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The map label for this gene is mtaD [H]

Identifier: 74316965

GI number: 74316965

Start: 1007134

End: 1008459

Strand: Reverse

Name: mtaD [H]

Synonym: Tbd_0947

Alternate gene names: 74316965

Gene position: 1008459-1007134 (Counterclockwise)

Preceding gene: 74316985

Following gene: 74316964

Centisome position: 34.66

GC content: 70.14

Gene sequence:

>1326_bases
ATGAAAGCCTCCGCCGACCTTCTTCTCCTGCCGCAGTGGGTGGTCCCTGTCGACCCGGAAGGGGTGCTGACCGACCACGC
CGTCGTCGTCGCGGACGGACGCATCGTCGACGTTCTGCCGGCCGAGGTGGCGCGCGCCCGCTACGCCGCTGCCAAGACGG
TCGCGCTGCCGGGCGAGGCCCTGATCCCGGGCCTGGTCAACCTGCATGGCCACGCCGCGATGTCGCTGTTTCGCGGCTTC
GCCGACGACCGCCCGCTGATGGCCTGGCTGACCGGGCACATCTGGCCGGCCGAGAAGAAGCACGTCTCCGAGACCTTCGT
GCGCGATGGCACCCTGCTCGCGGCGGCCGAGATGCTCGCCGGCGGCATCACCACCTGCAACGACATGTACTTCTTCCCGC
GGGCGGCGAGCGAAGCCTTCCTGCAGGCCGGCATGCGCGCGGTCGTCGGCATGATCGTGCTCGAATTCCCGACCGCCTAC
GCCGCGGACGCCGACGGCTATCTGTCCAAGGGGCTCGCGCTGCGCGACGAATTCAGGGGCGAGCCGCTGCTCGGCTTCGC
CTTCGCGCCGCACGCGCCGTACACGGTCTCGGACACAAGCTTCAGCCGTATCCACACCTTGGCCGACCAGCTCGGCCTGC
CGATCCACACCCACATCCACGAAACCCGGGACGAGATCGCCGACAGCCTCAAGGAGCATGGCGTGCGTCCGCTCGAGCGG
CTCGCCCGGCTCGGCCTGCTCGGGCCGAACTTCATCGGCGTGCACGCCGTGCACATGACCGAGGCCGAAACGGAGTTGCT
GGCCGAGCACGGCTGCCACATCGCCCATTGCCCGACTTCCAACCTCAAGCTCGCATCGGGCGTCGCGCCCGTGGCCGAGT
TCGCGCGCGCCGGCGTCGGCGTCGGCCTCGGTACCGATGGCGCCGCGAGCAGCAACCGCCTCGACCTCTTCGCCGAAATG
CGGCTGGCCGCGCTGCTCGCCAAGGGCATGAGCGGCGACGCCGCCGCGCTGCCCGCGGCCGCGGCGCTGAAAGCGGCCAC
GCTCGACGGCGCACGCGCGCTCAACCTCGATAGCGAGATCGGCAGCATCGCTGCCGGCAAGCGGGCCGACCTCGTCGCCG
TGAACCTGCACGGCGTATCGCGGCAGCCCGTGTTTGACCCGGCTTCGCACCTGGTTTACGTTGCGGGGCGCGAAGACGTC
ACCCACGTCTGGGTCGACGGCAAGCCCAAACTCAGGGAACGCAGCCTGGTCGGGCTCGACGCCGACGACCTCGCCGCCCG
CGCCGTCTACTGGCGCACCAAACTCACCGCAGAAGGACAGTCATGA

Upstream 100 bases:

>100_bases
CCGGCTTTATACCCAAGCTTCAAAGAGGGCGATTTTAGCATGGCCGCCTGCCCCGCCCGCCTTTGCCAAACGGCAGGCAA
ACAGTGAGAATGCGGCCACC

Downstream 100 bases:

>100_bases
GCAACGTCGACGCTGCCGAAATCGCCAAGTTTTCCGAGCTTGCCCACCGCTGGTGGGACCCGAACTCCGAATTCAAGCCG
CTGCACGAAATCAACCCGCT

Product: N-ethylammeline chlorohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MKASADLLLLPQWVVPVDPEGVLTDHAVVVADGRIVDVLPAEVARARYAAAKTVALPGEALIPGLVNLHGHAAMSLFRGF
ADDRPLMAWLTGHIWPAEKKHVSETFVRDGTLLAAAEMLAGGITTCNDMYFFPRAASEAFLQAGMRAVVGMIVLEFPTAY
AADADGYLSKGLALRDEFRGEPLLGFAFAPHAPYTVSDTSFSRIHTLADQLGLPIHTHIHETRDEIADSLKEHGVRPLER
LARLGLLGPNFIGVHAVHMTEAETELLAEHGCHIAHCPTSNLKLASGVAPVAEFARAGVGVGLGTDGAASSNRLDLFAEM
RLAALLAKGMSGDAAALPAAAALKAATLDGARALNLDSEIGSIAAGKRADLVAVNLHGVSRQPVFDPASHLVYVAGREDV
THVWVDGKPKLRERSLVGLDADDLAARAVYWRTKLTAEGQS

Sequences:

>Translated_441_residues
MKASADLLLLPQWVVPVDPEGVLTDHAVVVADGRIVDVLPAEVARARYAAAKTVALPGEALIPGLVNLHGHAAMSLFRGF
ADDRPLMAWLTGHIWPAEKKHVSETFVRDGTLLAAAEMLAGGITTCNDMYFFPRAASEAFLQAGMRAVVGMIVLEFPTAY
AADADGYLSKGLALRDEFRGEPLLGFAFAPHAPYTVSDTSFSRIHTLADQLGLPIHTHIHETRDEIADSLKEHGVRPLER
LARLGLLGPNFIGVHAVHMTEAETELLAEHGCHIAHCPTSNLKLASGVAPVAEFARAGVGVGLGTDGAASSNRLDLFAEM
RLAALLAKGMSGDAAALPAAAALKAATLDGARALNLDSEIGSIAAGKRADLVAVNLHGVSRQPVFDPASHLVYVAGREDV
THVWVDGKPKLRERSLVGLDADDLAARAVYWRTKLTAEGQS
>Mature_441_residues
MKASADLLLLPQWVVPVDPEGVLTDHAVVVADGRIVDVLPAEVARARYAAAKTVALPGEALIPGLVNLHGHAAMSLFRGF
ADDRPLMAWLTGHIWPAEKKHVSETFVRDGTLLAAAEMLAGGITTCNDMYFFPRAASEAFLQAGMRAVVGMIVLEFPTAY
AADADGYLSKGLALRDEFRGEPLLGFAFAPHAPYTVSDTSFSRIHTLADQLGLPIHTHIHETRDEIADSLKEHGVRPLER
LARLGLLGPNFIGVHAVHMTEAETELLAEHGCHIAHCPTSNLKLASGVAPVAEFARAGVGVGLGTDGAASSNRLDLFAEM
RLAALLAKGMSGDAAALPAAAALKAATLDGARALNLDSEIGSIAAGKRADLVAVNLHGVSRQPVFDPASHLVYVAGREDV
THVWVDGKPKLRERSLVGLDADDLAARAVYWRTKLTAEGQS

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=392, Percent_Identity=27.8061224489796, Blast_Score=132, Evalue=6e-31,
Organism=Escherichia coli, GI1789249, Length=347, Percent_Identity=28.8184438040346, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI87082177, Length=404, Percent_Identity=25, Blast_Score=83, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17540282, Length=394, Percent_Identity=23.3502538071066, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319963, Length=370, Percent_Identity=23.7837837837838, Blast_Score=107, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24643849, Length=380, Percent_Identity=29.7368421052632, Blast_Score=125, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 46707; Mature: 46707

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKASADLLLLPQWVVPVDPEGVLTDHAVVVADGRIVDVLPAEVARARYAAAKTVALPGEA
CCCCCCEEEECCEECCCCCCCCEECCEEEEECCEEEEECCHHHHHHHHHHHHEEECCCHH
LIPGLVNLHGHAAMSLFRGFADDRPLMAWLTGHIWPAEKKHVSETFVRDGTLLAAAEMLA
HCCHHHHCCHHHHHHHHHHCCCCCCHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHH
GGITTCNDMYFFPRAASEAFLQAGMRAVVGMIVLEFPTAYAADADGYLSKGLALRDEFRG
CCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCHHHHHCC
EPLLGFAFAPHAPYTVSDTSFSRIHTLADQLGLPIHTHIHETRDEIADSLKEHGVRPLER
CCEEEEEECCCCCEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHH
LARLGLLGPNFIGVHAVHMTEAETELLAEHGCHIAHCPTSNLKLASGVAPVAEFARAGVG
HHHHCCCCCCCEEEEEEEECHHHHHHHHHCCCEEEECCCCCCCHHCCCHHHHHHHHCCCC
VGLGTDGAASSNRLDLFAEMRLAALLAKGMSGDAAALPAAAALKAATLDGARALNLDSEI
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHCCCCEEECCCHHH
GSIAAGKRADLVAVNLHGVSRQPVFDPASHLVYVAGREDVTHVWVDGKPKLRERSLVGLD
HHHCCCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCEECCC
ADDLAARAVYWRTKLTAEGQS
HHHHHHHHHEEEEEEECCCCC
>Mature Secondary Structure
MKASADLLLLPQWVVPVDPEGVLTDHAVVVADGRIVDVLPAEVARARYAAAKTVALPGEA
CCCCCCEEEECCEECCCCCCCCEECCEEEEECCEEEEECCHHHHHHHHHHHHEEECCCHH
LIPGLVNLHGHAAMSLFRGFADDRPLMAWLTGHIWPAEKKHVSETFVRDGTLLAAAEMLA
HCCHHHHCCHHHHHHHHHHCCCCCCHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHH
GGITTCNDMYFFPRAASEAFLQAGMRAVVGMIVLEFPTAYAADADGYLSKGLALRDEFRG
CCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCHHHHHCC
EPLLGFAFAPHAPYTVSDTSFSRIHTLADQLGLPIHTHIHETRDEIADSLKEHGVRPLER
CCEEEEEECCCCCEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHH
LARLGLLGPNFIGVHAVHMTEAETELLAEHGCHIAHCPTSNLKLASGVAPVAEFARAGVG
HHHHCCCCCCCEEEEEEEECHHHHHHHHHCCCEEEECCCCCCCHHCCCHHHHHHHHCCCC
VGLGTDGAASSNRLDLFAEMRLAALLAKGMSGDAAALPAAAALKAATLDGARALNLDSEI
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHCCCCEEECCCHHH
GSIAAGKRADLVAVNLHGVSRQPVFDPASHLVYVAGREDVTHVWVDGKPKLRERSLVGLD
HHHCCCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCEECCC
ADDLAARAVYWRTKLTAEGQS
HHHHHHHHHEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA