Click here to switch to the map view.

The map label for this gene is lpxA

Identifier: 74316815

GI number: 74316815

Start: 840041

End: 840817

Strand: Direct

Name: lpxA

Synonym: Tbd_0797

Alternate gene names: 74316815

Gene position: 840041-840817 (Clockwise)

Preceding gene: 74316814

Following gene: 74316816

Centisome position: 28.87

GC content: 66.15

Gene sequence:

>777_bases
ATGGCGACGATTCACCCCACAGCGCTAGTCGCGCCGGGCGCGCGGCTGGCCGACGACGTCGAGATCGGGCCTTACAGCGT
GATCGGCGAGCACGTCGAAATCGGCGCGGGCACCACGGTCGGCGCGCACGCGGTCCTCACCGGCCACACCACGATCGGCG
AACGCAACAAGATCTTCCATTTCGTCTCGCTCGGCGAGGCGCCGCAGGACAAGAAATACGCCGGGGAGCCGACGCGCCTG
GAGATCGGCGACTACAACGTCATCCGCGAGTTCTGCACCTTCAATATCGGCACCGTGCAGGACCGCGGCGTCACGAGAAT
TGGCCACCACAACTGGATCATGGCCTACGTTCACATCGCGCACGATTGCGTCGTCGGCGACCGTACCATCTTCGCCAACA
ACGCCTCGCTCGCGGGACACGCCGAAGTCGGCGACTGGGCGATCCTCGGCGGCTTCACCGGCGTGCATCAGTTCTGCAAG
GTCGGCGCCCATGTGATGACCGGCATATCGAGCGTCGTCTTCAAGGACATCCCGCCTTTCGTCATGGCGTCCGGCCAGCC
CGCCGCGCCGCACGGGCTCAACAACGAAGGCCTCAAGCGCCGCGGATTTTCGGCCGAGGCCCTGTCTGCGCTGAAGCGCG
CCTACAAGATCCTCTACCGCGAGGGCAACACGCTCGCGGAAGCGCAGGCCAAGCTCGCCCCCGAGGCGGCGAAGCACGCC
GAAGTGCAGCAGCTGCTCGATTTTCTTGCGCGCGCCGAGCGCGGCATCATCCGGTGA

Upstream 100 bases:

>100_bases
GAAGTGCGTGGCATCTGGAAGTACACCGGACGTGCCGAGGTCGACGGCGCGCTGGTCGCCGAGGCCGAATTGATGGCGAC
GCTGCGCGACAAACCCTGAG

Downstream 100 bases:

>100_bases
TTGATCTCGGCGTGGTTGCCGGCGAAGCGTCCGGTGACCTGCTCGGGGCGCATTTCTTCGACGCGCTGAAAAAAAACCGT
CCGGGCCTCACCGCGGCCGG

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MATIHPTALVAPGARLADDVEIGPYSVIGEHVEIGAGTTVGAHAVLTGHTTIGERNKIFHFVSLGEAPQDKKYAGEPTRL
EIGDYNVIREFCTFNIGTVQDRGVTRIGHHNWIMAYVHIAHDCVVGDRTIFANNASLAGHAEVGDWAILGGFTGVHQFCK
VGAHVMTGISSVVFKDIPPFVMASGQPAAPHGLNNEGLKRRGFSAEALSALKRAYKILYREGNTLAEAQAKLAPEAAKHA
EVQQLLDFLARAERGIIR

Sequences:

>Translated_258_residues
MATIHPTALVAPGARLADDVEIGPYSVIGEHVEIGAGTTVGAHAVLTGHTTIGERNKIFHFVSLGEAPQDKKYAGEPTRL
EIGDYNVIREFCTFNIGTVQDRGVTRIGHHNWIMAYVHIAHDCVVGDRTIFANNASLAGHAEVGDWAILGGFTGVHQFCK
VGAHVMTGISSVVFKDIPPFVMASGQPAAPHGLNNEGLKRRGFSAEALSALKRAYKILYREGNTLAEAQAKLAPEAAKHA
EVQQLLDFLARAERGIIR
>Mature_257_residues
ATIHPTALVAPGARLADDVEIGPYSVIGEHVEIGAGTTVGAHAVLTGHTTIGERNKIFHFVSLGEAPQDKKYAGEPTRLE
IGDYNVIREFCTFNIGTVQDRGVTRIGHHNWIMAYVHIAHDCVVGDRTIFANNASLAGHAEVGDWAILGGFTGVHQFCKV
GAHVMTGISSVVFKDIPPFVMASGQPAAPHGLNNEGLKRRGFSAEALSALKRAYKILYREGNTLAEAQAKLAPEAAKHAE
VQQLLDFLARAERGIIR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily

Homologues:

Organism=Escherichia coli, GI1786378, Length=257, Percent_Identity=54.863813229572, Blast_Score=296, Evalue=1e-81,
Organism=Escherichia coli, GI1786376, Length=247, Percent_Identity=25.5060728744939, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXA_THIDA (Q3SKM9)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_314555.1
- ProteinModelPortal:   Q3SKM9
- SMR:   Q3SKM9
- STRING:   Q3SKM9
- GeneID:   3673494
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_0797
- NMPDR:   fig|292415.3.peg.104
- eggNOG:   COG1043
- HOGENOM:   HBG659295
- OMA:   GHTSIGE
- PhylomeDB:   Q3SKM9
- ProtClustDB:   PRK05289
- BioCyc:   TDEN292415:TBD_0797-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00387
- InterPro:   IPR010137
- InterPro:   IPR011004
- PIRSF:   PIRSF000456
- TIGRFAMs:   TIGR01852

Pfam domain/function: SSF51161 Trimer_LpxA_like

EC number: =2.3.1.129

Molecular weight: Translated: 27706; Mature: 27575

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIHPTALVAPGARLADDVEIGPYSVIGEHVEIGAGTTVGAHAVLTGHTTIGERNKIFH
CCCCCCCEEECCCCCCCCCCCCCCHHHHCCEEEECCCCCCCCEEEEECCCCCCCCCCEEE
FVSLGEAPQDKKYAGEPTRLEIGDYNVIREFCTFNIGTVQDRGVTRIGHHNWIMAYVHIA
EEECCCCCCCCCCCCCCCEEEECCHHHHHHHHCCCCCCCCCCCCEEECCCCHHHHHHHHH
HDCVVGDRTIFANNASLAGHAEVGDWAILGGFTGVHQFCKVGAHVMTGISSVVFKDIPPF
HHHEECCCEEEECCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VMASGQPAAPHGLNNEGLKRRGFSAEALSALKRAYKILYREGNTLAEAQAKLAPEAAKHA
EEECCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHH
EVQQLLDFLARAERGIIR
HHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ATIHPTALVAPGARLADDVEIGPYSVIGEHVEIGAGTTVGAHAVLTGHTTIGERNKIFH
CCCCCCEEECCCCCCCCCCCCCCHHHHCCEEEECCCCCCCCEEEEECCCCCCCCCCEEE
FVSLGEAPQDKKYAGEPTRLEIGDYNVIREFCTFNIGTVQDRGVTRIGHHNWIMAYVHIA
EEECCCCCCCCCCCCCCCEEEECCHHHHHHHHCCCCCCCCCCCCEEECCCCHHHHHHHHH
HDCVVGDRTIFANNASLAGHAEVGDWAILGGFTGVHQFCKVGAHVMTGISSVVFKDIPPF
HHHEECCCEEEECCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VMASGQPAAPHGLNNEGLKRRGFSAEALSALKRAYKILYREGNTLAEAQAKLAPEAAKHA
EEECCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHH
EVQQLLDFLARAERGIIR
HHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA