Click here to switch to the map view.

The map label for this gene is hom [H]

Identifier: 74316861

GI number: 74316861

Start: 892316

End: 893629

Strand: Direct

Name: hom [H]

Synonym: Tbd_0843

Alternate gene names: 74316861

Gene position: 892316-893629 (Clockwise)

Preceding gene: 74316860

Following gene: 74316862

Centisome position: 30.67

GC content: 66.59

Gene sequence:

>1314_bases
ATGAAGCCCATCCATGTCGGCCTCCTAGGCCTTGGAACCGTCGGCGGCGGCACGCTCACCGTGCTGCGCCGCAACGCCGA
AGAAATTACCCGCCGCGCCGGCCGCGAGATTCGCGTCGTGCGCGCGGCCGTCCGCAACCTCGACAAAGCCGAGGCGCTCG
CAGGCGGCCTGCCGCTGACGACCAATCCCTTCGACGTCGTCGACGATCCCGAGATAGACATCGTCGTCGAACTGATCGGC
GGGCTCGAGCCGGCGCGCGAACTCGTCATGCAGGCGATCGCCAACGGCAAGCACGTCGTCACCGCCAACAAGCACCTCGT
CGCCAAGTACGGCAACGAGATCTTCGCGGCGGCGCAGGCCAAGGGCGTGATGGTCACCTTCGAGGCCGCCGTCGCAGGCG
GCATCCCGATCATCAAGGCCTTGCGCGAAGGTCTCACGGCCAACCGCATCGAGTGGCTCGCCGGCATCATCAACGGCACC
AGTAATTTCATCCTGAGCGAAATGCGCGACAAGGGCGCGGCCTTCGACGACGTGTTGAAGGAAGCGCAGCGCCTCGGCTA
CGCGGAAGCCGACCCGACCTTCGACATCGAGGGCATCGATGCGGCGCACAAGCTCACGATCCTCTCCGCGATCGCGTTCG
GCATCCCGATGCAGTTCGAACGTGCCTATACCGAGGGGATTTCGCAGCTGACGCGCGAGGACGTGCGCTACGCCGAGGAA
CTCGGCTACCGCATCAAGCTTCTCGGCATCGCGCGTCGCGCCGAAAACGGCATCGAACTGCGCGTGCACCCGACGCTGAT
TCCCGAGCGCCGCCTGATCGCCAACGTCGACGGCGCGATGAACGCGGTGCTCGTCAAGGGCGACGCGGTCGGGCCGACGC
TCTACTACGGCGCAGGTGCCGGCAGCGAGCCGACGGCGTCGGCCGTCGTCGCCGATCTCGTCGACGTGACGCGTCTGCAC
ACGGCCGATCCGCATCACCGCGTGCCGCATCTGGCGTTCCAGCCGGACCAGCTGGCCGACACGCCGATCCTGCCGATGGA
AGCGGTGCGCACCGCGTATTACCTGCGGCTGCGTGCTTTCGACCGGCCCGGCGTGCTCGCCGACATCACGCGCATCCTCG
CCGACAGCAGTATTTCGATCGACGCGATGGTGCAGAAAGAGCCCGCCGAGGGCGAGGAGCAGGTCGACATCATCCTGCTG
ACCCACGTCACGCTCGAGAAGAACGTCAACGCCGCGATCGCGAAGATCGAAGCGCTCGACGCCGTGGCGGGCAAGGTCAT
GCGCATCCGACTCGAGGACCTGGGCGCCAAATGA

Upstream 100 bases:

>100_bases
CCGCACGAAGAGGATTTGACCGAGGCGATCGGACGCATGAGCCGTTTCCTCGATCGCCAGCGCGCGCATCGCTGACTTTT
ACCGGAACCAGACGAGAACA

Downstream 100 bases:

>100_bases
ACTACCTCAGCACGCGGGGCCTCGCGCCGCAACTCCGCTTTTCCGACATCCTGCTCGGCGGGCTGGCCGACGACGGCGGC
CTCTACGTGCCCGAGGCGTA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MKPIHVGLLGLGTVGGGTLTVLRRNAEEITRRAGREIRVVRAAVRNLDKAEALAGGLPLTTNPFDVVDDPEIDIVVELIG
GLEPARELVMQAIANGKHVVTANKHLVAKYGNEIFAAAQAKGVMVTFEAAVAGGIPIIKALREGLTANRIEWLAGIINGT
SNFILSEMRDKGAAFDDVLKEAQRLGYAEADPTFDIEGIDAAHKLTILSAIAFGIPMQFERAYTEGISQLTREDVRYAEE
LGYRIKLLGIARRAENGIELRVHPTLIPERRLIANVDGAMNAVLVKGDAVGPTLYYGAGAGSEPTASAVVADLVDVTRLH
TADPHHRVPHLAFQPDQLADTPILPMEAVRTAYYLRLRAFDRPGVLADITRILADSSISIDAMVQKEPAEGEEQVDIILL
THVTLEKNVNAAIAKIEALDAVAGKVMRIRLEDLGAK

Sequences:

>Translated_437_residues
MKPIHVGLLGLGTVGGGTLTVLRRNAEEITRRAGREIRVVRAAVRNLDKAEALAGGLPLTTNPFDVVDDPEIDIVVELIG
GLEPARELVMQAIANGKHVVTANKHLVAKYGNEIFAAAQAKGVMVTFEAAVAGGIPIIKALREGLTANRIEWLAGIINGT
SNFILSEMRDKGAAFDDVLKEAQRLGYAEADPTFDIEGIDAAHKLTILSAIAFGIPMQFERAYTEGISQLTREDVRYAEE
LGYRIKLLGIARRAENGIELRVHPTLIPERRLIANVDGAMNAVLVKGDAVGPTLYYGAGAGSEPTASAVVADLVDVTRLH
TADPHHRVPHLAFQPDQLADTPILPMEAVRTAYYLRLRAFDRPGVLADITRILADSSISIDAMVQKEPAEGEEQVDIILL
THVTLEKNVNAAIAKIEALDAVAGKVMRIRLEDLGAK
>Mature_437_residues
MKPIHVGLLGLGTVGGGTLTVLRRNAEEITRRAGREIRVVRAAVRNLDKAEALAGGLPLTTNPFDVVDDPEIDIVVELIG
GLEPARELVMQAIANGKHVVTANKHLVAKYGNEIFAAAQAKGVMVTFEAAVAGGIPIIKALREGLTANRIEWLAGIINGT
SNFILSEMRDKGAAFDDVLKEAQRLGYAEADPTFDIEGIDAAHKLTILSAIAFGIPMQFERAYTEGISQLTREDVRYAEE
LGYRIKLLGIARRAENGIELRVHPTLIPERRLIANVDGAMNAVLVKGDAVGPTLYYGAGAGSEPTASAVVADLVDVTRLH
TADPHHRVPHLAFQPDQLADTPILPMEAVRTAYYLRLRAFDRPGVLADITRILADSSISIDAMVQKEPAEGEEQVDIILL
THVTLEKNVNAAIAKIEALDAVAGKVMRIRLEDLGAK

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=245, Percent_Identity=27.3469387755102, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322599, Length=162, Percent_Identity=31.4814814814815, Blast_Score=73, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 47058; Mature: 47058

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS01042 HOMOSER_DHGENASE ; PS00318 HMG_COA_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPIHVGLLGLGTVGGGTLTVLRRNAEEITRRAGREIRVVRAAVRNLDKAEALAGGLPLT
CCCEEEEEEEECCCCCCEEEEEECCHHHHHHHCCCHHHHHHHHHHCCHHHHHHHCCCCCC
TNPFDVVDDPEIDIVVELIGGLEPARELVMQAIANGKHVVTANKHLVAKYGNEIFAAAQA
CCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCEEEEHHCCHHEEECCC
KGVMVTFEAAVAGGIPIIKALREGLTANRIEWLAGIINGTSNFILSEMRDKGAAFDDVLK
CCEEEEEEHHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHH
EAQRLGYAEADPTFDIEGIDAAHKLTILSAIAFGIPMQFERAYTEGISQLTREDVRYAEE
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
LGYRIKLLGIARRAENGIELRVHPTLIPERRLIANVDGAMNAVLVKGDAVGPTLYYGAGA
CCCEEEEEEEHHHCCCCCEEEEECCCCCCCHHHCCCCCCCEEEEEECCCCCCEEEECCCC
GSEPTASAVVADLVDVTRLHTADPHHRVPHLAFQPDQLADTPILPMEAVRTAYYLRLRAF
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHEEEEC
DRPGVLADITRILADSSISIDAMVQKEPAEGEEQVDIILLTHVTLEKNVNAAIAKIEALD
CCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEEEEEEEEECCCCCHHHHHHHHHH
AVAGKVMRIRLEDLGAK
HHHHHEEEEEEHHCCCC
>Mature Secondary Structure
MKPIHVGLLGLGTVGGGTLTVLRRNAEEITRRAGREIRVVRAAVRNLDKAEALAGGLPLT
CCCEEEEEEEECCCCCCEEEEEECCHHHHHHHCCCHHHHHHHHHHCCHHHHHHHCCCCCC
TNPFDVVDDPEIDIVVELIGGLEPARELVMQAIANGKHVVTANKHLVAKYGNEIFAAAQA
CCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCEEEEHHCCHHEEECCC
KGVMVTFEAAVAGGIPIIKALREGLTANRIEWLAGIINGTSNFILSEMRDKGAAFDDVLK
CCEEEEEEHHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHH
EAQRLGYAEADPTFDIEGIDAAHKLTILSAIAFGIPMQFERAYTEGISQLTREDVRYAEE
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
LGYRIKLLGIARRAENGIELRVHPTLIPERRLIANVDGAMNAVLVKGDAVGPTLYYGAGA
CCCEEEEEEEHHHCCCCCEEEEECCCCCCCHHHCCCCCCCEEEEEECCCCCCEEEECCCC
GSEPTASAVVADLVDVTRLHTADPHHRVPHLAFQPDQLADTPILPMEAVRTAYYLRLRAF
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHEEEEC
DRPGVLADITRILADSSISIDAMVQKEPAEGEEQVDIILLTHVTLEKNVNAAIAKIEALD
CCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEEEEEEEEECCCCCHHHHHHHHHH
AVAGKVMRIRLEDLGAK
HHHHHEEEEEEHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]