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The map label for this gene is lpxB

Identifier: 74316816

GI number: 74316816

Start: 840829

End: 841947

Strand: Direct

Name: lpxB

Synonym: Tbd_0798

Alternate gene names: 74316816

Gene position: 840829-841947 (Clockwise)

Preceding gene: 74316815

Following gene: 74316817

Centisome position: 28.9

GC content: 70.06

Gene sequence:

>1119_bases
GTGGTTGCCGGCGAAGCGTCCGGTGACCTGCTCGGGGCGCATTTCTTCGACGCGCTGAAAAAAAACCGTCCGGGCCTCAC
CGCGGCCGGAATCGCCGGCCCGCGCATGGTGGAGGCGGGCGTGAAGGCGATTTATCCGAGCGAGAAGCTCGCGGTCAACG
GCTATGTCGAGGTGCTGCGTCATCTGCCCGAGTTGCTGTGGATACGCGCGCGCATCACCCGCCATTTCCTCCGCGAGCGG
CCGCGCGTCTTCGTCGGCATCGACGCGCCGGACTTCAATTTCACGCTTGAAGCAGCGCTCAAGCGCGCCGGCGTCCCGAC
GATCCACTTCGTCAGCCCGTCGATCTGGGCCTGGCGCCCCGAGCGCATCGAGCGCATCAAGCAGGCGGTGTCGCACATGC
TCGTGGTGTTCCCGTTCGAGGAAGCGATCTATCGCGACGCCGGCATTCCGGTCAGCTACGTCGGGCATCCGCTCGCCGAC
GTGATCCCGCTCCAAGCGCCGACCGGCGCGGCGCGCGCGACGCTCGGCCTCGGTGACGGCCCCATCGTCGCGCTGCTGCC
GGGCAGCCGGCTTTCGGAAGTCGACCGTCACGCACGCCTCATGCTCGAGGCGGCGATGCAGGTCCGCGCCAAGGAAATGG
ACGTGCGTTTCGTGCTGCCCGCAGCGAGCGAAGCGGCGCGCGAACGGATCGCGCGGGCGGCGCAGGGCCTCGATCTGCCG
CTCACGGTGCTCGCCGGGCGCTCGCACCAGGCGCTGGCGGCGTGCGACGTCGCCGTCGTCGCCTCGGGCACCGCGACGCT
CGAAGCGGCCCTGTTCAAGAAACCGATGGTGATCACCTACCGCGTTCCGGCGCTGACCGCCCGTCTGATGCGGAAAAAGG
CCCTGCTGCCGTGGATCGGGCTGCCGAATATTCTCGCGCGCGACTTTGTCGTGCCGGAACGGGTGCAGGAAGCGGCAACG
CCCGATGCGCTCGCGGCCGACGTCCTGGCCTGGCTCGGCGACGCCGCCCGGCGCGCGGCGCTCGCTGTCACCTTCGACGC
GCTGCATCGCGATCTGCGGCAGGGCGCGAGTGCGCGCATCGCCGCCGCGATCGCCCCCTACCTCGAGGCCGCGCGATGA

Upstream 100 bases:

>100_bases
CCAAGCTCGCCCCCGAGGCGGCGAAGCACGCCGAAGTGCAGCAGCTGCTCGATTTTCTTGCGCGCGCCGAGCGCGGCATC
ATCCGGTGATTGATCTCGGC

Downstream 100 bases:

>100_bases
CAGGGCGTCGAACCGTCTCGCTGCACGTCGGTCCGGTCGGGCTGTGTGGCGTCGACGAGGCGGGACGGGGGCCGCTCGCG
GGTCCCGTCGTCGCCGCAGC

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MVAGEASGDLLGAHFFDALKKNRPGLTAAGIAGPRMVEAGVKAIYPSEKLAVNGYVEVLRHLPELLWIRARITRHFLRER
PRVFVGIDAPDFNFTLEAALKRAGVPTIHFVSPSIWAWRPERIERIKQAVSHMLVVFPFEEAIYRDAGIPVSYVGHPLAD
VIPLQAPTGAARATLGLGDGPIVALLPGSRLSEVDRHARLMLEAAMQVRAKEMDVRFVLPAASEAARERIARAAQGLDLP
LTVLAGRSHQALAACDVAVVASGTATLEAALFKKPMVITYRVPALTARLMRKKALLPWIGLPNILARDFVVPERVQEAAT
PDALAADVLAWLGDAARRAALAVTFDALHRDLRQGASARIAAAIAPYLEAAR

Sequences:

>Translated_372_residues
MVAGEASGDLLGAHFFDALKKNRPGLTAAGIAGPRMVEAGVKAIYPSEKLAVNGYVEVLRHLPELLWIRARITRHFLRER
PRVFVGIDAPDFNFTLEAALKRAGVPTIHFVSPSIWAWRPERIERIKQAVSHMLVVFPFEEAIYRDAGIPVSYVGHPLAD
VIPLQAPTGAARATLGLGDGPIVALLPGSRLSEVDRHARLMLEAAMQVRAKEMDVRFVLPAASEAARERIARAAQGLDLP
LTVLAGRSHQALAACDVAVVASGTATLEAALFKKPMVITYRVPALTARLMRKKALLPWIGLPNILARDFVVPERVQEAAT
PDALAADVLAWLGDAARRAALAVTFDALHRDLRQGASARIAAAIAPYLEAAR
>Mature_372_residues
MVAGEASGDLLGAHFFDALKKNRPGLTAAGIAGPRMVEAGVKAIYPSEKLAVNGYVEVLRHLPELLWIRARITRHFLRER
PRVFVGIDAPDFNFTLEAALKRAGVPTIHFVSPSIWAWRPERIERIKQAVSHMLVVFPFEEAIYRDAGIPVSYVGHPLAD
VIPLQAPTGAARATLGLGDGPIVALLPGSRLSEVDRHARLMLEAAMQVRAKEMDVRFVLPAASEAARERIARAAQGLDLP
LTVLAGRSHQALAACDVAVVASGTATLEAALFKKPMVITYRVPALTARLMRKKALLPWIGLPNILARDFVVPERVQEAAT
PDALAADVLAWLGDAARRAALAVTFDALHRDLRQGASARIAAAIAPYLEAAR

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=367, Percent_Identity=43.0517711171662, Blast_Score=267, Evalue=9e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_THIDA (Q3SKM8)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_314556.1
- ProteinModelPortal:   Q3SKM8
- STRING:   Q3SKM8
- GeneID:   3673495
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_0798
- NMPDR:   fig|292415.3.peg.105
- eggNOG:   COG0763
- HOGENOM:   HBG584837
- OMA:   DFTHRVA
- PhylomeDB:   Q3SKM8
- BioCyc:   TDEN292415:TBD_0798-MONOMER
- HAMAP:   MF_00392
- InterPro:   IPR003835
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 40189; Mature: 40189

Theoretical pI: Translated: 10.36; Mature: 10.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAGEASGDLLGAHFFDALKKNRPGLTAAGIAGPRMVEAGVKAIYPSEKLAVNGYVEVLR
CCCCCCCCCHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHH
HLPELLWIRARITRHFLRERPRVFVGIDAPDFNFTLEAALKRAGVPTIHFVSPSIWAWRP
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCH
ERIERIKQAVSHMLVVFPFEEAIYRDAGIPVSYVGHPLADVIPLQAPTGAARATLGLGDG
HHHHHHHHHHHHEEEEEEHHHHHHHCCCCCHHHCCCCHHHHCCCCCCCCCCCEEEECCCC
PIVALLPGSRLSEVDRHARLMLEAAMQVRAKEMDVRFVLPAASEAARERIARAAQGLDLP
CEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHCCCCCC
LTVLAGRSHQALAACDVAVVASGTATLEAALFKKPMVITYRVPALTARLMRKKALLPWIG
EEEEECCCCCHHHHHCCCEEECCHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHCCCCCC
LPNILARDFVVPERVQEAATPDALAADVLAWLGDAARRAALAVTFDALHRDLRQGASARI
CCHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
AAAIAPYLEAAR
HHHHHHHHHHCC
>Mature Secondary Structure
MVAGEASGDLLGAHFFDALKKNRPGLTAAGIAGPRMVEAGVKAIYPSEKLAVNGYVEVLR
CCCCCCCCCHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHH
HLPELLWIRARITRHFLRERPRVFVGIDAPDFNFTLEAALKRAGVPTIHFVSPSIWAWRP
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCH
ERIERIKQAVSHMLVVFPFEEAIYRDAGIPVSYVGHPLADVIPLQAPTGAARATLGLGDG
HHHHHHHHHHHHEEEEEEHHHHHHHCCCCCHHHCCCCHHHHCCCCCCCCCCCEEEECCCC
PIVALLPGSRLSEVDRHARLMLEAAMQVRAKEMDVRFVLPAASEAARERIARAAQGLDLP
CEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHCCCCCC
LTVLAGRSHQALAACDVAVVASGTATLEAALFKKPMVITYRVPALTARLMRKKALLPWIG
EEEEECCCCCHHHHHCCCEEECCHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHCCCCCC
LPNILARDFVVPERVQEAATPDALAADVLAWLGDAARRAALAVTFDALHRDLRQGASARI
CCHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
AAAIAPYLEAAR
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA