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The map label for this gene is nuoD

Identifier: 74317163

GI number: 74317163

Start: 1198545

End: 1199798

Strand: Direct

Name: nuoD

Synonym: Tbd_1145

Alternate gene names: 74317163

Gene position: 1198545-1199798 (Clockwise)

Preceding gene: 74317162

Following gene: 74317164

Centisome position: 41.19

GC content: 63.16

Gene sequence:

>1254_bases
ATGGCAGAAATCAGAAACTACACGATGAACTTCGGTCCGCAGCATCCGGCCGCGCACGGTGTTCTGCGCCTCGTGCTGGA
ACTGGACGGCGAAGTCATCCAGCGTGCCGACCCGCACATCGGGCTCCTGCACCGTGCGACCGAAAAGCTGGCGGAACACA
AGACCTTCCTTCAGGCGCTCCCGTACATGGACCGTCTCGACTACGTGTCGATGATGGTCAACGAGCACGCCTACGTCATG
GCGATCGAGAAGCTGCTCGGCATCGAGGTGCCCGAGCGCGCGCAATACATCCGCGTGATGTTCGACGAGATCACCCGCGT
CCTCAACCACCTGCTGTGGCTCGGCGCGCATGCGCTCGACGTCGGCGCGATGACCGTGTTCCTCTACGCCTTCCGCGAGC
GCGAAGACCTCATGGACTGCTACGAGGCGGTGTCCGGGGCGCGCATGCACGCGGCGTACTACCGGCCTGGCGGCGTCTAC
CGCGACCTGCCCGACCGCATGCCGCAGTATCAGGCGCAGCACACGCGCAACGAGTCGACGATGAAGTCGATGAACGCGAA
CCGACAGGGTTCGCTGCTCGATTTCATTGAGGATTTCACGACCCGCTTCCCGGCTTACGTTGACGAGTACGAAACCCTGC
TGACCGACAACCGCATCTGGAAGCAGCGCACCGTCGGCATCGGCGTCGTCGCCCCGGAACGGGCGCTGGCCCTGGGTTTT
ACCGGGCCCATGCTGCGCGGTTCCGGCGTCGAGTGGGATCTGCGCAAGAAGCAGCCCTACGAAGTGTACGAGCGCATGGA
TTTCGACATCCCGGTCGGGACCAACGGCGACTGCTACGACCGCTACCTGGTGCGCATCGAGGAGATGCGCCAGTCCAACC
GCATCATCAGGCAATGCGTCGACTGGCTGCGCAAGAACCCCGGCCCGATTATGGTCGACAACCACAAGGTCTCGCCGCCG
CCGCGGGTCGACATGAAGCAGAACATGGAAGAGCTGATCCACCATTTCAAGCTCTTCACCGAGGGCATGCACGTGCCCGC
CGGGGAAGCCTACGCCGCGGTCGAACACCCCAAGGGCGAGTTCGGCATCTATCTCGTCTCCGACGGTGCGAACAAGCCTT
ACCGCATGAAGATTCGCGCGCCCGGCTTCGCCCATCTCGAGGCGCTCGACGAGATGAGCCGCGGGCACATGATTGCCGAC
GTCGTCGCGATCATCGGGACGCAGGATATCGTTTTCGGGGAGATCGATCGTTGA

Upstream 100 bases:

>100_bases
GCGCGACAACGTGCCGCGCGTCGTGCGCGACGAAAGCTACGGCGACGGGCGGGCATGATGTCGCTCGATCGCATCACGGG
CCCGAAGGGGGTCTGACGCC

Downstream 100 bases:

>100_bases
TGGCCGATCAGGATGTGAAAGACAAGGTCGAGCTCAGCGCCGAGGCGCTGGCTTTGATCGACGCCGAAGTCGCCAAATAC
CCGGCGGACCAGAAGCAGTC

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MAEIRNYTMNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAEHKTFLQALPYMDRLDYVSMMVNEHAYVM
AIEKLLGIEVPERAQYIRVMFDEITRVLNHLLWLGAHALDVGAMTVFLYAFREREDLMDCYEAVSGARMHAAYYRPGGVY
RDLPDRMPQYQAQHTRNESTMKSMNANRQGSLLDFIEDFTTRFPAYVDEYETLLTDNRIWKQRTVGIGVVAPERALALGF
TGPMLRGSGVEWDLRKKQPYEVYERMDFDIPVGTNGDCYDRYLVRIEEMRQSNRIIRQCVDWLRKNPGPIMVDNHKVSPP
PRVDMKQNMEELIHHFKLFTEGMHVPAGEAYAAVEHPKGEFGIYLVSDGANKPYRMKIRAPGFAHLEALDEMSRGHMIAD
VVAIIGTQDIVFGEIDR

Sequences:

>Translated_417_residues
MAEIRNYTMNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAEHKTFLQALPYMDRLDYVSMMVNEHAYVM
AIEKLLGIEVPERAQYIRVMFDEITRVLNHLLWLGAHALDVGAMTVFLYAFREREDLMDCYEAVSGARMHAAYYRPGGVY
RDLPDRMPQYQAQHTRNESTMKSMNANRQGSLLDFIEDFTTRFPAYVDEYETLLTDNRIWKQRTVGIGVVAPERALALGF
TGPMLRGSGVEWDLRKKQPYEVYERMDFDIPVGTNGDCYDRYLVRIEEMRQSNRIIRQCVDWLRKNPGPIMVDNHKVSPP
PRVDMKQNMEELIHHFKLFTEGMHVPAGEAYAAVEHPKGEFGIYLVSDGANKPYRMKIRAPGFAHLEALDEMSRGHMIAD
VVAIIGTQDIVFGEIDR
>Mature_416_residues
AEIRNYTMNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAEHKTFLQALPYMDRLDYVSMMVNEHAYVMA
IEKLLGIEVPERAQYIRVMFDEITRVLNHLLWLGAHALDVGAMTVFLYAFREREDLMDCYEAVSGARMHAAYYRPGGVYR
DLPDRMPQYQAQHTRNESTMKSMNANRQGSLLDFIEDFTTRFPAYVDEYETLLTDNRIWKQRTVGIGVVAPERALALGFT
GPMLRGSGVEWDLRKKQPYEVYERMDFDIPVGTNGDCYDRYLVRIEEMRQSNRIIRQCVDWLRKNPGPIMVDNHKVSPPP
RVDMKQNMEELIHHFKLFTEGMHVPAGEAYAAVEHPKGEFGIYLVSDGANKPYRMKIRAPGFAHLEALDEMSRGHMIADV
VAIIGTQDIVFGEIDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=414, Percent_Identity=62.56038647343, Blast_Score=530, Evalue=1e-151,
Organism=Homo sapiens, GI260898743, Length=408, Percent_Identity=61.7647058823529, Blast_Score=514, Evalue=1e-146,
Organism=Escherichia coli, GI145693162, Length=413, Percent_Identity=38.9830508474576, Blast_Score=311, Evalue=4e-86,
Organism=Escherichia coli, GI1789076, Length=421, Percent_Identity=29.2161520190024, Blast_Score=138, Evalue=7e-34,
Organism=Escherichia coli, GI1788832, Length=408, Percent_Identity=27.6960784313726, Blast_Score=117, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17555284, Length=415, Percent_Identity=59.7590361445783, Blast_Score=504, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI17568379, Length=415, Percent_Identity=59.0361445783133, Blast_Score=501, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24638644, Length=415, Percent_Identity=60.9638554216868, Blast_Score=530, Evalue=1e-151,
Organism=Drosophila melanogaster, GI221459469, Length=417, Percent_Identity=55.1558752997602, Blast_Score=475, Evalue=1e-134,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOD_THIDA (Q3SJQ4)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_314903.1
- HSSP:   Q56220
- ProteinModelPortal:   Q3SJQ4
- SMR:   Q3SJQ4
- STRING:   Q3SJQ4
- GeneID:   3673217
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_1145
- NMPDR:   fig|292415.3.peg.1145
- eggNOG:   COG0649
- HOGENOM:   HBG459705
- OMA:   GVFIQGN
- PhylomeDB:   Q3SJQ4
- ProtClustDB:   PRK06075
- BioCyc:   TDEN292415:TBD_1145-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 47961; Mature: 47830

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEIRNYTMNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAEHKTFLQAL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
PYMDRLDYVSMMVNEHAYVMAIEKLLGIEVPERAQYIRVMFDEITRVLNHLLWLGAHALD
CHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGAMTVFLYAFREREDLMDCYEAVSGARMHAAYYRPGGVYRDLPDRMPQYQAQHTRNEST
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHCHHHHHHHCCCHHH
MKSMNANRQGSLLDFIEDFTTRFPAYVDEYETLLTDNRIWKQRTVGIGVVAPERALALGF
HHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHCCEEEEECCCHHEEECC
TGPMLRGSGVEWDLRKKQPYEVYERMDFDIPVGTNGDCYDRYLVRIEEMRQSNRIIRQCV
CCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DWLRKNPGPIMVDNHKVSPPPRVDMKQNMEELIHHFKLFTEGMHVPAGEAYAAVEHPKGE
HHHHCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCC
FGIYLVSDGANKPYRMKIRAPGFAHLEALDEMSRGHMIADVVAIIGTQDIVFGEIDR
EEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHCCCCEEECCCCC
>Mature Secondary Structure 
AEIRNYTMNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAEHKTFLQAL
CCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
PYMDRLDYVSMMVNEHAYVMAIEKLLGIEVPERAQYIRVMFDEITRVLNHLLWLGAHALD
CHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGAMTVFLYAFREREDLMDCYEAVSGARMHAAYYRPGGVYRDLPDRMPQYQAQHTRNEST
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHCHHHHHHHCCCHHH
MKSMNANRQGSLLDFIEDFTTRFPAYVDEYETLLTDNRIWKQRTVGIGVVAPERALALGF
HHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHCCEEEEECCCHHEEECC
TGPMLRGSGVEWDLRKKQPYEVYERMDFDIPVGTNGDCYDRYLVRIEEMRQSNRIIRQCV
CCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DWLRKNPGPIMVDNHKVSPPPRVDMKQNMEELIHHFKLFTEGMHVPAGEAYAAVEHPKGE
HHHHCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCC
FGIYLVSDGANKPYRMKIRAPGFAHLEALDEMSRGHMIADVVAIIGTQDIVFGEIDR
EEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA