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The map label for this gene is hflK [H]

Identifier: 74316621

GI number: 74316621

Start: 631538

End: 632725

Strand: Direct

Name: hflK [H]

Synonym: Tbd_0603

Alternate gene names: 74316621

Gene position: 631538-632725 (Clockwise)

Preceding gene: 74316620

Following gene: 74316622

Centisome position: 21.7

GC content: 65.57

Gene sequence:

>1188_bases
ATGGCCTGGAACGACCCGCAATGGGGCAACAAGGGCAACCGCAACAACAGCGGTCCGCCCGATCTGGACGAGCTTTGGCG
GCGCCTGAACCAGCGCCTCGGCGGCATGTTCGGCAACCGCTCGCCGCGCGGAGGCGGGGGCGGCGACGGCCTGCCTTCCA
ACATGCCGGGGGGCGGCAACTTCGTCGGACTGCTCATCGGCGCGCTGGTGATGATCTGGATCGCGAGCGGGTTCTACATC
GTCGACACCGGCCAGCGCGGCGTCGTCCTCCGCTTCGGCAAGTACGTCGAGACGACCGACCCGGGACCGCGCTGGCATCT
GCCGTGGCCGATCGAATCGCGCGAGATGGTCAACGTCGACCAGGTGCGTACGGTCGAGATCGGCTATCGCAACAACGTCC
GCAGCAAGGTGCTCAAGGAGTCGCTGATGCTGACCGACGACGAGAACATCATCGATCTGCAGTTCGCGGTGCAGTACATT
CTCAAGGACCCGCAGGATTTCCTCTTCATCAACCGCGCCCCCGAAGACACGGTGCTGCAGGTTGCGGAAACCGCGATGCG
CGAAATCGTCGGCAAGAACAAGATGGACTACGTGCTGTACGAAGGCCGGGCGGACATCGCCGCGCGCGCCAAGCTGCTGA
TGCAGCAGATACTCGACCGCTACAAGACCGGCATCAGCATCAGCCAGGTGACGCTGCAGAACATCCAGCCGCCCGAGCAG
GTGCAGGCCGCGTTCGACGACGCCGTCAAAGCGGGCCAGGACCGCGAGCGCCTGAAGAACGAAGCCGAGGCGTATTCGAA
CGACGTCGTTCCGCGCGCCCGCGGCCTTGCCTCGCGCCTCAAGGAGGAAGCCGAAGGCTACAAGCTCGCGGTAATCGCCA
ACGCCCAGGGTGAGGCGAGCCGCTTCGCGCAGATACTCGACGAATACCAGAAGGCGCCGCAAGTGACGCGCCAGCGGCTC
TACCTCGACACCATGCAGACCGTCATGAACAACAGCAGCAAAGTGCTCGTCGACCAGAAGGGCGGCAACAGCCTGTTGTA
TCTGCCGCTCGACAAGTTGCAGCAGATTGTCGGCCAGCCCGGCAGTGCGCTGCCCGAAGCCTTGGGATCGCCGACCGCGG
CGCCGCCCGCGGCGGCTGCGCGTACGCGCGACAGCCTGGGCGGACGTGACCGGGAGGAGCGGCCATGA

Upstream 100 bases:

>100_bases
TTTACGCGATGCCCTGTCAGAAACGCTGCTCGCGGCACGCGAAACGGGTGCATCGGAAACGCCTTCTTCCCCATCCACAG
TTCACTCTGCATAACAACAT

Downstream 100 bases:

>100_bases
GCAGGAATATTGGTACGCTGCTGATCGCGCTGGTCGTGGCGCTGGTGATCCTGAGCGGAAGCATGTACACGGTCGACCAG
CGGCAGAACGCGCTGGTGTT

Product: HflK

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MAWNDPQWGNKGNRNNSGPPDLDELWRRLNQRLGGMFGNRSPRGGGGGDGLPSNMPGGGNFVGLLIGALVMIWIASGFYI
VDTGQRGVVLRFGKYVETTDPGPRWHLPWPIESREMVNVDQVRTVEIGYRNNVRSKVLKESLMLTDDENIIDLQFAVQYI
LKDPQDFLFINRAPEDTVLQVAETAMREIVGKNKMDYVLYEGRADIAARAKLLMQQILDRYKTGISISQVTLQNIQPPEQ
VQAAFDDAVKAGQDRERLKNEAEAYSNDVVPRARGLASRLKEEAEGYKLAVIANAQGEASRFAQILDEYQKAPQVTRQRL
YLDTMQTVMNNSSKVLVDQKGGNSLLYLPLDKLQQIVGQPGSALPEALGSPTAAPPAAAARTRDSLGGRDREERP

Sequences:

>Translated_395_residues
MAWNDPQWGNKGNRNNSGPPDLDELWRRLNQRLGGMFGNRSPRGGGGGDGLPSNMPGGGNFVGLLIGALVMIWIASGFYI
VDTGQRGVVLRFGKYVETTDPGPRWHLPWPIESREMVNVDQVRTVEIGYRNNVRSKVLKESLMLTDDENIIDLQFAVQYI
LKDPQDFLFINRAPEDTVLQVAETAMREIVGKNKMDYVLYEGRADIAARAKLLMQQILDRYKTGISISQVTLQNIQPPEQ
VQAAFDDAVKAGQDRERLKNEAEAYSNDVVPRARGLASRLKEEAEGYKLAVIANAQGEASRFAQILDEYQKAPQVTRQRL
YLDTMQTVMNNSSKVLVDQKGGNSLLYLPLDKLQQIVGQPGSALPEALGSPTAAPPAAAARTRDSLGGRDREERP
>Mature_394_residues
AWNDPQWGNKGNRNNSGPPDLDELWRRLNQRLGGMFGNRSPRGGGGGDGLPSNMPGGGNFVGLLIGALVMIWIASGFYIV
DTGQRGVVLRFGKYVETTDPGPRWHLPWPIESREMVNVDQVRTVEIGYRNNVRSKVLKESLMLTDDENIIDLQFAVQYIL
KDPQDFLFINRAPEDTVLQVAETAMREIVGKNKMDYVLYEGRADIAARAKLLMQQILDRYKTGISISQVTLQNIQPPEQV
QAAFDDAVKAGQDRERLKNEAEAYSNDVVPRARGLASRLKEEAEGYKLAVIANAQGEASRFAQILDEYQKAPQVTRQRLY
LDTMQTVMNNSSKVLVDQKGGNSLLYLPLDKLQQIVGQPGSALPEALGSPTAAPPAAAARTRDSLGGRDREERP

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=397, Percent_Identity=38.7909319899244, Blast_Score=233, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR020980
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7; PF12221 HflK_N [H]

EC number: NA

Molecular weight: Translated: 43793; Mature: 43662

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAWNDPQWGNKGNRNNSGPPDLDELWRRLNQRLGGMFGNRSPRGGGGGDGLPSNMPGGGN
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
FVGLLIGALVMIWIASGFYIVDTGQRGVVLRFGKYVETTDPGPRWHLPWPIESREMVNVD
HHHHHHHHHHHHHHHCCCEEEECCCCCEEEEECCEEECCCCCCCCCCCCCCCCCCCCCCC
QVRTVEIGYRNNVRSKVLKESLMLTDDENIIDLQFAVQYILKDPQDFLFINRAPEDTVLQ
CEEEEEECCCCCHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHCCCCEEEEECCCCHHHHH
VAETAMREIVGKNKMDYVLYEGRADIAARAKLLMQQILDRYKTGISISQVTLQNIQPPEQ
HHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHH
VQAAFDDAVKAGQDRERLKNEAEAYSNDVVPRARGLASRLKEEAEGYKLAVIANAQGEAS
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCHH
RFAQILDEYQKAPQVTRQRLYLDTMQTVMNNSSKVLVDQKGGNSLLYLPLDKLQQIVGQP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECHHHHHHHHCCC
GSALPEALGSPTAAPPAAAARTRDSLGGRDREERP
CCHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
AWNDPQWGNKGNRNNSGPPDLDELWRRLNQRLGGMFGNRSPRGGGGGDGLPSNMPGGGN
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
FVGLLIGALVMIWIASGFYIVDTGQRGVVLRFGKYVETTDPGPRWHLPWPIESREMVNVD
HHHHHHHHHHHHHHHCCCEEEECCCCCEEEEECCEEECCCCCCCCCCCCCCCCCCCCCCC
QVRTVEIGYRNNVRSKVLKESLMLTDDENIIDLQFAVQYILKDPQDFLFINRAPEDTVLQ
CEEEEEECCCCCHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHCCCCEEEEECCCCHHHHH
VAETAMREIVGKNKMDYVLYEGRADIAARAKLLMQQILDRYKTGISISQVTLQNIQPPEQ
HHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHH
VQAAFDDAVKAGQDRERLKNEAEAYSNDVVPRARGLASRLKEEAEGYKLAVIANAQGEAS
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCHH
RFAQILDEYQKAPQVTRQRLYLDTMQTVMNNSSKVLVDQKGGNSLLYLPLDKLQQIVGQP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECHHHHHHHHCCC
GSALPEALGSPTAAPPAAAARTRDSLGGRDREERP
CCHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]