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The map label for this gene is thrC [H]

Identifier: 74316862

GI number: 74316862

Start: 893626

End: 895068

Strand: Direct

Name: thrC [H]

Synonym: Tbd_0844

Alternate gene names: 74316862

Gene position: 893626-895068 (Clockwise)

Preceding gene: 74316861

Following gene: 74316863

Centisome position: 30.71

GC content: 65.21

Gene sequence:

>1443_bases
ATGAACTACCTCAGCACGCGGGGCCTCGCGCCGCAACTCCGCTTTTCCGACATCCTGCTCGGCGGGCTGGCCGACGACGG
CGGCCTCTACGTGCCCGAGGCGTACCCGCGTTTCACGGCGGCCGAGCTCGAGGCGATGCGGGCGATGAACTACCGCGAAC
TCGCGTTCGCGGTGCTGTCGCGACTCGTCGACGACATTCCGGCGGACGACCTGCGCGCGCTGATCGACAAGACCTATACC
GCCGACGTCTACCGCTATGTCGGCCGCGGCGAGAATGCTGCCGACATCACGCCGCTCAAGACGCTGGAGCCCGGTCTGCA
CGTGCTCGCGCTGTCGAACGGCCCGACGCTCGCGTTCAAGGACATGGCGATGCAGCTCCTCGGCAACCTGTTCGAGTACG
TGCTCGGCAAGACCGGGGGCGAACTCAACATCGTCGGCGCGACCTCGGGCGACACGGGTTCGGCGGCCGAATACGCCATG
CGCGGCAAGAAGGGCGTGCGCGTCTTCATGCTGTCGCCGGAGCATGGCATGACGCGCTTCCAGCAGGCGCAGATGTACGC
GCTGCGCGACGACAACATCCACAACCTCGTGATTCGCGGCGTCTTCGACCAATGCCAGGACATGGTCAAGGCCGTGGCGA
ACGACCTGCCGTTCAAGGCGAAATACCATATCGGCGCGGTCAACTCGATCAACTGGGCGCGCGTCGCGGCGCAGAGCGTC
TACTACTTCAAGGCGTATTTCGCGGCGACCCACAGCAACACGCAAAGCGTTTCGTTCTCGGTGCCGTCGGGCAATTTCGG
CAACGTCTATGCCGGGCACGTCGCGCGCCAGATGGGCCTGCCGATCAACAAGCTGATCGTCGCGACCAACGAGAACGACG
TGCTCGACGAATTCTTCAAGACCGGCGTCTACCGTCCGCGCCCGGAGACAAAACACACGTCGAGCCCCTCGATGGATATT
TCCAAGGCATCGAATTTCGAACGCTTCGTCTTCGACCTGAGCGGCCGCGACGTCGCGAAGGTGCGCGACCTCTGGCGCGC
GGTCGAGTCGGGCGGCAGCTTCGATCTCAAGACCCACGCCGCGCCGGGCGGCGGCAGCTTGTTCGAGCGCATCGCCGATT
TCGGCATGGTCTCGGGTTCGAGCAACCATGCCAACCGCATCGACACGATCCGTACGGTCTACGAGGTCTACGGCACGATG
ATCGATCCACACACGGCCGACGGCCTCAAGGTCGGGCTCGAGCACCGCGAGCCGGGCGTGCCGCTCGTGTGCATGGAAAC
GGCGCAGCCCGCCAAGTTCGAGGACGCGATTCGCGAAGCGCTCGGCATCGACCCGGTCCGTCCGGCCGAGCTCGCCGACC
TCGAAACCCAGCCGCAGAAGAAGCACGTCATGGACGCCGACGTCGATGCGGTCAAGCGCTTCCTCGTCGAACACGCCGGC
TGA

Upstream 100 bases:

>100_bases
CGCTCGAGAAGAACGTCAACGCCGCGATCGCGAAGATCGAAGCGCTCGACGCCGTGGCGGGCAAGGTCATGCGCATCCGA
CTCGAGGACCTGGGCGCCAA

Downstream 100 bases:

>100_bases
GCCGCACGGCACGGGCACGGTGCCGCGCGGGCAGTCTGCCGCCGGCGGCGCCTTCGCCGACCTGCTCGCGCGCGTCGCCG
CCTGCACCGCCTGCGCCGAA

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 480; Mature: 480

Protein sequence:

>480_residues
MNYLSTRGLAPQLRFSDILLGGLADDGGLYVPEAYPRFTAAELEAMRAMNYRELAFAVLSRLVDDIPADDLRALIDKTYT
ADVYRYVGRGENAADITPLKTLEPGLHVLALSNGPTLAFKDMAMQLLGNLFEYVLGKTGGELNIVGATSGDTGSAAEYAM
RGKKGVRVFMLSPEHGMTRFQQAQMYALRDDNIHNLVIRGVFDQCQDMVKAVANDLPFKAKYHIGAVNSINWARVAAQSV
YYFKAYFAATHSNTQSVSFSVPSGNFGNVYAGHVARQMGLPINKLIVATNENDVLDEFFKTGVYRPRPETKHTSSPSMDI
SKASNFERFVFDLSGRDVAKVRDLWRAVESGGSFDLKTHAAPGGGSLFERIADFGMVSGSSNHANRIDTIRTVYEVYGTM
IDPHTADGLKVGLEHREPGVPLVCMETAQPAKFEDAIREALGIDPVRPAELADLETQPQKKHVMDADVDAVKRFLVEHAG

Sequences:

>Translated_480_residues
MNYLSTRGLAPQLRFSDILLGGLADDGGLYVPEAYPRFTAAELEAMRAMNYRELAFAVLSRLVDDIPADDLRALIDKTYT
ADVYRYVGRGENAADITPLKTLEPGLHVLALSNGPTLAFKDMAMQLLGNLFEYVLGKTGGELNIVGATSGDTGSAAEYAM
RGKKGVRVFMLSPEHGMTRFQQAQMYALRDDNIHNLVIRGVFDQCQDMVKAVANDLPFKAKYHIGAVNSINWARVAAQSV
YYFKAYFAATHSNTQSVSFSVPSGNFGNVYAGHVARQMGLPINKLIVATNENDVLDEFFKTGVYRPRPETKHTSSPSMDI
SKASNFERFVFDLSGRDVAKVRDLWRAVESGGSFDLKTHAAPGGGSLFERIADFGMVSGSSNHANRIDTIRTVYEVYGTM
IDPHTADGLKVGLEHREPGVPLVCMETAQPAKFEDAIREALGIDPVRPAELADLETQPQKKHVMDADVDAVKRFLVEHAG
>Mature_480_residues
MNYLSTRGLAPQLRFSDILLGGLADDGGLYVPEAYPRFTAAELEAMRAMNYRELAFAVLSRLVDDIPADDLRALIDKTYT
ADVYRYVGRGENAADITPLKTLEPGLHVLALSNGPTLAFKDMAMQLLGNLFEYVLGKTGGELNIVGATSGDTGSAAEYAM
RGKKGVRVFMLSPEHGMTRFQQAQMYALRDDNIHNLVIRGVFDQCQDMVKAVANDLPFKAKYHIGAVNSINWARVAAQSV
YYFKAYFAATHSNTQSVSFSVPSGNFGNVYAGHVARQMGLPINKLIVATNENDVLDEFFKTGVYRPRPETKHTSSPSMDI
SKASNFERFVFDLSGRDVAKVRDLWRAVESGGSFDLKTHAAPGGGSLFERIADFGMVSGSSNHANRIDTIRTVYEVYGTM
IDPHTADGLKVGLEHREPGVPLVCMETAQPAKFEDAIREALGIDPVRPAELADLETQPQKKHVMDADVDAVKRFLVEHAG

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=473, Percent_Identity=31.2896405919662, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI153792148, Length=482, Percent_Identity=31.7427385892116, Blast_Score=221, Evalue=1e-57,
Organism=Escherichia coli, GI1786185, Length=468, Percent_Identity=28.4188034188034, Blast_Score=189, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6319901, Length=476, Percent_Identity=39.4957983193277, Blast_Score=324, Evalue=2e-89,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 52643; Mature: 52643

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYLSTRGLAPQLRFSDILLGGLADDGGLYVPEAYPRFTAAELEAMRAMNYRELAFAVLS
CCCCCCCCCCCCCCHHHEEEECCCCCCCEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHH
RLVDDIPADDLRALIDKTYTADVYRYVGRGENAADITPLKTLEPGLHVLALSNGPTLAFK
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCEEEEEECCCCCCHHH
DMAMQLLGNLFEYVLGKTGGELNIVGATSGDTGSAAEYAMRGKKGVRVFMLSPEHGMTRF
HHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHCCCCCCEEEEECCCHHHHHH
QQAQMYALRDDNIHNLVIRGVFDQCQDMVKAVANDLPFKAKYHIGAVNSINWARVAAQSV
HHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHH
YYFKAYFAATHSNTQSVSFSVPSGNFGNVYAGHVARQMGLPINKLIVATNENDVLDEFFK
HHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCHHHEEEEECCCHHHHHHHH
TGVYRPRPETKHTSSPSMDISKASNFERFVFDLSGRDVAKVRDLWRAVESGGSFDLKTHA
CCCCCCCCCCCCCCCCCCCHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEECC
APGGGSLFERIADFGMVSGSSNHANRIDTIRTVYEVYGTMIDPHTADGLKVGLEHREPGV
CCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCC
PLVCMETAQPAKFEDAIREALGIDPVRPAELADLETQPQKKHVMDADVDAVKRFLVEHAG
CEEEECCCCCCHHHHHHHHHHCCCCCCCCHHHCCCCCCHHHHCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MNYLSTRGLAPQLRFSDILLGGLADDGGLYVPEAYPRFTAAELEAMRAMNYRELAFAVLS
CCCCCCCCCCCCCCHHHEEEECCCCCCCEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHH
RLVDDIPADDLRALIDKTYTADVYRYVGRGENAADITPLKTLEPGLHVLALSNGPTLAFK
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCEEEEEECCCCCCHHH
DMAMQLLGNLFEYVLGKTGGELNIVGATSGDTGSAAEYAMRGKKGVRVFMLSPEHGMTRF
HHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHCCCCCCEEEEECCCHHHHHH
QQAQMYALRDDNIHNLVIRGVFDQCQDMVKAVANDLPFKAKYHIGAVNSINWARVAAQSV
HHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHH
YYFKAYFAATHSNTQSVSFSVPSGNFGNVYAGHVARQMGLPINKLIVATNENDVLDEFFK
HHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCHHHEEEEECCCHHHHHHHH
TGVYRPRPETKHTSSPSMDISKASNFERFVFDLSGRDVAKVRDLWRAVESGGSFDLKTHA
CCCCCCCCCCCCCCCCCCCHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEECC
APGGGSLFERIADFGMVSGSSNHANRIDTIRTVYEVYGTMIDPHTADGLKVGLEHREPGV
CCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCC
PLVCMETAQPAKFEDAIREALGIDPVRPAELADLETQPQKKHVMDADVDAVKRFLVEHAG
CEEEECCCCCCHHHHHHHHHHCCCCCCCCHHHCCCCCCHHHHCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8117070 [H]