translated_400_residues
MYSDRVLSGMRPTGRLHLGHYHGVLKNWLRLQNEYQCLFFVADWHALTTHYDAPQAIDQNVRDMVVDWLAAGIDPAQATL
FVQSRVLEHAELHLLLSMMTPLGWLERVPTYKDQQEKLSEKDLSTYGFLGYPLLQSADILIYRANLVPVGEDQVPHIEFT
REICRRFNHLYGREPGFEDKARSAVKKLGSKKARVYEECRTAYQEKGDQEALESARALLNDAQNLSMNDRERLFGYLEGS
GKMILAEPESLLTEASKMPGLDGQKMSKSYGNTIALREDPDVVAKKIRTMPTDPARVRRTDAGNPLNCPVWQFHLVYSDD
NVRQWVTAGCTSAGIGCIECKQPVIDGVLAELVPIRERAQYYEDNPDQVRNILADGSEKAQELARDTMRDVRESMGLTFG
>Mature_400_residues
MYSDRVLSGMRPTGRLHLGHYHGVLKNWLRLQNEYQCLFFVADWHALTTHYDAPQAIDQNVRDMVVDWLAAGIDPAQATL
FVQSRVLEHAELHLLLSMMTPLGWLERVPTYKDQQEKLSEKDLSTYGFLGYPLLQSADILIYRANLVPVGEDQVPHIEFT
REICRRFNHLYGREPGFEDKARSAVKKLGSKKARVYEECRTAYQEKGDQEALESARALLNDAQNLSMNDRERLFGYLEGS
GKMILAEPESLLTEASKMPGLDGQKMSKSYGNTIALREDPDVVAKKIRTMPTDPARVRRTDAGNPLNCPVWQFHLVYSDD
NVRQWVTAGCTSAGIGCIECKQPVIDGVLAELVPIRERAQYYEDNPDQVRNILADGSEKAQELARDTMRDVRESMGLTFG

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7710154, Length=395, Percent_Identity=29.1139240506329, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI41352700, Length=169, Percent_Identity=44.3786982248521, Blast_Score=143, Evalue=2e-34,
Organism=Escherichia coli, GI1789786, Length=167, Percent_Identity=44.311377245509, Blast_Score=155, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI71982800, Length=172, Percent_Identity=34.8837209302326, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI71982793, Length=172, Percent_Identity=34.8837209302326, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320474, Length=183, Percent_Identity=34.9726775956284, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24666151, Length=405, Percent_Identity=29.1358024691358, Blast_Score=162, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 45368; Mature: 45368

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSDRVLSGMRPTGRLHLGHYHGVLKNWLRLQNEYQCLFFVADWHALTTHYDAPQAIDQN
CCCCHHHCCCCCCCCEECHHHHHHHHHHHHHCCCCEEEEEEECHHHHHCCCCCHHHHHHH
VRDMVVDWLAAGIDPAQATLFVQSRVLEHAELHLLLSMMTPLGWLERVPTYKDQQEKLSE
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
KDLSTYGFLGYPLLQSADILIYRANLVPVGEDQVPHIEFTREICRRFNHLYGREPGFEDK
HHHHHHCCCCCHHHCCCCEEEEEECEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHH
ARSAVKKLGSKKARVYEECRTAYQEKGDQEALESARALLNDAQNLSMNDRERLFGYLEGS
HHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCC
GKMILAEPESLLTEASKMPGLDGQKMSKSYGNTIALREDPDVVAKKIRTMPTDPARVRRT
CCEEEECCHHHHHHHHHCCCCCCHHHHHHHCCEEEECCCHHHHHHHHHCCCCCHHHHEEC
DAGNPLNCPVWQFHLVYSDDNVRQWVTAGCTSAGIGCIECKQPVIDGVLAELVPIRERAQ
CCCCCCCCCEEEEEEEECCCCHHHHHHHCCHHCCCCHHHCCHHHHHHHHHHHHHHHHHHH
YYEDNPDQVRNILADGSEKAQELARDTMRDVRESMGLTFG
HCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MYSDRVLSGMRPTGRLHLGHYHGVLKNWLRLQNEYQCLFFVADWHALTTHYDAPQAIDQN
CCCCHHHCCCCCCCCEECHHHHHHHHHHHHHCCCCEEEEEEECHHHHHCCCCCHHHHHHH
VRDMVVDWLAAGIDPAQATLFVQSRVLEHAELHLLLSMMTPLGWLERVPTYKDQQEKLSE
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
KDLSTYGFLGYPLLQSADILIYRANLVPVGEDQVPHIEFTREICRRFNHLYGREPGFEDK
HHHHHHCCCCCHHHCCCCEEEEEECEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHH
ARSAVKKLGSKKARVYEECRTAYQEKGDQEALESARALLNDAQNLSMNDRERLFGYLEGS
HHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCC
GKMILAEPESLLTEASKMPGLDGQKMSKSYGNTIALREDPDVVAKKIRTMPTDPARVRRT
CCEEEECCHHHHHHHHHCCCCCCHHHHHHHCCEEEECCCHHHHHHHHHCCCCCHHHHEEC
DAGNPLNCPVWQFHLVYSDDNVRQWVTAGCTSAGIGCIECKQPVIDGVLAELVPIRERAQ
CCCCCCCCCEEEEEEEECCCCHHHHHHHCCHHCCCCHHHCCHHHHHHHHHHHHHHHHHHH
YYEDNPDQVRNILADGSEKAQELARDTMRDVRESMGLTFG
HCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]