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The map label for this gene is nuoL [H]

Identifier: 74317171

GI number: 74317171

Start: 1206570

End: 1208579

Strand: Direct

Name: nuoL [H]

Synonym: Tbd_1153

Alternate gene names: 74317171

Gene position: 1206570-1208579 (Clockwise)

Preceding gene: 74317170

Following gene: 74317172

Centisome position: 41.47

GC content: 63.33

Gene sequence:

>2010_bases
ATGCGGATGGACATGCAGACGCTTTATCTGGTCGTGGCGCTCGCGCCGCTGGTCGGTGCGATCATCGCCGGGCTGTTCGG
CAGGCTCGTCGGCCGCGTCGGTGCGCACACCGCGGCGATCGCCGGGGTGGCCGTGTCGTTCATCGCCTCGGTACTCGTGT
TCCAGGACGTGCTCGCGGGCAACGTCTACAACGGCACGGTCTACACGTGGATGACGGTCGGCGAGCTACGTTTCGAAGTC
GGCTTCCTGATCGATTCGCTGTCGGCGATGATGATGCTGGTGGTGACCTTCGTCTCGCTCATGGTGCACGTCTACACCAT
CGGCTACATGCACGACGACCCGGGCTACCAGCGTTTCTTCAGCTACATCTCGCTCTTCACCTTCTCGATGCTCATGCTCG
TCATGAGCAACAACTTCCTGCAGCTGTTCTTCGGCTGGGAGGCGGTGGGCCTCGTTTCCTATCTCCTCATCGGCTTCTGG
TACACGAAGGAAACCGCGATCTACGCCAACCTCAAGGCGTTCCTCGTCAACCGCGTGGGTGACTTCGGTTTCATCCTCGG
CATCGGCCTGGTCCTCGCGTATTTCGGCTCCCTCGATTACGCCACGGTCTTTGCCAAGGCGCCCGCGCTCGCCGACGAGA
CGATCACGCTGTGGCCGGACAGTCCGTGGATGCTGATGACCGTCATCGGCATCCTGCTGTTCATCGGTGCGATGGGGAAA
TCGGCCCAGTTTCCGCTGCACGTCTGGCTGCCCGATTCGATGGAAGGCCCGACGCCGATTTCGGCGCTGATCCACGCCGC
GACGATGGTCACCGCCGGCATCTTCATGGTCGCGCGCATGTCGCCGTTGTACGAACTGTCCGACGTCGCGCTGTCGTTCA
TCATGATCATCGGTGCCGTCACCGCGCTGTTCATGGGCCTGCTCGGCATCGTGCAGAATGACATCAAGCGGGTCGTCGCG
TATTCGACGCTCTCGCAACTGGGCTACATGACCGTCGCGCTCGGCGCGTCCGCGTATTCGGTCGCGGTGTTCCACCTCAT
GACGCACGCCTTCTTCAAGGCCTTGCTGTTCCTCGCCGCAGGCAGCGTCATCATCGCGCTGCACCACAACCAGGACATCC
GCTACATGGGCGGACTGAAGAAATACATGCCGATCACCTGGATCACCTCGCTGATCGGGTCGCTCGCGCTGATCGGCACA
CCCTTCCTGTCGGGCTTCTATTCCAAGGAAAGCATCATCGAAGCGGTCAGACTCTCGCACCTGCCGACCGCACAGATTGC
CTACTGGGCGGTGCTGATCGGCGTGTTCGTCACGGCCTTCTATTCGTTCCGCATGTACTTCCTCGTATTCCACGGCAAGG
AGCGTTTCCGCCAGGGTCACGCGCACGGCAACGAGCCCGACGCGCACGACGATCACGGGCATGGCCACGGCGGCACGCCG
CACGAAACCCCGTGGGTCGTGACCGGGCCACTGCTGGCGCTCGCGCTGCCGTCGCTGGCGATCGGCTACATGACAATCGA
GCCGATGCTGTTCGGCGATTTCTTCGACCGGGCGATCTACGTCTCCGACCGCCACCCCGTGATGGTCGAGCTCAACCAGC
ATTTCCATGGGGCGGCCGAAATGGGCCTCCATGCGCTGGCGACACTGCCGTTCTGGCTGGCGGCAGCCGGCGTCGCGCTC
GCGGCCGTGTTCTACCTGCGGCGTCCCGACATCCCGGCGGCGCTCGCGCAGCGCTTCGCGCCGATTCACCGCATGCTGCT
CAACAAATACTGGTTCGACGAGCTCTACAGCTGGGCGTTTGCCAAGGGCGCGCGCGTCCTCGGCGGCTCGCTGTGGCGAC
GCGGCGACCAGGCCTTCATCGACGGCGTCCTCGTCAACGGCTCGGCGCACGTGGTCGAGCGTGTCTCCCGTCTGACCAAG
CTTGTCCAGTCCGGCTACATCTACCATTACGCCTTCGCCATGCTGATCGGGGTCGTCGCCCTGGTGACCTGGTTCGCGCG
GCTTAACTAA

Upstream 100 bases:

>100_bases
TGGCGGCGGCCGAATCCGCGATCGGTCTAGCGATCCTGGTGCTGTTGTTCCGCAACCTGCGCACGATCAACGTCGACGAC
CTCGACCAATTGAAAGGCTG

Downstream 100 bases:

>100_bases
CAACAACGCCCATGTTCGGACAGTCGATTCTTTCCCTCGTCATCTGGGTCCCGATTCTTGCAGGTGCAGCGGTCCTCGCC
ACGGGCTCCGACCGCAACGC

Product: NADH dehydrogenase I subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 669; Mature: 669

Protein sequence:

>669_residues
MRMDMQTLYLVVALAPLVGAIIAGLFGRLVGRVGAHTAAIAGVAVSFIASVLVFQDVLAGNVYNGTVYTWMTVGELRFEV
GFLIDSLSAMMMLVVTFVSLMVHVYTIGYMHDDPGYQRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFW
YTKETAIYANLKAFLVNRVGDFGFILGIGLVLAYFGSLDYATVFAKAPALADETITLWPDSPWMLMTVIGILLFIGAMGK
SAQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLYELSDVALSFIMIIGAVTALFMGLLGIVQNDIKRVVA
YSTLSQLGYMTVALGASAYSVAVFHLMTHAFFKALLFLAAGSVIIALHHNQDIRYMGGLKKYMPITWITSLIGSLALIGT
PFLSGFYSKESIIEAVRLSHLPTAQIAYWAVLIGVFVTAFYSFRMYFLVFHGKERFRQGHAHGNEPDAHDDHGHGHGGTP
HETPWVVTGPLLALALPSLAIGYMTIEPMLFGDFFDRAIYVSDRHPVMVELNQHFHGAAEMGLHALATLPFWLAAAGVAL
AAVFYLRRPDIPAALAQRFAPIHRMLLNKYWFDELYSWAFAKGARVLGGSLWRRGDQAFIDGVLVNGSAHVVERVSRLTK
LVQSGYIYHYAFAMLIGVVALVTWFARLN

Sequences:

>Translated_669_residues
MRMDMQTLYLVVALAPLVGAIIAGLFGRLVGRVGAHTAAIAGVAVSFIASVLVFQDVLAGNVYNGTVYTWMTVGELRFEV
GFLIDSLSAMMMLVVTFVSLMVHVYTIGYMHDDPGYQRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFW
YTKETAIYANLKAFLVNRVGDFGFILGIGLVLAYFGSLDYATVFAKAPALADETITLWPDSPWMLMTVIGILLFIGAMGK
SAQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLYELSDVALSFIMIIGAVTALFMGLLGIVQNDIKRVVA
YSTLSQLGYMTVALGASAYSVAVFHLMTHAFFKALLFLAAGSVIIALHHNQDIRYMGGLKKYMPITWITSLIGSLALIGT
PFLSGFYSKESIIEAVRLSHLPTAQIAYWAVLIGVFVTAFYSFRMYFLVFHGKERFRQGHAHGNEPDAHDDHGHGHGGTP
HETPWVVTGPLLALALPSLAIGYMTIEPMLFGDFFDRAIYVSDRHPVMVELNQHFHGAAEMGLHALATLPFWLAAAGVAL
AAVFYLRRPDIPAALAQRFAPIHRMLLNKYWFDELYSWAFAKGARVLGGSLWRRGDQAFIDGVLVNGSAHVVERVSRLTK
LVQSGYIYHYAFAMLIGVVALVTWFARLN
>Mature_669_residues
MRMDMQTLYLVVALAPLVGAIIAGLFGRLVGRVGAHTAAIAGVAVSFIASVLVFQDVLAGNVYNGTVYTWMTVGELRFEV
GFLIDSLSAMMMLVVTFVSLMVHVYTIGYMHDDPGYQRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFW
YTKETAIYANLKAFLVNRVGDFGFILGIGLVLAYFGSLDYATVFAKAPALADETITLWPDSPWMLMTVIGILLFIGAMGK
SAQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLYELSDVALSFIMIIGAVTALFMGLLGIVQNDIKRVVA
YSTLSQLGYMTVALGASAYSVAVFHLMTHAFFKALLFLAAGSVIIALHHNQDIRYMGGLKKYMPITWITSLIGSLALIGT
PFLSGFYSKESIIEAVRLSHLPTAQIAYWAVLIGVFVTAFYSFRMYFLVFHGKERFRQGHAHGNEPDAHDDHGHGHGGTP
HETPWVVTGPLLALALPSLAIGYMTIEPMLFGDFFDRAIYVSDRHPVMVELNQHFHGAAEMGLHALATLPFWLAAAGVAL
AAVFYLRRPDIPAALAQRFAPIHRMLLNKYWFDELYSWAFAKGARVLGGSLWRRGDQAFIDGVLVNGSAHVVERVSRLTK
LVQSGYIYHYAFAMLIGVVALVTWFARLN

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=413, Percent_Identity=42.1307506053269, Blast_Score=308, Evalue=2e-83,
Organism=Escherichia coli, GI1788614, Length=672, Percent_Identity=37.0535714285714, Blast_Score=356, Evalue=2e-99,
Organism=Escherichia coli, GI1788829, Length=423, Percent_Identity=30.9692671394799, Blast_Score=155, Evalue=6e-39,
Organism=Escherichia coli, GI1788827, Length=415, Percent_Identity=30.1204819277108, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1788831, Length=355, Percent_Identity=29.0140845070423, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI2367154, Length=350, Percent_Identity=25.1428571428571, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI145693160, Length=356, Percent_Identity=25.2808988764045, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788613, Length=329, Percent_Identity=25.8358662613982, Blast_Score=69, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 73766; Mature: 73766

Theoretical pI: Translated: 7.52; Mature: 7.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMDMQTLYLVVALAPLVGAIIAGLFGRLVGRVGAHTAAIAGVAVSFIASVLVFQDVLAG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NVYNGTVYTWMTVGELRFEVGFLIDSLSAMMMLVVTFVSLMVHVYTIGYMHDDPGYQRFF
CCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHH
SYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFWYTKETAIYANLKAFLVNRVG
HHHHHHHHHHHHHHHCCCCEEEHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
DFGFILGIGLVLAYFGSLDYATVFAKAPALADETITLWPDSPWMLMTVIGILLFIGAMGK
HHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCC
SAQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLYELSDVALSFIMIIGAV
CCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
TALFMGLLGIVQNDIKRVVAYSTLSQLGYMTVALGASAYSVAVFHLMTHAFFKALLFLAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHC
GSVIIALHHNQDIRYMGGLKKYMPITWITSLIGSLALIGTPFLSGFYSKESIIEAVRLSH
CCEEEEEECCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHC
LPTAQIAYWAVLIGVFVTAFYSFRMYFLVFHGKERFRQGHAHGNEPDAHDDHGHGHGGTP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCCCCCCC
HETPWVVTGPLLALALPSLAIGYMTIEPMLFGDFFDRAIYVSDRHPVMVELNQHFHGAAE
CCCCEEEEHHHHHHHHHHHHHHHHEEHHHHHHHHHCCEEEECCCCCEEEEECCCCCCHHH
MGLHALATLPFWLAAAGVALAAVFYLRRPDIPAALAQRFAPIHRMLLNKYWFDELYSWAF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKGARVLGGSLWRRGDQAFIDGVLVNGSAHVVERVSRLTKLVQSGYIYHYAFAMLIGVVA
HCCHHHHHHHHHHCCCHHHHCCEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LVTWFARLN
HHHHHHHCC
>Mature Secondary Structure
MRMDMQTLYLVVALAPLVGAIIAGLFGRLVGRVGAHTAAIAGVAVSFIASVLVFQDVLAG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NVYNGTVYTWMTVGELRFEVGFLIDSLSAMMMLVVTFVSLMVHVYTIGYMHDDPGYQRFF
CCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHH
SYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFWYTKETAIYANLKAFLVNRVG
HHHHHHHHHHHHHHHCCCCEEEHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
DFGFILGIGLVLAYFGSLDYATVFAKAPALADETITLWPDSPWMLMTVIGILLFIGAMGK
HHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCC
SAQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLYELSDVALSFIMIIGAV
CCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
TALFMGLLGIVQNDIKRVVAYSTLSQLGYMTVALGASAYSVAVFHLMTHAFFKALLFLAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHC
GSVIIALHHNQDIRYMGGLKKYMPITWITSLIGSLALIGTPFLSGFYSKESIIEAVRLSH
CCEEEEEECCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHC
LPTAQIAYWAVLIGVFVTAFYSFRMYFLVFHGKERFRQGHAHGNEPDAHDDHGHGHGGTP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCCCCCCC
HETPWVVTGPLLALALPSLAIGYMTIEPMLFGDFFDRAIYVSDRHPVMVELNQHFHGAAE
CCCCEEEEHHHHHHHHHHHHHHHHEEHHHHHHHHHCCEEEECCCCCEEEEECCCCCCHHH
MGLHALATLPFWLAAAGVALAAVFYLRRPDIPAALAQRFAPIHRMLLNKYWFDELYSWAF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKGARVLGGSLWRRGDQAFIDGVLVNGSAHVVERVSRLTKLVQSGYIYHYAFAMLIGVVA
HCCHHHHHHHHHHCCCHHHHCCEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LVTWFARLN
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]