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The map label for this gene is ubiA

Identifier: 74316481

GI number: 74316481

Start: 486065

End: 486946

Strand: Reverse

Name: ubiA

Synonym: Tbd_0463

Alternate gene names: 74316481

Gene position: 486946-486065 (Counterclockwise)

Preceding gene: 74316482

Following gene: 74316476

Centisome position: 16.73

GC content: 65.19

Gene sequence:

>882_bases
ATGACACTTACCGAGCGTCTCTCGCTTTACGAAAAACTGGCGCGGCTGGACAAGCCGATCGGCATCCTGCTCCTGCTCTG
GCCGACGCTGTGGGCGCAATGGCTCGCGAGCAACGGCGACCCGGACTGGCTGATCCTGTGGATTTTCGTCATGGGCGTCG
TGCTGATGCGGTCCGCGGGCTGCGTCGTCAACGATTACGCGGATCGGGATTTCGACCCGCACGTCGCGCGCACGCGCGAC
CGCCCGATCGCTGCTGGCAAGGTGTCACCGAAGGAAGCGCTGCTGCTCGCCGCCGGCCTGTCGCTGCTCGCGTTTCTGCT
GATCCTGCCCTTGAATGCGCTGGTGCTGAAGCTTTCGCTCATCGCGCTGTTTCTTGCCGGGAGCTATCCCTTCACGAAAC
GCTTCTTTGCGATCCCCCAGGCCTATCTCGGCGTCGCGTTCGGCTTCGGCATCCCGATGAGCTACGCGGCGCTGTGGGGC
GAGGTGCCGGCCGAGGCCTGGCTCCTGCTGGCGGCAAACGTGTTCTGGGCGATCGCGTACGACACCGAGTACGCGATGGT
CGACCGTGCGGACGATCTCAAGATCGGCATCAAGACCTCCGCGATCACGTTCGGCCGCTTCGATCTCACGGCGATCGCCT
TCTGTTATGCCGCGACGCTCGCACTGCTCGCCTGGGTCGGTGCGCTGCGCGACTTCAGCGGCTGGTATTACGCGGGGCTG
GCGGCGGCCGGAGCGATCGCCGTCTATCACCTGCGGCTGATCCGGGAGCGCGATCCCCGCCAATGCTTCCGCGCGTTCCT
GCACAACACCTGGTTCGGCGCCGCGGTCTTCGGCGGCATCGTTCTTCACTTCCTGCTGCGCTCCGGCTCCCTTTTTCCGT
AG

Upstream 100 bases:

>100_bases
AGGTCGCCGAGCGCGCACTGTGGGCGCGGCGCTCGGTATTTTGCCTGGACGGCCACCCACTGCTGGTCAGTGAAGTCTTT
TTGCCCGCCCTATTAACGCC

Downstream 100 bases:

>100_bases
CCCCGCTTCAGCGCGGACAGGCGATGCGCGACTGCTGGCTGTTGGGATACGCCTGCCTGATCGCGCCGAGGTCTTTCAGC
GTGTCGGGATCGTCGCTGCG

Product: 4-hydroxybenzoate octaprenyltransferase

Products: NA

Alternate protein names: 4-HB polyprenyltransferase

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MTLTERLSLYEKLARLDKPIGILLLLWPTLWAQWLASNGDPDWLILWIFVMGVVLMRSAGCVVNDYADRDFDPHVARTRD
RPIAAGKVSPKEALLLAAGLSLLAFLLILPLNALVLKLSLIALFLAGSYPFTKRFFAIPQAYLGVAFGFGIPMSYAALWG
EVPAEAWLLLAANVFWAIAYDTEYAMVDRADDLKIGIKTSAITFGRFDLTAIAFCYAATLALLAWVGALRDFSGWYYAGL
AAAGAIAVYHLRLIRERDPRQCFRAFLHNTWFGAAVFGGIVLHFLLRSGSLFP

Sequences:

>Translated_293_residues
MTLTERLSLYEKLARLDKPIGILLLLWPTLWAQWLASNGDPDWLILWIFVMGVVLMRSAGCVVNDYADRDFDPHVARTRD
RPIAAGKVSPKEALLLAAGLSLLAFLLILPLNALVLKLSLIALFLAGSYPFTKRFFAIPQAYLGVAFGFGIPMSYAALWG
EVPAEAWLLLAANVFWAIAYDTEYAMVDRADDLKIGIKTSAITFGRFDLTAIAFCYAATLALLAWVGALRDFSGWYYAGL
AAAGAIAVYHLRLIRERDPRQCFRAFLHNTWFGAAVFGGIVLHFLLRSGSLFP
>Mature_292_residues
TLTERLSLYEKLARLDKPIGILLLLWPTLWAQWLASNGDPDWLILWIFVMGVVLMRSAGCVVNDYADRDFDPHVARTRDR
PIAAGKVSPKEALLLAAGLSLLAFLLILPLNALVLKLSLIALFLAGSYPFTKRFFAIPQAYLGVAFGFGIPMSYAALWGE
VPAEAWLLLAANVFWAIAYDTEYAMVDRADDLKIGIKTSAITFGRFDLTAIAFCYAATLALLAWVGALRDFSGWYYAGLA
AAGAIAVYHLRLIRERDPRQCFRAFLHNTWFGAAVFGGIVLHFLLRSGSLFP

Specific function: Synthesis of 3-octaprenyl-4-hydroxybenzoate

COG id: COG0382

COG function: function code H; 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family

Homologues:

Organism=Homo sapiens, GI260656052, Length=282, Percent_Identity=37.5886524822695, Blast_Score=168, Evalue=5e-42,
Organism=Escherichia coli, GI1790473, Length=284, Percent_Identity=50.7042253521127, Blast_Score=268, Evalue=4e-73,
Organism=Escherichia coli, GI1786631, Length=247, Percent_Identity=27.1255060728745, Blast_Score=68, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17553718, Length=285, Percent_Identity=36.4912280701754, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI32565247, Length=286, Percent_Identity=34.6153846153846, Blast_Score=141, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17553720, Length=345, Percent_Identity=29.5652173913043, Blast_Score=100, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI32565245, Length=141, Percent_Identity=41.8439716312057, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI32565243, Length=137, Percent_Identity=41.6058394160584, Blast_Score=88, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6324370, Length=286, Percent_Identity=31.4685314685315, Blast_Score=127, Evalue=2e-30,
Organism=Drosophila melanogaster, GI21355567, Length=282, Percent_Identity=37.2340425531915, Blast_Score=169, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIA_THIDA (Q3SLJ4)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_314221.1
- STRING:   Q3SLJ4
- GeneID:   3673096
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_0463
- NMPDR:   fig|292415.3.peg.24
- eggNOG:   COG0382
- HOGENOM:   HBG324383
- OMA:   YHYTLIR
- PhylomeDB:   Q3SLJ4
- BioCyc:   TDEN292415:TBD_0463-MONOMER
- HAMAP:   MF_01635
- InterPro:   IPR006370
- InterPro:   IPR000537
- TIGRFAMs:   TIGR01474

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 32456; Mature: 32324

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1f82fdcc)-; HASH(0x2097cfb4)-; HASH(0x1fb7b1f0)-; HASH(0x1fff353c)-; HASH(0x2097cda4)-; HASH(0x1fe6e99c)-; HASH(0x2097cc78)-; HASH(0x2063d6a8)-;

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLTERLSLYEKLARLDKPIGILLLLWPTLWAQWLASNGDPDWLILWIFVMGVVLMRSAG
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC
CVVNDYADRDFDPHVARTRDRPIAAGKVSPKEALLLAAGLSLLAFLLILPLNALVLKLSL
CEEECCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IALFLAGSYPFTKRFFAIPQAYLGVAFGFGIPMSYAALWGEVPAEAWLLLAANVFWAIAY
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHEEEE
DTEYAMVDRADDLKIGIKTSAITFGRFDLTAIAFCYAATLALLAWVGALRDFSGWYYAGL
CCCCHHHCCCCCCEEEEEECEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
AAAGAIAVYHLRLIRERDPRQCFRAFLHNTWFGAAVFGGIVLHFLLRSGSLFP
HHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCH
>Mature Secondary Structure 
TLTERLSLYEKLARLDKPIGILLLLWPTLWAQWLASNGDPDWLILWIFVMGVVLMRSAG
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC
CVVNDYADRDFDPHVARTRDRPIAAGKVSPKEALLLAAGLSLLAFLLILPLNALVLKLSL
CEEECCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IALFLAGSYPFTKRFFAIPQAYLGVAFGFGIPMSYAALWGEVPAEAWLLLAANVFWAIAY
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHEEEE
DTEYAMVDRADDLKIGIKTSAITFGRFDLTAIAFCYAATLALLAWVGALRDFSGWYYAGL
CCCCHHHCCCCCCEEEEEECEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
AAAGAIAVYHLRLIRERDPRQCFRAFLHNTWFGAAVFGGIVLHFLLRSGSLFP
HHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA