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The map label for this gene is nuoC

Identifier: 74317162

GI number: 74317162

Start: 1197900

End: 1198502

Strand: Direct

Name: nuoC

Synonym: Tbd_1144

Alternate gene names: 74317162

Gene position: 1197900-1198502 (Clockwise)

Preceding gene: 74317161

Following gene: 74317163

Centisome position: 41.17

GC content: 65.17

Gene sequence:

>603_bases
ATGTCGATCACGCTGGAGTCCTTGTCCGCCTGCCTGAAAAATGCCCTCGGTGACGCGCTCGTTCAGACGATCGAGCGCCT
CGGCGAACTGACGCTCGTGGTCAAGCCCCAGGCCTACGCGCCGGCGATGCTGGCCTTGCGCGACCACCCGGACTGCCGCT
TCGAGCAGTTGATCGACCTGTGCGGTGTCGACTATTCCGGGTATGGCGAGGGCGCCTGGGAGGGTCCGCGCTTTGCCGTC
GTCGCGCACCTGCTTTCGGTGTCGAAGAACGCCCGCGTGCGTGTGCGCGTGTTTTGCCCCGACGACGATTTGCCCGCGGT
CGCGTCCGTCGTGGATATCTGGCCCGCCGCGAGTTGGTTCGAGCGCGAGGCTTTCGATCTCTACGGCATCGTTTTCGAGG
GTCACCCGGACTTGCGTCGCATCCTCACCGACTACGGCTTCATCGGTCATCCTTTCCGCAAGGACTTCCCGCTTTCGGGC
AACGTCGAGATGCGTTACGACCCGACCCAGCAGCGCGTGATCTACCAGCCGGTGTCGATCGAGCCGCGCGACAACGTGCC
GCGCGTCGTGCGCGACGAAAGCTACGGCGACGGGCGGGCATGA

Upstream 100 bases:

>100_bases
ATTTACGTGCCCGGGTGCCCGCCGACGGCCGAGGCGCTCATATTCGGGATCATCCAGTTGCAGAAGAAGATCCGCCGCAC
CAACACCATCGCCCGCTGAC

Downstream 100 bases:

>100_bases
TGTCGCTCGATCGCATCACGGGCCCGAAGGGGGTCTGACGCCATGGCAGAAATCAGAAACTACACGATGAACTTCGGTCC
GCAGCATCCGGCCGCGCACG

Product: NADH dehydrogenase subunit C

Products: NA

Alternate protein names: NADH dehydrogenase I subunit C; NDH-1 subunit C

Number of amino acids: Translated: 200; Mature: 199

Protein sequence:

>200_residues
MSITLESLSACLKNALGDALVQTIERLGELTLVVKPQAYAPAMLALRDHPDCRFEQLIDLCGVDYSGYGEGAWEGPRFAV
VAHLLSVSKNARVRVRVFCPDDDLPAVASVVDIWPAASWFEREAFDLYGIVFEGHPDLRRILTDYGFIGHPFRKDFPLSG
NVEMRYDPTQQRVIYQPVSIEPRDNVPRVVRDESYGDGRA

Sequences:

>Translated_200_residues
MSITLESLSACLKNALGDALVQTIERLGELTLVVKPQAYAPAMLALRDHPDCRFEQLIDLCGVDYSGYGEGAWEGPRFAV
VAHLLSVSKNARVRVRVFCPDDDLPAVASVVDIWPAASWFEREAFDLYGIVFEGHPDLRRILTDYGFIGHPFRKDFPLSG
NVEMRYDPTQQRVIYQPVSIEPRDNVPRVVRDESYGDGRA
>Mature_199_residues
SITLESLSACLKNALGDALVQTIERLGELTLVVKPQAYAPAMLALRDHPDCRFEQLIDLCGVDYSGYGEGAWEGPRFAVV
AHLLSVSKNARVRVRVFCPDDDLPAVASVVDIWPAASWFEREAFDLYGIVFEGHPDLRRILTDYGFIGHPFRKDFPLSGN
VEMRYDPTQQRVIYQPVSIEPRDNVPRVVRDESYGDGRA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0852

COG function: function code C; NADH:ubiquinone oxidoreductase 27 kD subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 30 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758788, Length=154, Percent_Identity=46.1038961038961, Blast_Score=148, Evalue=3e-36,
Organism=Escherichia coli, GI145693162, Length=149, Percent_Identity=34.8993288590604, Blast_Score=85, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71990788, Length=152, Percent_Identity=44.078947368421, Blast_Score=137, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI32563621, Length=152, Percent_Identity=44.078947368421, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24656494, Length=152, Percent_Identity=44.7368421052632, Blast_Score=141, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOC_THIDA (Q3SEX6)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_314902.1
- ProteinModelPortal:   Q3SEX6
- SMR:   Q3SEX6
- STRING:   Q3SEX6
- GeneID:   3673216
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_1144
- NMPDR:   fig|292415.3.peg.1144
- eggNOG:   COG0852
- HOGENOM:   HBG727675
- OMA:   VFAPDDD
- ProtClustDB:   PRK06074
- BioCyc:   TDEN292415:TBD_1144-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01357
- InterPro:   IPR010218
- InterPro:   IPR001268
- InterPro:   IPR020396
- ProDom:   PD001581
- TIGRFAMs:   TIGR01961

Pfam domain/function: PF00329 Complex1_30kDa

EC number: =1.6.99.5

Molecular weight: Translated: 22442; Mature: 22311

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00542 COMPLEX1_30K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSITLESLSACLKNALGDALVQTIERLGELTLVVKPQAYAPAMLALRDHPDCRFEQLIDL
CEEEHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCEEEECCCCCCHHHHHHHH
CGVDYSGYGEGAWEGPRFAVVAHLLSVSKNARVRVRVFCPDDDLPAVASVVDIWPAASWF
HCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHCCHHHH
EREAFDLYGIVFEGHPDLRRILTDYGFIGHPFRKDFPLSGNVEMRYDPTQQRVIYQPVSI
HHHHHEEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCEEEECCCCC
EPRDNVPRVVRDESYGDGRA
CCCCCCCCEECCCCCCCCCC
>Mature Secondary Structure 
SITLESLSACLKNALGDALVQTIERLGELTLVVKPQAYAPAMLALRDHPDCRFEQLIDL
EEEHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCEEEECCCCCCHHHHHHHH
CGVDYSGYGEGAWEGPRFAVVAHLLSVSKNARVRVRVFCPDDDLPAVASVVDIWPAASWF
HCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHCCHHHH
EREAFDLYGIVFEGHPDLRRILTDYGFIGHPFRKDFPLSGNVEMRYDPTQQRVIYQPVSI
HHHHHEEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCEEEECCCCC
EPRDNVPRVVRDESYGDGRA
CCCCCCCCEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA