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The map label for this gene is dxr [H]

Identifier: 74316809

GI number: 74316809

Start: 833188

End: 834372

Strand: Direct

Name: dxr [H]

Synonym: Tbd_0791

Alternate gene names: 74316809

Gene position: 833188-834372 (Clockwise)

Preceding gene: 74316808

Following gene: 74316810

Centisome position: 28.63

GC content: 69.2

Gene sequence:

>1185_bases
GTGAGGCGCCGCGTTCTCACCGTCCTTGGCGCGACCGGGACGATAGGCGTCAATACGCTCGACGTCGTTTCACGCCACCC
CGAACGCTTCGAGATCTTCGCGCTCACGGGCGCGACCCAGGTCGAACGCATGTTTGAGCAGTGCCGCGCGCACCGGCCGC
GCTTCGCCGTCATGAGCGAGCCGGCCGCGGCGGCGGCGTTGCGCGCGCGACTTGCGGCCGACGGCCTTGCGGTCGAGGTG
CTCGAAGGCGCGGCCGCGCTGACAGAGGTCGCGATCGCGGCCGAAGTCGATACCGTCATGGCGGCGATCGTCGGCGCCGC
CGGTCTGCCGGCGACGCTCGCGGCGGCGCGCGCGGGCAAGCGCATCCTGCTCGCCAACAAGGAAACCCTCGTCGTCTCGG
GCCAGCTTTTCATGGACGCGGTCGCCGCCAGCGGCGCCGAACTCCTGCCGATCGATTCGGAACACAACGCGATCTTCCAG
GCCTTGCCGCGCGGATTCGACGGTGATTTCCAGCGCGCCGGCGTCAATACGCTGTGGCTCACCGCCTCCGGCGGCCCCTT
CCGCACGCTGTCGGCCGAGGCCATCGCGGCGGCGACACCCGAGCAGGCAGTGGCGCATCCGAACTGGGTCATGGGCAGAA
AGATCTCGGTCGATTCGGCGAGCCTCATGAACAAGGGGCTCGAAGTGATCGAGGCGCGCTGGCTGTTCAACGCGCGTCCC
GAGCAGATCAAGGTACTCGTGCACCCGCAGAGCATCGTGCATTCGATGGTCGAATACGTCGACGGCTCGGTGGTCGCGCA
AATGGGCACGCCCGACATGCGCACGCCGATCGCGTACGCACTCGGCTTTCCCGAACGGATCGCCGCCGGCGTGCCGATGC
TCGAACTCATGGGCAGGCAGCTCACGTTCGAAGCGCCCGACACGGTGCGCTTTCCCTGTCTGCAGCTCGCCTTCGACGCG
CTCGCGGCCGGCGGCAACGCCGCTGCCGTGCTGAACGCGGCCAACGAGGTCGCGGTCGCACGGTTTCTCGAAGGCGCGAT
CTCGTTTGGCGGCATCGCCGCGAGCATCGCCCACGCCCTCGATGCGGTGGCCGGGGGGCGCGCCGACACGCTCGACGAGC
TGCTCGACGCCGACCACCGGGCGCGTCGCGTCGCCGACGACTATCTCAGGTGCAGCTACGCATGA

Upstream 100 bases:

>100_bases
ACCTGCTGCCCGGTCACGGCGGCGTGCTCGACCGCATCGATGCGCTGACCTCGACGCTGCCCGTCGCTGCGGGACTCCTG
ATGTGGCTGGAGCACGGCGC

Downstream 100 bases:

>100_bases
ATCTGCTGACGACCCTGCTGTGGTTTCTGCTCGCCATCGGTATCCTCGTTGTGGCGCACGAGCTCGGCCATTATTTCGCG
GCGCGTCTGGCCGGCGTGAA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MRRRVLTVLGATGTIGVNTLDVVSRHPERFEIFALTGATQVERMFEQCRAHRPRFAVMSEPAAAAALRARLAADGLAVEV
LEGAAALTEVAIAAEVDTVMAAIVGAAGLPATLAAARAGKRILLANKETLVVSGQLFMDAVAASGAELLPIDSEHNAIFQ
ALPRGFDGDFQRAGVNTLWLTASGGPFRTLSAEAIAAATPEQAVAHPNWVMGRKISVDSASLMNKGLEVIEARWLFNARP
EQIKVLVHPQSIVHSMVEYVDGSVVAQMGTPDMRTPIAYALGFPERIAAGVPMLELMGRQLTFEAPDTVRFPCLQLAFDA
LAAGGNAAAVLNAANEVAVARFLEGAISFGGIAASIAHALDAVAGGRADTLDELLDADHRARRVADDYLRCSYA

Sequences:

>Translated_394_residues
MRRRVLTVLGATGTIGVNTLDVVSRHPERFEIFALTGATQVERMFEQCRAHRPRFAVMSEPAAAAALRARLAADGLAVEV
LEGAAALTEVAIAAEVDTVMAAIVGAAGLPATLAAARAGKRILLANKETLVVSGQLFMDAVAASGAELLPIDSEHNAIFQ
ALPRGFDGDFQRAGVNTLWLTASGGPFRTLSAEAIAAATPEQAVAHPNWVMGRKISVDSASLMNKGLEVIEARWLFNARP
EQIKVLVHPQSIVHSMVEYVDGSVVAQMGTPDMRTPIAYALGFPERIAAGVPMLELMGRQLTFEAPDTVRFPCLQLAFDA
LAAGGNAAAVLNAANEVAVARFLEGAISFGGIAASIAHALDAVAGGRADTLDELLDADHRARRVADDYLRCSYA
>Mature_394_residues
MRRRVLTVLGATGTIGVNTLDVVSRHPERFEIFALTGATQVERMFEQCRAHRPRFAVMSEPAAAAALRARLAADGLAVEV
LEGAAALTEVAIAAEVDTVMAAIVGAAGLPATLAAARAGKRILLANKETLVVSGQLFMDAVAASGAELLPIDSEHNAIFQ
ALPRGFDGDFQRAGVNTLWLTASGGPFRTLSAEAIAAATPEQAVAHPNWVMGRKISVDSASLMNKGLEVIEARWLFNARP
EQIKVLVHPQSIVHSMVEYVDGSVVAQMGTPDMRTPIAYALGFPERIAAGVPMLELMGRQLTFEAPDTVRFPCLQLAFDA
LAAGGNAAAVLNAANEVAVARFLEGAISFGGIAASIAHALDAVAGGRADTLDELLDADHRARRVADDYLRCSYA

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=388, Percent_Identity=53.6082474226804, Blast_Score=392, Evalue=1e-110,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 41528; Mature: 41528

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRRVLTVLGATGTIGVNTLDVVSRHPERFEIFALTGATQVERMFEQCRAHRPRFAVMSE
CCCEEEEEECCCCCCCCCHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEECC
PAAAAALRARLAADGLAVEVLEGAAALTEVAIAAEVDTVMAAIVGAAGLPATLAAARAGK
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCC
RILLANKETLVVSGQLFMDAVAASGAELLPIDSEHNAIFQALPRGFDGDFQRAGVNTLWL
EEEEECCCEEEEECHHHHHHHHCCCCEEEECCCCCHHHHHHCCCCCCCCHHHCCCCEEEE
TASGGPFRTLSAEAIAAATPEQAVAHPNWVMGRKISVDSASLMNKGLEVIEARWLFNARP
EECCCCCEECCHHHHHHCCCHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHCCCCC
EQIKVLVHPQSIVHSMVEYVDGSVVAQMGTPDMRTPIAYALGFPERIAAGVPMLELMGRQ
CCEEEEECCHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHCCCHHHHHCCCCHHHHCCCE
LTFEAPDTVRFPCLQLAFDALAAGGNAAAVLNAANEVAVARFLEGAISFGGIAASIAHAL
EEECCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DAVAGGRADTLDELLDADHRARRVADDYLRCSYA
HHHCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRRRVLTVLGATGTIGVNTLDVVSRHPERFEIFALTGATQVERMFEQCRAHRPRFAVMSE
CCCEEEEEECCCCCCCCCHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEECC
PAAAAALRARLAADGLAVEVLEGAAALTEVAIAAEVDTVMAAIVGAAGLPATLAAARAGK
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCC
RILLANKETLVVSGQLFMDAVAASGAELLPIDSEHNAIFQALPRGFDGDFQRAGVNTLWL
EEEEECCCEEEEECHHHHHHHHCCCCEEEECCCCCHHHHHHCCCCCCCCHHHCCCCEEEE
TASGGPFRTLSAEAIAAATPEQAVAHPNWVMGRKISVDSASLMNKGLEVIEARWLFNARP
EECCCCCEECCHHHHHHCCCHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHCCCCC
EQIKVLVHPQSIVHSMVEYVDGSVVAQMGTPDMRTPIAYALGFPERIAAGVPMLELMGRQ
CCEEEEECCHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHCCCHHHHHCCCCHHHHCCCE
LTFEAPDTVRFPCLQLAFDALAAGGNAAAVLNAANEVAVARFLEGAISFGGIAASIAHAL
EEECCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DAVAGGRADTLDELLDADHRARRVADDYLRCSYA
HHHCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA